الصفحة 3
الصفحة 3
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
Diverse Roles of Integrin Receptors in Articular Cartilage
Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
Current Perspectives in microRNAs (miRNA)
In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.
Coronavirus Replication and Reverse Genetics
This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.
Mammalian and Avian Transgenesis : New Approaches
Mammalian and Avian Transgenesis presents a collection of novel methods for the production of a wide range of transgenic animals. The manual focuses largely on mice, but also contains protocols for successful transgenesis in rats, cows, pigs and birds. The manual provides detailed, step-by-step protocols covering all aspects of the production of transgenic animals, including the use of lentiviral vectors in gene transfer, intracytoplasmic sperm injection, nuclear transfer, large insert transgenesis, conditional gene expression systems, the use of reporter genes in transgenesis and transgenesis in large animals and birds. The text is supplemented by superb color photos. While the focus is on newly established techniques, the fundamental methods of transgenesis are also covered for those new to the field. Thus this manual is perfectly suited for those wishing to adopt new technologies in transgenesis.
Lotus japonicus Handbook
Represents the first effort to compile basic descriptions and methods for research in Lotus, including symbiotic processes, cell and molecular biology protocols, functional genomics, mutants, gene tagging and genetic analysis, transformation and reverse genetic analysis, primary and secondary metabolism, and an exhaustive update of the scientific literature available on this plant.
Kaposi Sarcoma Herpesvirus : New Perspectives
Since the identificationof two sequences fromKSHV,wehave learnedmuch about this pathogen as reflected in this book. As it turned out, KSHV itself encodes for a number of cytokines, and induces cellular cytokine secretion, contributing to tumour growth. Moreover, KSHV vFLIP targets the IKKNFκB axis to encourage the inflammatory microenvironment observed by Gallo and his colleagues. KSHV continues to elucidate both mechanisms of viral oncogenesis, and cellular and immune pathways involved in non-viral driven neoplasia.
Computational and Statistical Approaches to Genomics
Computational and Statistical Approaches to Genomics, 2nd Edition, aims to help researchers deal with current genomic challenges. During the three years after the publication of the first edition of this book, the computational and statistical research in genomics have become increasingly more important and indispensable for understanding cellular behavior under a variety of environmental conditions and for tackling challenging clinical problems. In the first edition, the organizational structure was: data à analysis à synthesis à application. In the second edition, the same structure remains, but the chapters that primarily focused on applications have been deleted.
Communication in Plants : Neuronal Aspects of Plant Life
Plant neurobiology is a newly emerging field of plant sciences. It covers signalling and communication at all levels of biological organization – from molecules up to ecological communities. In this book, plants are presented as intelligent and social organisms with complex forms of communication and information processing. Authors from diverse backgrounds such as molecular and cellular biology, electrophysiology, as well as ecology treat the most important aspects of plant communication, including the plant immune system, abilities of plants to recognize self, signal transduction, receptors, plant neurotransmitters and plant neurophysiology. Further, plants are able to recognize the identity of herbivores and organize the defence responses accordingly. The similarities in animal and plant neuronal/immune systems are discussed too. All these hidden aspects of plant life and behaviour will stimulate further intense investigations in order to understand the communicative plants in their whole complexity.
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. developments of basic science into effective new approaches to the patient.
Chromatin and Disease
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics.
Cell Technology for Cell Products ; Proceedings of the 19th ESACT Meeting, Harrogate, UK, June 5-8, 2005
The 19th ESACT meeting was to highlight the novel capabilities of the industry to move the products towards the clinic and was attended by a wide range of workers in the industry and for many it was their first ESACT meeting. The meeting was started with a session on Transcription to Secretion with a notable set of presentations on the emerging issues. The other sessions that followed Therapeutic Cell Engineering, Gene Medicine, Cells to Tissue, Protein products and Process Technology guided the delegates through the advances made for the progression of the biotechnology towards the industrial application of the products from cells. The meeting was supported by some exceptional invited speakers from around the world whose contributions complemented the emerging technologies and the changes being made at the industrial end of the ESACT spectrum.
Cell and Molecular Biology of Plastids
The present book provides a comprehensive overview of our current knowledge on plastid biogenesis, plastid-nuclear communication, the regulation of plastid gene expression at all levels, and also assesses the state of the art in key technologies, such as proteomics and chloroplast transformation. Written by recognized experts in the field, it covers plastid differentiation and division, genome structure and function, plastid inheritance, recombination, DNA replication and repair, transcription, RNA processing and translation as well as crucial posttranslational processes in plastid biogenesis and function, including protein processing, the assembly of multiprotein complexes, protein stability and degradation, protein import and sorting.
Cancer Informatics in the Post Genomic Era : Toward Information-Based Medicine
Medical information science requires analytic tools. This is achieved by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools.Key challenges include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.Addressing important clinical questions in cancer research will benefit from expanding computational biology.
Cancer : Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related.
Biotechnology for the Future
One area that has attracted much attention is the use of cell factories for the production of a wide range of chemicals. This area illustrates very well the definition of biochemical engineering , and it has therefore been chosen as the focus of this volume. The use of cell factories for production of chemicals dates back to the production of penicillin, ethanol, acetone–butanol, glycerol and further to enzymes and other antibiotics. All these products were traditionally produced by cell factories that naturally produce these compounds. With the introduction of genetic engineering it has,This volume therefore contains chapters on concepts of metabolic engineering on detailed modeling of cellular systems
BioMEMS and biomedical nanotechnology ; Vol. II : Micro/Nano Technologies for Genomics and Proteomics
Numerous miniaturized DNA microarray, DNA chip, Lab on a Chip and biosensor devices have been developed and commercialized. Such devices are improving the way many impor-tant genomic and proteomic analyses are performed in both research and clinical diagnostic laboratories. The development of these technologies was enabled by a synergistic combina-tion of disciplines that include microfabrication, microfluidics, MEMS, organic chemistry and molecular biology. Some of these new devices and technologies utilize sophisticated mi-crofabrication processes developed by the semiconductor industry.
Bioinformatics research and development ; 2nd International Conference, BIRD 2008 Vienna, Austria, July 7-9, 2008 Proceedings
This book constitutes the refereed proceedings of the Second International Bioinformatics Research and Development Conference, BIRD 2008, held in Vienna, Austria in July 2008.
Bioinformatics research and applications ; 3rd International Symposium,ISBRA 2007, Atlanta, GA, USA, May 7-10, 2007, Proceedings
This book including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.
Bioinformatics of genome regulation and structure II
The conference was organized by the Laboratory of Theoretical Genetics, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. The material covers the most recent topics in bioinformatics, including (i) regulatory genomic sequences: databases, knowledge bases, computer analysis, modeling, and recognition; (ii) large-scale genome analysis and functional annotation; (iii) gene structure detection and prediction; (iv) comparative and evolutionary genomics; (v) computer analysis of genome polymorphism and evolution; computer analysis and modeling of transcription, splicing, and translation; structural computational biology: structure- function organization of genomic DNA, RNA, and proteins; (vi) gene networks, signal transduction pathways, and genetically controlled metabolic pathways: databases, knowledge bases, computer analysis, and modeling; principles of organization, operation, and evolution; (vii) data warehousing, knowledge discovery and data mining; and (viii) analysis of basic patterns of genome operation, organization, and evolution.
