الصفحة 4
الصفحة 4
Ethical Issues in Cancer Patient Care Second ed.
This updated edition addresses a variety of ethical issues that arise in the care of oncology patients, the chapters address issues that are central to contemporary medical practice and medical ethics inquiry.
Essentials of Clinical Research
Focuses on clinical trials, in contrast to the many excellent textbooks that address epidemiological research. With the recent interest in patient oriented research, this book should provide a knowledge base that is not necessarily covered in other texts.
Drugs and a methodological compendium : From bench to bedside
Provides a meticulous view on methodological drug discovery and development insights from bench to bedside. Focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. Covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Drug development for rare diseases
A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, caregivers, regulators, drug developers, and other stakeholders. This book is proposed to give an overview of the common issues facing rare disease drug developers, summarize challenges specific to clinical development in small populations, discuss drug development strategies in the evolving regulatory environment, explain generation and utilization of different data and evidence
Dose Finding in Drug Development
When you go to the pharmacy and fill a prescription, have you ever wondered if the dose of the medication is right for you? Can the dose be too low so that the drug will not work? This book answers some of these questions, and introduces the drug development process, the design and analysis of clinical trials.
Dermatoethics : Contemporary ethics and professionalism in dermatology
This extensively updated textbook reviews the ethical issues faced within dermatology. Bringing together practical real-life case scenarios and scholarly analysis, it covers the foundations of bioethics, as well as ethical issues associated with the various roles dermatologists play, including clinician, professional, educator, business person, and scholar. New chapters on the ethics of dermatologic care during pandemics, non-traditional interventions, private equity in dermatology, self-care and improvement, skin cancer screening, maintenance of certification, the ethics of clinical trial design are also included.
Dental biomaterials: from fundamental principles to clinical applications
Novel approaches are being developed to prevent and treat prevalent oral diseases like dental caries, periodontitis, and oral cancer. Researchers are also exploring the potential of biomaterials in regenerative dentistry, such as promoting bone growth and repairing damaged oral tissues.The ongoing research and development in dental materials and biomaterials holds great promise for improving oral health outcomes. However, it is imperative to maintain a sustained focus on research to fully leverage their potential and effectively address the existing gaps in dental care.In the special issue titled "Dental Biomaterials: From Fundamental Principles to Clinical Applications," significant findings have emerged from a variety of sources, including in vitro experiments and clinical trials.
Data Monitoring in Clinical Trials : A Case Studies Approach
Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obtaining the best evidence through clinical trials must be done within the boundaries of rigorous science and ethical principles. One fundamental principle is that trials should not continue longer than necessary to reach their objectives. Therefore, trials must be monitored for recruitment progress, quality of data, adherence to patient care or prevention standards, and early evidence of benefit or harm. Frequently, a group of external experts, independent from the investigators and trial sponsor, is charged with this monitoring responsibility, especially for safety and early benefit. This group is referred to by various names, such as a data monitoring committee or a data and safety monitoring board. This book, through a series of case studies presented by many distinguished clinical trial experts, illustrates the complexity of this monitoring process.No other text has as extensive a collection of cases which provide insight into the many issues, often conflicting, that must be examined before recommendations to continue or discontinue a trial can be made. While depth in statistical methods is not required, some familiarity with statistical design and analysis issues in clinical trials is helpful. The cases cover trials which were terminated early for convincing evidence of benefit, or for harmful effects. Cases with complex issues are also included. This series of cases should provide broad background information for potential monitoring committee members and better prepare them for the challenges that may exist in the trials for which they are responsible.
Cured II - LENT Cancer Survivorship Research and Education : Late Effects on Normal Tissues
Multimodal treatment lies at the heart of the improvement in cancer cure rates. However, the more aggressive the treatment delivery in terms of dose, time and volume for radiation and chemotherapy, the more adverse effects in normal tissues can be anticipated. Against this background, a major paradigm shift has taken place in that there is a new focus on cancer survivorship. Put another way, there has been a realization that prolongation of life must be accompanied by maintenance of the quality of life: the life worth saving must be worth living.
Contemporary Accounts in Drug Discovery and Development
Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field.
Clinical Trials in Rheumatoid Arthritis and Osteoarthritis
Designed to be a practical handbook on clinical trial management in these key therapeutic areas, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed at principal investigators pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases.
Clinical Trials in Osteoporosis
A practical handbook on clinical trials in the growing field of osteoporosis. Topics covered include study design, technical issues, data collection, quality assurance, data analysis and presentation. It takes the user through the process step-by-step from start to finish, also providing a background on regulatory guidelines, ethical implications, endpoints, current therapies and the ideal drug to use.
