الصفحة 33
الصفحة 33
Introduction to Computational Biology : An Evolutionary Approach
Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology. This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors.
Introduction to built asset management
Introduction to Built Asset Management is a systematic introduction to both the technology and management issues central to building maintenance and refurbishment. Covering the entire life cycle of built assets, the textbook reviews the role of framework agreements, describes key performance indicators, discusses recent advancements in the procurement of maintenance activities and more.
Introduction to Biosemiotics : The New Biological Synthesis
This book is addressed to students, researchers and academics who have barely heard of the emerging young science of Biosemiotics, and who want to know more about it. Written by many of the field’s major contributors, it provides a highly qualified introduction to Biosemiotics and illustrates the most recent views in its background and development.
Introduction to basics of pharmacology and toxicology ; Vol.3 : Experimental pharmacology : Research methodology and biostatistics
Elaborates on the general principles of experimental pharmacology. Describes about the screening methods for the evaluation of different categories of drugs. Summarizes the various aspects of research methodology and biostatistics.
Introduction to basics of pharmacology and toxicology ; Vol.2 : Essentials of systemic pharmacology : From principles to practice
Describes the pharmacology of drugs acting on different systems in the human body Analyses various human diseases and the pharmacological agents governing them Provides a valuable reference resource for academicians, researchers, and clinical practitioners Offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics.
Introduction to basics of pharmacology and toxicology ; Vol.1 : General and molecular pharmacology : Principles of drug action
Illustrates the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases.
Introduction pratique aux bases de données relationnelles = A practical introduction to relational databases
Cet ouvrage introduit le lecteur dans le domaine des bases de données relationnelles en présentant une vaste sélection de sujets portant sur la modélisation des données, les langages de base de données, l'architecture des systèmes et l'évolution post-relationnelle. - Notions fondamentales: le modèle relationnel, les composants d’un système de gestion de bases de données, l’organisation de la mise en œuvre d’une base de données, les tâches de gestion des données. - De l'analyse à la base de données : le modèle entité association, la généralisation et l’agrégation, les dépendances et les formes normales,les contraintes d’intégrité. - Aperçu des langages de requête et de manipulation des données: l’algèbre relationnelle, le calcul des prédicats, SQL, QUEL, QBE, le traitement des valeurs nulles, la protection des données. - Les composants de l'architecture d'un système de bases de données : la compilation, l’interprétation et l’optimisation des requêtes, l’environnement multiutilisateur, le concept de transaction et la sérialisation, les méthodes optimiste et pessimiste, les structures de stockage et les méthodes d’accès. L’intégration et la migration des bases de données: l’exploitation des bases de données hétérogènes, les bases de données sur le Web, les règles de conversion pour effectuer l’intégration et la migration, les variantes de migration des bases de données hétérogènes, la planification de l’intégration et de la migration.
Introducing Biological Rhythms : A Primer on the Temporal Organization of Life, with Implications for Health, Society, Reproduction, and the Natural Environment
Biological rhythms are a fundamental property of all life and encompass a wide range of frequencies, from seconds to a century or more. Introducing Biological Rhythms is a primer that serves to introduce individuals to the area of biological rhythms. It describes the major characteristics and discusses the implications and applications of these rhythms, while citing scientific results and references. Also, the primer includes essays that provide in-depth historic and other background information for those interested in more specific topics or concepts. Introducing Biological Rhythms covers a basic cross-section of the field of chronobiology clearly enough so that it can be understood by a novice, or an undergraduate student, but it is also sufficiently technical and detailed for the scientist.
Intraspecific Genetic Diversity : Monitoring, Conservation, and Management
Population and evolutionary genetics have been quickly developing ?elds of biological research over the past decades. This book compiles our current understanding of genetic processes in natural populations. In addition, the book provides the author’s original ideas and concepts based on the data obtained by himself and his close coworkers. The author introduces his pioneering concept of population genetic stability,and much of thebook is concerned with the factors and conditions of such stability. Why does genetic stability matter so much? Altukhov argues that the sustainable use of natural resources, including genetic resources of popu- tions, critically depends on the maintenance of their stability. The preser- tion of well-adapted genetic characteristics from one generation to the next is essential for this stability. Traditionally, population genetics has been - cusedonevolution andthe role of evolutionary factorsinshapinggenetic structures of populations. While the idea of a population as a dynamic unit of evolution has been widely accepted, the signi?cance of genetic stability and its implications for the long-term survival of populations and species have not been fully appreciated.
Intraperitoneal Cancer Therapy
The volume details major clinical trails to date, including immunotherapy, hyperthermic treatment of colo-rectal and ovarian cancers. Authors also examine regional approaches to therapy, systemic therapy, and the use of carboplatin and paclitaxel as the standard treatment for women with stages III and IV ovarian cancer. Other chapters also investigate techniques and procedures in treatment, as well as the future direction of both normothermic and hyperthermic intraperitoneal chemotherapy.
