الصفحة 31
الصفحة 31
Drug Discovery and Evaluation
The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described.
Drug discovery and development
Presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.
Drug delivery technology : Herbal bioenhancers in pharmaceuticals
Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.
Drug delivery aspects : Expectations and realities of multifunctional drug delivery systems ; Vol.4 : Expectations and realities of multifunctional drug delivery systems
Reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction.
Drug Courts : A New Approach to Treatment and Rehabilitation
This cutting-edge sourcebook is ideal for physicians, addiction treatment practitioners, probation officers, testing programs, judges and anyone else facing challenges in practice with the treatment of drug court participants. This book includes knowledge in treatment of addiction and withdrawal, treatment for patients with dual diagnoses of mental illness and addiction, and treatment of diseases associated with drug use, such as tuberculosis, hepatitis, and HIV infection. Unparalleled discussions of the drug court system and the medical problems of drug court patients are presented.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Driving smart medical diagnosis through AI-powered technologies and applications
Driving Smart Medical Diagnosis Through AI-Powered Technologies and Applications serves as a solution in this era of transformative healthcare and addresses these challenges head-on. It unravels the complexities surrounding the implementation of AI in healthcare, offering in-depth discussions on the latest breakthroughs. From unraveling the mysteries of AI-driven cataract detection to exploring the implications of decentralized mammography classification, the book is a valuable resource that equips scholars with the knowledge to navigate this innovative landscape.
Drawing with a tablet : Easy techniques for mastering digital drawing on location
learn step by step how to create amazing drawings while on the go. Shows sketchers how to take their digital drawing to the next level. Whether you are new to sketching or wish to try the latest technology, this useful guide shares expert tips and techniques for drawing on a tablet. With a focus on using the ProCreate tool, but with information that is relevant to other digital platforms, you will start with the basics, such as opening your file, choosing your resolution, determining your palette, and how to simplify your tools by creating a preferred set of brushes.Covers using layers and groups of layers, and shows you how to create a sketch from start to finish.
Double Fertilization : Embryo and Endosperm Development in Flowering Plants
Double Fertilization" provides a comprehensive overview of all aspects of this central event in the reproduction and development of flowering plants. Written by Val Raghavan, The Ohio State University, an acknowledged expert in plant developmental biology, the book vividly describes the molecular and cellular steps of the unique and complex fertilization process that culminates in the formation of embryo and endosperm, focusing on the latest results from the model plant Arabidopsis. The text is complemented by excellent illustrations, including 16 color plates.
Doppler Ultrasound in Obstetrics and Gynecology
Doppler Ultrasound in Obstetrics & Gynecology encompasses the full spectrum of clinical applications of Doppler ultrasound for the practicing obstetrician-gynecologist, including the latest advances in 3D and color Doppler and the newest techniques in 4D fetal echocardiography. Written by preeminent experts in the field, the book covers the basic and physical principles of Doppler ultrasound; the use of Doppler for fetal examination, including fetal cerebral circulation; Doppler echocardiography of the fetal heart; and the use of Doppler for postdated pregnancy and in cases of multiple gestation. Chapters on the use of Doppler for gynecologic investigation include ultrasound in ectopic pregnancy, for infertility, for benign disorders and for gynecologic malignancies.
Domain-driven design with Java, a practitioner's guide : create simple, elegant, and valuable software solutions for complex business problems
Helps you as a developer and architect to put your knowledge to work in order to create elegant software designs that are enjoyable to work with and easy to reason about. You'll begin with an introduction to the concepts of domain-driven design and discover various ways to apply them in real-world scenarios. You'll also appreciate how DDD is extremely relevant when creating cloud native solutions that employ modern techniques such as event-driven microservices and fine-grained architectures. As you advance through the chapters, you'll get acquainted with core DDD's strategic design concepts such as the ubiquitous language, context maps, bounded contexts, and tactical design elements like aggregates and domain models and events. You'll understand how to apply modern, lightweight modeling techniques such as business value canvas, Wardley mapping, domain storytelling, and event storming, while also learning how to test-drive the system to create solutions that exhibit high degrees of internal quality.
