الصفحة 30
الصفحة 30
Computational drug discovery and design
Provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery.
Computational drug discovery : methods and application
Covers a wide range of cutting-edge computational technologies and computational chemistry methods that are transforming drug discovery. The book delves into recent advances, particularly focusing on artificial intelligence (AI) and its application for protein structure prediction, AI-enabled virtual screening, and generative modeling for compound design. Additionally, it covers key technological advancements in computing such as quantum and cloud computing that are driving innovations in drug discovery.
Computational Discovery of Scientific Knowledge : Introduction, Techniques, and Applications in Environmental and Life Sciences
Advances in technology have enabled the collection of data from scientific observations, simulations, and experiments at an ever-increasing pace. For the scientist and engineer to benefit from these enhanced data collecting capabilities, it is becoming clear that semi-automated data analysis techniques must be applied to find the useful information in the data. Computational scientific discovery methods can be used to this end: they focus on applying computational methods to automate scientific activities, such as finding laws from observational data. In contrast to mining scientific data, which focuses on building highly predictive models, computational scientific discovery puts a strong emphasis on discovering knowledge represented in formalisms used by scientists and engineers, such as numeric equations and reaction pathways. This state-of-the-art survey provides an introduction to computational approaches to the discovery of scientific knowledge and gives an overview of recent advances in this area, including techniques and applications in environmental and life sciences.
Computational conflict research
This book brings together a set of original studies that use cutting-edge computational methods to investigate conflict at various geographic scales and degrees of intensity and violence.
Color in Dentistry : A Clinical Guide to Predictable Esthetics
Provides step-by-step protocols to help dental professionals accurately match, communicate, and reproduce the color of teeth and gingiva. These authors demonstrate how to implement color science in simple problem-solving instructions for predictable esthetics in both clinical protocols and laboratory techniques. An extensive presentation of clinical cases is included to illustrate the use of recommended protocols in general practice. An outstanding contribution to the practice and theory of color management in contemporary dentistry
Color Harmony for Artists : How to Transform Inspiration into Beautiful Watercolor Palettes and Paintings
In Color Harmony for Artists, you'll learn to create expressive palettes and paintings through artist Ana Victoria Calderon's stunning work and inspiring instruction.
Color Atlas of Congenital Heart Surgery
Color Atlas of Congenital Heart Surgery covers the full spectrum of congenital heart defects, first depicting the pathology in pre-repair photographs and then detailing step-by-step the operative procedure. Dr. Litwin depicts the most common procedures along with the most complex ones, providing a range of information vital to residents and fellows in training as well as clinicians in practice.
Collins English dictionary and thesaurus : All-in-one support for everyday use ; 4th ed.
The perfect word reference to broaden your knowledge of English, ideal for everyday use, at home, in the office or at school. Matching dictionary and thesaurus entries are shown together for easy reference, with synonyms clearly shown in shaded boxes. Collins English Dictionary and Thesaurus combines a comprehensive dictionary with all the alternatives and opposites you need on the same page.
Collective Phenomena in Synchrotron Radiation Sources : Prediction, Diagnostics, Countermeasures
This book helps to dispel the notion that collective phenomena, which have become increasingly important in modern storage rings, are an obscure and inaccessible topic. Despite an emphasis on synchrotron light sources, the basic concepts presented here are valid for other facilities as well. Graduate students, scientists and engineers working in an accelerator environment will find this to be a systematic exposition of the principles behind collective instabilities and lifetime-limiting effects. Experimental methods to identify and characterize collective effects are also surveyed. Among other measures to improve the performance of a projected or existing facility, a detailed account of feedback control of instabilities is given.
