الصفحة 4
الصفحة 4
Hubble : 15 Years of Discovery
This book forms part of the European Space Agency’s 15th anniversary celebration activities for the 1990 launch of the NASA/ESA Hubble Space Telescope. As an observatory in space, Hubble is one of the most successful scientific projects of all time, both in terms of scientific output and its immediate public appeal.Hubble creates an enormous impact by exploiting a unique scientific niche where no other instruments can compete. It consistently delivers super-sharp images and clean, uncontaminated spectra over the entire near-infrared and ultraviolet regions of the electromagnetic spectrum. This has opened up new scientific territory and resulted in many paradigm-breaking discoveries.
High-Resolution Approaches in Stratigraphic Paleontology
This volume delves into a spectrum of theoretical as well as applied aspects of high-resolution stratigraphic approaches in paleontology. It explores how increasingly detailed knowledge of the fossil record can enhance our understanding of the evolution of life on Earth and also allows geoscientists to address a broad range of important evolutionary and environmental questions in this arena.
High-Latitude Bioerosion : The Kosterfjord Experiment
Bioerosion is the major force driving the degradation of marine skeletal carbonates and limestone coasts. A wide spectrum of mechanical and/or chemical boring, scraping or crushing organisms break down calcereous substrates, comprising various grazers, macroborers and especially microborers. Their traces on and within hard substrates are known from fossil carbonates as old as the Precambrian and serve as valuable palaeoenvironmental indicators. Bioerosion processes have been extensively studied in tropical seas, while corrsponding investigations from cold-temperate to polar settings remain sparse. For the first time, an experimental study yields insight into the pace of carbonate degradation and the chronology of boring community development along a bathymetric gradient in a high-latitude setting.
Hepatitis C virus-host interactions and therapeutics : Current insights and future perspectives
The burden of hepatitis C virus (HCV) infection on the public health care system continues to remain significant despite the remarkable progress made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored. Researchers and scientists still strive to understand virus-host interactions to map the disease’s progression along with extrahepatic manifestations and virus invasion strategies impacting the host’s immune system. This book briefly discusses the biology of HCV infection, virus-host interactions, molecular epidemiology of the infection, and the full spectrum of immune responses to hepatitis C. It also provides in-depth information about HCV, clinical diagnostics, and therapeutic knowledge to all stakeholders involved in HCV screening, diagnosis, treatment, and management.
Hepatitis C Virus Disease
Emphasizes the most recent advances on the Hepatitis C virus infection (HCV) moving from basic research to clinical application. In spite of the numerous studies on HCV infection, its pathogenesis and medical treatment have not been fully explained. The first chapters of this volume analyize the full spectrum of immune responses to HCV taking into account either innate or adoptive immunity involvement. The volume also includes a series of contributions which explain the state of art of IFN-alpha treatment in HCV patients and the effectiveness of therapy also in relation to HCV genotypes. The use and applications of pegylated IFNs will also be discussed as well as the complicated HCV disease and its treatment. Hepatitis C Virus Disease: Immunobiology and Clinical Applications is an ideal volume for researchers, scientists, professionals, clinicians, physicians and graduate students in the fields of infectious disease, immunology, virology, microbiology, pharmacology and medicine.
Hedgehog-Gli Signaling in Human Disease
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Handbook of pharmaceutical wet granulation : Theory and practice in a quality by design paradigm
Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm offers a single and comprehensive reference dedicated to all aspects of pharmaceutical wet granulation, taking a holistic approach by combining introductory principles with practical solutions. Chapters are written by international experts across industry, academic and regulatory settings, and cover a wide spectrum of relevant and contemporary wet granulation topics, techniques and processes. The books' focus on process analytical technology, quality by design principles, granulation equipment, modeling, scale-up, control and real time release makes it a timely and valuable resource for all those involved in pharmaceutical wet granulation.
Handbook of pharmaceutical manufacturing formulations ; Vol.6 : Sterile products
An authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this six-volume set compiles data from FDA new drug applications, patent applications, and other sources of generic and proprietary formulations to cover the broad spectrum of GMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent
Handbook of pharmaceutical manufacturing formulations ; Vol.5 : Over-the-counter products
An authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this six-volume set compiles data from FDA new drug applications, patent applications, and other sources of generic and proprietary formulations to cover the broad spectrum of GMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent
Handbook of pharmaceutical manufacturing formulations ; Vol.4 : Semisolid products
An authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this six-volume set compiles data from FDA new drug applications, patent applications, and other sources of generic and proprietary formulations to cover the broad spectrum of GMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent
Handbook of pharmaceutical manufacturing formulations ; Vol.3 : Liquid products
An authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this six-volume set compiles data from FDA new drug applications, patent applications, and other sources of generic and proprietary formulations to cover the broad spectrum of GMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent
Handbook of pharmaceutical manufacturing formulations ; Vo.1 : Compressed solid products
An authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this first volume of a six-volume set, compiles data from FDA new drug applications, patent applications, and other sources of generic and proprietary formulations to cover the broad spectrum of GMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent
Handbook of paleoanthropology ; Vol I : Principles, methods and approaches Vol II : Primate evolution and human origins Vol III : Phylogeny of hominids
Paleoanthropology is perhaps the most multidisciplinary of all the sciences. The three volumes of this handbook bring together contributions by the world´s leading specialists that reflect the broad spectrum of modern paleoanthropology, thus presenting an indispensable resource for both professionals and students alike.
