الصفحة 3
الصفحة 3
Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue
The present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within tendons and ligaments are directly correlated. In selected anatomical samples of human origin the distribution pattern of certain components of the extracellular matrix is assessed. Investigations are carried out at the extensor tendons of toes and fingers, at the transverse ligament of the atlas, at the transverse ligament of the acetabulum, and at the tendon of the superior oblique muscle and its trochlea. The molecular components of the extracellular matrix are detected with standardized immunohistochemical methods. The results show that certain molecules only occur due to compressive stress, others due to tensile stress. The molecular spectrum of the extracellular matrix allows qualifying conclusions to the mechanical situation of a given part of the tissue. The spatial expansion of the fibrocartilaginous adaptation zones in tendons and ligaments roughly corresponds with the zones subjected to compressive force; tensile stress alone does not result in a production of fibrocartilage.
Molecular Neurosurgery with Targeted Toxins
Focuses on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
Molecular Beams in Physics and Chemistry : From Otto Stern's Pioneering Exploits to Present-Day Feats
This book gives a comprehensive account of both the history and current achievements of molecular beam research. In 1919, Otto Stern launched the revolutionary molecular beam technique. This technique made it possible to send atoms and molecules with well-defined momentum through vacuum and to measure with high accuracy the deflections they underwent when acted upon by transversal forces. These measurements revealed unforeseen quantum properties of nuclei, atoms, and molecules that became the basis for our current understanding of quantum matter. This volume shows that many key areas of modern physics and chemistry owe their beginnings to the seminal molecular beam work of Otto Stern and his school. Written by internationally recognized experts, the contributions in this volume will help experienced researchers and incoming graduate students alike to keep abreast of current developments in molecular beam research as well as to appreciate the history and evolution of this powerful method and the knowledge it reveals.
Models of the Atomic Nucleus
Models of the Atomic Nucleus is a largely non-technical introduction to nuclear theory – an attempt to explain the nucleus in a way that makes nuclear physics as comprehensible as chemistry or cell biology. Unlike many other scientific fields, the "popularization" of nuclear physics has not previously been successful because many fundamental issues remain controversial and a unified theory of nuclear structure has not yet been established. The theme developed in this book is that the many models of nuclear theory each provide a partial perspective on the nucleus and that the many models can in fact be integrated into a coherent whole and expressed in terms of a lattice of nucleons.
Modelling community structure in freshwater ecosystems
"The book presents approaches and methodologies for predicting the structure and diversity of key aquatic communities (namely diatoms, benthic macroinvertebrates and fish), under natural conditions and under man-made disturbance. Such an approach will make it possible to: 1) set up procedures for robust and sensitive ecosystem evaluation, based on the prediction of the excepted community structure; 2) model community structure in disturbed ecosystems, taking into account all the relevant ecological variables; 3) test ecosystem sensitivity to natural and anthropic disturbance; and 4) explore specific actions to be taken for the restoration of ecosystem integrity."--Jacket.
Modeling of Soft Matter
Soft matter plays a role in a wide variety of important processes and application. For example, gel swelling and dynamics are an essential part of many biological and individual processes, such as motility mechanisms in bacteria and the transport and absorption of drugs. Ferroelectrics, liquid crystals, and elastomers are being used to design ever faster switching devices. Experimental studies, such as scattering, optical and electron microscopy, have provided a great deal of detailed information on structures. But the integration of mathematical modeling and analysis with experimental approaches promises to greatly increase our understanding of structure-property relationships and constitutive equations. The workshop on Modeling of Soft Matter has taken such an integrated approach.
Minimally invasive glaucoma surgery
This book covers all aspects of minimally invasive glaucoma surgery (MIGS) and provides detailed information on each MIGS device, including its mechanism of action; patient selection; implantation techniques; post-operative management; and a review of the existing literature. Step-by-step descriptions are provided for the surgical technique used in implanting each MIGS device, accompanied by clear photographs of each surgical stage. Other areas covered include intra-operative gonioscopy (with tips on optimising the view of the anterior chamber angle) and the management of the intra-operative and post-operative complications. Essential information on the anatomy and physiology of the different aqueous outflow pathways is also included.
Micro-Tomographic Atlas of the Mouse Skeleton
Micro-Tomographic Atlas of the Mouse Skeleton serves as an essential guide containing unique systematic description of all calcified components of the mouse. This detailed atlas fulfils an emerging need for high resolution anatomical details as mice become a standard laboratory animal in skeletal research and the use of m CT technology is rapidly increasing as a key analytical tool in the study of bone.
Micromechanics and Nanosimulation of Metals and Composites : Advanced Methods and Theoretical Concepts
This book provides insight into advanced numerical and experimental investigations of the microstructural aspects of strength and damage of metals and metal-based composites. In particular, atomistic and dislocation models, micromechanical simulations and homogenization techniques, as well as experimental observations in combination with computer simulations, are described. These methods are successfully applied to analyze the mechanical behavior of metals and metal-matrix composites.
Micro- and opto-electronic materials and Structures : Physics, mechanics, design, reliability, packaging ; Vol. I : Materials physics - materials mechanics ; Vol. II : Physical design - reliability and packaging
Micro- and Opto-Electronic Materials and Structures: Physics, Mechanics, Design, Reliability, Packaging is the first comprehensive reference to collect and present the most, up-to-date, in-depth, practical and easy-to-use information on the physics, mechanics, reliability and packaging of micro- and opto-electronic materials, assemblies, structures and systems. The chapters in these two volumes contain summaries of the state-of-the-art and present new information on recently developed important methods or devices. Furthermore, practical recommendations are offered on how to successfully apply current knowledge and recently developed technology to design, manufacture and operate viable, reliable and cost-effective electronic components or photonic devices. The emphasis is on the science and engineering of electronic and photonic packaging, on physical design problems, challenges and solutions.
