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Future approaches for safe and effective pain management
Pain is defined as an unpleasant sensory and emotional experience that is associated with actual or potential tissue damage or described in terms of such damage. It is subjective and considered an important physiological mechanism by which humans prevent themselves from developing tissue injury. However, pain patients do not respond to treatment in the same way, which makes it challenging to issue a consistent treatment for all pain conditions. Excessive pain can markedly increase psychological health problems and decrease health‐related quality of life; therefore, pain should be managed appropriately by analgesics. Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. Pain severities as well as responses to analgesics, can also be very variable among sufferer.
Functional Properties of Nanostructured Materials
Nanostructured materials are becoming of major significance, and their investigations require a comprehensive approach. The fundamental properties of these materials are remarkably altered as the size of their constituent grains or phases decreases to the nanometer scale. These novel materials made of nanosized building blocks offer unique and entirely different electrical, optical, mechanical, and magnetic properties compared to conventional micro- or millimetre-size materials owing to their distinctive size, shape, topology, surface properties, etc.
Food - drug interactions
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects.
Fault Diagnosis and Tolerance in Cryptography ; 3rd International Workshop, FDTC 2006, Yokohama, Japan, October 10, 2006, Proceedings
The sophistication of the underlying cryptographic algorithms, the high complexity of the implementations, and the easy access and low cost of cryptographic devices resulted in increased concerns regarding the reliability and security of crypto-devices. The effectiveness of side channel attacks on cryptographic devices, like timing and power-based attacks, has been known for some time. Several recent investigations have demonstrated the need to develop methodologies and techniques for designing robust cryptographic systems (both hardware and software) to protect them against both accidental faults and maliciously injected faults with the purpose of extracting the secret key. This trend has been particularly motivated by the fact that the equipment needed to carry out a successful side channel attack based on fault injection is easily accessible at a relatively low cost (for example, laser beam technology), and that the skills needed to use it are quite common.
Fas Signaling
Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.
Facing the Complexities of Womens Sexual Desire
Whether they involve excess, a decrease, or complete absence, problems of sexual desire drive women to consult sex therapists, couples counselors, and other practitioners (to say nothing of self-help books and talk-show hosts). Facing the Complexities of Women’s Sexual Desire, by veteran sex therapist Vera Sonja Maass, is one of the few books to address these intimate phenomena in practical clinical detail.
Exploring the Secrets of the Aurora
This new edition of Exploring the Secrets of the Aurora is based on the author's own experiences as a scientist. It describes the history of progress made in auroral science and magnetospheric physics by providing examples of ideas, controversies, struggles, acceptance, and success.
Exploring Ancient Skies : An Encyclopedic Survey of Archaeoastronomy
Exploring Ancient Skies brings together the methods of archaeology and the insights of modern astronomy to explore the science of astronomy as it was practiced in various cultures prior to the invention of the telescope. The book reviews an enormous and growing body of literature on the cultures of the ancient Mediterranean, the Far East, and the New World (particularly Mesoamerica), putting the ancient astronomical materials into their archaeological and cultural contexts. The authors begin with an overview of the field and proceed to essential aspects of naked-eye astronomy, followed by an examination of specific cultures. The book concludes by taking into account the purposes of ancient astronomy: astrology, navigation, calendar regulation, and (not least) the understanding of our place and role in the universe. Skies are recreated to display critical events as they would have appeared to ancient observers - events such as the supernova of 1054, the 'lion horoscope' or the 'Star of Bethlehem.'
Evolutionary Epistemology, Language and Culture : A Non-Adaptationist, Systems Theoretical Approach
Today we know that natural selection and evolution are far from synonymous and that they do not explain isomorphic phenomena in the world. ‘Taking Darwin seriously’ is the way to go, but today the time has come to take alternative and complementary theories that developed after the Modern Synthesis, equally seriously, and, furthermore, to examine how language and culture can merit from these diverse disciplines.As this volume will make clear, a specific inter- and transdisciplinary approach is one of the next crucial steps that needs to be taken, if we ever want to unravel the secrets of phenomena such as language and culture.
Evolution, Monitoring and Predicting Models of Rockburst : Precursor Information for Rock Failure
Focuses on investigating predicting precursor information and key points of rockburst in mining engineering through laboratory experiment, theoretical analysis, numerical simulation and case studies. Understanding the evolution patterns for the microstructure instability of rock is a prerequisite for rockburst prediction. The book provides a guide for readers seeking to understand the evolution patterns for the microstrucure of rock failure, the predicting key point of rock failure and the rockburst predicting model. It will be an essential reference to understand mechanism of rockburst and sheds new light on dynamic disasters prediction. Chapters are carefully developed to cover (1) The evolution patterns for the microstructure instability of rock; (2) Rockburst hazard monitoring and predicting criterion and predicting models. The book addresses the issue with a holistic and systematic approach that investigates the occurrence mechanism of rockburst based on the evolution patterns for the microstructure of rock failure and establishes the predicting model of rockburst.