Handbook of Intellectual and Developmental Disabilities
Changes within the interdisciplinary field of intellectual and developmental disabilities are evolving at a rapid pace. Clinicians, academics, administrators, and a variety of mental health providers alike need easy-to-access, reliable information that enables them to stay abreast of the numerous advances in research, assessment, treatment, and service delivery within a real-world sociopolitical framework. To that end, the Handbook of Intellectual and Developmental Disabilities is an essential resource for any professional who works with this vulnerable population. This volume examines in detail the numerous advances in the field, summarizing major domains and emerging subspecialties into one eminently useful reference.
Handbook of Evidence-Based Therapies for Children and Adolescents : Bridging Science and Practice
Growing numbers of young people—some 10% to 20% of school-age populations—have mental health problems requiring intervention, and current policy initiatives identify evidence-based therapies as the most effective and relevant forms of treatment. By reviewing evidence-based treatments (EBTs) across a wide spectrum of conditions, the Handbook of Evidence-Based Therapies for Children and Adolescents: Bridging Science and Practice closes the gaps between children’s needs and services as well as those between research, training, and practice, Several EBT options, both proved and promising, are offered for each covered disorder and are bolstered by case examples, tables, and reference lists. Features include chapters on implementation issues such as diversity, family treatment, assessment strategies, and community settings, and step-by-step guidance for the researcher looking to gather empirical support for therapies.
Handbook of Epidemiology
Represents a comprehensive reference source on practical epidemiology. the handbook covers a very wide spectrum of problems and is a very good reference material.bridging the gap between standard textbooks of epidemiology and publications for specialists with a narrow focus on specific areas. It reviews the key issues, methodological approaches and statistical concepts pertinent to the field for which the reader seeks a detailed overview.
Group B Coxsackieviruses
This monograph reviews information published since 1997 on the group B coxsackieviruses (CVB), a large and important group of human enteroviruses. The CVB were discovered in the mid-20th century, during the search for other poliovirus types, and within a very few years of this discovery, the CVB had been implicated as causes of human myocarditis and pancreatitis. The study of the CVB is still inextricably linked with the fate of their well-known relatives, the polioviruses, for as poliovirus eradication proceeds around the world, the CVB emerge more prominently as the enteroviruses best suited for continuing studies in enteroviral molecular biology as well as understanding the mechanisms underlying enteroviral pathogenesis. This volume reviews and presents modern views on the spectrum of CVB biologies, from interaction of the virus with its receptor through replication, speciation, and induction of disease.
Graph theory, combinatorics and algorithms: interdisciplinary applications
focuses on discrete mathematics and combinatorial algorithms interacting with real world problems in computer science, operations research, applied mathematics and engineering. The book contains eleven chapters written by experts in their respective fields, and covers a wide spectrum of high-interest problems across these discipline domains.The chapters focus on "real world" applications, all of which will be of considerable interest across the areas of Operations Research, Computer Science, Applied Mathematics, and Engineering. These problems include Internet congestion control, high-speed communication networks, multi-object auctions, resource allocation, software testing, data structures, etc. In sum, this is a book focused on major, contemporary problems, written by the top research scholars in the field, using cutting-edge mathematical and computational techniques.
Glucose-6-phosphate dehydrogenase deficiency
Glucose-6-phosphate dehydrogenase deficiency, the most common enzyme deficiency worldwide, causes a spectrum of disease including neonatal hyperbilirubinemia, acute hemolysis, and chronic hemolysis. Persons with this condition also may be asymptomatic. This X-linked inherited disorder most commonly affects persons of African, Asian, Mediterranean, or MiddleEastern descent. Because acute hemolysis is caused by exposure to an oxidative stressor in the form of an infection, oxidative drug, or fava beans, treatment is geared toward avoidance of these and other stressors.
Globalization and Regional Economic Modeling
Globalization is affecting regional economies in a broad spectrum of aspects, from labor market conditions and development policies to climate change. To understand better how this works, we need both conceptual and methodological contributions. We need new schemes to organize our thinking, direct our attention, and frame thought experiments on the basis of which guidance may be offered. And we need methodological innovations that enable us to carry out studies and thought experiments at levels of spatial and temporal resolution and formal complexity adequate to capture and account for the phenomena that characterize globalization. The chapters of this volume, written by an international cast of eminent regional scientists, represent contributions of both types, in many cases introducing and demonstrating the use of new tools for analyzing and understanding enormous changes underway in regional economies around the world.