DNA vaccines : Methods and protocols
Details practical procedures on the latest DNA vaccine technology. Chapters guide readers through methods and protocols on DNA vaccine design, the adjuvant influence, production and purification methodologies, delivery systems, and approaches of the influence of DNA vaccines in the immunological response performance and in the cancer immunotherapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
DNA manipulation and analysis
Details technologies on recombinant DNA and nucleic acid manipulation that underpin much of the biological sciences and instructions on how to conduct them successfully. Chapters guide the reader through the basics of oligonucleotide synthesis and DNA sequencing; recombinant DNA plasmid work; cell-free experiments and the latest developments in CRISPR approaches to genome modification.
DNA barcoding : Methods and protocols
Covers the latest advancements and methods used to study DNA barcoding. The chapters in this book are organized into six parts: theory, DNA manipulation, specialized barcoding methods, analysis of DNA barcodes, completing a successful DNA barcode project, and barcoding as citizen science. Part One looks at several theoretical issues in DNA barcoding concerned with DNA barcodes that can and should be used. Part Two discusses protocols for processing samples into DNA barcodes, including DNA isolation, sequencing and managing samples, and the resulting DNA barcodes. Part Three explores the next generation of DNA barcoding such as FRET-based detection, dual nanopore detection, skimming, and closed-tube methods. Part Four addresses programs and websites that handle DNA barcoding data, and includes character-based approaches, barcode gap methods, integrated approaches, and Barcode of Life Database
Distributed Multimedia Retrieval Strategies for Large Scale Networked Systems
Distributed Multimedia Retrieval Strategies for Large Scale Networked Systems presents an up-to-date research status in the domain of distributed video retrieval. This professional book will include several different techniques that are in place for long duration video retrieval. An experimentally tested technology under the JINI platform, demonstrates a practical working system which serves as a feasibility study, as well as the first step in realizing such a technology.
Distributed and Parallel Systems : In Focus : Desktop Grid Computing
In this book contributors investigate parallel and distributed techniques, algorithms, models and applications; present innovative software tools, environments and middleware; focus on various aspects of grid computing; and introduce novel methods for development, deployment, testing and evaluation.
Dissecting the Criminal Corpse : Staging Post-Execution Punishment in Early Modern England
Those convicted of homicide were hanged on the public gallows before being dissected under the Murder Act in Georgian England. Yet, from 1752, whether criminals actually died on the hanging tree or in the dissection room remained a medical mystery in early modern society. Dissecting the Criminal Corpse takes issue with the historical cliché of corpses dangling from the hangman’s rope in crime studies. Some convicted murderers did survive execution in early modern England. Establishing medical death in the heart-lungs-brain was a physical enigma. Criminals had large bullnecks, strong willpowers, and hearty survival instincts. Extreme hypothermia often disguised coma in a prisoner hanged in the winter cold. The youngest and fittest were capable of reviving on the dissection table. Many died under the lancet. Capital legislation disguised a complex medical choreography that surgeons staged. They broke the Hippocratic Oath by executing the Dangerous Dead across England from 1752 until 1832.
Disorders of the Respiratory Tract : Common Challenges in Primary Care
In Disorders of the Respiratory Tract: the author covers the range of knowledge needed to provide excellent care for patients with respiratory disease, from the basics of pulmonary function testing to understanding and caring for common respiratory illnesses, including chronic obstructive pulmonary disease, asthma, allergic rhinitis, and pneumonia. Less common illnesses.
Diseases of the Pancreas : Current Surgical Therapy
"Diseases of the Pancreas" is based on the latest comprehensive data about molecular mechanism of acute pancreatitis, chronic pancreatitis and pancreatic cancer. The diagnostic techniques including histology, radiology, sonography etc.
Diseases of the Abdomen and Pelvis 2018-2021 : Diagnostic Imaging - IDKD Book
This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.
