الصفحة 4
الصفحة 4
Molecular Biology of Human Cancers: An Advanced Student's Textbook
Presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Molecular Biology in Plant Pathogenesis and Disease Management : Microbial Plant Pathogens ; Vol.1
Studies on molecular biology of pathogens, infection process and disease resistance, have provided information essentially required to understand the vulnerable stages at which the pathogens can be tackled effectively and to adopt novel strategies to incorporate disease resistance genes from diverse sources and /or to induce resistance of cultivars with desirable agronomic attributes using biotic or abiotic agents. The nature of interaction between the gene products of the pathogen and plant appears to determine the outcome of the interaction resulting in either disease progression or suppression. Transgenic plants with engineered genes show promise for effective exploitation of this approach for practical application. Research efforts during the recent years to sequence the whole genomes of the pathogens and plants may lead to development of better ways of manipulating disease resistance mechanisms enabling the grower to achieve higher production levels and the consumer to enjoy safer food and agricultural products. Experimental protocols included in appropriate chapters will be useful for researchers and graduate students.
Molecular Beams in Physics and Chemistry : From Otto Stern's Pioneering Exploits to Present-Day Feats
This book gives a comprehensive account of both the history and current achievements of molecular beam research. In 1919, Otto Stern launched the revolutionary molecular beam technique. This technique made it possible to send atoms and molecules with well-defined momentum through vacuum and to measure with high accuracy the deflections they underwent when acted upon by transversal forces. These measurements revealed unforeseen quantum properties of nuclei, atoms, and molecules that became the basis for our current understanding of quantum matter. This volume shows that many key areas of modern physics and chemistry owe their beginnings to the seminal molecular beam work of Otto Stern and his school. Written by internationally recognized experts, the contributions in this volume will help experienced researchers and incoming graduate students alike to keep abreast of current developments in molecular beam research as well as to appreciate the history and evolution of this powerful method and the knowledge it reveals.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modern natural product synthesis
Describes the details of the synthesis routes including unexpected reactions and syntheses. By presenting detailed stories behind the total synthesis developments, including those routes that were unsuccessful the book provides the reader with a better understanding of how other researchers devise their strategy and overcome difficulties in their studies. The contributions in the book have focused on highlighting the research from Japan however it is appealing to researchers and students worldwide. This compilation of cutting-edge natural product synthesis provides high-quality expertise, especially to graduate students and young researchers, regarding research on synthetic organic chemistry. It can be utilized as teaching material in university seminars as well as provide guidance to researchers in the area of total synthesis.
Modelling Critical and Catastrophic Phenomena in Geoscience : A Statistical Physics Approach
This book presents a broad survey of models for critical and catastrophic phenomena in the geosciences, with strong emphasis on earthquakes. It assumes the perspective of statistical physics, which provides the theoretical frame for dealing with complex systems in general. This volume addresses graduate students wishing to specialize in the field and researchers working or interested in the field having a background in the physics, geosciences or applied mathematics.
Modeling Uncertainty : An Examination of Stochastic Theory, Methods, and Applications
Modeling Uncertainty: An Examination of Stochastic Theory, Methods, and Applications, is a volume undertaken by the friends and colleagues of Sid Yakowitz in his honor. Fifty internationally known scholars have collectively contributed 30 papers on modeling uncertainty to this volume. Each of these papers was carefully reviewed and in the majority of cases the original submission was revised before being accepted for publication in the book. The papers cover a great variety of topics in probability, statistics, economics, stochastic optimization, control theory, regression analysis, simulation, stochastic programming, Markov decision process, application in the HIV context, and others. There are papers with a theoretical emphasis and others that focus on applications. A number of papers survey the work in a particular area and in a few papers the authors present their personal view of a topic. It is a book with a considerable number of expository articles, which are accessible to a nonexpert - a graduate student in mathematics, statistics, engineering, and economics departments, or just anyone with some mathematical background who is interested in a preliminary exposition of a particular topic. Many of the papers present the state of the art of a specific area or represent original contributions which advance the present state of knowledge. In sum.
Modeling of Biological Materials
This interdisciplinary collection of surveys highlights the central role played by the mathematical modeling of mechanical properties having an effect on the biology, chemistry, and physics of living matter. One of the main goals of the book is to present—in a single, self-contained resource—topics that are widely scattered across the literature in a variety of journals having mutually nonintersecting communities of readers, such as applied mathematicians, engineers, biologists, and physicians. Readers coming from diverse backgrounds are provided with basic modeling ideas and tools to address important problems in the medical and health sciences. Presented are appropriate models as well as their implementation through numerical and computer simulations, which may lead to potential technological innovations useful in medicine.
Modeling of Adhesively Bonded Joints
A lot of recent developments have been made about adhesively bonded joints modeling using various methods of analysis. The increasing application of adhesives in industry is partly due to the increased sophistication and reliability of adhesive joints modeling. The book proposed intends to provide the designer with the most advanced stress analyses techniques in adhesive joints to reinforce the use of this promising bonding technique.
Modeling Chemical Systems using Cellular Automata
The book will be of great value in undergraduate courses in chemistry, physics, biology, applied mathematics, and bioinformatics, and as a supplement for laboratory courses in introductory chemistry, organic chemistry, physical chemistry, medicinal chemistry, chemical engineering and other courses dealing with statistical and dynamic systems. It allows the exploration of a wide range of dynamic phenomena, many of which are not normally accessible within conventional laboratory settings due to limitations of time, cost, and experimental equipment. The book is both a textbook on applied Cellular Automata and a lab manual for chemistry (physics, engineering) courses with lab activity. It would supplement other lab work and be an additonal book the students would use in the course.
