الصفحة 3
الصفحة 3
Free Energy and Self-Interacting Particles
This book examines a system of parabolic-elliptic partial differential eq- tions proposed in mathematical biology, statistical mechanics, and chemical kinetics. In the context of biology, this system of equations describes the chemotactic feature of cellular slime molds and also the capillary formation of blood vessels in angiogenesis. There are several methods to derive this system. One is the biased random walk of the individual, and another is the reinforced random walk of one particle modelled on the cellular automaton. In the context of statistical mechanics or chemical kinetics, this system of equations describes the motion of a mean field of many particles, interacting under the gravitational inner force or the chemical reaction
Fluid-structure interaction : Modelling, simulation, optimisation
Fluid-structure interactions (FSI), that is interactions of some movable or deformable structure with an internal or surrounding fluid flow, are among the most important and, with respect to both modelling and computational issues, the most challenging multi-physics problems. The variety of FSI occurrences is abundant and ranges from tent-roofs to micropumps, from parachutes via airbags to blood flow in arteries.
Fluid volume monitoring with glucose dilution
Decision making regarding fluid volume loading, fluid restriction, or administration of vasoactive drugs may vary among physicians, depending solely upon their clinical experience in the absence of evidence-based measurement. The initial distribution volume of glucose (IDVG) is believed to be clinically relevant as a marker of cardiovascular and fluid management in critically ill patients without a significant modification of glucose metabolism. This book covers all aspects of IDVG measurement, including the basic concept, its relationship with other fluid volumes, and the clinical application of this technique in the intensive care unit based on both the authors’ studies and their clinical experience with more than 4000 IDVG determinations. When the concept of IDVG is properly understood and its measurement is then performed routinely, daily fluid and cardiovascular management in critically ill patients can be improved based on evidence-based measurement.
Flow cytometry in hematopathology : A visual approach to data analysis and interpretation
Although instrumentation and laboratory techniques for flow cytometry (FCM) immunophenotyping of hematopoietic malignancies are well documented, there is relatively little information on how best to perform data analysis, a critical step in FCM testing. In Flow Cytometry in Hematopathology: A Visual Approach to Data Analysis and Interpretation, three physicians highly experienced in laboratory hematopathology and FCM offer a unique systematic approach to FCM data analysis and interpretation based on the visual inspection of dual parameter FCM graphics. This step-by-step approach to optimal FCM data analysis is demonstrated by means of numerous FCM graphics derived from actual well-documented clinical cases.The focus of the additional material is on the TCR-Vb eight-tube kit which has greatly facilitated the evaluation mature T-cell disorders, and on the DNA dye DRAQ5 for improved grading of malignant lymphoma. The authors also include notes on "tricks of the trade" and pitfalls to avoid. The discussion, covering leukemias, lymphomas, and other conditions, moves from simple to complex specimens, with an emphasis on visual pattern analysis.
Filgrastim in clinical oncology : Guarding against neutropenia
Granulocyte colony-stimulating factor (G-CSF) has driven the attention of researchers as a therapeutic agent for curing patients suffering from neutropenia. Despite the successful use of G-CSF, it currently requires daily injections, which are inconvenient, expensive, and distressing for children. Therefore, an alternative strategy for using G-CSF for treatment is needed. Understanding the G-CSF structure, expression, mechanism of action, and how it induces neutrophils mobilization is crucial to producing promising cancer therapy. The ability of G-CSF to mobilize hematopoietic stem cells from the bone marrow into the blood circulation was consequently exploited and altered the practice of hematopoietic stem cell transplantation.
Fetal compromise in labor
Sixty years ago, the purpose of introducing electronic fetal heart rate monitoring (EFM) was to reduce the incidence of intrapartum stillbirth. However, by the early 1980s, with falling stillbirth rates, fetal blood sampling had been widely abandoned, as many considered that EFM was sufficient on its own. Unfortunately, while the sensitivity of EFM for the detection of potential fetal compromise is high, specificity is low, and there is a high false positive rate which has been associated with a rising cesarean section rate. The authors suggest that EFM is considered and analyzed as a classic screening test and not a diagnostic test. Furthermore, it requires contextualization with other risk factors to achieve improved performance. A new proposed metric, the Fetal Reserve Index, takes into account additional risk factors and has demonstrated significantly improved performance metrics. It is going through the phases of further development, evaluation, and wider clinical implementation.
