الصفحة 3
الصفحة 3
Exosomes based drug delivery strategies for brain disorders
Provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.
Error-Correction Coding and Decoding : Bounds, Codes, Decoders, Analysis and Applications
This book discusses both the theory and practical applications of self-correcting data, commonly known as error-correcting codes. The applications included demonstrate the importance of these codes in a wide range of everyday technologies, from smartphones to secure communications and transactions. Written in a readily understandable style,This book is a valuable resource for anyone interested in error-correcting codes and their applications, ranging from non-experts to professionals at the forefront of research in their field.
Enterprising worlds : A geographic perspective on economics, environments & ethics
Enterprising World represents the culmination of several years of work by geographers, planners, and economists. The chapters included in this volume represent the collective efforts of the International Geographical Union’s Commission on the Dynamics of Economic Spaces. This collection is the result of the 2005 annual meeting in Toledo, Ohio (USA). The chapters have been selected based on their contribution to the broader community of economic geographers and policymakers and to demonstrate the inherent interconnectedness of these themes (and at times the conceptual tension that exists between ethics, economics, and the environment) insofar as these important issues shape the contours and cleavages of contemporary regional development.
Emerging Threats to Energy Security and Stability; Proceedings of the NATO Advanced Research Workshop on Emerging Threats to Energy Security and Stability, London, United Kingdom, from 23 to 25 January 2004
In particular, it sought to assess emerging threats to energy security and stability and discuss new security strategies to protect global energy supplies from regional instability and terrorism. The format involved a wide-ranging international group of poli- formers and advisers from NATO, Partner and other countries, in a unique forum for intensive expert discussion. Background The international community is increasingly conscious of the need to develop new energy security strategies in order to protect global energy supplies from regional instability and terrorism. Energy security is a vital element in international stability. However, a variety of energy-related economic, technical, and military/political factors pose serious challenges to the international community’s pursuit of energy security and stability: The global economy is expected to continue to be largely dependent on oil and gas for the next twenty to thirty years.
Electrical Diseases of the Heart : Genetics, Mechanisms, Treatment, Prevention
Electrical Diseases of the Heart is a thorough clinical reference on the current status of cardiac electrophysiological disease,emphasizing common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology, and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science.
Diet and nutrition in neurological disorders
Offers readers a comprehensive reference on the effect of dietary regimes in a wide variety of neurological diseases. With coverage of different types of diets, including Mediterranean or DASH, this broad coverage allows readers to learn about diets and their affect on specific disorders which may well be relevant to other conditions. This includes diseases such as Alzheimer’s, Parkinson’s, ALS, MS and severe neurological conditions such as brain injury, stroke, headache and migraine. This volume provides a platform for research on new dietary regimes and on future investigations of diet and nutrition.
Designing Inclusive Futures
Designing Inclusive Futures reflects the need to explore, in a coherent way, the issues and practicalities that lie behind design that is intended to extend our active future lives. This encompasses design for inclusion in daily life at home but also extends to the workplace and for products within these contexts.
Designing Accessible Technology
This book was stimulated by the third CWUAAT workshop, held in Cambridge, England in April 2006; the contributors representing leading researchers in the fields of Inclusive Design, Rehabilitation Robotics, Universal Access and Assistive Technology. Contributions focus on the following topics: design issues for a more inclusive world / enabling computer access and the development of new technologies / assistive technology and rehabilitation robotics and understanding users and involving them in design.
Deep Brain Stimulation in Neurological and Psychiatric Disorders
Deep Brain Stimulation in Neurological and Psychiatric Disorders discusses today’s most current and cutting-edge applications of DBS. Initially used to treat Parkinson’s disease and essential tremor, DBS now has new clinical indications, new anatomic targets, and new technologies that enable an expanded role for DBS in the treatment of other movement disorders.
Crypto Wars : Faked Deaths, Missing Billions and Industry Disruption
Unveils the biggest scams and frauds that have shocked the world of cryptocurrency, from the disappearing Crypto Queen with OneCoin, to Bitconnect, the initial coin offering crash and Quadriga where the founder seems to have faked his own death to escape prosecution Contains exclusive interviews and commentaries from many of the key people who have been actively investigating the biggest crypto-scams, from the Metropolitan police, to insolvency practitioners, researchers, BBC journalists and tech geeks Goes beyond the sensationalist and concludes on the real potential for change and good that cryptocurrencies bring; from challenging the greedy practices of the banking and remittance industries, to reaching over 2.5 billion unbanked users, allowing for greater transparency and ethical behaviours
Critical practices in architecture : The unexamined
Embraces the idea that in today's complex world, multiple, emerging perspectives are critical to the design fields, the environment, and society. It also brings authors into conversation to focus on the built environment from the perspective of critical practice.
County lines : Criminal networks and evolving drug markets in Britain
This brief sheds light on evolving drug markets and the county lines phenomenon in the British context. Drawing upon empirical research gathered in the field between 2012-2019 across two sites, Scotland’s West Coast and Merseyside in England, adopts a grounded approach to the drug supply model, detailing how drugs are purchased, sold and distributed at every level of the supply chain at both sites.
