الصفحة 4
الصفحة 4
Current Topics in Complement
Complement has been regarded as a pivotal effector arm of the innate immune response. Many scientists convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics, to discuss the advances in this field. This volume represents a collection of topics discussed during the conference.
Cough : Pathophysiology, diagnosis and treatment
This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understanding of the diagnostic workup of cough, still one of the most frequent and challenging symptoms in daily medical practice. The book also provides insights into cough’s features and pathogenesis, as well as into pharmacologic and non-pharmacologic treatments. The most frequent causes of chronic cough (asthma, postnasal drip, gastroesophageal reflux and chronic hypersensitivity syndrome) and different types of pediatric cough are also explored.
Coronaviruses : Methods and Protocols
Aims to describe a variety of techniques that reflects the wide range of research currently performed in the field of coronavirology, and begins with an overview of current understandings of coronavirus replication and pathogenesis to introduce specialists and non-specialists to the field. The rest of the book is divided into several sections of chapters beginning with those that describe identification, diagnosis, and study of the evolution of coronaviruses. The next few chapters discuss the preparation of cells and organ cultures useful in propagating coronaviruses and titration techniques, as well as techniques for analyzing virus functions that require purification of the viruses. The next chapters describe two commonly used reverse genetics techniques for coronaviruses, and techniques detailing identification of cellular receptors, binding profiles of viral attachment proteins, and virus-cell fusion. The final chapters cover a broad spectrum of techniques to identify virus-host protein-protein interactions, confirm the functional role of these proteins in virus replication, study host cell responses through genome-wide or pathway-specific approaches, and visualize virus replication complexes. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Coronavirus Replication and Reverse Genetics
This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.
Cornea and External Eye Disease : Corneal Allotransplantation, Allergic Disease and Trachoma
The 8 recurring volumes of the "Essentials in Ophthalmology" series cover the most recent developments in one of eight subspecialties in Ophthalmology.
Contrast Agent and Nephropathy
Diagnostic tests such as MRIs (magnetic resonance imaging), CT (Computed tomography) scans and angiograms are routinely used because they provide important information about many diseases or injuries and can help in diagnosis and treatment. In many cases, the use of a contrast dye is necessary to enhance these tests, but sometimes these dyes can either lead to kidney problems, or cause problems in patients with kidney disease. There are two rare but serious disorders associated with contrast dyes and the kidneys: contrast induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF).
Color Atlas of Chemical Peels
This book is the first atlas on chemical peels, representing the state of the art in this field. It is a fully illustrated text, becoming an ideal reference tool for dermatologists dealing with cosmetology. It is a practical and simple guide: in the first part the peeling techniques are displayed in a step-by-step manner with an exhaustive text supporting the illustrations; in the second part different diseases are discussed in their pathogenesis and treatment options.
Management of Complications in Refractive Surgery
This guide offers the reader practical pearls to the solution and prevention of the different complications of corneal and refractive surgery. All complications are described and lavishly illustrated from its pathogenesis to its treatment modalities.
Management of atopic dermatitis : Methods and challenges
This new edition builds upon the foundational knowledge covered in the first edition, covering the epidemiology, pathogenesis, and clinical presentation of atopic dermatitis in both pediatric and adult patients. It provides an overview of the mechanism and presentation of atopic dermatitis and focuses on the management methods experienced dermatologists have used to successfully manage atopic dermatitis. The book includes new chapters describing the special considerations for atopic dermatitis in skin of color patients, dedicated chapters on topical and oral prescription management reflected the latest FDA-approved treatments, and also a chapter covering the updated guidelines from the American Academy of Dermatology. A final chapter includes updates on the future of atopic dermatitis treatment.
Malignant Mesothelioma : Pathogenesis, Diagnosis, and Translational Therapies
(Review from JAMA) Malignant mesothelioma is an uncommon neoplasm usually associated with exposure to asbestos. Because of its low incidence, thorough reviews of the topic are hard to find. Harvey Pass and colleagues have edited an up-to-date, comprehensive book that includes a wide range of information, from a historical perspective to descriptions of the latest treatment. The authors . . . have written chapters on the carcinogenesis, molecular genetics, and clinical aspects of mesothelioma. Malignant Mesothelioma is suitable for a broad audience. Laboratory researchers will use it as a resource for information about the pathogenesis, animal models, molecular genetics, and cell lines of mesothelioma. . . . Clinicians will benefit from this complete guide to the presentation, prognosis, imaging, and treatment of the disease. I highly recommend this book to all who are interested in mesothelioma.
Macular Degeneration
Macular Degeneration: Science and Medicine in Practice provides a unique overview of current thinking in the pathogenesis, incidence and treatment of AMD. It includes, for the first time, a synthesis of the views of the world's leading scientists and practitioners regarding retinal biology, basic mechanisms, clinical and pathogenetic processes, and rational approaches to intervention.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lung biology and pathophysiology
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
Liver carcinogenesis : Methods and protocols
Discusses the latest advancements in modern methodologies used to study liver carcinogenesis. The first half of this book describes pertinent preclinical models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), established either through orthotopic induction of ectopic implantation. The second half of this book covers a diverse array of techniques applied to characterize the biochemical and cellular composition of hepatic malignancies that operate at the single-cell and histological levels. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Listeria Monocytogenes : Pathogenesis and Host Response
This comprehensive volume, written by experts in the field, includes concise and timely reviews of Listeria monocytogenes, one of the most intensively studied bacterial pathogens. Listeria monocytogenes is the cause of listeriosis, a potentially fatal disease that arises from the consumption of contaminated food. During the past two decades, studies of this organism have uncovered a wealth of information on its virulence factors, its genome organization, and its interactions with host cells and the immune system.
Lindhe's Clinical Periodontology and Implant Dentistry ; 2 Vol. Set ; 7th ed.
Provides an introduction to anatomy, including periodontal tissues, the edentulous ridge, the mucosa at teeth and implants, and osseointegration Discusses the epidemiology of periodontal and peri-implant diseases Explores the microbiology, including dental biofilms and calculus, periodontal infections, peri-implant infections, the pathogenesis of gingivitis and periodontitis, and the genetic susceptibility to periodontal disease Includes the latest perio- and peri-implant disease classifications Contains updated evidence-based preventive and treatment modalities for the treatment of periodontal and peri-implant diseases Features the latest evidence-based therapeutic alternatives on the use of dental implants to rehabilitate the lost dentition
Legionella Pneumophila : Pathogenesis and Immunity
Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. The volume brings together all of the lastest research on this pathogen, the interest in which is rapidly growing.
Kindling 6
A broad array of themes concerned with research on epilepsy and kindling is covered in the book: Pathogenesis of kindling, including developmental patterns; electrophysiology; anatomy, morphology, and neural circuitry; genes, species, and strains; synaptic pharmacology and neurochemistry ; Behavioral consequences of kindling ; Drugs and interventions against kindling ; Clinical relevance of kindling for our understanding of epilepsy in patients
Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.
Cigarette Smoke and Oxidative Stress
From a public health point of view, there is little doubt that one of the most important preventable causes of disease worldwide is tobacco smoking. From a scientifc point of view, we found it of interest to make a comprehensive ov- view of what we presently know about oxidative stress and tobacco smoke, because sm- ing is presently the best-known common condition associated with oxidative stress, and it may serve as a model for others. To this end, we have asked distinguished researchers from the public and the private sectors to evaluate the present scientifc status in their particular area. Authors were selected purely because of their scientifc merits.
