الصفحة 4
الصفحة 4
Genetic Engineering of Mesenchymal Stem Cells
MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.
Genetic Engineering : Principles and Methods
Genetic Engineering: Principles and Methods presents state-of-the-art discussions in modern genetics and genetic engineering. Recent volumes have covered gene therapy research, genetic mapping, plant science and technology, transport protein biochemistry, and viral vectors in gene therapy, among many other topics.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene Expression Programming : Mathematical Modeling by an Artificial Intelligence
This monograph provides all the implementation details of GEP so that anyone with elementary programming skills will be able to implement it themselves. The book also includes a self-contained introduction to this new exciting field of computational intelligence, including several new algorithms for decision tree induction, data mining, classifier systems, function finding, polynomial induction, times series prediction, evolution of linking functions, automatically defined functions, parameter optimization, logic synthesis, combinatorial optimization, and complete neural network induction. The book also discusses some important and controversial evolutionary topics that might be refreshing to both evolutionary computer scientists and biologists.
Gene Expression and Regulation
This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. Presented in the following five sections, this book covers a full spectrum of topics: The History; The Machinery; The Regulators; The Genome; and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The Special Topics section discusses several selected topics ranging from bacterial and plant gene expression to DNA topology and interference RNA. The book’s focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Functional Data Analysis
This monograph presents many ideas and techniques for such data. Included are expressions in the functional domain of such classics as linear regression, principal components analysis, linear modeling, and canonical correlation analysis, as well as specifically functional techniques such as curve registration and principal differential analysis. Data arising in real applications are used throughout for both motivation and illustration, showing how functional approaches allow us to see new things, especially by exploiting the smoothness of the processes generating the data. The data sets exemplify the wide scope of functional data analysis; they are drawn from growth analysis, meteorology, biomechanics, equine science, economics, and medicine.The book presents novel statistical technology, much of it based on the authors’ own research work, while keeping the mathematical level widely accessible.
Frontiers in Biochip Technology
This comprehensive collection covers emerging technologies and cutting –edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field. Key topics and current trends in biochip technology covered include: -microarray technology and its applications - microfluidics - drug discovery - detection technology - lab-on-chip technology and bioinformatics.
Foundations of Microsoft® Expression Web : The Basics and Beyond
Expression Web, one of the excellent programs within the suite, is a powerful web site creation tool that allows you to rapidly build up standards-compliant web pages, style them with CSS, add dynamic ASP.NET functionality to them, and publish them to the weball from the comfort of one program, and "Foundations of Microsoft Expression Web: The Basics and Beyond" is one of the first books available on the program.
Foundation Expression Blend 2 : Building applications in WPF and silverlight
This book shows you how to take full advantage of Blend's interface, together with and Silverlight's vastly improved designer-developer workflow, guiding you through every step of development from downloading and installing of the development environment through creating finished, functional projects. You'll learn how to create simple drawing applications with the InkCanvas, make tabbed and scrollable interfaces, as well as build fully featured media players, photo galleries, and interactive 3D designs. Each chapter discusses major WPF and Silverlight features, provides a hands-on tutorial, and explains how that feature is implemented in the real world. In the end, you will have a collection of impressive WPF and Silverlight applications that can be added to your portfolio.
Foundation ActionScript 3.0 with Flash CS3 and Flex
If you want to create exciting dynamic web sites that will amaze your online audience, then the Flash platform is a great way to go, with it's many features, including powerful graphical and sound and video capabilities. To really harness the power of Flash though, you need to make use of ActionScript to provide dynamic effects, enable user interaction, and manipulate data. ActionScript 3.0, the Flash Platform's scripting language, offers a lot of new and powerful features. ActionScript is now a full-fledged programming language, with complete object-oriented capabilities, improved event handling, sound and video support, drawing capabilities, support for regular expressions, and much more. This book covers all the essential techniques from the ground up, allowing you to get up and running quickly and easily. Starting with the fundamentals, you'll learn about using ActionScript objects, manipulating sound and video, and harnessing the power of regular expressions and XML.
