الصفحة 4
الصفحة 4
Metastasis of Breast Cancer
The book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies.
Metaphor and Analogy in Science Education
This book brings together powerful ideas and new developments from internationally recognised scholars and classroom practitioners to provide theoretical and practical knowledge to inform progress in science education. This is achieved through a series of related chapters reporting research on analogy and metaphor in science education. Throughout the book, contributors not only highlight successful applications of analogies and metaphors, but also foreshadow exciting developments for research and practice. Themes include metaphor and analogy: best practice, as reasoning; for learning; applications in teacher development; in science education research; philosophical and theoretical foundations. Accordingly, the book is likely to appeal to a wide audience of science educators –classroom practitioners, student teachers, teacher educators and researchers.
Metamorphoses of Hamiltonian Systems with Symmetries
Modern notions and important tools of classical mechanics are used in the study of concrete examples that model physically significant molecular and atomic systems. The parametric nature of these examples leads naturally to the study of the major qualitative changes of such systems (metamorphoses) as the parameters are varied. The symmetries of these systems, discrete or continuous, exact or approximate, are used to simplify the problem through a number of mathematical tools and techniques like normalization and reduction. The book moves gradually from finding relative equilibria using symmetry, to the Hamiltonian Hopf bifurcation and its relation to monodromy and, finally, to generalizations of monodromy.
Metaheuristics for Scheduling in Distributed Computing Environments
This volume presents meta-heuristics approaches for Grid scheduling problems. Due to the complex nature of the problem, meta-heuristics are primary techniques for the design and implementation of efficient Grid schedulers. The volume brings new ideas, analysis, implementations and evaluation of meta-heuristic techniques for Grid scheduling, which make this volume novel in several aspects. The 13 chapters of this volume have identified several important formulations of the problem, which we believe will serve as a reference for the researchers in the Grid computing community.
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Mediterranean Island Landscapes : Natural and Cultural Approaches
Mediterranean islands exhibit many similarities in their biotic ecological, physical and environmental characteristics. There are also many differences in terms of their human colonization and current anthropogenic pressures. This book addresses in three sections these characteristics and examines the major environmental changes that the islands experienced during the Quaternary period. The first section provides details on natural and cultural factors which have shaped island landscapes. It describes the environmental and cultural changes of the Holocene and their effects on biota, as well as on the current human pressures that are now threats to the sustainability of the island communities. The second section focuses on the landscapes of the largest islands namely Sicily, Sardinia, Corsica, Cyprus, Crete, Malta and the Balearics. Each island chapter includes a special topic reflecting a particular characteristic of the island. Part three presents strategies for action towards sustainability in Mediterranean islands and concludes with a comparison between the largest islands.
Medical Malpractice : A Physician's Sourcebook
In Medical Malpractice: A Physician's Sourcebook, a panel of physicians, attorneys, academics, researchers, and insurance industry experts consider these and other questions about the origin, nature, and ramifications of the medical malpractice litigation crisis, as well as possible solutions and alternatives to the current system. The authors focus on the clinical face of litigation from the perspective of the practicing physician in a variety of specialties, ranging from family and emergency medicine to anesthesiology, obstetrics, gynecology, and plastic surgery. Special consideration is given to breast cancer and Pap smear litigation, risk management for the family physician, and the importance of effective patient communication.. Authoritative and wide-ranging, Medical Malpractice: A Physician's Sourcebook gets to the heart of issues facing physicians and surgeons today. It focuses on the practical aspects of medical malpractice lawsuits, and prepares physicians and surgeons to participate in the public policy debate by addressing current topics that will help them understand the crisis, the threat to healthcare access, and the possibilities for legal reform.
Mechanics and natural philosophy before the scientific revolution
This volume deals with a variety of moments in the history of mechanics when conflicts arose within one textual tradition, between different traditions, or between textual traditions and the wider world of practice. Its purpose is to show how the accommodations sometimes made in the course of these conflicts ultimately contributed to the emergence of modern mechanics.
