الصفحة 3
الصفحة 3
Molecular recognition in pharmacology
Traces the behavior of the drug substance, starting from the initial pre-contact stage, and ending with the formation of the complex. Molecular recognition lies in the foundation of every life form and includes many mysteries. Currently, studies on this topic in pharmacology are limited to determining the properties of complexes of medicinal substances (drugs) with specific (complementary) biomolecules: receptors, enzymes, ion channels etc. The results present the mechanisms preventing drugs from such non-specific binding. This direction is very fruitful, although the phenomenon of molecular recognition is far wider.
Molecular mechanisms of functional food
Provides information on the development and validation of functional foods towards their market and industrial application. It covers the available information on developments, efficacy, and testing and safety, while demonstrating the proven or potential effects of food on health and disease.
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Molecular Beams in Physics and Chemistry : From Otto Stern's Pioneering Exploits to Present-Day Feats
This book gives a comprehensive account of both the history and current achievements of molecular beam research. In 1919, Otto Stern launched the revolutionary molecular beam technique. This technique made it possible to send atoms and molecules with well-defined momentum through vacuum and to measure with high accuracy the deflections they underwent when acted upon by transversal forces. These measurements revealed unforeseen quantum properties of nuclei, atoms, and molecules that became the basis for our current understanding of quantum matter. This volume shows that many key areas of modern physics and chemistry owe their beginnings to the seminal molecular beam work of Otto Stern and his school. Written by internationally recognized experts, the contributions in this volume will help experienced researchers and incoming graduate students alike to keep abreast of current developments in molecular beam research as well as to appreciate the history and evolution of this powerful method and the knowledge it reveals.
Molecular analysis of B lymphocyte development and activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Modern architecture and climate design before air conditioning
explores how leading architects of the twentieth century incorporated climate-mediating strategies into their designs, and shows how regional approaches to climate adaptability were essential to the development of modern architecture. Focusing on the period surrounding World War II'before fossil-fuel powered air-conditioning became widely available'Daniel Barber brings to light a vibrant and dynamic architectural discussion involving design, materials, and shading systems as means of interior climate control. He looks at projects by well-known architects such as Richard Neutra, Le Corbusier, Lúcio Costa, Mies van der Rohe, and Skidmore, Owings, and Merrill, and the work of climate-focused architects such as MMM Roberto, Olgyay and Olgyay, and Cliff May. Drawing on the editorial projects of James Marston Fitch, Elizabeth Gordon, and others, he demonstrates how images and diagrams produced by architects helped conceptualize climate knowledge, alongside the work of meteorologists, physicists, engineers, and social scientists. Barber describes how this novel type of environmental media catalyzed new ways of thinking about climate and architectural design.
Models for computer aided tolerancing in design and manufacturing ; Selected conference papers from the 9th CIRP International Seminar on Computer-aided tolerancing, held at Arizona State University, Tempe, Arizona, USA, 10-12 April, 2005
Computer Aided Tolerancing (CAT) is an important topic in any field of design and production where parts move relative to one another and/or are assembled together. Geometric variations from specified dimensions and form always occur when parts are manufactured. Improvements in production systems can cause the amounts of the variations to become smaller, but their presence does not disappear. To shorten the time from concept to market of a product, it has been increasingly important to take clearances and the tolerancing of manufacturing variations into consideration right from the beginning, at the stage of design. Hence, geometric models are defined that represent both the complete array of geometric variations possible during manufacture and also the influence of geometry on the function of individual parts and on assemblies of them.
Modelling Regional Scenarios for the Enlarged Europe : European Competitiveness and Global Strategies
The aim of this book is to tackle the question of what the European territory will look like over the next fifteen years by providing quali-quantitative territorial scenarios for the enlarged Europe, under different assumptions on future globalisation strategies of BRIC (Brazil, Russia, India and China) and East and West European countries. The approach is as neutral as possible vis-à-vis the results, leaving to a new forecasting model, the MASST model, built by the authors, to produce the tendencies and behavioural paths of regional GDP and population growth in each individual European region under alternative assumptions on the competitiveness strategies of different blocks of countries. The results are accompanied by strong policy messages intended to encourage long-term strategic thinking among a wide range of actors, scientists and policy makers in response to the risks and opportunities that the European territory will face.
