الصفحة 3
الصفحة 3
Metal Catalyzed Cascade Reactions
Transition metal-catalyzed cascade reactions are an elegant approach to complex molecular scaffolds. Besides their esthetics and increase in structural complexity, they have also become mechanistic challenges for the combination of organometallic elementary steps. As a consequence, cascade reactions have revolutionized synthetic strategies and conceptual thinking. The authors highlight cyclization via carbopalladation and acylpalladation and Heck-pericyclic sequences. They discuss p-allyl palladium-based cascade reactions, Michael-type additions as an entry to transition-metal-promoted cyclizative transformations, and sequential or consecutive palladium-catalyzed processes, and show Pauson-Khand cascades, metal-catalyzed cyclizations of acyclic precursors, as well as cascade and sequential ruthenium-catalyzed transformations. Therefore, the reader finds overview of an exciting and highly dynamic field of a new and innovative methodological concept
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Iron Nutrition in Plants and Rhizospheric Microorganisms
This book uses an interdisciplinary approach to provide a comprehensive review on the status of iron nutrition in plants. International scientists discuss research on acquisition of iron by strategy I and strategy II plants. These reviews summarize a variety of plant species and include both laboratory and field observations. Topics covered in this book include: plants as a source of iron for animals and humans, iron translocation in the plants, iron-stimulated activities that influence crop yield and fruit tree productivity, iron uptake by plants as influenced by microorganisms (i.e. free living soil microorganisms, symbiotic nitrogen-fixing and pathogenic bacteria), the role of plant hormones in iron transport, iron-metal competition in phytoremediation, root zone activities involving interactions between minerals and organic matter, the role of microbial siderophores in rhizospheric iron cycling, iron storage as phytoferritin, proteomic and metabolic studies associated with iron stress response, methods for studying iron metabolism including stable isotopes, and the correction of iron deficiency through the use of synthetic or natural chelates.
Ion Channels
Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field.
Introduction to organic and medicinal chemistry
Designed to be an undergraduate reference textbook for students of chemistry who aim to select degree modules geared towards medicinal chemistry. The first two chapters offer an overview of basic organic chemistry, followed by organic synthesis in Chapter 3, with an emphasis on the importance of synthetic procedures in relation to the chemistry of drug design. In Chapter 4, the book covers foundational aspects of biochemistry and biomedical science to provide a basis for students understanding where and how drugs work on selected targets. Later, the book explains how medicines have been created for selected topics in medicinal chemistry – namely against pathogens, cancer and neurological targets.
Introduction to Ion Beam Biotechnology
It presents treatment of modern ion beam biotechnology and with respect to applications of ion beam bombardment of living cellular material in the hybrid field of ion beam physics and biology.Key Topics include: – Ion beam formation – Ion implantation fundamentals – Interaction between energetic ions and biological organisms – Reaction processes of ion implanted biological small molecules – Damage and repair of ion-bombarded DNA – Cell damage due to ion bombardment – Biological effects of ion implantation – Fundamentals of ion-bombardment-induced genetic variation – Ion beam mutation breeding of crops – Ion beam mutation breeding of microbes – Ion beam induced gene transfer – Ion beam induced synthesis of organic molecules – Single-ion bombardment mutation of cells
Introduction to blender 3.0 : Learn organic and architectural modeling, lighting, materials, painting, rendering, and compositing with blender
Explains modeling, materials, lighting, painting, and more with Blender and other external tools. You will configure a 3D architectural environment and set up the workflow of an art and design project within Blender. You will use Blender's main tools—mesh modeling and sculpting—to create virtual objects and environments. And, you will explore building materials and light scenes, followed by drawing and virtual painting. Chapters cover rendering scenes and transforming them into 2D images or videos. You will learn to use Blender 3.0 for video editing as a compositor and video sequence editor (VSE or sequencer) with a wide range of effects available through the nodal system. You Will Learn : Create objects and architectural buildings with different techniques of 3D modeling / Master creating an environment for your objects and how to light them / Determine how to create node materials and assign them to your Blender objects / Pick up UV unwrapping and texture painting / Get closer to painting and drawing in Blender / Render your scenes and create stunning videos
Intestinal Microorganisms of Termites and Other Invertebrates
Soil microorganisms play a major role in the degradation and recycling of organic material. Microbes are involved in the food web and strongly contribute to soil fertility. In the past, attention was mainly directed towards free-living or particle-bound microorganisms, while the role of intestinal microbes of soil animals has been neglected. For the first time, "Intestinal Microorganisms of Termites and Other Invertebrates" focuses on the microbes in gut systems of soil animals. It starts with a profound overview of the biology of soil invertebrates. A major part deals with the gut microbiota of termites, the best investigated gut system of invertebrates. Termites are important soil processors in tropical and subtropical regions. Insight is given into the intestinal microbiota of further relevant primary litter decomposers, such as earthworms, springtails, millipeds, and woodlice. Novel techniques for studying intestinal microbes complete the volume.
Intermolecular Forces and Clusters II
This slim volume, contains papers written by leading researchers of intermolecular forces and clusters in honor of Anthony Stone. Taken together, the articles provide an accurate snapshot of current work on selected aspects of intermolecular forces and clusters that are primarily, but not exclusively, theoretical, Scientists and students interested in pursuing research on intermolecular forces and/or clusters would benefit
Intermolecular Forces and Clusters I
the present volume is a collection of reviews, here intended to describe the present state-of-the-art in the construction and use of intermolecular force fields. In particular, this is Part I of a two-part collection dedicated to Anthony J. Stone, a pioneer in both high-level ab initio quantum chemistry and the theory and practice of intermolecular forces. ...