Metamorphoses of Hamiltonian Systems with Symmetries
Modern notions and important tools of classical mechanics are used in the study of concrete examples that model physically significant molecular and atomic systems. The parametric nature of these examples leads naturally to the study of the major qualitative changes of such systems (metamorphoses) as the parameters are varied. The symmetries of these systems, discrete or continuous, exact or approximate, are used to simplify the problem through a number of mathematical tools and techniques like normalization and reduction. The book moves gradually from finding relative equilibria using symmetry, to the Hamiltonian Hopf bifurcation and its relation to monodromy and, finally, to generalizations of monodromy.
Memories : Molecules and Circuits
This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.
Medical Imaging and Augmented Reality ; 4th International Workshop Tokyo, Japan, August 1-2, 2008 Proceedings
Constitutes the refereed proceedings of the 4th International Workshop on Medical Imaging and Augmented Reality, MIAR 2008, held in Tokyo, Japan, in August 2008.The 44 revised full papers presented together with 3 invited papers were carefully reviewed and selected from 90 submissions. The papers are organized in topical sections on surgical planning and simulation, medical image computing, image analysis, shape modeling and morphometry, image-guided robotics, image-guided intervention, interventional imaging, image registration, augmented reality, and image segmentation.
Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 ; 11th International Conference, New York, NY, USA, September 6-10, 2008, Proceedings, Part II
The program committee carefully selected 258 revised papers from numerous submissions for presentation in two volumes, based on rigorous peer reviews. The first volume includes 127 papers related to medical image computing, segmentation, shape and statistics analysis, modeling, motion tracking and compensation, as well as registration. The second volume contains 131 contributions related to robotics and interventions, statistical analysis, segmentation, intervention, modeling, and registration.
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2005 ; 8th International Conference, Palm Springs, CA, USA, October 26-29, 2005, Proceedings, Part I
This paper presents a method for classification of medical images, using machine learning and deformation-based morphometry. A morphological representation of the anatomy of interest is first obtained using highdimensional template warping, from which regions that display strong correlations between morphological measurements and the classification (clinical) variable are extracted using a watershed segmentation, taking into account the regional smoothness of the correlation map which is estimated by a crossvalidation strategy in order to achieve robustness to outliers. A Support Vector Machine-Recursive Feature Elimination (SVM-RFE) technique is then used to rank computed features from the extracted regions, according to their effect on the leave-one-out error bound. Finally, SVM classification is applied using the best set of features, and it is tested using leave-one-out. The results from a group of 61 brain images of female normal controls and schizophrenia patients demonstrate not only high classification accuracy (91.8%) and steep ROC curves, but also exceptional stability with respect to the number of selected features and the SVM kernel size
Measuring emission of agricultural greenhouse gases and developing mitigation options using nuclear and related Techniques : Applications of nuclear techniques for GHGs
This book is an outcome of the collaboration between the Soil and Water Management & Crop Nutrition Section, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna, Austria, and the German Science Foundation research unit DASIM (Denitrification in Agricultural Soils: Integrated control and Modelling at various scales) and other institutes.
McCance-Huether’s pathophysiology : The biologic basis for disease in adults and children
Helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. It’s the most comprehensive and authoritative pathophysiology text available!
Maxillofacial Imaging
Maxillofacial imaging has evolved dramatically over the past two decades with development of new cross-sectional imaging techniques. Traditional maxillofacial imaging was based on plain films and dental imaging. However, today’s advanced imaging techniques with CT and MRI have only been partially implemented for maxillofacial questions. This book bridges the gap between traditional maxillofacial imaging and advanced medical imaging. We have applied CT and MRI to a variety of maxillofacial cases and these are illustrated with high-quality images and multiple planes. A comprehensive chapter on imaging anatomy is also included. This book is useful for oral and maxillofacial radiologists, oral and maxillofacial surgeons, dentists, radiologists, plastic surgeons, head and neck surgeons, and others that work with severe maxillofacial disorders.
Maxillofacial Imaging
Demonstrates how advanced medical imaging techniques can be successfully applied to dental and maxillofacial conditions. There is a focus on CT and MRI, but the use of all contemporary imaging techniques are illustrated including PET, PET/CT, ultrasonography, and cone beam CT. The presentation is in atlas style, with succinct, bulleted text and a wealth of high-quality images in multiple planes. All images for each patient are grouped to enable the reader very quickly to gain an imaging overview of the condition under consideration. After a comprehensive introductory chapter on normal imaging anatomy, the role of advanced imaging techniques is described in pathologic conditions of the mandible and maxilla, temporomandibular joint, regions closely related to the jaw, paranasal sinuses, oral cavity, salivary glands, and structures adjacent to the maxillofacial region. A concluding chapter examines the use of interventional procedures for diagnosis and treatment of maxillofacial conditions. Compared with the first edition, numerous additional cases have been incorporated and a completely new chapter focuses on cone beam CT.
Intraoperative Neurophysiological Monitoring
Intraoperative neurophysiological monitoring (IOM) has proven itself a versatile technique that reduces the risks of acquiring intraoperative neurological deficits, shortens operating time, and lowers the costs of medical care and rehabilitation. It can also reduce the risks of medical malpractice suits and serve as a research tool to better understand nervous system disorders and promote improved treatments.
