الصفحة 339
الصفحة 339
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Aritmetica, crittografia e codici = Arithmetic, cryptography and codes
The basic techniques of algebra and number theory useful in recent applications to cryptography and codes are developed, with the aim of being elementary and self-sufficient. The emphasis is on computational problems. This part of the volume can be useful as a textbook for a first course in algebra for mathematicians, computer scientists or engineers. Important applications of algebra and geometry to cryptography and codes are then illustrated. Both, cryptography and codes have significant applications in daily life which are illustrated here. Cryptography is developed in detail in much of its classic and current aspects, and both private and public key cryptography are developed. Cryptography with the use of elliptic curves on finite fields is also illustrated. A chapter introducing the subject is dedicated to linear codes.
Arithmetical investigations : Representation theory, orthogonal polynomials, and quantum interpolations
In this volume the author further develops his philosophy of quantum interpolation between the real numbers and the p-adic numbers. The p-adic numbers contain the p-adic integers Zp which are the inverse limit of the finite rings Z/pn. This gives rise to a tree, and probability measures w on Zp correspond to Markov chains on this tree. From the tree structure one obtains special basis for the Hilbert space L2(Zp,w). The real analogue of the p-adic integers is the interval [-1,1], and a probability measure w on it gives rise to a special basis for L2([-1,1],w) - the orthogonal polynomials, and to a Markov chain on "finite approximations" of [-1,1]. For special (gamma and beta) measures there is a "quantum" or "q-analogue" Markov chain, and a special basis, that within certain limits yield the real and the p-adic theories. This idea can be generalized variously. In representation theory, it is the quantum general linear group GLn(q)that interpolates between the p-adic group GLn(Zp), and between its real (and complex) analogue -the orthogonal On (and unitary Un )groups. There is a similar quantum interpolation between the real and p-adic Fourier transform and between the real and p-adic (local unramified part of) Tate thesis, and Weil explicit sums.
Arithmetic of finite fields ; 1st International Workshop, WAIFI 2007, Madrid, Spain, June 21-22, 2007, Proceedings
This book presented structures in finite fields, efficient implementation and architectures, efficient finite field arithmetic, classification and construction of mappings over finite fields, curve algebra, cryptography, codes, and discrete structures.
ARIS design platform : Advanced process modelling and administration
ARIS is ranked as the leading Business Process Modelling tool in the Gartner Quadrant for Business Process Analysis and Optimization. The ARIS Design Platform is being used as a business process management (BPM) tool for projects in BPM, quality management, business analysis and design, software development, implementation of service-oriented architectures and so forth. Following on from Rob Davis’ successful introductory text, ARIS Design Platform: Getting Started with BPM, this new book covers in detail some of the more advanced concepts of using ARIS Business Architect in the new ARIS 7 Design Platform. Written in a reader-friendly style, it contains detailed explanations of key concepts combined with numerous examples, hints and tips gained from many years of practical experience of using ARIS.
Argumentative Indicators in Discourse : A Pragma-Dialectical Study
Argumentative Indicators: A Pragma-Dialectical Study identifies and analyses English words and expressions that are crucial for an adequate reconstruction of argumentative discourse. It provides the analyst of argumentative discussions and texts with a systematic set of instruments for giving a well-founded analysis which results in an analytic overview of the elements that are relevant for the evaluation of the argumentation. In the book a systematic connection is made between linguistic insights into the characteristics of argumentative discourse and insights from argumentation theory into the resolution of differences of opinion by means of argumentation.
Argumentation in Science Education : Perspectives from Classroom-Based Research
This book brings together the work of leading experts in argumentation in science education. It presents research combining theoretical and empirical perspectives relevant for secondary science classrooms. Since the 1990s, argumentation studies have increased at a rapid pace, from stray papers to a wealth of research exploring ever more sophisticated issues. This volume constitutes a unique collection and covers fundamental issues in argumentation such as cognitive, methodological and epistemological aspects; classroom-based research in teaching and learning of argumentation in science classrooms; and argumentation in context such as in socio-scientific and moral contexts. The book’s underlying premise is that argumentation is a significant aspect of scientific inquiry and plays an important role in teaching and learning of science.
Area-wide control of insect pests : From research to field implementation
This new textbook on area-wide control of insect pests collates a series of selected papers that attempts to address various funda- mental components of AW-IPM, e.g. the importance of relevant problem-solving research, the need for essential baseline data, thesignificanceofadequatetoolsforappropri-atecontrolstrategies,andthevalueofpilottri- als, etc.
Arctic Alpine ecosystems and people in a changing environment
This book addresses the significant environmental changes experienced by high latitude and high altitude ecosystems at the beginning of the 21st c- tury. Increased temperatures and precipitation, reduction in sea ice and glacier ice, the increased levels of UV-radiation and the long-range tra- ported contaminants in arctic and alpine regions are stress factors that challenge terrestrial and aquatic ecosystems. The large natural variation in the physical parameters of these extreme environments is a key factor in structuring the biodiversity and biotic productivity, and the effect of the new stress factors can be critical for the population structures and the - teraction between species. These changes may also have socio-economic effects if the changes affect the bio-production, which form the basis for the marine and terrestrial food chains. The book is uniquely multidisciplinary and provides examples of va- ous aspects of contemporary environmental change in arctic and alpine - gions. The 21 chapters of the book are organised under the fields of •Climate change and ecosystem response, •Long range transport of poll- ants and ecological impacts, and •UV radiation and biological effects, each also including aspects of the •Socio-economic effects of environmental change. The introductory chapter presents and explains the internal c- nection and integration of all chapters.