Intraoperative Neurophysiological Monitoring
Intraoperative neurophysiological monitoring (IOM) has proven itself a versatile technique that reduces the risks of acquiring intraoperative neurological deficits, shortens operating time, and lowers the costs of medical care and rehabilitation. It can also reduce the risks of medical malpractice suits and serve as a research tool to better understand nervous system disorders and promote improved treatments.
Intramembrane-Cleaving Proteases (I-CLiPs)
The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.
Intracranial vascular malformations and aneurysms : From diagnostic work-up to endovascular therapy ; 2nd ed.
This book describes the pathoanatomical, pathophysiological, and imaging features of vascular malformations and aneurysms of the brain and the modern, minimally invasive endovascular methods and techniques employed in their treatment.
Intracranial vascular malformations and aneurysms : From diagnostic work-up to endovascular therapy ; 1st ed.
This book describes the pathoanatomical, pathophysiological, and imaging features of vascular malformations and aneurysms of the brain and the modern, minimally invasive endovascular methods or techniques employed in their treatment. Individual chapters are devoted to venous malformations, capillary telangiectasias and cavernomas, pial arteriovenous malformations, dural arteriovenous malformations, and intracranial aneurysms. Each chapter is subdivided into four principal sections on pathology, clinical presentation, diagnostic imaging, and therapy, ensuring a standardized approach throughout. The book is richly illustrated with numerous informative CT, MR and DSA images.
Intracranial Pressure and Brain Monitoring XII
88 short papers originating from the 12th International Symposium on Intracranial Pressure and Brain Monitoring held in August 2004 in Hong Kong present experimental as well as clinical research data on invasive and non-invasive intracranial pressure and brain biochemistry monitoring. The papers have undergone a peer-reviewing and are organized in nine sections: ICP management in head injury, neurochemical monitoring, intracranial hypertension, neuroimaging, hydrocephalus, clinical trails, experimental studies, brain compliance and biophysics.
Intracellular Mechanisms for Neuritogenesis
This book present in novel, distinct, but highly related aspects of the intracellular mechanisms required for the formation of a functional neurite, which include cytoskeletal organization, membrane traffic, and signal transduction.
Intestinal Microorganisms of Termites and Other Invertebrates
Soil microorganisms play a major role in the degradation and recycling of organic material. Microbes are involved in the food web and strongly contribute to soil fertility. In the past, attention was mainly directed towards free-living or particle-bound microorganisms, while the role of intestinal microbes of soil animals has been neglected. For the first time, "Intestinal Microorganisms of Termites and Other Invertebrates" focuses on the microbes in gut systems of soil animals. It starts with a profound overview of the biology of soil invertebrates. A major part deals with the gut microbiota of termites, the best investigated gut system of invertebrates. Termites are important soil processors in tropical and subtropical regions. Insight is given into the intestinal microbiota of further relevant primary litter decomposers, such as earthworms, springtails, millipeds, and woodlice. Novel techniques for studying intestinal microbes complete the volume.
Interventions for Persisting Ductus Arteriosus in the Preterm Infant
Over the past few years a remarkably rapid evolution in the professional level of neonatology and in the survival of immature infants has been witnessed. Persisting ductus arteriosus is common in this population and is associated with impaired longterm outcome. Many uncertainties exist concerning indication, approach, best time, and side effects of necessary measurements and interventions to avoid later neurodevelopmental handicaps of the survivors. Experts in neonatology and pediatric cardiology give their opinion in this book. We are sure it will help to define the level of evidence and to develop standards of intervention for persisting ductus arteriosus in Europe. Adequate dealing with the ductus will become a challenge for every perinatal center.
Interventional Radiology in Pain Treatment
Disease whether it is acute, chronic, or at end stage, is all too regularly accompanied by pain. Pain is often difficult to control, in malignant disease in particular, even by using appropriate medications. Anesthesiologists and pain therapists have developed new invasive therapies including nerve block, sympatholysis, and neurolysis useful for both diagnosis and pain management. To insure the efficiency and safety of these procedures, and furthermore for elaborate techniques such as vertebroplasty, cementoplasty, and radio frequency bone ablation, imaging guidance becomes mandatory. This state-of-the-art book describes the techniques elaborated by interventional radiologists in the treatment and palliation of a variety of benign and malignant painful conditions.
Interventional Management of Urological Diseases
This eighth volume in the series Recent Advances in Endourology brings together the latest clinical findings regarding various endourological treatment modalities and innovative materials. In this book, world-recognized experts outline their techniques clearly and concisely to provide an updated review of state-of-the-art endourological techniques.
