الصفحة 3
الصفحة 3
Financial management for technology start-ups : How to power growth, track performance and drive innovation
Develops the financial intelligence you need to communicate effectively with investors, implement business strategies and pinpoint emerging pathways for profit / Outlines how to analyze your performance and undertake risk-return assessments to tactically grow your start-up / Offers proven methods for tracking your start-up's progress to ensure that growth is maintained and continuous / Analysis of financial statements directly from start-ups, new case studies on companies that have scaled up, focus on new digital technologies and market opportunities for start-ups, information on new players and potential future tech start-ups
Exploring the Vertebrate Central Cholinergic Nervous System
The volume’s eleven chapters cover a wide variety of topics including the complexity of synthesis of acetylcholine, cholinesterases, cholinergic teratology, anticholinesterase agents, clinical use of cholinergic drugs, central cholinergic pathways and behaviors with cholinergic correlates. The figures and diagrams help illustrate various subjects and its photographs of "cholinergikes" of the past and present bring a personal note to the book. The book illustrates the peaks that have been reached in the course of the history of cholinergic research and challenges the perennial frontier of human science: the understanding of ourselves.
Evolutionary computation, machine learning and data mining in bioinformatics ; 6th European Conference, EvoBIO 2008, Naples, Italy, March 26-28, 2008. Proceedings
The feld of bioinformatics has two main objectives: the creation and main- nance of biological databases, and the discovery of knowledge from life sciences data in order to unravel the mysteries of biological function, leading to new drugs and therapies for human disease. Life sciences data come in the form of biological sequences, structures, pathways, or literature. One major aspect of discovering biological knowledge is to search, predict, or model specifc infortioninagivendatasetinorderto generate new in teresting knowledge.Computer science methods such as evolutionary computation, machine learning, and data mining all have a great deal to ofer the feld of bioinformatics.
Evaluation of the use of medicine plants in cancer treatment
Turmeric (Curcuma longa) and ginger (Zingiber officinale) have been widely studied for their potential anticancer effects, primarily due to the bioactive compounds curcumin and gingerol. Both compounds exhibit significant therapeutic properties, including anti-inflammatory, antioxidant, pro-apoptotic, and anti-angiogenic activities, which target key pathways implicated in cancer progression, such as NF-κB, STAT-3, and mTOR. Through these mechanisms, curcumin and gingerol inhibit tumor growth, reduce metastasis, and enhance the efficacy of conventional cancer treatments.
European Higher Education Area: The Impact of Past and Future Policies
Sketches a vivid picture of the state of higher education in Europe almost 30 years after the fall of the Berlin Wall. The emphasis is on the role of the Bologna Process, The authors document long-term transformations and recent cracks in the established higher education pathways and the broader policy narratives that supported them for the last 20-30 years.Are we witnessing the advent of a new era? If so, that raises questions regarding the future of higher education, some of which are addressed in this volume. How will this new historical situation influence higher education? What can be done in higher education, building on what has been already achieved in these past years, including the Bologna Process itself, to benefit citizens, institutions, countries, and Europe as a whole?
Ethnobotany : A phytochemical perspective
Explores the chemistry behind hundreds of plant medicines, dyes, fibers, flavors, poisons, insect repellants, and many other uses of botanicals. Bridging the gap between ethnobotany and chemistry, this book presents an introduction to botany, ethnobotany, and phytochemistry to clearly join these fields of study and highlight their importance in the discovery of botanical uses in modern industry and research. Part I. Ethnobotany, explores the history of plant exploration, current issues such as conservation and intellectual property rights, and a review of plant anatomy. An extensive section on plant taxonomy highlights particularly influential and economically important plants from across the plant kingdom. Part II. Phytochemistry, provides fundamentals of secondary metabolism, includes line drawings of biosynthetic pathways and chemical structures, and describes traditional and modern methods of plant extraction and analysis. The last section is devoted to the history of native plants and people and case studies on plants that changed the course of human history from five geographical regions: Africa, the Americas, Asia, Europe, and Ocean. Throughout the entire book, vivid color photographs bring science to life, capturing the essence of human botanical knowledge and the beauty of the plant kingdom.
Energy Metabolism and Obesity : Research and Clinical Applications
Elucidate the most important aspects of genetic background, neuropeptide secretion and action, neuronal pathways, adipokines, gut hormones, and environmental influences (physical activity, pharmacologic agents, and surgical alteration of the gastrointestinal tract), as well as the complex interactions among them.
Energy in Africa : Challenges and Opportunities
This open access book presents a picture of the current energy challenges on the African continent (and the Sub-Saharan region in particular) and proposes pathways to an accelerated energy transition. Starting with an analysis of the status quo and the outlook for Africa’s energy demand and energy access, it provides an account of the available resources, including hydrocarbons and renewable energy resources, which are playing an increasingly crucial role. It then moves on to analyze the level of investment required to scale-up Africa’s energy systems, shedding light on the key barriers and elaborating on potential solutions. It also provides a suggestion for improving the effectiveness of EU–Africa cooperation. While mainly intended for policymakers and academics, this book also speaks to a broader audience interested in gaining an overview of the challenges and opportunities of the African energy sector today and in the future.