Architectures of sound
Architects are used to designing visually. In order to expand their basic design tools, this book explores the interactions between sound, space, hearing, and architecture. To this end, the author uses contemporary and historic buildings and projects, but also fictional, philosophical, and theoretical approaches – the idea is not only to define sound as a source, but also as an instrument of architectural space.
Architectures of festival in early modern Europe : Fashioning and re-fashioning urban and courtly space
Draws on up-to-date research by a Europe-wide group of academic scholars and museum and gallery curators to provide a unique, intellectually-stimulating and beautifully-illustrated account of temporary architecture created for festivals of the sixteenth and seventeenth centuries, together with permanent architecture pressed into service for festival occasions across major European locations including Italian, French, Austrian, Scottish and German.
Architecture of normal : the colonization of the American landscape
Charts the patterns created by reigning modes of transportation and examines how people came to accept the bland, branded boxes lining America's streets and freeways as architecture. Beginning with a portrait of ambulatory Native American societies and the introduction of horses by the Spaniards, Kaven discusses the built environment shaped by trains, cars, planes and rockets, and looks toward a future architecture defined by autonomous cars and air taxis
Architecture of computing systems ; 34th International Conference, ARCS 2021, Virtual Event, June 7–8, 2021, Proceedings
This book constitutes the proceedings of the 34th International Conference on Architecture of Computing Systems, ARCS 2021, held virtually in July 2021. The 12 full papers in this volume were carefully reviewed and selected from 24 submissions. 2 workshop papers (VEFRE) are also included. ARCS has always been a conference attracting leading-edge research outcomes in Computer Architecture and Operating Systems, including a wide spectrum of topics ranging from fully integrated, self-powered embedded systems up to high-performance computing systems. It also provides a platform covering newly emerging and cross-cutting topics, such as autonomous and ubiquitous systems, reconfigurable computing and acceleration, neural networks and artificial intelligence. The selected papers cover a variety of topics from the ARCS core domains, including heterogeneous computing, memory optimizations, and organic computing.
Architecture of computing systems - ARCS 2008 ; 21st International Conference, Dresden, Germany, February 25-28, 2008. Proceedings
This book constitutes the refereed proceedings of the 21st International Conference on Architecture of Computing Systems, ARCS 2008, held in Dresden, Germany, in February 2008.
Architecture of computing systems - ARCS 2007 ; 20th International Conference, Zurich, Switzerland, March 12-15, 2007, Proceedings
The ARCS is reporting hi- quality results in computer architecture and operating systems research.It is also represent a - namic, evolving community that closely follows new research trends and topics. ARCS has evolved towards a strong focus on s- tem aspects of pervasive computing and self-organization techniques (organic and autonomic computing).
Architecture of computing systems - ARCS 2006 ; 19th International Conference, Frankfurt / Main, Germany, March 13-16, 2006, Proceedings
Technological progress is one of the driving forces behind the dramatic devel- mentofcomputersystemarchitecturesoverthe pastthreedecades.Eventhough it is quite clear that this development cannot only be measured by the ma- mum number of components on a chip, Moore’s Law may be and is often taken as a simple measure for the non-braked growth of computational power over the years. The more components are realizable on a chip, the more innovative and unconventional ideas can be realized by system architects. As a result, research in computer system architectures is more exciting than ever before. This book coversthe trends that shape the ?eld of computer system archit- tures.
Architecture in context : Designing in the Middle East
Provides a foundation for understanding the critical context of architecture and design in this region. It does this by: presenting a practical overview of architectural know-how in the Middle East, and its potential for cultivating a sense of place introducing local architectural vocabularies and styles, and how they can still be reactivated in contemporary design exploring the cultural and contextual meaning of forms as references that may influence contemporary architecture discussing important discourses and trends in architecture that allow a rethinking of the current global/local dichotomy.
Architecture for residential care and ageing communities : Spaces for dwelling and healthcare
A guide to the planning, architecture, and design of schools that are healthy, stimulating, and will conserve energy and resources. Written with the needs of architects, construction professionals, educators, and school administration in mind, the book provides a road map for sustainable planning, design, construction, and operations.
Architecture description languages ; IFIP TC-2 workshop on architecture description languages (WADL), World Computer Congress, Aug. 22-27, 2004, Toulouse, France
These proceedings record the papers presented at the Workshop onArchitecture Description Languages held in the city of Toulouse in thesouth of France.The aim of an ADL (Architecture Description Language) is to formallydescribe software and hardware architectures. Usually, an ADL describescomponents, their interfaces, their structures, their interactions (structureof data flow and control flow) and the mappings to hardware systems. Amajor goal of such descriptions is to allow analysis with respect to severalaspects like timing, safety, reliability, ...
Architecture constructed : Notes on a discipline
In this book, acclaimed architectural theorist Mark Jarzombek examines this tension head-on, and uses it to rethink the nature of the history of architecture. He reveals architecture to be a troubled, interconnected realm, incomplete and unstable, where labor, craft, and occupation are the ‘invisible’ complements to the work of the architect.