Means, Ends and Medical Care
In this remarkable book, Gary Wright brings his thirty years of experience as a physician in pediatric and family medicine together with his Ph.D. in philosophy to address the important problem of the nature of good medical reasoning. Wright gives a brilliant analysis of the complex internal structure of our concepts of health and disease, showing that our present models are wholly incapable of dealing with the realities of actual human disease. He then shows the error of assuming that we always know in advance what the medical and moral ends are for any medical situation. This leads to a radical questioning of so-called "rational actor" or "economic" models of rationality that are popular in medicine today.
Meaning in Action : Constructions, Narratives, and Representations
are far from genetically ? xing what behavioral preferences they may possess. Instead, learning mechanisms offer a ? exible way of attaining locally important cultural knowledge within temporal windows of opportunity as has been convi- ingly shown by research in language and culture attainment. Similar mechanisms are likely to exist for other social capacities, such as mate preferences, for example. It is this role of our biological inheritance that social science must appreciate in order to furnish a more complete understanding of human behavior. Within the natural range of variation of capacities and armed with biologically conditioned learning mechanisms we live out lives of meaning – in which we hold some things to be real, rational, valuable or morally right, and others not. It is this world of meaning in which we ? nd love and hate, struggles for justice, power, and money, and the dramas that lend to life both its depth and passion.
Maturing Usability : Quality in Software, Interaction and Value
Divided into three parts, ‘Quality in Software’ looks at how using development tools can enhance usability of a system, and how methods and models can be integrated into the development process to produce effective user interfaces. ‘Quality in Interaction’ addresses theoretical frameworks on the nature of interactions; techniques and metrics for evaluation interaction quality; and the transfer of concepts and methods from research to practice. Finally, ‘Quality in Value’ assesses the impact that a system has in the real world, focusing on increasing the value of usability practice for software development and on increasing value for the users.
Mathematics and the Historians Craft : The Kenneth O. May Lectures
Mathematical practitioners, for pedagogical reasons or to contextualize the work, tend to focus on finding the antecedents for current mathematical theories in a search for how particular subdisciplines and results came to be as they are today. On the other hand, historians of mathematics bypass the current state of affairs, and are more interested in questions that bear on the changing nature of the discipline itself.
Mathematical Models of Distribution Channels
In Chapters 1 and 2 the authors provide an introduction to the current, analytical literature on distribution channels, and they present an intuitively appealing prologue to the Channel Myths that are developed rigorously in later Chapters. In Chapters 3, 4, and 10 they extend the literature by ascertaining the relationship between the manufacturer-optimal wholesale-price strategy and channel breadth. Specific analyses include multiple, non-competing retailers, multiple states-of-nature, and multiple, competing retailers. In Chapters 5-7 the authors determine the profitability of various wholesale-price strategies; this analysis culminates in Chapters 8 and 9 with the determination of the (very limited) conditions under which channel coordination can be optimal for the manufacturer. In Chapter 11 they prove that existing methods of measuring the effect of a change in the degree of inter-retailer substitutability are totally misleading. They then develop an original, theoretical basis for measuring the impact of a change in the degree of inter-retailer substitutability that yields insightful, intuitively appealing results. In Chapter 12 the authors set forth an agenda for future research based on a meta-model that embraces all existing models in the literature. They also issue an appeal for creation of a "Unifying Theory of Distribution Channels" that will enable researchers to work independently and yet to contribute toward the common goal of deepening the marketing science professions’ understanding of distribution channels.
Islamic banking and finance
Explores the nature and role of money in modern economies and elaborates on the process of credit deposit creation, trade cycles and instruments for the creation of value in financial markets through the perspectives of Islamic finance. The author explains its characteristics, especially the rationale for the lack of interest-based financial activities. He examines the intrinsic ethical and humanistic frameworks that govern financial theories and practices and the models for the creation of value, risk-sharing and socially responsible investing, as well as the governance and regulation that these systems follow. The author also does a comparative assessment of conventional financial systems with Islamic finance with relevant examples, assesses the performance of Islamic systems and examines existing and expanding markets for Islamic finance.