Costi sociali e aspetti farmacoeconomici = Social costs and pharmacoeconomic aspects
La sclerosi multipla (SM) rappresenta la seconda causa di disabilità neurologica nel giovane adulto, dopo i traumi cranici. Negli ultimi anni, l'introduzione di nuovi farmaci, potenzialmente in grado di modificare il decorso della malattia, ha richiamato l'attenzione sui costi sociali della SM e sugli aspetti farmaco-economici. Si sono avanzati, da un lato, timori che il costo dei nuovi farmaci costituisca un onere insostenibile per il sistema sanitario. Dall'altro lato, recenti studi economici hanno sottolineato l'importanza di una valutazione inserita in una prospettiva più ampia, considerando la possibilità che le nuove terapie possano ridurre i costi sociali di malattia nel lungo termine, ritardando o evitando lo sviluppo di invalidità. Questo volume rivede la letteratura internazionale sui costi sociali della SM, e gli studi farmaco-economici sui nuovi farmaci per la malattia.
Cognitive Behavioral Treatment of Insomnia : A Session-by-Session Guide
Cognitive behavior therapy which has been adapted to treat so many problems, has also brought data-driven and data-yielding treatment to insomnia. Focusing on this evidence-based modality, Cognitive Behavioral Treatment of Insomnia is a much-needed treatment manual that provides clinicians with the why’s and how’s of this approach in concise and practical terms.
Co-enzyme Q10
Coenzyme Q10 is a vitamin like substance that has been found in both microorganisms and plants as well as in animals and humans. In this research we will talk about CoenzymeQ10, it’s biochemical functions and roles in health and diseases such as Parkinson, cardiovascular diseases, diabetes, male fertility, cancers , covid19 and immune functions. Some coQ10 determination methods in foods will be discussed. At the last can we use it as asupplement? Does it have an adverse effects and contraindications? and what are the factors that affect on it’s plasma concentrations ? .
Clinical Pharmacology of Sleep
This volume covers the clinical and pharmacological treatment of several important sleep disorders such as insomnia, sleep apnea, narcolepsy, restless legs syndrome, and periodic limb movement syndrome. It further addresses the use of sleep medications in children, adolescents, and in the elderly. It offers a comprehensive overview of the currently available hypnotic medications and covers aspects of chronopharmacology and its implications for the pharmacology of sleep. It also reviews the basic science of sleep and sleep disorders, and thus the potential development of new pharmacological approaches. The book will be useful for physicians, psychopharmacologists, psychiatrists, sleep disorder specialists and other healthcare professionals such as nurses, social workers and graduate medical students.
Macro-Engineering : A Challenge for the Future
Macro-engineering involves the large-scale modification and manipulation of natural systems for the benefit of mankind. The primary goals of some Earth-based macroprojects described in this book are power production, land reclamation, food production, climate change, environment, water, transport and coastal protection. Other Earth or space projects considered here have a more futuristic ring, but our present-day technical skill makes their realization possible. Earth-based macroprojects usually combine different aspects and aims. They have a major impact on the ecology of a region and the inhabitants' means of living (like tourism, fishing, shipping). Its effects may be felt worldwide, like the rise in global sea level after the damming and evaporation of large ocean gulfs for power production, or the change in climate following the regional reduction of solar insolation.
Justice in extreme cases: criminal law theory meets international criminal law
Shows how to use moral theory to challenge and improve ICL, and how extreme cases can challenge and improve criminal law theory. It will appeal to scholars and jurists in ICL, as well as scholars of criminal law theory or legal philosophy.
Its Not About the Technology : Developing the Craft of Thinking for a High Technology Corporation
This book is not about a new concept, or a new technique. It tackles the big questions of how to develop the craft of the thinking that is required of us in high technology companies. It is predicated on a radical notion that, even though the problematic is the execution in a high technology corporation, neither a high level market strategy nor the kind of technology itself matters, insofar as learning the craft of execution goes. How marketers and engineers comprehend a context uniquely shapes the ways they interact, engage in decision-making phenomenon, and eventually their execution performance in a company. The breakdown of their interaction occurs when the individual contexts of a marketer and an engineer are permanently secluded from one another.this book methodically demystifies the key to successful execution in the high technology space
Component-Based Software Development for Embedded Systems : An Overview of Current Research Trends
Embedded systems are ubiquitous. They appear in cell phones, microwave ovens, refrigerators, consumer electronics, cars, and jets. Some of these embedded s- tems are safety- or security-critical such as in medical equipment, nuclear plants, and X-by-wire control systems in naval, ground and aerospace transportation - hicles. With the continuing shift from hardware to software, embedded systems are increasingly dominated by embedded software. Embedded software is complex. Its engineering inherently involves a mul- disciplinary interplay with the physics of the embedding system or environment. Embedded software also comes in ever larger quantity and diversity. The next generation of premium automobiles will carry around one gigabyte of binary code. The proposed US DDX submarine is e?ectively a ?oating embedded so- ware system, comprising 30 billion lines of code written in over 100 programming languages. Embedded software is expensive. Cost estimates are quoted at around US$15– 30 per line (from commencement to shipping). In the defense realm, costs can range up to $100, while for highly critical applications, such as the Space Shuttle, the cost per line approximates $1,000. In view of the exponential increase in complexity, the projected costs of future embedded software are staggering.