Clinical trial registries : A practical guide for sponsors and researchers of medicinal products
A necessary addition to the library of all researchers who plan to publish their results in top-tier, peer-reviewed journals. ICMJE editors and other journal editors require registration of clinical trial information on publicly available Web sites before enrollment of study subjects and some countries and regions also require this information, as well as timely publication of study results. Not only does this book discuss the genesis of these requirements, it also provides practical information for researchers and sponsors on how to establish a workflow for a clinical registry project, how to file to a registry, and how to post results. More than 25 current Web addresses for registries are provided as well as a comprehensive annotated bibliography of papers on the topic of clinical trial registries. This book is a valuable source of information for all sponsors of medicinal products.
Materials for medical applications : Principles and practices
Discusses advanced knowledge about the synthesis and application of materials in the medical field for diagnostic and therapeutic conditions. These materials have been extensively used in various biological and medical applications, especially in drug delivery, tumor screening, bioimaging, diagnosis, and therapies. Materials for Medical Applications provides comprehensive but concise information about materials and their medical applications. The readers will get information about the trends in materials and their medical applications, as well as current material-based products that are used in the medical field. The book also discusses how materials are tested in research laboratories, preclinical (animal) trials, and clinical (human) trials, and how material-based products go through various regulatory and safety phases before reaching patients. It also discusses topics such as materials delivery, imaging, and treatments for various diseases. It includes a chapter dedicated to regulatory guidelines and policies in the application of nanomaterials and will include current clinical trial information on the materials. Finally, the book has topics such as health safety, toxicity, dosages, and long-term implications of materials.
Management of atopic dermatitis : Methods and challenges
This new edition builds upon the foundational knowledge covered in the first edition, covering the epidemiology, pathogenesis, and clinical presentation of atopic dermatitis in both pediatric and adult patients. It provides an overview of the mechanism and presentation of atopic dermatitis and focuses on the management methods experienced dermatologists have used to successfully manage atopic dermatitis. The book includes new chapters describing the special considerations for atopic dermatitis in skin of color patients, dedicated chapters on topical and oral prescription management reflected the latest FDA-approved treatments, and also a chapter covering the updated guidelines from the American Academy of Dermatology. A final chapter includes updates on the future of atopic dermatitis treatment.
Macular Degeneration
Macular Degeneration: Science and Medicine in Practice provides a unique overview of current thinking in the pathogenesis, incidence and treatment of AMD. It includes, for the first time, a synthesis of the views of the world's leading scientists and practitioners regarding retinal biology, basic mechanisms, clinical and pathogenetic processes, and rational approaches to intervention.
Machine learning for neurodegenerative disorders : advancements and applications
Explores the application of machine learning to the understanding, early diagnosis, and management of neurodegenerative disorders. With a specific focus on its role in ongoing clinical trials, the book covers essential topics such as data collection, pre-processing, feature extraction, model development, and validation techniques. It delves into the applications of neuroimaging techniques like magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) in the diagnosis and understanding of neurodegenerative disorders. Additionally, the book examines various machine-learning algorithms employed for biomarker discovery in neurodegenerative disorders. It highlights the role of neuroinformatics and big data analysis in advancing the understanding and management of neurodegenerative disorders. Furthermore, the book reviews future prospects and presents the ethical considerations and regulatory challenges associated with implementing machine learning approaches in the diagnosis, treatment, and prevention of neurodegenerative disorders.
Leveraging Data Science for Global Health
Explores ways to leverage information technology and machine learning to combat disease and promote health, especially in resource-constrained settings. It focuses on digital disease surveillance through the application of machine learning to non-traditional data sources.
Leptomeningeal Metastases
Leptomeningeal Metastases provides the reader with an overview of the state-of-the-art therapy for the leptomeningeal patient with additional information on epidemiology, symptom management, new clinical trials, and current basic research in animal models for experimental therapies. "Leptomeningeal metastases remains a devastating manifestation of hematologic malignancies and solid tumors. Leading figures in the field review the pathophysiology and clinical consequences of this process. State-of-the-art treatment strategies are presented highlighting advances in current management."
Key Clinical Trials in Erectile Dysfunction
Represents a critical appraisal of the major clinical trials that have had a significant impact on clinical research and practice during the last decade. Each trial follows a strict format, starting with reference to the original source of publication, details on the key investigators and their methods of research. The strengths and weaknesses of each trial are discussed as well as their influence on clinical practice. Articles are complemented by a diagrammatic summary of the trial design and the key findings.