Collaborative networks and their breeding environments ; IFIP TC 5 WG 5.5 Sixth IFIP Working Conference on VIRTUAL ENTERPRISES, 26-28 September 2005, Valencia, Spain
This book contains selected articles from PRO-VE'05, the sixth working conference on virtual enterprises, which was sponsored by the International Federation for Information Processing (IFIP) and held in Valencia, Spain. Being recognized as the most focused scientific / technical conference on Collaborative Networks, PRO-VE continues offering the opportunity for the presentation and discussion of both the latest research developments and practical application case studies. Following the IFIP vision. The articles included in this book represent a comprehensive overview of recent advances in various domains and lines of development of collaborative networks. Of particular relevance are the topics of holistic approaches and breeding environments management, creation and management of virtual organizations and professional virtual communications, performance measurement and management, benefit analysis, trust management, process modeling and meta-modeling, ICT infrastructures and support services, legal issues, and case studies.
Collaborating against child abuse : Exploring the Nordic Barnahus model
This edited collection explores the background and implementation of the Nordic Barnahus (or 'Children's House') model – recognised as one of the most important reforms related to children who are the victims of crime in the Nordic region. This book discusses both its potential to affect change and the challenges facing it. The model was introduced as a response to a growing recognition of the need for more integrated and child-centred services for children exposed to violence and sexual abuse. In the Barnahus structure, different professions work together to ensure that victimized children receive help and treatment and that their legal rights are met. This original study is organised into four broad themes: child-friendliness, support and treatment; the forensic child investigative interview; children’s rights perspectives; and interagency collaboration and professional autonomy.
Cold-Water Corals and Ecosystems
Following the exciting exploration of hot vent and cold seep ecosystems, the rediscovery of cold-water coral ecosystems with high-technology instrumentation is currently another hot topic in multidisciplinary marine research. Conventionally, coral reefs are regarded as restricted to warm and well-illuminated tropical seas, not associated with cold and dark waters of higher latitudes. However, ongoing scientific missions have shed light on the global significance of this overlooked ecosystem. Cold-water coral ecosystems are involved in the formation of large seabed structures such as reefs and giant carbonate mounds, and they represent unexploited paleo-environmental archives of earth history. Like their tropical cousins, cold-water coral ecosystems harbour rich species diversity. Despite the great water depths, commercial interests overlap more and more with the coral occurrences. Human activities already impinge directly on cold-water coral reefs causing severe damage to this vulnerable ecosystem. In this volume, the current key institutions involved in cold-water coral research have contributed 62 state-of-the-art articles from geology and oceanography to biology and conservation.
Cold War Civil Defence in Western Europe : Sociotechnical Imaginaries of Survival and Preparedness
This edited collection brings together established and new perspectives on Cold War civil defence in Western Europe within a common analytical framework that also facilitates comparative and transnational dimensions. The current interest in creating disaster-resilient societies demands new histories of civil defence. Historical contextualization is essential in order to understand what is at stake in preparing, devising, and implementing forms of preparedness, protection, and security that are specifically targeted at societies and citizens. Applying the concept of sociotechnical imaginaries to civil defence history, the chapters of this volume cover a range of new themes, from technology and materiality to media, memory, and everyday experience.
Coercive human rights: positive duties to mobilise the criminal law under the ECHR
Traditionally, human rights have protected those facing the sharp edge of the criminal justice system. But over time human rights law has become increasingly infused with duties to mobilise criminal law towards protection and redress for violation of rights. These developments give rise to a whole host of questions concerning the precise parameters of coercive human rights, the rationale(s) that underpin them, and their effects and implications for victims, perpetrators, domestic legal systems, and for the theory and practice of human rights and criminal justice. This collection addresses these questions with a focus on the rich jurisprudence of the European Court of Human Rights (ECtHR).
Coastal architectures and politics of tourism : Leisurescapes in the global sunbelt
Offers a critical and complicated picture of how leisure tourism connected the world after the World War II, transforming coastal lands, traditional societies, and national economies in new ways. Analyzes selected case studies of architectures and landscapes around the world, contextualizing them within economic geographies of national development, the geopolitics of the Cold War, the legacies of colonialism, and the international dynamics of decolonization. Postwar leisure tourism evokes a rich array of architectural spaces and altered coastal landscapes, which is explored in this collection through discussions of tourism developments in the Mediterranean littoral, such as Greece, Turkey, and southern France, as well as compelling analyses of Soviet bloc seaside resorts along the Black Sea and Baltic coasts, and in beachscapes and tourism architectures of western and eastern hemispheres, from Southern California to Sri Lanka, South Korea, and Egypt.
