الصفحة 4
الصفحة 4
Neonatal Immunity
New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
Nearest Neighbor Search : A Database Perspective
Modern applications are both data and computationally intensive and require the storage and manipulation of voluminous traditional (alphanumeric) and nontraditional data sets (images, text, geometric objects, time-series). Examples of such emerging application domains are: Geographical Information Systems (GIS), Multimedia Information Systems, CAD/CAM, Time-Series Analysis, Medical Information Sstems, On-Line Analytical Processing (OLAP), and Data Mining. These applications pose diverse requirements with respect to the information and the operations that need to be supported. From the database perspective, new techniques and tools therefore need to be developed towards increased processing efficiency. This monograph explores the way spatial database management systems aim at supporting queries that involve the space characteristics of the underlying data, and discusses query processing techniques for nearest neighbor queries. It provides both basic concepts and state-of-the-art results in spatial databases and parallel processing research, and studies numerous applications of nearest neighbor queries.
Natural Language Processing and Information Systems ; Vol. 3513 ; 10th International Conference on Applications of Natural Language to Information Systems, NLDB 2005, Alicante, Spain, June 15-17, Proceedings
The development and convergence of computing, telecommunications and information systems has already led to a revolution in the way that we work, communicate with each other, buy goods and use services, and even in the way that we entertain and educate ourselves.The revolution continues, and one of its results is that large volumes of information will increasingly be held in a form which is more natural for users than the data presentation formats typical of computer systems of the past. Natural language processing (NLP) is crucial in solving these problems, and language technologies will make an indispensable contribution to the success of information systems. We hope that NLDB 2005 was a modest contribution to this goal. NLDB 2005 contributed to advancing the goals and the high international standing of these conferences, largely due to its Program Committee, composed of renowned researchers in the field of natural language processing and inf- mation system engineering. Papers were reviewed by three reviewers from the Program Committee. This clearly contributed to the significant number of - pers submitted (95). Twenty-nine were accepted as regular papers, while 18 were accepted as short papers.
National Systems of Innovation in Comparison : Structure and Performance Indicators for Knowledge Societies
The book documents major elements of the joint work of eight leading German institutes, elaborated in the context of a regular annual report on Germany's technological performance. It provides much more than the pure compilation of quantitative indicators for international benchmarking, but gives support to an appropriate interpretation of the referring results and suggests relevant conclusions for innovation policy. A special focus is on Germany; so the book also aims at non-German readers interested in specific features of the German innovation system.
Nanotechnology : Assessment and Perspectives
A new definition of Nanotechnology by the authors is used as an anchor for the various sections of the book. This leads to an integrated text reflecting the multidimensional challenges occurring around Nanotechnology. The most important results of the study are transferred into acting recommendations concerning scientific progress, industrial relevance, economic potential, educational needs, potential adverse health effects and philosophical aspects of Nanotechnology.
Nanoparticle-Based Drug Delivery in Cancer Treatment
Discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Focuses on : Recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Material platforms that establish NPs and both localized and controlled gene silencing The most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment The most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells
Multiscale Dissipative Mechanisms and Hierarchical Surfaces : Friction, Superhydrophobicity, and Biomimetics
Multiscale Dissipative Mechanisms and Hierarchical Surfaces covers the rapidly developing topics of hierarchical surfaces, roughness-induced superhydrophobicity and biomimetic surfaces. The research in these topics has been progressing rapidly in the recent years due to the advances in the nanosciences and surfaces science and due to potential applications in nanotechnology. The first in its field, this monograph provides a comprehensive review of these subject and presents the background introduction as well as recent and new results in the area.
Multirate Statistical Signal Processing
This book introduces a statistical theory for extracting information from signals that have di?erent sampling rates. This new theory generalizes the conventional (deterministic) theory of multirate systems beyond many of its constraints.Furthermore,itallowsfortheformulationofseveralnewproblems such as spectrum estimation, time-delay estimation and sensor fusion in the realm of multirate signal processing. I have arrived at the theory presented here by integrating concepts from diverse areas such as information theory, inverse problems and theory of - equalities. The process of merging a variety of concepts of di?erent origin results in both merits and shortcomings. The former include the fresh and - di?erentiated view of an amateur, providing scope of application. The latter include a lack of in-depth experience in each of the original ?elds. Granted, this may lead to gaps in continuity, however it goes without saying that a complete theory can seldom be achieved by one person and in a short time.
Multiplicative Invariant Theory
Multiplicative invariant theory, as a research area in its own right within the wider spectrum of invariant theory, is of relatively recent vintage. The present text offers a coherent account of the basic results achieved thus far.. Multiplicative invariant theory is intimately tied to integral representations of finite groups. Therefore, the field has a predominantly discrete, algebraic flavor. Geometry, specifically the theory of algebraic groups, enters through Weyl groups and their root lattices as well as via character lattices of algebraic tori.
Multiplicative Ideal Theory in Commutative Algebra : A Tribute to the Work of Robert Gilmer
This volume, a tribute to the work of Robert Gilmer, consists of twenty-four articles authored by his most prominent students and followers. These articles combine surveys of past work by Gilmer and others, recent results which have never before seen print, open problems, and extensive bibliographies.
Multiple Heterogeneous Unmanned Aerial Vehicles
Aerial robots can be considered as an evolution of the Unmanned Aerial Vehicles (UAVs). This book provides a quite complete overview of issues related to aerial robotics, addressing problems ranging from flight control to terrain perception and mission planning and execution. The major challenges and potentials of heterogeneous UAVs are comprehensively explored. It builds on the results of the European project COMETS, and highlights a number of key research topics in the area of UAV development, including communication, perception, teleoperation and decision making. The monograph emphasizes the current state of technology, the existing problems and potentialities of systems consisting of multiple UAVs which are heterogeneous in view of the different characteristics of the aerial vehicles, the different on-board payloads, and the different on-board information processing capabilities. The book also examines potential applications of UAVs and details a relevant application case: forest fire detection and monitoring.