Investigations Into the Phenomenology and the Ontology of the Work of Art : What are Artworks and How Do We Experience Them?
This book investigates the nature of aesthetic experience and aesthetic objects. Written by leading philosophers, psychologists, literary scholars and semioticians, the book addresses two intertwined issues. The first is related to the phenomenology of aesthetic experience: The understanding of how human beings respond to artworks, how we process linguistic or visual information, and what properties in artworks trigger aesthetic experiences. The examination of the properties of aesthetic experience reveals essential aspects of our perceptual, cognitive, and semiotic capacities. The second issue studied in this volume is related to the ontology of the work of art: Written or visual artworks are a specific type of objects, containing particular kinds of representation which elicit a particular kind of experience.
Introduction to Data Envelopment Analysis and Its Uses : With DEA-Solver Software and References
Recent years have seen a great variety of applications of DEA (Data Envelopment Analysis) for use in evaluating the performances of many different kinds of entities engaged in many different activities in many different contexts in many different countries. One reason is that DEA has opened up possibilities for use in cases which have been resistant to other approaches because of the complex (often unknown) nature of the relations between multiple inputs and multiple outputs involved in many of these activities (which are often reported in non-commeasurable units). It provide a systematic introduction to DEA and its uses as a multifaceted tool for evaluating problems in a variety of contexts.
Introduction to Cryptography : Principles and Applications
In the first part, this book covers the key concepts of cryptography on an undergraduate level, from encryption and digital signatures to cryptographic protocols. In the second part, more advanced topics are addressed, such as the bit security of one-way functions and computationally perfect pseudorandom bit generators.
International Actors and the Formation of Laws
This book addresses the discourse that creates, modifies, and reshapes the law, as well as discourse participants. The book focuses on the actors operating in legal regimes and their subtly, bluntly, or even outright aggressive impact on the formation of laws. As the book examines the intersection of domestic, European, international, and even transnational, legal regimes where new law emerges as a product of this discourse, it contributes to the understanding of the mobility of law and contemporary law’s interactive nature. This book provides enlightening examples of diverse legal fields influenced by international, non-domestic actors. It covers a wide range of relevant topics, from financial sanctions to the rights of indigenous peoples, and addresses actors ranging from the European Union and the European Court of Human Rights to disability organizations. By exploring actors, the book stresses their objectives and driving forces behind their efforts to influence law. The book reveals an array of diverging methods used by international actors to influence law. Additionally, the book resonates with Nordic legal tradition and highlights Nordic commitment to rule of law and equality.
Interior Design Concept : Critical Practices, Processes and Explorations in Interior Architecture and Design
Combines a comprehensive introduction to design concept, with a reflective examination upon the various ways it can be understood, harnessed, and implemented. Within interior architecture and design, the power of conceptual thinking to fuel creativity, innovation, and collaboration is evident in the use of design concept. Broadly accepted as an essential component in the design process, design concept is a notoriously elusive topic which has, until now, received little critical attention. This book offers a reevaluation of current academic ideas about design methodologies and the nature of inspiration, alongside brand-new data from an international research study to help clarify what creativity really means in the modern world.
Interactive Curve Modeling : With Applications to Computer Graphics, Vision and Image Processing
Interactive curve modeling techniques and their applications are extremely useful in a number of academic and industrial settings, and specifically play a significant role in multidisciplinary problem solving, such as in font design, designing objects, CAD/CAM, medical operations, scientific data visualization, virtual reality, character recognition, and object recognition, etc. Various problems such as iris, fingerprint, and signature recognition, can also be intelligently solved and automated using curve techniques.