Familial mediterranean fever
Familial Mediterranean Fever (FMF), a genetic disorder causing recurrent inflammatory attacks. It delves into various aspects of FMF, including: Definition and historical background of FMF Underlying causes, signs, and symptoms of the disease Modes of transmission through autosomal recessive inheritance Diagnostic methods encompassing genetic, urine, blood, and imaging tests, emphasizing the significance of early diagnosis The link between FMF and amyloidosis, a serious complication...
Executing magic in the modern era : Criminal bodies and the Gallows in popular medicine
This book explores the magical and medical history of executions from the eighteenth to the early twentieth century by looking at the afterlife potency of criminal corpses, the healing activities of the executioner, and the magic of the gallows site. The use of corpses in medicine and magic has been recorded back into antiquity. The lacerated bodies of Roman gladiators were used as a source of curative blood, for instance. In early modern Europe, a great trade opened up in ancient Egyptian mummies and the fat of executed criminals, plundered as medicinal cure-alls. However, this is the first book to consider the demand for the blood of the executed, the desire for human fat, the resort to the hanged man’s hand, and the trade in hanging rope in the modern era. It ends by look at the spiritual afterlife of dead criminals.
Erythropoietins and Erythropoiesis : Molecular, Cellular, Preclinical, and Clinical Biology
The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.
Erythropoietin and the Nervous System
Erythropoietin and the Nervous System is the first book of its kind to bring together researchers from many different disciplines of neuroscience to present a current state-of-the-art review of multiple aspects of erythropoietin research as it relates to the nervous system. Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system.
Enhancing the Dissolution Rate of Atorvastatin by Solid Dispersion Technique
In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable carrier and methodology in the preparation of SDs play a significant role in the biological behavior of the SDs. Atorvastatin is a statin group HMG-CoA reductase inhibitor drug that is commonly used to adverse cardiovascular events and to lower blood total cholesterol and LDL-cholesterol. the solubility of atorvastatin in water is very low (0.1 mg mL− 1), which results in reduced bioavailability. In order to enhance its solubility, we have prepared solid dispersions (SDs) of atorvastatin at different drug: polymer ratios (1:2, 1:10, 1:20,1:25 and 1:40), using polyethylene glycol 6000 as polymer and different preparation methods (co-precipitate and melting methods) The characterization of the SDs was performed using differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) The solubility of AT was improved by the incorporation PEG6000.
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
It includes about 56% more words than the 1,392-page 2nd edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. Cross-references among entries are expanded. The statements are supported by references; more than 14,000 journal papers and more than 3,000 books are listed. The book includes ~1,800 current databases and web servers. Retractions and corrigenda are pointed out.It covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, patents, etc. Similar integrated information is not available in textbooks or on the Internet. The journal reviews called it the best, high-quality resource for researchers, instructors and students of basic and applied biology, as well as for physicians and lawyers or even for interested laymen because of the clarity of presentation.
Effect of Cranberry in the Treatment of E. Coli
Escherichia coli (E. coli) bacteria normally live in the intestines of healthy people and animals. It may cause severe stomach cramps, bloody diarrhoea, vomiting and UTI. You may be exposed to E. coli from contaminated water or food especially raw vegetables and undercooked ground beef. Healthy adults usually recover from infection with E. coli within a week. Young children and older adults have a greater risk of developing a life-threatening form of kidney failure. Cranberries are a popular superfood. People can consume them in the form of a sauce or a juice. They can also add them to stuffing, casseroles, or dessert. In fact, research has linked the nutrients in cranberries to a lower risk of urinary tract infection (UTI), the prevention of certain types of cancer, improved immune function, and decreased blood pressure
Effect of antioxidants in plant extracts and free radicals on blood sample
Antioxidants are substances that inhibit and regulate the formation of free radicals, and prevent or slow down the damage to cells caused by free radicals. There is a balance between antioxidants and free radicals throughout the body, and free radicals become dangerous when the balance is disturbed Free radicals play a key role in many physiological decisions in cells. Since free radicals are toxic to cellular components, it is known that they cause DNA damage, contribute to DNA instability and mutation and thus favor carcinogenesis.Low levels of free radicals and steady state levels of antioxidant enzymes are responsible for the fine tuning of redox status inside cells. A change in redox state is a way to modify the physiological status of the cell.Many healthful foods contain antioxidants. If a person consumes some or all of these foods regularly, they may increase their antioxidant levels, potentially helping them prevent the damage that doctors associate with oxidative stress.
