الصفحة 35
الصفحة 35
Gene Therapy of Autoimmune Disease
Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene Expression and Regulation
This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. Presented in the following five sections, this book covers a full spectrum of topics: The History; The Machinery; The Regulators; The Genome; and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The Special Topics section discusses several selected topics ranging from bacterial and plant gene expression to DNA topology and interference RNA. The book’s focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Gender Innovation and Migration in Switzerland
This book analyses migration and its relation to socio-political transformation in Switzerland. It addresses how migration has made new forms of life possible and shows how this process generated gender innovation in different fields: the changing division of work, the establishment of a nursery infrastructure, access to higher education for women, and the struggle for female suffrage. Seeing society through the lens of migration alters the perspective from which our past and thus our present is told—and our future imagined.
Gender and migration : IMISCOE short reader
This short reader offers a critical review of the debates on the transformation of migration and gendered mobilities primarily in Europe, though also engaging in wider theoretical insights. Building on empirical case studies and grounded in an analytical framework that incorporates both men and women, masculinities, sexualities and wider intersectional insights, this reader provides an accessible overview of conceptual developments and methodological shifts and their implications for a gendered understanding of migration in the past 30 years. It explores different and emerging approaches in major areas, such as: gendered labour markets across diverse sectors beyond domestic and care work to include skilled sectors of social reproduction; the significance of families in migration and transnational families.
Gastroesophagal reflux disease (GERD)
Gastroesophageal reflux disease (GERD) is a common disease with a high prevalence worldwide and a great socioeconomic burden. GERD is a multifactorial disease in which anatomical and functional factors both play a pathogenetic role. The disease can manifest in various symptoms which can be grouped into typical, atypical and extra-esophageal symptoms. The pathophysiology of GERD is complex and not completely understood. An abnormal LES pressure and increased reflux during transient LES relaxations are believed to be key etiologic factors. Prolonged exposure of the esophagus to acid is another. Heartburn and acid regurgitation are the most common symptoms of GERD, although pathologic reflux can result in a wide variety of clinical presentations.
Gas Transport in Porous Media
This book presents a compilation of state-of-the art studies on gas and vapor transport processes in porous and fractured media. A broad set of models and processes is presented, including advection/diffusion, the Dusty Gas Model, enhanced vapor diffusion, phase change, coupled processes, solid/vapor sorption, and vapor-pressure lowering. Numerous applications are also presented that illustrate these processes and models in current problems facing the scientific community.
Gap Junctions in Development and Disease
Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed.
Game Theory : A Multi-Leveled Approach
This book presents the basics of game theory both on an undergraduate level and on a more advanced mathematical level. It covers most topics of interest in game theory, including cooperative game theory. Part I presents introductions to all these topics on a basic yet formally precise level. It includes chapters on repeated games, social choice theory, and selected topics such as bargaining theory, exchange economies, and matching. Part II goes deeper into noncooperative theory and treats the theory of zerosum games, refinements of Nash equilibrium in strategic as well as extensive form games, and evolutionary games. Part III covers basic concepts in the theory of transferable utility games, such as core and balancedness, Shapley value and variations, and nucleolus. Some mathematical tools on duality and convexity are collected in Part IV. Every chapter in the book concludes with a problem section. Hints, answers and solutions are included.
Gallium Nitride Processing for Electronics, Sensors and Spintronics
Semiconductor spintronics is expected to lead to a new generation of transistors, lasers and integrated magnetic sensors that can be used to create ultra-low power, high speed memory, logic and photonic devices. Useful spintronic devices will need materials with practical magnetic ordering temperatures and current research points to gallium and aluminium nitride magnetic superconductors as having great potential.Gallium Nitride Processing for Electronics, Sensors and Spintronics details current research into the properties of III-nitride semiconductors and their usefulness in novel devices such as spin-polarized light emitters, spin field effect transistors, integrated sensors and high temperature electronics.
Galactose Regulon of Yeast : From Genetics to Systems Biology
The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. The book starts with a brief historical overview on yeast research, i.e. early observations in enzyme adaptation, classical genetics, formulating hypotheses based on genetic inference. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. The power of mutational analysis in deciphering molecular mechanisms is conveyed. Further, contemporary topics such as genomics, evolution, single cell analysis of transcriptional switching, binary and graded responses, biological consequences of feed back regulation in genetic circuits, and stochasticity are addressed.
Fuzzy set approach to multidimensional poverty measurement
This volume brings together advanced thinking on the multidimensional measurement of poverty, including the theoretical background, applications to cross-sections using contemporary European examples, and longitudinal aspects of multidimensional fuzzy poverty analysis that pay particular attention to the transitory, or impermanent, conditions that often occur during transitions to market economies.
