الصفحة 4
الصفحة 4
Molecular Targeting in Oncology
In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice. The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more. Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.
Molecular Pharmacognosy
This book discusses the application of molecular biology in resource science and authentication of traditional Chinese medicine (TCM). It also reviews the latest developments in pharmacognosy, introduces new perspectives and insights, discusses the hotspots and focuses in the field of molecular pharmacognosy, and predicts new directions of study. In the last five years, the technologies and scope of molecular pharmacognosy have constantly expanded and evolved. As such, this new edition includes extra content, such as the molecular phylogeography of medicinal plants, functional genome of medicinal plants, and synthetic biology of active compounds. Elucidating the concept, theory, and methodology of molecular pharmacognosy, it promotes the full use of the newly developed technologies and methodologies within the framework of molecular pharmacognosy to solve problems in the field.
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
This book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies
Molecular Biology of Metal Homeostasis and Detoxification : From Microbes to Man
One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.
Molecular analyses : Medical genomics and proteomics
Methods for extraction, manipulation, and characterization of nucleic acids, peptides, and proteins have been rapidly developed. Extraction from a variety of tissues and samples have become routine and automated. Next generation sequencing (NGS) methods have been developed. This book focuses on medically-focused methods
Modern Sports Dentistry
A one-stop reference that will assist primary care community dentists, sports physicians, athletic trainers, and emergency room physicians in meeting the needs of athletes when managing facial and dental trauma and sports-related oral diseases. The opening chapters provide a complete review of sports-related dentoalveolar trauma, with coverage of emergent care, the role of endodontics, surgical issues, and restorative considerations. Prevention of dental trauma by means of mouthguards is then examined, with attention to materials and design, public policy concerning the use of mouthguards, and the role of mouthguards in relation to the ever more pressing issue of concussion in sport. Dental erosion in athletes, for example due to energy drinks, is discussed, as are the possible sequelae of use of spit tobacco, performance-enhancing drugs, and ergogenic aids. The new topic of the potential value of dental appliances in enhancing sports performance is also addressed.
Modern pharmaceutics
Covers the curriculum and syllabus developed by the Pharmacy Council of India, providing students with the necessary knowledge and skills required in the field of pharmaceutical services
Modern Multidimensional Scalin : Theory and Applications
The book provides a comprehensive treatment of multidimensional scaling (MDS), a family of statistical techniques for analyzing the structure of (dis)similarity data. This book may be used as an introduction to MDS for students in psychology, sociology, and marketing. The prerequisite is an elementary background in statistics. The book is also well suited for a variety of advanced courses on MDS topics. All the mathematics required for more advanced topics is developed systematically. This second edition adds some 140 pages of new material. Many chapters are revised or have sections reflecting new insights and developments in MDS. There are two new chapters, one on asymmetric models and the other on unfolding. There are also numerous exercises that help the reader to practice what he or she has learned, and to delve deeper into the models and its intricacies.
Modern Morphometrics in Physical Anthropology
Morphometrics has undergone a revolutionary transformation in the past two decades as new methods have been developed to address shortcomings in the traditional multivirate analysis of linear distances, angles, and indices. While there is much active research in the field, the new approaches to shape analysis are already making significant and ever-increasing contributions to biological research, including physical anthropology. Modern Morphometrics in Physical Anthropology highlights the basic machinery of the most important methods, while introducing novel extensions to these methods and illustrating how they provide enhanced results compared to more traditional approaches. Modern Morphometrics in Physical Anthropology provides a comprehensive sampling of the applications of modern, sophisticated methods of shape analysis in anthropology, and serves as a starting point for the exploration of these practices by students and researchers who might otherwise lack the local expertise or training to get started. This text is an important resource for the general morphometric community that includes ecologists, evolutionary biologists, systematists, and medical researchers.
Modern medicines from plants : Botanical histories of some of modern medicine’s most important drugs
Features information on plants from which we obtain modern prescription medicines. It outlines their historical uses as herbal medicines in the past two millennia, using primary sources, and describes how extracts from them, and their semisynthetic and synthetic derivatives, were developed to be today’s therapeutic drugs and diagnostic chemicals. This book describes medicinal plants and their habitats, the diseases that their medicines treat, and the science of how they work.
Modern Differential Geometry in Gauge Theories : Maxwell Fields ; Vol. I
Differential geometry, in the classical sense, is developed through the theory of smooth manifolds. Modern differential geometry from the author’s perspective is used in this work to describe physical theories of a geometric character without using any notion of calculus (smoothness). Instead, an axiomatic treatment of differential geometry is presented via sheaf theory (geometry) and sheaf cohomology (analysis). Using vector sheaves, in place of bundles, based on arbitrary topological spaces, this unique approach in general furthers new perspectives and calculations that generate unexpected potential applications .Volume 1, the focus is on Maxwell fields. All the basic concepts of this mathematical approach are formulated and used thereafter to describe elementary particles, electromagnetism, and geometric prequantization. Maxwell fields are fully examined and classified in the language of sheaf theory and sheaf cohomology.
Modern Circuit Placement : Best Practices and Results
This book has four unique characteristics. First, it focuses on the most recent highly scalable placement techniques used for multi-million gate circuit designs, with consideration of many practical aspects of modern circuit placement, such as density and routability control, mixed-size placement support, and area I/O support. Second the book addresses dominant techniques being used in the field. Although these tools are developed by academia, many core techniques in these tools are being used extensively in industry and represent today’s advanced placement techniques. Third, the book provides quantitative comparison among the various techniques on common benchmark circuits derived from real-life industrial designs. The book includes significant amounts of analysis on each technique, such as trade-offs between quality-of-results (QoR) and runtime. Finally, analysis of the optimality of the placement techniques is included.