Endosperm : Developmental and Molecular Biology
This book is the first comprehensive overview of the developmental and molecular biology of endosperm. The text covers cereal endosperm development from fertilization to maturity, including molecular and cell biology of the syncytial phase, the cellularization process and cell fate specification of the embryo surrounding region cells, the basal transfer cells, the starchy endosperm and aleurone cells. In addition, endosperm development in the model species Arabidopsis thaliana is covered, along with recent progress in endosperm in vitro culture. Special features of endosperm, such as imprinting, polyploidy, programmed cell death and anthocyanin biosynthesis, are described in separate chapters. Finally, the genes and pathways for the main nutritional components of endosperm, storage proteins and starch are covered in detail.
EGFR Signaling Networks in Cancer Therapy
EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis.
Effector-triggered immunity : methods and protocols
Presents a collection of protocols to study effector-triggered immunity (ETI) in both plants and animals from eminent groups in the field. Cover topics such as genetic manipulation of plant and animal pathogens, host cells, and the analysis of key host responses; and techniques used for the analysis of inflammasome activation, cell death pathways, and mitochondria damage in response to pathogens. All of these topics cover a broad spectrum of immunological, biochemical, cell biological, and structural biology approaches to examine ETI.
Drug Addiction : From Basic Research to Therapy
Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume covers the translation of basic research into novel therapies, not only of drug addiction but a spectrum of related CNS disorders, including pain. Chapters are written by leading scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and development, drug targeting, and quantitative therapeutics, providing an unprecedented overview of a complex field of high societal signficance.
Dislocation and Degradation of Proteins from the Endoplasmic Reticulum
The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made.
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
Decision Making under Deep Uncertainty : From Theory to Practice
Focuses on both the theory and practice associated with the tools and approaches for decisionmaking in the face of deep uncertainty. It explores approaches and tools supporting the design of strategic plans under deep uncertainty, and their testing in the real world, including barriers and enablers for their use in practice. The book broadens traditional approaches and tools to include the analysis of actors and networks related to the problem at hand. It also shows how lessons learned in the application process can be used to improve the approaches and tools used in the design process. The book offers guidance in identifying and applying appropriate approaches and tools to design plans, as well as advice on implementing these plans in the real world. For decisionmakers and practitioners, the book includes realistic examples and practical guidelines that should help them understand what decisionmaking under deep uncertainty is and how it may be of assistance to them.
Cross cultural issues in consumer science and consumer psychology : Current perspectives and future directions
Shows cross-cultural issues in consumer psychology and consumer science as the world becomes an increasingly global marketplace. An international panel of experts analyzes current trends in consumer behavior across diverse countries worldwide and across cultural groups within countries, depicting commonly-used cross-cultural frameworks and research methods. Beginning with conceptualizing and quantifying culture at the national level, the volume then moves to individual levels of analysis of consumer decision-making, examining consumer data as they affect business decisions in marketing products internationally. The resulting work synthesizes the consumer science, international business, and consumer psychology literatures for a deeper understanding of all three disciplines and pathways to future research as cultures interact and tastes evolve.
Computational Materials Chemistry : Methods and Applications
As a result of the advancements in algorithms and the huge increase in speed of computers over the past decade, electronic structure calculations have evolved into a valuable tool for characterizing surface species and for elucidating the pathways for their formation and reactivity. It is also now possible to calculate, including electric field effects, STM images for surface structures. To date the calculation of such images has been dominated by density functional methods, primarily because the computational cost of - curate wave-function based calculations using either realistic cluster or slab models would be prohibitive. DFT calculations have proven especially valuable for elucidating chemical processes on silicon and other semiconductor surfaces. However, it is also clear that some of the systems to which DFT methods have been applied have large non-dynamical correlation effects, which may not be properly handled by the current generation of Kohn-Sham-based density functionals. For example, our CASSCF calculations on the Si(001)/acetylene system reveal that at some geometries there is extensive 86 configuration mixing. This, in turn, could signal problems for DFT cal- lations on these systems.
Computational Discovery of Scientific Knowledge : Introduction, Techniques, and Applications in Environmental and Life Sciences
Advances in technology have enabled the collection of data from scientific observations, simulations, and experiments at an ever-increasing pace. For the scientist and engineer to benefit from these enhanced data collecting capabilities, it is becoming clear that semi-automated data analysis techniques must be applied to find the useful information in the data. Computational scientific discovery methods can be used to this end: they focus on applying computational methods to automate scientific activities, such as finding laws from observational data. In contrast to mining scientific data, which focuses on building highly predictive models, computational scientific discovery puts a strong emphasis on discovering knowledge represented in formalisms used by scientists and engineers, such as numeric equations and reaction pathways. This state-of-the-art survey provides an introduction to computational approaches to the discovery of scientific knowledge and gives an overview of recent advances in this area, including techniques and applications in environmental and life sciences.
Cohen's Pathways of the Pulp
Full color illustrations and detailed radiographs guide readers through each step of endodontic care — from diagnosis and treatment planning to proven techniques for managing pulpal and periapical diseases. This new twelfth edition also boasts the very latest evidence-based research and techniques, reorganized and condensed chapters, plus other features designed to help you locate important information quickly and easily. Complete with access to Expert Consult, it’s everything you need to stay ahead in the field of endodontics.
Clinical Pathways in Stroke Rehabilitation : Evidence-based Clinical Practice Recommendations
This book focuses on practical clinical problems that are frequently encountered in stroke rehabilitation. Consequences of diseases, e.g. impairments and activity limitations, are addressed in rehabilitation with the overall goal to reduce disability and promote participation.