Modelling Environmental Dynamics : Advances in Geomatic Solutions
Modelling environmental dynamics is critical to understanding and predicting the evolution of the environment in response to the large number of influences including urbanisation, climate change and deforestation. Simulation and modelling provide support for decision making in environmental management.
Modeling Income Distributions and Lorenz Curves
The parameterization of income distributions and Lorenz Curves is a useful approach for representing how income is distributed within a given population. It provides a way of describing how the data are generated, why the level of inequality is what it is, and what happens to the poorer sections of the population. This book brings together classic papers in the field, including Camilo Dagum’s most influential contribution, survey papers outlining the state-of-the-art of the field, and cutting-edge research contributions. While providing a thorough overview of the methodology of income distribution modeling, the book emphasizes its relevance on development economics and its importance for policy makers who design and assess poverty alleviation and income redistribution policies.
Modeling Financial Time Series with S-PLUS®
This book represents an integration of theory, methods, and examples using the S-PLUS statistical modeling language and the S+FinMetrics module to facilitate the practice of financial econometrics. This is the first book to show the power of S-PLUS for the analysis of time series data.It covers S+FinMetrics 2.0 and includes new chapters on copulas, nonlinear regime switching models, continuous-time financial models, generalized method of moments, semi-nonparametric conditional density models, and the efficient method of moments.
Modeling and Simulation in Scilab
Scilab is a free open-source software package for scientific computation. It includes hundreds of general purpose and specialized functions for numerical computation, organized in libraries called toolboxes, which cover such areas as simulation, optimization, systems and control, and signal processing. One important Scilab toolbox is Scicos. Scicos provides a block diagram graphical editor for the construction and simulation of dynamical systems. The objective of this book is to provide a tutorial for the use of Scilab/Scicos with a special emphasis on modeling and simulation tools. The book is divided into two parts. The first part concerns Scilab and includes a tutorial covering the language features, the data structures and specialized functions for doing graphics, importing, exporting data and interfacing external routines. It also covers in detail Scilab numerical solvers for ordinary differential equations and differential-algebraic equations. Even though the emphasis is placed on modeling and simulation applications, this part provides a global view of Scilab. The second part is dedicated to modeling and simulation of dynamical systems in Scicos. This type of modeling tool is widely used in industry because it provides a means for constructing modular and reusable models. This part contains a detailed description of the editor and its usage, which is illustrated through numerous examples.
Model tests and numerical simulations of liquefaction and lateral spreading ; LEAP-UCD-2017
This book presents work collected through the Liquefaction Experiments and Analysis Projects (LEAP) in 2017. It addresses the repeatability, variability, and sensitivity of lateral spreading observed in twenty-four centrifuge model tests on mildly sloping liquefiable sand.
Misbehaving Proteins : Protein (Mis)Folding, Aggregation, and Stability
Misfoldedaggregatedproteinoncewasconsideredasinterestingasyesterday’strash—a bothersome by-product of important and productive activities, to be disposed of and forgotten as quickly as possible. Yesterday’s trash has become today’s focus of cons- erable scienti?c interest for at least two reasons: (1) protein aggregates are at the core of a number of chronic degenerative diseases such as Alzheimer’s disease, and (2) - gregation poses signi?cant obstacles to the manufacture of safe, ef?cacious, and stable protein products. As interest in protein misfolding, aggregation, and stability has soared beyond the core group of traditional protein-folding scientists, and as substantial scienti?c progress in understanding and controlling protein misfolding has been achieved, the need to summarize the state of the art became manifest. Although there are many excellent texts and edited collections on protein structure and folding, these volumes tend to relegate protein misfolding and aggregation to a minor role. Review articles and books focused on the biological role of protein aggregates in diseases have been published recently.