Interior Spaces : Space, Light, Materials
Space, light and material: from the meditative ambiance of a chapel or synagogue to the colourful, organic forms of fashion boutiques, the design of an interior space - composed of lighting, the surfaces, textures and colours of materials, finishing and features - creates atmosphere and lends specific character. The growing willingness on the part of designers in recent years to experiment with colours, materials and spatial concepts is demonstrated in the range and diversity of international examples presented in this, the third volume in the series "In Detail". All plans and drawings of interiors and furnishings have been carefully researched and drawn by the staff of DETAIL.
Interactive Music Center
مع تقدم الأزمنة وتطور الحضارات وظهور الشباب الحيوي كانت الموسيقى مصدر جذب الشباب اليافع بالإضافة لكونها مهنة ومصدر دخل العديد جاء مركز هارموني ليجمع اهداف الموسيقى العديدة باختلافها سواء الترفيهي او الثقافي أو التعليمي في مكان واحد وبهذا فان الهدف الأساسي من المشروع هو خلق بيئة جاذبة لمتذوقي الموسيقى بشتى الوسائل وباختلاف الطرق سواء الكترونية تفاعليه أو محسوسة.
Institutional Dynamics in Environmental Governance
This book presents fresh analyses of a number of well-known cases, but does so from one comprehensive view, the so-called policy arrangement approach. Cases discussed range over organic farming, integrated water management, nature policy, cultural heritage policy, integrated region-oriented policy, corporate environmental management and target group policy, always in search of the commonality of experience and conclusions to be drawn in understanding the past and in formulating future perspectives.
Inorganic Scintillators for Detector Systems : Physical Principles and Crystal Engineering
The development of new scintillators as components of modern detector systems is increasingly defined by the end user's needs. This book provides an introduction to this emerging topic at the interface of physics and materials sciences, with emphasis on bulk inorganic scintillators. After surveying the end user's needs in a vast range of applications, ranging from astrophysics to industrial R & D, the authors move on to review scintillating mechanisms and the properties of the most important materials used. A chapter on crystal engineering and examples of recent developments in the field of high-energy physics and medical imaging introduce the reader to the practical aspects. This book will benefit researchers and scientists working in academic and industrial R & D related to the development of scintillators.
Inorganic Reactions in Water
Organized to facilitate reference to the reagents involved, this book describes the reactions of the elements and their mostly simpler compounds, primarily inorganic ones and primarily in water. It emphasizes the similarities and differences in actual chemical behavior, as opposed to electronic structures and theories, although not exclusively.Inorganic Reactions in Water again makes available some of the more comprehensive coverage of descriptive aqueous chemistry found in older sources, but now corrected and interpreted with the added insights of the last seven decades. It also provides new information, including reactions of the recently discovered elements.
Inorganic Polymeric Nanocomposites and Membranes
This series presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and materials science. It is addressed to all scientists at universities and in industry who wish to keep abreast of advances in the topics covered.This Book reviews different methods of synthesis of polysilalkylene or silarylene siloxanes that are sometimes called "hybrid" silicones. This special type of silicone has been developed to avoid the drawback of the depolymerization of classical polysiloxanes in certain conditions and to obtain elastomers with enhanced thermal and fuel resistance properties.
Inorganic Constituents in Soil : Basics and Visuals
A must-read for students of and beginners in soil science. In a well-organized and easy-to-follow manner, it provides basic outlines of soil minerals, new methods and recent developments in the field, with a special focus on visual aids. The chapters on primary minerals, secondary minerals, non-crystalline inorganic constituents and inorganic constituents sensitive to varying redox conditions will help readers understand the basic components of soils. Further, readers are introduced to new analytical methods with the aid of microscopy and recent developments in the field. Uniquely, the book features case studies on the identification and isolation methods for vivianite crystals from paddy field soils, as well as a identical procedure for identifying noncrystalline constituents such as volcanic glasses and plant opals, which can also be applied to other soils depending on the local conditions.
Inorganic and Organometallic Polymers
This book has its origins in courses taught by the author to various und- graduate and graduate students at the Indian Institute of Technology, K- pur, India. The diversity of inorganic chemistry and its impact on polymer chemistry has been profound. This subject matter has grown considerably in the last decade and the need to present it in a coherent manner to young minds is a pedagogic challenge. The aim of this book is to present to the students an introduction to the developments in Inorganic and - ganometallic polymers. This book is divided into eight chapters. Chapter 1 provides a general overview on the challenges of Inorganic polymer synthesis. This is f- lowed by a survey of organic polymers and also includes some basic f- tures of polymers. Chapters 3-8 deal with prominent families of inorganic and organometallic polymers. Although the target group of this book is the undergraduate and graduate students of chemistry, chemical engineering and materials science it is also hoped that chemists and related scientists in industry would find this book useful.
Inorganic and Organometallic Macromolecules : Design and Applications
Polymers containing metals and metal-like atoms are essential materials for the extended opportunities and demands of the 21st century. This book describes the synthesis of some of these polymers and their potential application in many fields such as materials, biomedicine, engineering, communications, and ceramics.
Inherited inborn errors in amino acids metabolism
Proteins are the most abundant organic molecules in animals, playing important roles in all aspects of cell structure and function. Proteins are biopolymers of acids, so named because the amino group is bonded to the carbon atom, next to the carbonyl group.