Modeling biological systems : Principles and applications
This extensively revised second edition of Modeling Biological Systems: Principles and Applications describes the essentials of creating and analyzing mathematical and computer simulation models for advanced undergraduates and graduate students. It offers a comprehensive understanding of the underlying principle, as well as details and equations applicable to a wide variety of biological systems and disciplines. Students will acquire from this text the tools necessary to produce their own models. The text contains two major sections: Principles and Applications. The first section discusses the principles of biological systems with a thorough description of the essential modeling activities of formulation, implementation, validation, and analysis. These activities are illustrated by a set of example models taken from recent and classical literature, chosen for their breadth of coverage and current timeliness. The new edition updates extensively many of these topics, especially quantitative model formulation, validation and model discrimination using information theory measures and Bayesian probability, and stability analysis and non-dimensionalization.
Modeling and Management of Fuzzy Semantic RDF Data
Presents the latest research findings in fuzzy RDF data modeling and management. Fuzziness widely exist in many data and knowledge intensive applications. With the increasing amount of metadata available, efficient and scalable management of massive semantic data with uncertainty is of crucial importance. This book goes to great depth concerning the fast-growing topic of technologies and approaches of modeling and managing fuzzy metadata with Resource Description Framework (RDF) format. Its major topics include representation of fuzzy RDF data, fuzzy RDF graph matching, query of fuzzy RDF data, and persistence of fuzzy RDF data in diverse databases. The objective of the book is to provide the state-of-the-art information to researchers, practitioners, and postgraduates students who work on the area of big data intelligence and at the same time serve as the uncertain data and knowledge engineering professional as a valuable real-world reference.
Modeling and Analysis of Transient Processes in Open Resonant Structures : New Methods and Techniques
The principal goal of the book is to describe new accurate and robust algorithms for open resonant structures with substantially increased efficiency. The book presents a systematic approach to the study of electromagnetic waves scattering which can be introduced in undergraduate/postgraduate education in theoretical and applied radiophysics and different advanced engineering courses on antenna and wave-guide technology.
Model-Driven Software Development
Abstraction is the most basic principle of software engineering. Abstractions are provided by models. Modeling and model transformation constitute the core of model-driven development. Models can be refined and finally be transformed into a technical implementation, i.e., a software system. The aim of this book is to give an overview of the state of the art in model-driven software development. Achievements are considered from a conceptual point of view in the first part, while the second part describes technical advances and infrastructures. Finally, the third part summarizes experiences gained in actual projects employing model-driven development. Beydeda, Book and Gruhn put together the results from leading researchers in this area, both from industry and academia. The result is a collection of papers which gives both researchers and graduate students a comprehensive overview of current research issues and industrial forefront practice, as promoted by OMG’s MDA initiative.
Model-based Fault Diagnosis Techniques : Design Schemes, Algorithms, and Tools
The objective of this book is to introduce basic model-based FDI schemes, advanced analysis and design algorithms and the needed mathematical and control theory tools at a level for graduate students and researchers as well as for engineers.
Mobile World : Past, Present and Future
Key reading for all those involved with the future of mobile communications, this book is a valuable resource, particularly for advanced undergraduate and postgraduate students on Mobile Technology courses, practitioners, and researchers working in mobile communications, CSCW and HCI. This volume is a sequel to Brown et al: Wireless World: Social and Interactional Aspects of the Mobile Age, also in the CSCW series. "This book presents a rich insight into how and why the mobile has become so important in today’s society. It explores the strong emotional attachment that people have to these devices, and argues that it is people and not the technology that developers must put at the heart of future mobile offerings. A valuable book for industry and academics alike."
Mobile 3D Graphics
Historically, not enough was understood about how to deliver a high quality playing experience on handheld, small screen, small memory devices, plus there has been considerable confusion about the hardware’s abilities and restrictions. By addressing these issues this book provides: • A comprehensive explanation of 3D mobile graphics programming • Includes an extensive range of code samples in both C and Java • Combines 3D and 2D mobile graphics methods • Covers recent advances in mobile computer graphics techniques and applications. The book teaches fundamental 3D mobile graphics programming with standard APIs, and covers the basic and advanced application programme interfaces behind the major wireless and mobile devices supporting 3D graphics applications. Advanced undergraduates and postgraduates, as well as mobile application and games developers, will find this an excellent reference source.
Mitochondria and the Heart
The function of the heart is highly dependent on oxidative energy that is generated in mitochondria. Defects in mitochondrial structure and function can be found in association with cardiovascular diseases. Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal growth, development and aging. In addition, nonbioenergetic, biogenesis and degradation pathways are explored. Understanding these pathways and the effects that mitochondrial defects have in cardiac pathology is extremely important in establishing the diagnosis and treatment of mitochondrial-based cardiac diseases.
Microscale and Nanoscale Heat Transfer
Constitutes a particularly complete and original collection of ideas, models, numerical methods and experimental tools which will prove invaluable in the study of microscale and nanoscale heat transfer. It should be of interest to research scientists and thermal engineers who wish to carry out theoretical research or metrology in this field, but also to physicists concerned with the problems of heat transfer, or teachers requiring a solid foundation for an undergraduate university course in this area.
Microorganisms in the deterioration and preservation of cultural heritage
This book offers a comprehensive overview of the role and potential of microorganisms in the degradation and preservation of cultural materials (e.g. stone, metals, graphic documents, textiles, paintings, glass, etc.).