Earthquake alert with smartwatch = تنبيه الزلازل باستخدام الساعة الذكية
After the recent events and earthquakes that affected the region, resulting in the deaths of many individuals due to the lack of timely emergency response, the idea for this project emerged Earthquake Alert with Smartwatch. Initially, our application gathers information about the user, such as age, family members, and any existing medical conditions. In the event of an earthquake, the application sends an alert to the user. It receives earthquake information, such as ‘magnitude, time, location…’ from United States Geological Survey “USGS” through an API. If the user is within the geographical area affected by the earthquake, the application will assist the Smartwatch in calculating vital signs such as ‘heart rate and blood pressure’. Additionally, there is another artificial intelligence model that receives the user's audio recordings and converts them into written texts. All this information, along with the user's geographical location, will be sent to the nearest emergency point for the purpose of aiding those individuals trapped under the rubble.
Early Nutrition and its Later Consequences : New Opportunities; Perinatal Programming of Adult Health - EC Supported Research
Health problems such as hypertension, tendency to diabetes, obesity, blood lipids, vascular disease, bone health, behaviour and learning and longevity may be ‘imprinted’ during early life. This process is defined as ‘programming’ whereby a nutritional stimulus operating at a critical, sensitive period of pre and postnatal life imprints permanent effects on the structure, physiology and metabolism. For this reason, academics and industry set-up the EC supported Scientific Workshop -Early Nutrition and its Later Consequences: New Opportunities. The prime objective of the Workshop was to generate a sound exchange of the latest scientific developments within the field of early nutrition to look for opportunities for new preventive health concepts. Further, a closer look was taken at the development of food applications which could provide (future) mothers and infants with improved nutrition that will ultimately lead to better future health. The Workshop was organised by the Dept. of Pediatrics, University of Munich, Germany in collaboration with the Danone Institutes and the Infant Nutrition Cluster, a collaboration of three large research projects funded by the EU.
Diabetes genetic finder & predictor = أداة البحث والتنبؤ الجيني لمرض السكري
The diabetes genetic finder & predictor app is a comprehensive, user-friendly solution that revolutionizes diabetes care. This powerful app integrates a wide array of features designed to empower diabetes patients and enhance their overall well-being. A standout feature of the app is its ability to predict the risk of hereditary diabetes diseases, offering users early detection and intervention opportunities. It also predicts general diabetes risk, diabetic foot complications, and retinopathy. Users can monitor their blood sugar levels, heart rate, and oxygenation either manually or through smart watch integration. Additionally, users can enter their diabetes type and HbA1c levels.The app's medication management feature simplifies the complex task of tracking and organizing medications, providing timely reminders to ensure adherence to treatment plans. Users can scan QR codes on products to check their sugar content and suitability, schedule their medications, generate reports for specific periods, and access a comprehensive list of frequently asked questions about diabetes..
Development of breast cancer therapy and gender
Breast cancer is a disease in which abnormal cells in the breast tissues multiply and form an invasive (or malignant) tumor. Such tumors can invade and damage the tissue around them and spread to other parts of the body through the lymphatic or vascular systems. We will describe in our study several types of breast cancer, since they are classified into two main categories: “invasive” and “non-invasive,” or in situ. While invasive cancer has spread from the breast ducts or glands to other parts of the breast, non-invasive cancer has not spread from the original tissue. Our study will focus on the best tests that examine the breasts which are used to detect and diagnose breast cancer: Physical exam and health history, Clinical breast exam (CBE), Mammogram, Ultrasound exam, MRI (magnetic resonance imaging), Blood chemistry studies and Biopsy. We will include the value of such tests after breast cancer has been diagnosed, to find out if cancer cells have spread within the breast or to other parts of the body.
Developing burn ointment using seasam oil, tea tree oil, and,shea butter
The objective of our research project is to develop a burn healing ointment (Meburn) and to compare it with a well-known ointment, MEBO®. The second formula shows very good accelerated stability test results, its histology test was very promising, its ability to accelerate blood vessel formation in heat burns is significant, and, the rats that have been treated with (Meburn and Mebo®) started to get back to their normal weight after 2 weeks in approximate results. Results obtained from our study using rats as an animal model, showed that our proposed ointment (Meburn) has burn healing efficacy similar to Mebo® ointment.
Dermatopathology
The book describes the principles of histopathologic patterns in selected acquired skin diseases, together with short clinical descriptions and case reports. The underlying, or possible underlying, mechanisms are elucidated, and controversial concepts are discussed. To facilitate the understanding of underlying mechanisms, the first chapters of the book comprise summaries of basic histology of lymphatics and blood vessels, relevant parts of general pathology, immunology, and molecular cell biology.
