الصفحة 31
الصفحة 31
Anti Cancer medicines derived from plants
Cancer is a broad term. It describes the disease that results when cellular changes cause the uncontrolled growth and division of cells. Some types of cancer cause rapid cell growth, while others cause cells to grow and divide ata slower rate. Certain forms of cancer result in visible growths called tumors, while others, such as leukemia, do not. Most of the body’s cells have specific functions and fixed lifespans. While it may sound like a bad thing, cell death is part of a natural and beneficial phenomenon called apoptosis.
Anthropologies of Global Maternal and Reproductive Health : From Policy Spaces to Sites of Practice
This open access edited book brings together new research on the mechanisms by which maternal and reproductive health policies are formed and implemented in diverse locales around the world, from global policy spaces to sites of practice. The authors – both internationally respected anthropologists and new voices – demonstrate the value of ethnography and the utility of reproduction as a lens through which to generate rich insights into professionals’ and lay people’s intimate encounters with policy.
Antarctic ecosystems : Environmental contamination, climate change, and human impact
This volume provides an overview of climate change data, its effects on the structure and functioning of Antarctic ecosystems, and the occurrence and cycling of persistent contaminants. It discusses the unique physico-chemical characteristics of the Antarctic environment, ecophysiological adaptations of terrestrial and marine organisms, the transfer of contaminants in pelagic and neritic food chains and the possible consequences for animals at higher trophic levels.
Angiogenesis in Inflammation : Mechanisms and Clinical Correlates
This volume relates the lessons learned from tumour biology applied to inflammation. This issue of Angiogenesis in Inflammation: Mechanisms and Clinical Correlates develops current knowledge on the mechanisms at the molecular and cellular levels as they relate to inflammation, including acute and chronic inflammation, neurogenic initiation, and the role of the multiple cellular components that comprise inflammation: granulocytes, macrophages, fibroblasts, dendritic cells and lymphocytes. This is related to inflammatory disease: not only the familiar angiogenesis dependent diseases of rheumatoid arthritis and psoriasis, but also loci such as the lung, gastric ulcers, the eye with uveitis, wound healing and periodontal disease and their therapy, how this knowledge may be used in the discovery of novel therapeutics. The volume brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and disease, culminating in a discourse on areas for future therapies.
Ane's Encyclopedic Dictionary of General & Applied Entomology
Keeping the requirements of teachers and researchers in mind, this encyclopedic dictionary presents the terminology in entomology and pest management in the most authentic and comprehensive way. It also includes terms related to the close relatives of insects, such as mites and ticks and some other organisms which are pests of crops.
Analyzing uncertainty in civil engineering
This volume addresses the issue of uncertainty in civil engineering from design to construction. Failures do occur in practice. Attributing them to a residual system risk or a faulty execution of the project does not properly cover the range of causes. A closer scrutiny of the adopted design, the engineering model, the data, the soil-construction-interaction and the model assumptions is required. Usually, the uncertainties in initial and boundary conditions are abundant. Current engineering practice often leaves these issues aside, despite the fact that new scientific tools have been developed in the past decades that allow a rational description of uncertainties of all kinds, from model uncertainty to data uncertainty. It is the aim of this volume to have a critical look at current engineering risk concepts in order to raise awareness of uncertainty in numerical computations, shortcomings of a strictly probabilistic safety concept, geotechnical models of failure mechanisms and their implications for construction management, execution, and the juristic question of responsibility. In addition, a number of the new procedures for modelling uncertainty are explained.
Analysis and Synthesis of Logics : How to Cut and Paste Reasoning Systems
Starting with simple examples showing the relevance of cutting and pasting logics, the monograph develops a mathematical theory of combining and decomposing logics, ranging from propositional and first-order based logics to higher-order based logics as well as to non-truth functional logics. The theory covers mechanisms for combining semantic structures and deductive systems either of the same or different nature (for instance, two Hilbert calculi or a Hilbert calculus and a tableau calculus). The important issue of preservation of properties is extensively addressed. For instance, sufficient conditions are provided for a combined logic to be sound and complete when the original component logics are known to be sound and complete.
Analysis and Numerics for Conservation Laws
The physical and chemical mechanisms as well as the sizes of these processes are quite different. So are the motivations for studying them scientifically.The super- 8 nova is a thermo-nuclear explosion on a scale of 10 cm. Astrophysicists try to understand them in order to get insight into fundamental properties of the universe. In hows around airfoils of commercial airliners at the scale of 3 10 cm shock waves occur that influence the stability of the wings as well as fuel consumption in ight. This requires appropriate design of the shape and structure of airfoils by engineers. Knocking occurs in combustion, a chemical 1 process, and must be avoided since it damages motors. The scale is 10 cm and these processes must be optimized for efficiency and environmental conside- tions. The common thread is that the underlying ?uid ?ows may at a certain scale of observation be described by basically the same type of hyperbolic s- tems of partial differential equations in divergence form, called conservation laws. Astrophysicists, engineers and mathematicians share a common interest in scientific progress on theory for these equations and the development of computational methods for solutions of the equations. Due to their wide applicability in modeling of continua. A substantial portion of mathematical research is related to the analysis and numerical approximation of solutions to such equations. Hyperbolic conservation laws in two or more space dimensions still poseone of the main challenges to modern mathematics.