Modern architecture and climate design before air conditioning
explores how leading architects of the twentieth century incorporated climate-mediating strategies into their designs, and shows how regional approaches to climate adaptability were essential to the development of modern architecture. Focusing on the period surrounding World War II'before fossil-fuel powered air-conditioning became widely available'Daniel Barber brings to light a vibrant and dynamic architectural discussion involving design, materials, and shading systems as means of interior climate control. He looks at projects by well-known architects such as Richard Neutra, Le Corbusier, Lúcio Costa, Mies van der Rohe, and Skidmore, Owings, and Merrill, and the work of climate-focused architects such as MMM Roberto, Olgyay and Olgyay, and Cliff May. Drawing on the editorial projects of James Marston Fitch, Elizabeth Gordon, and others, he demonstrates how images and diagrams produced by architects helped conceptualize climate knowledge, alongside the work of meteorologists, physicists, engineers, and social scientists. Barber describes how this novel type of environmental media catalyzed new ways of thinking about climate and architectural design.
Models of the Atomic Nucleus
Models of the Atomic Nucleus is a largely non-technical introduction to nuclear theory – an attempt to explain the nucleus in a way that makes nuclear physics as comprehensible as chemistry or cell biology. Unlike many other scientific fields, the "popularization" of nuclear physics has not previously been successful because many fundamental issues remain controversial and a unified theory of nuclear structure has not yet been established. The theme developed in this book is that the many models of nuclear theory each provide a partial perspective on the nucleus and that the many models can in fact be integrated into a coherent whole and expressed in terms of a lattice of nucleons.
Models in Cooperative Game Theory : Crisp, Fuzzy, and Multi-Choice Games
This book investigates the classical model of cooperative games with transfer able utility (TU-games) and models in which the players have the possibility to cooperate partially, namely fuzzy and multichoice games. In a crisp game the agents are either fully involved or not involved at all in cooperation with some other agents, while in a fuzzy game players are allowed to cooperate with infinitely many different participation levels, varying from non-cooperation to full cooperation. A multichoice game describes an intermediate case in which each player may have a fixed number of activity levels. Part I of the book is devoted to the most developed model in the theory of cooperative games, that of a classical TU-game with crisp coalitions, which we refer to as crisp game along the book. It presents basic notions, solutions concepts and classes of cooperative crisp games in such a way that allows the reader to use this part as a reference toolbox when studying the corresponding concepts from the theory of fuzzy games (Part II) and from the theory of multichoice games (Part III).
Modelling of Powder Die Compaction
In particular, the book presents a number of case studies that have been developed to test compaction models. Full details of the data required for input to compaction models of these case studies is given, together with a survey of the techniques used to generate the data. Details are also given of methods to produce and assess components for validation of die compaction models. The inclusion of information on case studies then provides a reference for the testing and validation of compaction models.
Modelling and Control of Mini-Flying Machines
Modelling and Control of Mini-Flying Machines is an exposition of models developed for various types of mini-aircraft. Modelling and Control of Mini-Flying Machines provides valuable insights to the application of real-time nonlinear techniques in an always challenging area.
Modeling Performance Measurement : Applications and Implementation Issues in DEA
MODELING PERFORMANCE MEASUREMENT: Applications and Implementation Issues in DEA presents unified results from authors’ recent DEA research. These new DEA methodology and techniques are developed in application-driven scenarios that go beyond the identification of the best-practice frontier and seek solutions to aid managerial decisions. These new DEA developments are well-grounded in real world applications. Both DEA researchers and practitioners will find this book helpful. Theory is provided for DEA researchers for further development and possible extensions. However, it should also be mentioned that each theory is presented in practical terms with numerical examples, simple real management cases and verbal descriptions. It is felt that these concrete examples will be of value to researchers, students, and practitioners , This book also provides an easy-to-use DEA software — DEAFrontier (www.deafrontier.com). This DEA software is an Add-In for Microsoft Excel and provides a custom menu of DEA approaches The DEAFrontier does not set limit on the number of units, inputs or outputs.
Model-Based Engineering of Collaborative Embedded Systems : Extensions of the SPES Methodology
This book presents the results of the "Collaborative Embedded Systems" (CrESt) project, aimed at adapting and complementing the methodology underlying modeling techniques developed to cope with the challenges of the dynamic structures of collaborative embedded systems (CESs) based on the SPES development methodology.
Model Reduction and Coarse-Graining Approaches for Multiscale Phenomena
Model reduction and coarse-graining are important in many areas of science and engineering. How does a system with many degrees of freedom become one with fewer? How can a reversible micro-description be adapted to the dissipative macroscopic model? These crucial questions, as well as many other related problems, are discussed in this book. Specific areas of study include dynamical systems, non-equilibrium statistical mechanics, kinetic theory, hydrodynamics and mechanics of continuous media, (bio)chemical kinetics, nonlinear dynamics, nonlinear control, nonlinear estimation, and particulate systems from various branches of engineering. The generic nature and the power of the pertinent conceptual, analytical and computational frameworks helps eliminate some of the traditional language barriers, which often unnecessarily impede scientific progress and the interaction of researchers between disciplines such as physics, chemistry, biology, applied mathematics and engineering. All contributions are authored by experts, whose specialities span a wide range of fields within science and engineering.
