الصفحة 39
الصفحة 39
Dynamic Modeling of Monetary and Fiscal Cooperation Among Nations
The first four chapters introduce the reader to the dynamics of fiscal and monetary policy cooperation. Issues covered include: fiscal coordination, fiscal stringency requirements, structural and bargaining power asymmetries and the design of monetary and fiscal policymaking in a monetary union. In the four last chapters multiple-player settings with aspects of fiscal and/or monetary coordination are analyzed using the endogenous coalition formation approach. The analysis is focused on shock and model asymmetries and issues of multi-country coordination in the presence of (possibly many) monetary unions.
Dynamic Methods for Damage Detection in Structures
Presents an overview of dynamic methods for structural health monitoring and damage detection in structures. This book explains both theoretical and experimental aspects of dynamic non-destructive methods and their connection with inverse and identification problems in structural dynamics.
Dynamic Games : Theory and Applications
Dynamic games continue to attract strong interest from researchers interested in modelling competitive as well as conflict situations exhibiting an intertemporel aspect. Applications of dynamic games have proven to be a suitable methodology to study the behaviour of players (decision-makers) and to predict the outcome of such situations in many areas including engineering, economics, management science, military, biology and political science. Dynamic Games: Theory and Applications collects thirteen articles written by established researchers.
Dynamic Epistemic Logic
Dynamic Epistemic Logic is the logic of knowledge change. This is not about one logical system, but about a whole family of logics that allows us to specify static and dynamic aspects of multi-agent systems. This book provides various logics to support such formal specifications, including proof systems. Concrete examples and epistemic puzzles enliven the exposition. The book also contains exercises including answers and is eminently suitable for graduate courses in logic.
Dry Mouth : A Clinical Guide on Causes, Effects and Treatments
This wide-ranging guide to dry mouth, or xerostomia, is intended to meet the needs of dentists by providing information on all clinically relevant aspects. After introductory discussion of salivary secretion and function, the potential causes of dry mouth, including diseases affecting saliva production, drugs and irradiation, are examined.
Drugs of abuse : Body fluid testing
The authors discuss the various body fluid specimens suitable for testing for illicit drugs describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls sometimes encountered when using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Political, social, and legal issues are also considered in articles on privacy, the use of drug testing in courts, and the problem of sample adulteration.
Drugs in palliative care
While palliative care has adopted a holistic approach to treatment / medication-driven symptom management ostensibly forms the critical aspect of care. Prescribing in palliative care can be extremely complex because the patient may often have comorbidity / or occasionally multimorbidity. The associated polypharmacy further complicates the pharmacological management of symptoms being caused by the palliative condition. This can be daunting for healthcare professionals and can negatively impact upon the effectiveness of care provided. Fully revised and updated / the third edition of Drugs in Palliative Care provides a detailed / yet concise overview of topics that are encountered in palliative care clinical practice. The book will appeal to a variety of healthcare professionals involved in the provision of palliative care and medicines information.
Drug utilization research : Methods and applications
Drug Utilization Research (DUR) is a discipline which combines aspects of pharmacotherapy, epidemiology, and health services research into an interdisciplinary set of methods for analyzing and assessing the prescribing, dispensing and consumption of medicines. It combines both qualitative and quantitative approaches to facilitate the safe and effective use of pharmaceuticals. Drug Utilization Research: Methods and Applications provides a comprehensive introduction to this discipline, prepared by an international team of authors with broad experience in numerous fields. Now reorganized and updated to reflect the latest research and global challenges, it is an indispensable resource for understanding the use of pharmaceuticals.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug target selection and validation
Focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
Drug Selectivity : An Evolving Concept in Medicinal Chemistry
Provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Drug safety evaluation : Methods and protocols
Focuses on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
Drug discovery and development
Presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.
Drug delivery via nasal route
Over the past 10 years, the interest in intranasal drug delivery has increased. The objective of this research is to summarize recent developments on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, nevertheless, there are still formulation limitations and side effects to be optimized. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This research describes the anatomical, histological and physiological basis and summarizes currently approved drugs for administration via intranasal delivery. Further, the research focuses on advantages and disadvantages of intranasal applied compounds and discusses formulation aspects that need to be considered for drug development.
Drug delivery aspects : Expectations and realities of multifunctional drug delivery systems ; Vol.4 : Expectations and realities of multifunctional drug delivery systems
Reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction.
Drop acid
Our most respected scientific literature is bursting with evidence that elevated uric acid levels lie at the root of many pervasive health conditions, but mainstream medicine for the most part remains unaware of this connection. This is especially alarming because many people don’t know they are suffering from sky-high levels, putting them at risk for developing or exacerbating potentially life-threatening illnesses.
Double Fertilization : Embryo and Endosperm Development in Flowering Plants
Double Fertilization" provides a comprehensive overview of all aspects of this central event in the reproduction and development of flowering plants. Written by Val Raghavan, The Ohio State University, an acknowledged expert in plant developmental biology, the book vividly describes the molecular and cellular steps of the unique and complex fertilization process that culminates in the formation of embryo and endosperm, focusing on the latest results from the model plant Arabidopsis. The text is complemented by excellent illustrations, including 16 color plates.
Domain Decomposition Methods - Algorithms and Theory
This book offers a comprehensive presentation of some of the most successful and popular domain decomposition preconditioners for finite and spectral element approximations of partial differential equations. It places strong emphasis on both algorithmic and mathematical aspects. It covers in detail important methods such as FETI and balancing Neumann-Neumann methods and algorithms for spectral element methods.
DNA nanotechnology for cell research : from bioanalysis to biomedicine
Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery.
DNA computing ; Vol. 3384 10th International workshop on DNA computing, DNA10, Milan, Italy, June 7-10, 2004, Revised Selected Papers
This book constitutes the thoroughly refereed postproceedings of the 10th International Workshop on DNA Based Computers, DNA10, held in Milano, Italy in June 2004. The 39 revised full papers presented were carefully selected during two rounds of reviewing and improvement from an initial total of 94 submissions. The papers address all current issues in DNA based computing and biomolecular computing ranging from theoretical and methodological issues to implementations and experimental aspects.