Analgesia
Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use.
An Introduction to Sequential Dynamical Systems
This text is the first to provide a comprehensive introduction to SDS. Driven by numerous examples and thought-provoking problems, the presentation offers good foundational material on finite discrete dynamical systems which leads systematically to an introduction of SDS. Techniques from combinatorics, algebra and graph theory are used to study a broad range of topics, including reversibility, the structure of fixed points and periodic orbits, equivalence, morphisms and reduction. Unlike other books that concentrate on determining the structure of various networks, this book investigates the dynamics over these networks by focusing on how the underlying graph structure influences the properties of the associated dynamical system.
An Introduction to Language Processing with Perl and Prolog : An Outline of Theories, Implementation, and Application with Special Consideration of English, French, and German
This book teaches the principles of natural language processing, first covering linguistics issues such as encoding, entropy, and annotation schemes; defining words, tokens and parts of speech; and morphology. It then details the language-processing functions involved, including part-of-speech tagging using rules and stochastic techniques; using Prolog to write phase-structure grammars; parsing techniques and syntactic formalisms; semantics, predicate logic and lexical semantics; and analysis of discourse, and applications in dialog systems. The key feature of the book is the author's hands-on approach throughout, with extensive exercises, sample code in Prolog and Perl, and a detailed introduction to Prolog. The reader is supported with a companion website that contains teaching slides, programs, and additional material.
Amino acids and the asymmetry of life : Caught in the act of formation
This book describes how the basic building blocks of life, the amino acids, formed. After a comprehensible introduction into stereochemistry, the author addresses the inherent property of amino acids in living organisms, namely the preference for left-handedness. What was the cause for violation of parity of amino acids in the emergence of life on Earth? All the fascinating models proposed by physicists, chemists and biologist are vividly presented including the scientific conflicts.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Alpha-1 antitrypsin : Methods and protocols
Provides a collection of protocols that will allow researchers to further explore the multiple, fascinating activities of Alpha-1 Antitrypsin (AAT) isoforms in innate immunity, and gene therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Allosteric Regulatory Enzymes
This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Allocating public and private resources across generations : Riding the age waves ; Vol .2
The chapters in this volume greatly develop our understanding of the nature and measurement of transfers, their motives and mechanisms, and their macro-level dimensions, especially in the context of demographic transitions.
Alkaliphiles : Genetic properties and applications of enzymes
The pioneering work of Dr. Koki Horikoshi on the discovery, research and applications of alkaliphilic bacteria are described here in their entirety. The isolation, distribution and taxonomy of alkaliphilic microorganisms as well as their cell structure and physiology are discussed for a basic understanding of these entities. The molecular biology and genome sequencing of some alkaliphilic bacterial strains are also presented. Part II of the volume focuses on enzymes of alkaliphiles and their applications. These include alkaline proteases, starch-degrading enzymes and numerous others. Some of these enzymes are currently in wide commercial use as laundry detergent additives and in wastewater treatment. Alkaliphiles are a relatively recent field of research that will no doubt provide avenues to a wide range of further discoveries and applications for a new generation of workers in bioscience and technology.
Algae and Cyanobacteria in Extreme Environments
ALGAE AND CYANOBACTRIA IN EXTREME ENVIRONMENTS is a unique collection of essays, contributed by leading scientists from around the world, devoted to algae – and some related microbes – observed in unexpected harsh habits, which it seems are an oasis or Garden of Eden for these organisms. This timely book on Extremophilic alga, including its especially impressive micrographs, may provide clues about the edges of life on Earth and possibly elsewhere in the universe. This volume is a must for students of the field of biodiversity, as well as those in Phycology, ecology and general biological research.
Agrobacterium : From Biology to Biotechnology
Agrobacterium’ is a comprehensive book on Agrobacterium research, including its history, application, basic biology discoveries, and effects on human society. Although the book largely focuses on providing a detailed review of virtually all molecular events of the genetic transformation process, it also provides coverage of ethical and legal issues relevant to the use of Agrobacterium as a "genetic transformation machine". The result is an all-inclusive text which readers—including scientists and students involved in plant genetic engineering—will find useful as a reference source for all major aspects of the Agrobacterium-mediated genetic transformation of plant and non-plant organisms.