CMOS single chip fast frequency hopping synthesizers for Wireless multi-gigahertz applications : Design methodology, analysis, and implementation
Describes an efficient design and characterization methodology that has been developed to study loop trade-offs in both open and close loop modelling techniques. This is based on a simulation platform that incorporates both behavioral models and measured/simulated sub-blocks of the chosen frequency synthesizer. The platform predicts accurately the phase noise, spurious and switching performance of the final design. Therefore excellent phase noise and spurious performance can be achieved while meeting all the specified requirements. The design methodology reduces the need for silicon re-spin enabling circuit designers to directly meet cost, performance and schedule milestones. The developed knowledge and techniques have been used in the successful design and implementation of two high speed multi-mode fractional-N frequency synthesizers for the IEEE 801.11a/b/g standards. Both synthesizer designs are described in details.
Clinical Ultrasound in Benign Proctology : 2-D and 3-D Anal, Vaginal and Transperineal Techniques
Anal US may provide the clinician with useful information for both classification, diagnosis and management of anorectal sepsis, anal incontinence and anorectal-perineal chronic pain. Almost any case presented in this Atlas shows both imaging and clinical pictures, thus allowing both the radiologist and the clinician to assess the reliability of the exam and the outcome of the selected treatment.
Mathematical Models for Registration and Applications to Medical Imaging
Image registration is an emerging topic in image processing with many applications in medical imaging, picture and movie processing. The classical problem of image registration is concerned with ?nding an appropriate transformation between two data sets. This fuzzy de?nition of registration requires a mathematical modeling and in particular a mathematical speci?cation of the terms appropriate transformations and correlation between data sets. Depending on the type of application, typically Euler, rigid, plastic, elastic deformations are considered. The variety of similarity p measures ranges from a simpleL distance between the pixel values of the data to mutual information or entropy distances. This goal of this book is to highlight by some experts in industry and medicine relevant and emerging image registration applications and to show new emerging mathematical technologies in these areas. Currently, many registration application are solved based on variational prin- ple requiring sophisticated analysis, such as calculus of variations and the theory of partial differential equations, to name but a few. Due to the numerical compl- ity of registration problems ef?cient numerical realization are required. Concepts like multi-level solver for partial differential equations, non-convex optimization, and so on play an important role. Mathematical and numerical issues in the area of registration are discussed by some of the experts in this volume.
Mathematical Modelling for Sustainable Development
Mathematics needs Sustainable Development. When science was gradually reinvented in European medieval societies, it was legitimised as contributing to the disclosure of God’s divine creation. The conflicts that emerged became well known as a result of the clash between Galileo and the Church. Science found a new legitimacy through recognition that it was a powerful force against superstition. In the Enlightenment the argument was pushed forward by attributing Progress to the advancement of science: science could produce a better world by promoting rationality. In our modern society, science has become intimately linked to technology. Science for its own sake unfortunately rarely has positive outcomes in terms of research grant applications. Meanwhile, science and technology, and the progress they are supposed to produce, meet with wide scale scepticism. We all know of the current global problems: climate change, resource depletion, a thinning ozone layer, space debris, declining biodiversity, malnutrition, dying ecosystems, global inequity, and the risk of unprecedented nuclear wars
Mathematical and Computational Models for Congestion Charging
This book presents rigorous treatments of issues related to congestion pricing. The chapters describe recent advances in areas such as mathematical and computational models for predicting traffic congestion, determining when, where, and how much to levy tolls, and analyzing the impact of tolls on transporation systems. The analyses and methodologies developed in this book provide Mechanisms that aid in determining and comparing congestion pricing schemes; Methodologies for evaluating the efficiency of existing and proposed congestion pricing schemes; A means to predict the impact of pricing on urban transporation systems; and Information essential to the financial and political success of congestion pricing programs.