Future space-transport-system components under high thermal and mechanical loads : results from the DFG Collaborative Research Center TRR40
This book presents the findings of Collaborative Research Center Transregio 40 (TRR40), initiated in July 2008 and funded by the German Research Foundation (DFG). Gathering innovative design concepts for thrust chambers and nozzles, as well as cutting-edge methods of aft-body flow control and propulsion-component cooling, it brings together fundamental research undertaken at universities, testing carried out at the German Aerospace Center (DLR) and industrial developments from the ArianeGroup
Future data and security engineering ; 7th International conference, FDSE 2020, Quy Nhon, Vietnam, November 25–27, 2020, Proceedings
This book constitutes the proceedings of the 7th International Conference on Future Data and Security Engineering, FDSE 2020, which was supposed to be held in Quy Nhon, Vietnam, in November 2020, but the conference was held virtually due to the COVID-19 pandemic. The 24 full papers (of 53 accepted full papers) presented together with 2 invited keynotes were carefully reviewed and selected from 161 submissions. The other 29 accepted full and 8 short papers are included in CCIS 1306. The selected papers are organized into the following topical headings: security issues in big data; big data analytics and distributed systems; advances in big data query processing and optimization; blockchain and applications; industry 4.0 and smart city: data analytics and security; advanced studies in machine learning for security; and emerging data management systems and applications.
Future data and security engineering : Big data, security and privacy, smart city and industry 4.0 applications ; 7th International Conference, FDSE 2020, Quy Nhon, Vietnam, November 25–27, 2020, Proceedings
This book constitutes the proceedings of the 7th International Conference on Future Data and Security Engineering, FDSE 2020, held in Quy Nhon, Vietnam, in November 2020.* The 29 full papers and 8 short were carefully reviewed and selected from 161 submissions. The selected papers are organized into the following topical headings: big data analytics and distributed systems; security and privacy engineering; industry 4.0 and smart city: data analytics and security; data analytics and healthcare systems; machine learning-based big data processing; emerging data management systems and applications; and short papers: security and data engineering.
Fungal Genomics
Presents an overview on mutualistic and pathogenic interactions between fungi and plants. This book offers reviews on fungal lifestyles, mechanisms of their interactions with their host plants, signal perception and transduction, and plant defense responses directed against attack by fungal pathogens. It is suitable for students in microbiology.
Fundamentals of Sustainability in Civil Engineering
Provides a foundation to understand the development of sustainability in civil engineering, and tools to address the three pillars of sustainability: economics, environment, and society. It includes case studies in the five major areas of civil engineering: environmental, structural, geotechnical, transportation, and construction management.
Fundamentals of Solid State Engineering
Fundamentals of Solid State Engineering, 2nd Edition, provides a multi-disciplinary introduction to Solid State Engineering, combining concepts from physics, chemistry, electrical engineering, materials science and mechanical engineering. Basic physics concepts are introduced, followed by a thorough treatment of the technology for solid state engineering. Topics include compound semiconductor bulk and epitaxial thin films growth techniques, current semiconductor device processing and nano-fabrication technologies. Examples of semiconductor devices and a description of their theory of operation are then discussed, including transistors, semiconductor lasers and photodetectors.
Fundamentals of Semiconductors : Physics and Materials Properties
This third updated edition of Fundamentals of Semiconductors attempts to fill the gap between a general solid-state physics textbook and research articles by providing detailed explanations of the electronic, vibrational, transport, and optical properties of semiconductors. The approach is physical and intuitive rather than formal and pedantic. Theories are presented to explain experimental results. This textbook has been written with both students and researchers in mind. Its emphasis is on understanding the physical properties of Si and similar tetrahedrally coordinated semiconductors. The explanations are based on physical insights. Each chapter is enriched by an extensive collection of tables of material parameters, figures, and problems. Many of these problems "lead the student by the hand" to arrive at the results.
Fundamentals of Robotic Mechanical Systems : Theory, Methods, and Algorithms
Fundamentals of Robotic Mechanical Systems, Third Edition addresses robots at large - such as multi-fingered hands, walking machines, flight simulators, and machine tools - that rely on mechanical systems to perform their tasks. The author establishes the foundations on which the design, control, and implementation of the underlying mechanical subsystems are based. The treatment assumes familiarity with some calculus, linear algebra, and elementary mechanics; however, the elements of rigid-body mechanics and linear transformations are reviewed in the first chapters, making the presentation self-contained.