Mirror Geometry of Lie Algebras, Lie Groups and Homogeneous Spaces
As K. Nomizu has justly noted [K. Nomizu, 56], Differential Geometry ever will be initiating newer and newer aspects of the theory of Lie groups. This monograph is devoted to just some such aspects of Lie groups and Lie algebras. New differential geometric problems came into being in connection with so called subsymmetric spaces, subsymmetries, and mirrors introduced in our works dating back to 1957 [L.V. Sabinin, 58a,59a,59b]. In addition, the exploration of mirrors and systems of mirrors is of interest in the case of symmetric spaces. Geometrically, the most rich in content there appeared to be the homogeneous Riemannian spaces with systems of mirrors generated by commuting subsymmetries, in particular, so called tri-symmetric spaces introduced in [L.V. Sabinin, 61b]. As to the concrete geometric problem which needs be solved and which is solved in this monograph, we indicate, for example, the problem of the classification of all tri-symmetric spaces with simple compact groups of motions. Passing from groups and subgroups connected with mirrors and subsymmetries to the corresponding Lie algebras and subalgebras leads to an important new concept of the involutive sum of Lie algebras [L.V. Sabinin, 65]. This concept is directly concerned with unitary symmetry of elementary par- cles (see [L.V. Sabinin, 95,85] and Appendix 1). The first examples of involutive (even iso-involutive) sums appeared in the - ploration of homogeneous Riemannian spaces with and axial symmetry. The consideration of spaces with mirrors [L.V. Sabinin, 59b] again led to iso-involutive sums.
Mineral Trioxide Aggregate in Dentistry : From Preparation to Application
Concisely presents information on diverse aspects of MTA and its use with a view to making it more widely available to clinicians and researchers. The topics covered include the development of MTA and its introduction into clinical dentistry, its chemical composition and setting characteristics, manipulation and placement, material properties, reactivity and the influence of environmental factors.
Migration, urbanity and cosmopolitanism in a globalized world
This book draws a theoretically productive triangle between urban studies, theories of cosmopolitanism, and migration studies in a global context. It provides a unique, encompassing and situated view on the various relations between cosmopolitanism and urbanity in the contemporary world.
Middleware 2007 ; ACM/IFIP/USENIX 8th International Middleware Conference, Newport Beach, CA, USA, November 26-30, 2007, Proceedings
This book constitutes the refereed proceedings of the ACM/IFIP/USENIX 8th International Middleware Conference 2007, held in Newport Beach, CA, USA, in November 2007.
Microscopy of Semiconducting Materials 2007 ; Proceedings of the 15th Conference, 2-5 April 2007, Cambridge, UK
The conference focused upon the most recent advances in the study of the structural and electronic properties of semiconducting materials by the application of transmission and scanning electron microscopy, scanning probe microscopy and X-ray-based methods. Conference sessions concentrated on key topics including state-of-the-art studies in high resolution imaging and analytical electron microscopy, advanced scanning probe microscopy, scanning electron microscopy and focused ion beam applications, novel epitaxial layer phenomena, the properties of quantum nanostructures, III-nitride developments, GeSi/Si for advanced devices, metal-semiconductor contacts and silicides and the important effects of critical device processing treatments.
Methods of microarray data analysis V
In this volume, all investigators analyzed a single dataset on the lifecycle of the most deadly of malaria parasites, Plasmodium falciparum. The emphasis this year is on the application of novel and existing computational methodologies towards infectious disease. We highlight an introductory chapter by Raphael D. Isokpehi, a leading expert in the field of malaria. Ten of the papers presented at the conference are included, which range from the inference of genetic networks to the analysis of the spatial correlation of array data. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art in microarray data analysis.