Flavonoids as nutraceuticals
Flavonoids are well-known plant metabolites that have extraordinary properties that can be used for treating health issues. The pharmaceutical importance of flavonoids is due to their anti-depressant, anti-viral, anti-inflammatory, and antioxidant capacities. They are also of great importance when it comes to neuroprotection, cardiovascular disorders, and many types of cancer. Flavonoids are also easily available and produce less harmful side effects than some conventional therapeutics. This new volume examines the growing use of flavonoids for prevention and treatment of diseases and discusses their beneficial mechanisms. Chapters in the volume address diverse uses as anti-aging tools, as anti-inflammatory agents, for treating pregnancy-induced disorders, as a promising tool to combat infection of Covid-19, etc. The book explores their specific therapeutic antiviral potentials, the gene expression by flavonoids, and the role of flavonoids in agriculture.
Finite-state methods and natural language processing ; 5th International Workshop, FSMNLP 2005, Helsinki, Finland, September 1-2, 2005, Revised Papers
This book constitutes the thoroughly refereed post-proceedings of the 5th International Workshop on Finite-State Methods in Natural Language Processing, FSMNLP 2005, held in Helsinki, Finland, September 2005. The book presents 24 revised full papers and seven revised poster papers together with two invited contributions and abstracts of six software demos. Topics include morphology, optimality theory, some special FSM families, weighted FSM algorithms, FSM representations, exploration, ordered structures, and surface parsing.
Fine-Tuning of RNA Functions by Modification and Editing
This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression.
Filgrastim in clinical oncology : Guarding against neutropenia
Granulocyte colony-stimulating factor (G-CSF) has driven the attention of researchers as a therapeutic agent for curing patients suffering from neutropenia. Despite the successful use of G-CSF, it currently requires daily injections, which are inconvenient, expensive, and distressing for children. Therefore, an alternative strategy for using G-CSF for treatment is needed. Understanding the G-CSF structure, expression, mechanism of action, and how it induces neutrophils mobilization is crucial to producing promising cancer therapy. The ability of G-CSF to mobilize hematopoietic stem cells from the bone marrow into the blood circulation was consequently exploited and altered the practice of hematopoietic stem cell transplantation.
Fast Track to MDX
Fast Track to MDX gives you all the necessary background to let you to write useful, powerful MDX expressions and introduces the most frequently used MDX functions and constructs. No prior knowledge is assumed and examples are used throughout the book to rapidly develop your MDX skills to the point where you can solve real business problems.
Factors Influencing Mammalian Kidney Development : Implications for Health in Adult Life
In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are.
Facilitative glucose transporters in articular chondrocytes : Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory Cytokines
In this multidisciplinary article we review the molecular and morphological aspects of GLUT expression and function in chondrocytes and their mesenchymal and embryonic stem cell precursors and propose key roles for these proteins in glucose sensing and metabolic regulation in cartilage.
Existence: Semantics and Syntax
This collection is an important contribution to the semantic and syntactic analysis of the expression of existence. The volume focuses on the three main linguistic constructions expressing existence: copular clauses, existential sentences, and (in)definiteness. The papers analyze the interaction between the basic notion of existence and pervasive phenomena of natural language, such as quantification and presupposition. The contributions represent state of the art research on theoretical and comparative issues related to the expression of existence, and make extensive reference to the semantic and syntactic facts of English and of various other languages. The richness of new data and the juxtaposition of different theoretical stances bring a number of new questions into focus.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Endosperm : Developmental and Molecular Biology
This book is the first comprehensive overview of the developmental and molecular biology of endosperm. The text covers cereal endosperm development from fertilization to maturity, including molecular and cell biology of the syncytial phase, the cellularization process and cell fate specification of the embryo surrounding region cells, the basal transfer cells, the starchy endosperm and aleurone cells. In addition, endosperm development in the model species Arabidopsis thaliana is covered, along with recent progress in endosperm in vitro culture. Special features of endosperm, such as imprinting, polyploidy, programmed cell death and anthocyanin biosynthesis, are described in separate chapters. Finally, the genes and pathways for the main nutritional components of endosperm, storage proteins and starch are covered in detail.