Multiobjective Optimization : Interactive and Evolutionary Approaches
Multiobjective optimization deals with solving problems having not only one, but multiple, often conflicting, criteria. Such problems can arise in practically every field of science, engineering and business, and the need for efficient and reliable solution methods is increasing. The task is challenging due to the fact that, instead of a single optimal solution, multiobjective optimization results in a number of solutions with different trade-offs among criteria, also known as Pareto optimal or efficient solutions. Hence, a decision maker is needed to provide additional preference information and to identify the most satisfactory solution. Depending on the paradigm used, such information may be introduced before, during, or after the optimization process. Clearly, research and application in multiobjective optimization involve expertise in optimization as well as in decision support.
Multi-Objective Evolutionary Algorithms for Knowledge Discovery from Databases
The present volume provides a collection of seven articles containing new and high quality research results demonstrating the significance of Multi-objective Evolutionary Algorithms (MOEA) for data mining tasks in Knowledge Discovery from Databases (KDD). These articles are written by leading experts around the world. It is shown how the different MOEAs can be utilized, both in individual and integrated manner, in various ways to efficiently mine data from large databases.
Multimodal Processing and Interaction : Audio, Video, Text
Multimodal Processing and Interaction: Audio, Video and Text presents high quality, state-of-the-art research ideas and results from theoretic, algorithmic and application viewpoints. This edited volume contains both state-of-the-art reviews and original contributions by leading experts in the scientific and technological field of multimedia. It grew out of a four-year collaboration among research groups participating in the European network of Excellence on Multimedia Understanding, Semantics, Computation and Learning (MUSCLE).
Multimodal Concepts for Integration of Cytotoxic Drugs
The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies, derived from recent advances in molecular oncology. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. In addition, the topics of acute and late toxicity, supportive treatment and tolerance in elderly patients are reviewed.
Multimedia Services in Intelligent Environments : Advanced Tools and Methodologies
This book presents a sample of recent research results in multimedia services. Besides the introductory chapter, this book includes fourteen additional chapters. Nine of these chapters cover various aspects of data processing in multimedia services in intelligent environments, such as storage, recognition and classification, transmission, information retrieval, and information securing. Four additional chapters present multimedia services in noise and hearing monitoring and measuring, augmented reality, automated lecture rooms and rights management and licensing. Finally, the last chapter is devoted to an intelligent recommender service in scientific digital libraries.
Multilingual Information Access for Text, Speech and Images ; 5th Workshop of the Cross-Language Evaluation Forum, CLEF 2004, Bath, UK, September 15-17, 2004, Revised Selected Papers
The ?fth campaign of the Cross-Language Evaluation Forum (CLEF) for Eu- pean languages was held from January to September 2004. Participation in the CLEF campaigns has increased each year and CLEF 2004 was no exception: 55 groups submitted results for one or more of the di?erent tracks compared with 42 groups in the previous year. CLEF 2004 also marked a breaking point with respect to previous campaigns. The focus was no longer mainly concentrated on multilingual document retrieval as in previous years but was diversi?ed to include di?erent kinds of text retrieval across languages (e. g. , exact answers in the question-answering track) and retrieval on di?erent kinds of media (i. e. , not just plain text but collections containing image and speech as well). In ad- tion, increasing attention was given to issues that regard system usability and user satisfaction with tasks to measure the e?ectiveness of interactive systems or system components being included in both the cross-language question - swering and image retrieval tasks with the collaboration of the coordinators of the interactive track. The campaign culminated in a two-and-a-half-day workshop held in Bath, UK, 15–17 September, immediately following the 8th European Conference on Digital Libraries. The workshop was attended by nearly 100 researchers and s- tem developers.
Multifield Problems in Solid and Fluid Mechanics
This book summarizes the main scientific results of the Collaborative Research Center on Multifield Problems in Continuum Mechanics. The book is divided into three main sections: A: Volume-Coupled Problems, devoted to fields which are coupled inside the processing domain or volume, B: Boundary-Coupled Problems, here physical fields and processes are coupled via domain boundaries, C: Fundamental Methods, search into the mathematical concepts and backgrounds of multifield and multiscale modeling.
Multidimensional Screening
The book brings into a focus all necessary mathematical knowledge necessary to understand the economics of multidimensional results screening and applies them straightaway to economic models. The first part of this book contains a review of vector calculus, the theory of partial differential equations, and the theory of generalized convexity. These techniques are extensively used in multidimensional screening models. Part II is devoted to the economics of sceening models. It starts with a detailed discussion of economics and mathematics of unidimensional screening problems and three approaches to their solution: direct, dual, and Hamiltonian. It uses the Hamiltonian approach to unify all known results, which were previously obtained using different arguments. Then the major difficulties with direct and dual approach in the multidimensional context are discussed and the Hamiltonian approach is used to provide the most complete characterization of the solution known in the literature.
Multidetector-Row CT Angiography
Multidetector-row CT has dramatically improved the results of computed tomography in all clinical applications, but its beneficial impact has been most striking in vascular imaging. The simplicity of acquisition and the wide availability of equipment make this modality especially suitable for routine clinical application. In this book the basic aspects of multidetector-row CT angiography are comprehensively reviewed. Individual chapters are included on technical principles, image processing techniques and contrast agent administration. All clinical applications are then discussed in depth, with lucid descriptions of the examination technique for particular clinical indications and of the findings that characterize specific diseases. Limitations and advantages in comparison with other imaging modalities are considered. A large number of high-quality black and white and color illustrations help to explain the clinical findings.
