الصفحة 3
الصفحة 3
Micrometastasis
Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information. In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed. The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.
Methods in Nonlinear Analysis
Nonlinear analysis has developed rapidly in the last three decades. Theories, techniques and results in many different branches of mathematics have been combined in solving nonlinear problems. This book collects and reorganizes up-to-date materials scattered throughout the literature from the methodology point of view, and presents them in a systematic way. It contains the basic theories and methods with many interesting problems in partial and ordinary differential equations, differential geometry and mathematical physics as applications.There are five chapters that cover linearization, fixed-point theorems based on compactness and convexity, topological degree theory, minimization and topological variational methods. Each chapter combines abstract, classical and applied analysis. Particular topics included are bifurcation, perturbation, gluing technique, transversality, Nash–Moser technique, Ky Fan's inequality and Nash equilibrium in game theory, setvalued mappings and differential equations with discontinuous nonlinear terms, multiple solutions in partial differential equations, direct method, quasiconvexity and relaxation, Young measure, compensation compactness method and Hardy space, concentration compactness and best constants, Ekeland variational principle, infinite-dimensional Morse theory, minimax method, index theory with group action, and Conley index theory.
Metathesis Polymerization
Clearly illustrated and demonstrated by the entire series of Advances in Polymer Science., the area of polymer science is a rapidly developing and growing field, strongly influencing other areas of chemistry. Among other polymerization techniques, those based on metathesis polymerization have experienced significant progress. With a rapidly developing armory of initiators on hand, one is now capable of polymerizing various types of functional monomers by metathesis-based techniques.The latest developments in all these areas of metathesis-based polymerizations are summarized in this book. It is designed to attract equally students and advanced scientists working in the areas of polymer science, physical, and organometallic chemistry by providing both extensive background information and up-to-date interdisciplinary knowledge. Special consideration has been given to the literature sections in order to facilitate further reading.
Mémento de la recherche biomédicale portant sur un médicament à usage humain = Summary of biomedical research on a medicinal product for human use
Presents the reference texts, structures and authorities that govern clinical research in France, as well as its practical aspects. It is aimed at all of its stakeholders, both caregivers and patients. It will allow the most novices to familiarize themselves with the specific vocabulary of this discipline, to answer the questions raised during the conduct or participation in a therapeutic trial, and the most experienced to consider setting up a research structure. clinic in the rules of art.
Medicinal Chemistry for Practitioners
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Medical image synthesis : Methods and clinical applications
Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties.
Iron Nutrition in Plants and Rhizospheric Microorganisms
This book uses an interdisciplinary approach to provide a comprehensive review on the status of iron nutrition in plants. International scientists discuss research on acquisition of iron by strategy I and strategy II plants. These reviews summarize a variety of plant species and include both laboratory and field observations. Topics covered in this book include: plants as a source of iron for animals and humans, iron translocation in the plants, iron-stimulated activities that influence crop yield and fruit tree productivity, iron uptake by plants as influenced by microorganisms (i.e. free living soil microorganisms, symbiotic nitrogen-fixing and pathogenic bacteria), the role of plant hormones in iron transport, iron-metal competition in phytoremediation, root zone activities involving interactions between minerals and organic matter, the role of microbial siderophores in rhizospheric iron cycling, iron storage as phytoferritin, proteomic and metabolic studies associated with iron stress response, methods for studying iron metabolism including stable isotopes, and the correction of iron deficiency through the use of synthetic or natural chelates.
Ion Channels
Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field.
Inverse Problems and Imaging : Lectures given at the C.I.M.E. Summer School held in Martina Franca, Italy September 15–21, 2002
Nowadays we are facing numerous and important imaging problems: nondestructive testing of materials, monitoring of industrial processes, enhancement of oil production by efficient reservoir characterization, emerging developments in noninvasive imaging techniques for medical purposes - computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), X-ray and ultrasound tomography, etc. In the CIME Summer School on Imaging (Martina Franca, Italy 2002), leading experts in mathematical techniques and applications presented broad and useful introductions for non-experts and practitioners alike to many aspects of this exciting field. The volume contains part of the above lectures completed and updated by additional contributions on other related topics: a general presentation and introduction (Moscoso), X-ray tomography (Natterer), Electromagnetic imaging (Dorn, Bertete-Aguirre, Papanicolaou), coherent imaging in telecommunications in a multiple input-multiple output setup (Dorn), polarization based optical imaging (Moscoso), topological derivatives used in shape reconstruction related to inverse scattering problems (Carpio, Rapún), Point interactions (Dell’Antonio, Figari, Teta).
Introduction to Lie Algebras
This book provides an elementary introduction to Lie algebras. It starts with basic concepts. A section on low-dimensional Lie algebras provides readers with experience of some useful examples. This is followed by a discussion of solvable Lie algebras and a strategy towards a classification of finite-dimensional complex Lie algebras. The next chapters cover Engel's theorem, Lie's theorem and Cartan's criteria and introduce some representation theory. The root-space decomposition of a semisimple Lie algebra is discussed, and the classical Lie algebras studied in detail. The authors also classify root systems, and give an outline of Serre's construction of complex semisimple Lie algebras. An overview of further directions then concludes the book and shows the high degree to which Lie algebras influence present-day mathematics.The only prerequisite is some linear algebra and an appendix summarizes the main facts that are needed. The treatment is kept as simple as possible with no attempt at full generality.
