الصفحة 3
الصفحة 3
Intraspecific Genetic Diversity : Monitoring, Conservation, and Management
Population and evolutionary genetics have been quickly developing ?elds of biological research over the past decades. This book compiles our current understanding of genetic processes in natural populations. In addition, the book provides the author’s original ideas and concepts based on the data obtained by himself and his close coworkers. The author introduces his pioneering concept of population genetic stability,and much of thebook is concerned with the factors and conditions of such stability. Why does genetic stability matter so much? Altukhov argues that the sustainable use of natural resources, including genetic resources of popu- tions, critically depends on the maintenance of their stability. The preser- tion of well-adapted genetic characteristics from one generation to the next is essential for this stability. Traditionally, population genetics has been - cusedonevolution andthe role of evolutionary factorsinshapinggenetic structures of populations. While the idea of a population as a dynamic unit of evolution has been widely accepted, the signi?cance of genetic stability and its implications for the long-term survival of populations and species have not been fully appreciated.
Integrated Management and Biocontrol of Vegetable and Grain Crops Nematodes
The second volume of the IMPD series describes aspects related to most important phytoparasitic nematodes, considering the integration of biological control methods with other management practices and technologies, including the use of predatory nematodes and microbial rhizosphere antagonists. Chapters cover topics like the mode of action and interactions of nematophagous fungi, the efficacy of controll and management of plant parasitic nematode communities through a soil conservation approach, and exploitation of nematodes-bacteria antagonistic relationships.
Influenza Vaccines for the Future
The threat constituted by the multiple outbreaks of avian influenza during the last few years is urgently calling for the development of new influenza vaccines. Fortunately, a quantum leap in technology has revolutionized the study of influenza and the engineering of new vaccine strains by reverse genetics. This volume provides a historical background and state-of-the-art information about the recent advances in the biology of influenza and the design of new influenza vaccines.
Inflammatory Bowel Disease and Familial Adenomatous Polyposis : Clinical Management and Patients' Quality of Life
Inflammatory bowel disease (IBD) and familial adenomatous polyposis (FAP) are complex diseases, which are subject to numerous medical researches. IBD and FAP represent a challenge for a multidisciplinary medical approach where different personnel play major roles in different stages of the patient’s treatment.
In Vitro Culture of Mycorrhizas
biologists have made important progress in understanding better the functioning of AM fungi. An in vitro technique has been developed using mycorrhizal root organ cultures, which made it possible to investigate the genetics, cell biology and physiology of AM fungi. We can now be objective enough to critically evaluate the impacts the in vitro technique has had to improve our knowledge on mycorrhizal symbiosis.
Immunology, phenotype first : How mutations have established new principles and pathways in immunology
This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists.
Immunoinformatics
Immunoinformatics is an emerging subdiscipline of bioinformatics. It utilizes mathematics, information science, computer engineering, genomics, proteomics and immunological methods to bridge immunology and informatics. Similar to bioionformatics which became a driving force in genome research, immunoinformatics enables data-driven research strategies and systems approaches that aim at understanding the networks regulating the immune system. Considering the breath of topic, Immunoinformatics was composed to provide a cross-section of research ranging from data integration, epitope predictions to systems level applications. In ten chapters experts in the field introduce and discuss research strategies for immunologists and bioinformaticians who wish to endeavour existing and new approaches to gain insight into the workings of the immune system.
Immunogenetics: Methods and Protocols
Explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive immune receptor repertoire. Many chapters are dedicated to lab protocols, bioinformatics, and immunoinformatics analysis of high-resolution immunome analysis, exemplified by numerous applications. Additionally, the newest technological variations on these protocols are discussed, including non-amplicon, single-cell, and cell-free strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Immune Mechanisms in Inflammatory Bowel Disease
Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
I recettori dellangiotensina : Dalla biologia molecolare alla terapia con gli antagonisti recettoriali
Describes all the structural and functional characteristics of angiotensin receptors, with particular reference to their molecular and pharmacological properties. The therapeutic applications of AT1 receptor antagonists and the results obtained from large trials are also discussed, especially in arterial hypertension, heart failure, diabetic nephropathy and stroke.
Human tooth and developmental dental defects : compositional and genetic implications
Focuses on the qualitative and quantitative properties of the sound enamel and dentin as well as the affected human tooth structures. It examines how genetics impact oral and dental health, the role of fluoride and trace elements in mineralization and the related clinical implications, and the impact of different approaches to diagnose and treat these developmental disorders.
Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population
Old-age survival has considerably improved in the second half of the twentieth century. In this book, these fundamental questions are explored by experts from such diverse fields as biology, medicine, epidemiology, demography, sociology, and mathematics: they report on recent cutting-edge studies about essential issues of human longevity such as evolution of lifespan of species, genetics of human longevity, reasons for the recent improvement in survival of the elderly, medical and behavioral causes of deaths among very old people, and social factors of long survival in old age.
Human genetics : concepts and applications
Human genetics is about variation more than about illnesses, and increasingly about the common rather than about the rare. Once an obscure science or an occasional explanation for an odd collection of symptoms, human genetics is now part of everyday conversation. This book shows students how and why that is true.
Hox Gene Expression
The study of Hox genes is crucial not only in exploring the enigma of homeosis but also in understanding normal development at the fundamental molecular level. "Hox Gene Expression" starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes- their evolution, structure, normal and abnormal function. Researchers and graduate students in Biology and Medicine will benefit from this integrated overview of Hox gene activities.
Homing Endonucleases and Inteins
This book provides detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein combinations.
Heterogeneity in statistical genetics : How to assess, address, and account for mixtures in association studies
Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon.In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association.
Hereditary Peripheral Neuropathies
"Hereditary Peripheral Neuropathies" deals with the Charcot-Marie-Tooth group of neuropathies and related primary hereditary neuropathies. The knowledge in this field has grown exponentially during the last ten years. The book is divided into two sections. The first section deals with the clinical presentation, electrophysiological features and differential diagnosis of these disorders as well as with the general biology of the peripheral nerve. The second section gives a detailed account of the known disease entities. The book will be interesting for both the clinician with a special interest in PNS diseases as well as for the researcher.
Hepatitis Delta Virus ; Vol. 307
Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
Hematologic Malignancies : Acute Leukemias
Several chapters in this volume describe current knowledge of acute leukemia biology and discuss new classification systems that have arisen consequent to emerging insights into pathogenesis. Treatment has also improved for particular types of acute leukemia.