Estrogen Effects in Psychiatric Disorders
A number of studies, mostly focusing on estrogen replacement therapy in women, have reported beneficial actions of these hormones on various neurobiological and neuropathological parameters in health and disease. Recent research has focused on gender differences and there is increasing evidence that estrogens exert protective effects in schizophrenia. Hormonal fluctuations or lack of estrogen may increase the risk of depression among vulnerable women. Treatment of depression with estrogen may stabilize and restore disrupted homeostasis – as during post-partum, premenstrual, or perimenopausal conditions – and act as a psychomodulator to offset vulnerability to dysphoric mood when estrogen levels are significantly decreased, as in the case of postmenopausal women. Studies on the effect of estrogens on Alzheimer’s Disease are still rather controversial, they do, however, facilitate the hypothesis that estrogens may have a modifying effect on the onset and course of AD, at least in subgroups of patients.
Entrepreneurship, the new economy and public policy : Schumpeterian perspectives
Silicon Valley is the most salient example of high-tech industrial clusters. Public policy makers throughout the world would like to learn the secrets of Silicon Valley in order to build their own high-tech economies. The existing literature on ind- trial clusters, which traces back to Marshall (1920), focuses on the way in which ?rms bene?t from locating in a cluster; it suggests that once a cluster comes into existence However, a more important question is how to reach this critical mass in the ?rst place. In contrast to the literature, evidence suggests that entrepreneurs rarely move when they est- lish high-tech start-ups. This contradicts the notion that location choice analyses lead entrepreneurs to a high-tech cluster. A high-tech industrial cluster such as Silicon Valley is characterized by c- centrated entrepreneurship.
Energy Resources in East Africa: Opportunities and Challenges
East African states have historically shared several resources including energy and common heritage of its people. This book provides information on available sources of energy in the region and how the energy suppliers can exploit them in an integrated form to produce the right blend of energy for various applications e.g., industrial, domestic and recreational uses. We provide an in-depth analysis of the advantages and disadvantages of different energy sources in-terms of environmental, industrialization, distribution costs and impacts. We hope that the book will contribute towards a sustainable exploitation of energy resources for the improvement of the people’s quality of life.
Energy Metabolism and Obesity : Research and Clinical Applications
Elucidate the most important aspects of genetic background, neuropeptide secretion and action, neuronal pathways, adipokines, gut hormones, and environmental influences (physical activity, pharmacologic agents, and surgical alteration of the gastrointestinal tract), as well as the complex interactions among them.
Endocrinology : Basic and Clinical Principles
For this new edition of Conn & Melmed's Endocrinology: Basic and Clinical Principles, a panel of distinguished scientists and clinicians has completely rewritten every chapter to reflect the latest advances in our understanding of the endocrine system. Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, the authors have succinctly summarized in 450 pages the latest findings on hormone secretion and hormone action, as well as all of the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in humans and the lower species, and the mechanisms subserving hormone secretion.
Emergency Radiology : Imaging and Intervention
There is an increasing trend towards the use of tries, hospital emergency departments have become a MDCT to evaluate traumatic injuries and non-traumatic major part of the healthcare safety net. In the last decade emergencies. The use of workstations for reporting and for economically-driven structural changes in health care further image reconstruction becomes standard practice. delivery have caused a dramatic increase in emergency On the occasion of the European Congress of Radiology department visits. In response to capacity and staffing (ECR) 2003 and 2004 a Categorical Course on “Emergency pressures, hospitals are developing and implementing a Radiology”has been organized to assess current devel- variety of strategies designed to improve patient flow and ments and concepts in this rapidly growing field. reduce overcrowding in the emergency department. Numerous radiologists,all outstanding and international- Several factors are considered critical for success, such as ly renowned experts in their field,have made superb c- having the right multidisciplinary teams in place and opti- tributions in an ECR syllabus.
Effect of Cranberry in the Treatment of E. Coli
Escherichia coli (E. coli) bacteria normally live in the intestines of healthy people and animals. It may cause severe stomach cramps, bloody diarrhoea, vomiting and UTI. You may be exposed to E. coli from contaminated water or food especially raw vegetables and undercooked ground beef. Healthy adults usually recover from infection with E. coli within a week. Young children and older adults have a greater risk of developing a life-threatening form of kidney failure. Cranberries are a popular superfood. People can consume them in the form of a sauce or a juice. They can also add them to stuffing, casseroles, or dessert. In fact, research has linked the nutrients in cranberries to a lower risk of urinary tract infection (UTI), the prevention of certain types of cancer, improved immune function, and decreased blood pressure
Dry Mouth : A Clinical Guide on Causes, Effects and Treatments
This wide-ranging guide to dry mouth, or xerostomia, is intended to meet the needs of dentists by providing information on all clinically relevant aspects. After introductory discussion of salivary secretion and function, the potential causes of dry mouth, including diseases affecting saliva production, drugs and irradiation, are examined.
Drug safety evaluation : Methods and protocols
Focuses on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
Distribution and phenotype of proliferating cells in the Forebrain of adult macaque monkeys after transient global cerebral ischemia
The authors' results show that ischemia differentially activates endogenous neural precursors residing in diverse locations of the adult primate central nervous system. A limited endogenous potential for postischemic neuronal repair exists in neocortex and striatum, but not in the hippocampus proper of the adult macaque monkey brain. The presence of putative parenchymal progenitors and of sustained progenitors in germinative centers opens novel possibilities for precursor cell recruitment.