Introduction to Bayesian Statistics
This is the second and translated edition of the German book “Einf ̈uhrung in die Bayes-Statistik, Springer-Verlag, Berlin Heidelberg New York, 2000”. It has been completely revised and numerous new developments are pointed out together with the relevant literature. The Chapter 5.2.4 is extended by the stochastic trace estimation for variance components. The new Chapter 5.2.6 presents the estimation of the regularization parameter of type Tykhonov regularization for inverse problems as the ratio of two variance components.The reconstruction and the smoothing of digital three-dimensional images is demonstrated in the new Chapter 5.3. The Chapter 6.2.1 on importance sampling for the Monte Carlo integration is rewritten to solve a more general integral. This chapter contains also the derivation of the SIR (sampling-importance-resampling) algorithm as an alternative to the rejection method for generating random samples. Markov Chain Monte Carlo methods are now frequently applied in Bayesian statistics.
Introduction to Bayesian Scientific Computing : Ten Lectures on Subjective Computing
Inverse problems are closely related to statistical inference problems, where the observations are used to infer on an underlying probability distribution. This connection between statistical inference and inverse problems is a central topic of the book. Inverse problems are typically ill-posed: small uncertainties in data may propagate in huge uncertainties in the estimates of the unknowns. To cope with such problems, efficient regularization techniques are developed in the framework of numerical analysis. The counterpart of regularization in the framework of statistical inference is the use prior information.
Introduction to basics of pharmacology and toxicology ; Vol.3 : Experimental pharmacology : Research methodology and biostatistics
Elaborates on the general principles of experimental pharmacology. Describes about the screening methods for the evaluation of different categories of drugs. Summarizes the various aspects of research methodology and biostatistics.
Introduction to Agricultural Engineering Technology : A Problem Solving Approach
Agricultural Engineering Technology: A problem Solving Approach is an invaluable text for agriculture students at the introductory level. The third edition has been thoroughly updated and reorganized to meet the current units and standards of the American Society of Agricultural and Biological Engineers (ASABE).The book aims to: Familiarize students with a wide range of applications of engineering principles to agriculture, Discuss a selection of independent but related topics, Advance students’ problem solving abilitiesEach chapter lists education objects, introductory material, and example problems where appropriate. In addition problems using ISO (metric) units, are now included.
Internal Migration, Urbanization and Poverty in Asia : Dynamics and Interrelationships
The chapters within this volume examine those complexities using a range of traditional and nontraditional measures—such as multidimensional poverty, gaps, and polarization—to arrive at the conclusion that poverty is now an urban issue. This volume offers an essential resource for economic policy makers and students of development economics to understand the interrelationships between internal migration, urbanization, and poverty in Asia, paving the way for the improved management of internal migration, and disadvantaged and vulnerable populations.
Intentional acts and institutional facts : Essays on John Searle’s social ontology
This book includes ten original essays that critically examine central themes of John Searle’s ontology of society, as well as a new essay by Searle that summarizes and further develops his work in that area. The critical essays are grouped into three parts. Part I (Aspects of Collective Intentionality) . Part II (From Intentions to Institutions: Development and Evolution) . Part III (Aspects of Institutional Reality).
Intelligence and Security Informatics ; Vol. 3917 ; International Workshop, WISI 2006, Singapore, April 9, 2006, Proceedings
Intelligence and security informatics (ISI) can be broadly defined as the study of the development and use of advanced information technologies and systems for national and international security-related applications. The First and Second Symposiums on ISI were held in Tucson, Arizona, in 2003 and 2004, respectively. In 2005, the IEEE International Conference on ISI was held in Atlanta, Georgia. These ISI conferences brought together academic researchers, law enforcement and intelligence experts, information technology consultants and practitioners to discuss their research and practice related to various ISI topics including ISI data management, data and text mining for ISI applications, terrorism informatics, deception detection, terrorist and criminal social network analysis, crime analysis, monitoring and surveillance, policy studies and evaluation, and information assurance, among others. We continued these stream of ISI conferences by organizing the Workshop on Intelligence and Security Informatics (WISI 2006) in conjunction with the Pacific Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2006).
Intelligence and security informatics ; Vol. 3495 : IEEE International Conference on Intelligence and Security Informatics, ISI 2005, Atlanta, GA, USA, May 19-20, 2005, Proceedings
Intelligence and security informatics (ISI) can be broadly defined as the study of the development and use of advanced information technologies and systems for national and international security-related applications, through an integrated technological, organizational, and policy-based approach. In the past few years, ISI research has experienced tremendous growth and attracted substantial interest from academic researchers in related fields as well as practitioners from both government agencies and industry. The first two meetings (ISI 2003 and ISI 2004) in the ISI symposium and conference series were held in Tucson, Arizona, in 2003 and 2004, respectively. They provided a stimulating intellectual forum for discussion among previously disparate communities: academic researchers in information technologies, computer science, public policy, and social studies; local, state, and federal law enforcement and intelligence experts; and information technology industry consultants and practitioners.
Intelligence and security informatics : Biosurveillance ; 2nd NSF Workshop, BioSurveillance 2007, New Brunswick, NJ, USA, May 22, 2007, Proceedings
The 2007 NSF BioSurveillance Workshop (BioSurveillance 2007) was built on the success of the first NSF BioSurveillance Workshop, hosted by the University of Arizona’s NSF BioPortal Center in March 2006.
Integrative Pain Medicine : The Science and Practice of Complementary and Alternative Medicine in Pain Management
This important book fills a need in the developing area of Pain Medicine, providing physicians with an up-to-date resource that would detail the current understanding about the basic science underlying the mechanism of action of the various CAM therapies used for pain, summarizing the clinical evidence both for efficacy and safety, and then end with practical guidelines about how such treatments could be successfully and safely integrated into a Pain practice.
