الصفحة 29
الصفحة 29
Earthquake Geotechnical Engineering ; 4th International Conference on Earthquake Geotechnical Engineering-Invited Lectures
This book contains the full papers on which the invited lectures of the 4th International Conference on Geotechnical Earthquake Engineering (4ICEGE) were based. It provides a comprehensive overview of the progress achieved to date in soil dynamics and geotechnical earthquake engineering, as well as in engineering seismology and seismic risk assessment and management. In situ and laboratory testing, theoretical issues and numerical modeling of soil dynamics, seismic hazard with emphasis on the long-period ground motion displacements, site effects and microzonation, liquefaction assessment and mitigation, soil-structure interaction, performance based design of geotechnical structures, earthquake resistant design and performance of shallow and deep foundations, retaining structures, embankments and dams, underground structures and lifelines, are all among the different topics covered in this book. Interdisciplinary subjects such as vulnerability assessment of, transportation networks and lifelines as well as of geotechnical structures are also discussed. Finally, the book provides a thorough presentation of the existing worldwide important large-scale testing facilities and geotechnical strong ground motion arrays.
Earth science satellite remote sensing ; Vol.1 : Science and instruments
Satellite remote sensing for Earth science data has been rapidly expanding during the last decade. Volume 1 of this two volume monograph covers missions/sensors, such as Sea-viewing Wide Field-of-view Sensor (SeaWiFS), Tropical Rainfall Measuring Mission (TRMM), Total Ozone Mapping Spectrometer (TOMS), Atmospheric Infrared Sounder (AIRS), and Advanced Microwave Sounding Unit (AMSU). It also discusses the NPOESS and NPP missions. Emphasis was placed on the recently launched Moderate Resolution Imaging Spectroradiometer (MODIS) on board of both Terra and Aqua. Some key MODIS science team members were invited to contribute several chapters. The core of this monograph arose from the workshop for Earth Science Satellite Remote Sensing held at George Mason University (GMU) in October 2002. Both volumes are designed to give scientists and graduate students with limited remote sensing background a thorough introduction to current and future NASA, NOAA and other Earth science remote sensing missions.
Dynamics of MEMS : Models, Methods, Experiments and Applications
This work presents a systematic view of the dynamics of MEMS (microelectromechanical systems), microstructures, and their responses. The focus is on the mecahnical/structural micro domain and the compliant nature of mechanical transmission. Features of this work include: An in-depth treatment of problems that involve reliable modeling, analysis and design, Analytical models with correct dependences on service dimensions, Cantilever based systems for nanofabrication researchers and designers, and Dynamics of complex spring and beam microsystems.
Dynamics of Freezing-Thawing Soil around Subway Shield Tunnels
Addresses development laws for axial strain and excess pore water pressure in silty clay around subway shield tunnels before and after freezing-thawing when subjected to subway loading, as well as the effect of freezing-thawing on the dynamic parameters of silty clay, including the dynamic modulus and damping ratio, introducing readers to the design and construction of bypasses in subway tunnels with the artificial freezing method. On this basis, it then studies the microstructures of silty clay before and after freezing-thawing cyclic loading by means of scanning electron microscope tests and mercury intrusion porosimetry tests. Lastly, the book presents a numerical simulation of the dynamics of silty clay around subway tunnels before and after thawing.
Dynamics AX : A guide to microsoft axapta
The world’s leading Axapta 3.0 experts will take you from Axapta novice to pro in this book. This authoritative and comprehensive guide walks you gently through the bulk of what you need to know to productively apply the system in the real worldwith real data, sizing guidelines, deployment architectures, and code. By the book’s end, you will have acquired practical hands-on experience. You’ll be able to get Axapta 3.0 up and running, and identify gaps between the out-of-the-box product and your actual business needs. You’ll also know how to automate real-world business functions.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology
Dynamic contrast-enhanced MRI is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. This is assisting clinical practitioners in the management of patients with solid tumors and is finding prominence in the assessment of tumor treatments, including anti-angiogenics, chemotherapy, and radiotherapy. In this book, targeted at both clinical practitioners and basic scientists, the principles of the methods, their practical implementation, and their application to specific tumor types are discussed by the leading authorities in the field today. The book will serve as an invaluable single-volume reference covering all the latest developments in contrast-enhanced oncological MRI.
Drug safety evaluation : Methods and protocols
Focuses on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug interactions in infectious diseases : Antimicrobial drug interactions
Delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
Drug discovery targeting drug-resistant bacteria
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included.
Drug delivery trends ; Vol. 3 : Expectations and realities of multifunctional drug delivery systems
Examines a drift in the pharmaceutical field across the wide range of dosage forms, drug delivery systems (micro and nanoparticulate), at the regulatory front and on new types of therapies in the market. This book covers the challenges on drug delivery systems in terms of preclinical and current ways of determining quality and the options to solve the challenges associated with this. Most small-medium scale industries and academics struggle with initial regulatory challenges so a detailed discussion on regulatory trend covers the necessary basic understanding of regulatory procedures and provides the required guidance.
Domain-driven design with Java, a practitioner's guide : create simple, elegant, and valuable software solutions for complex business problems
Helps you as a developer and architect to put your knowledge to work in order to create elegant software designs that are enjoyable to work with and easy to reason about. You'll begin with an introduction to the concepts of domain-driven design and discover various ways to apply them in real-world scenarios. You'll also appreciate how DDD is extremely relevant when creating cloud native solutions that employ modern techniques such as event-driven microservices and fine-grained architectures. As you advance through the chapters, you'll get acquainted with core DDD's strategic design concepts such as the ubiquitous language, context maps, bounded contexts, and tactical design elements like aggregates and domain models and events. You'll understand how to apply modern, lightweight modeling techniques such as business value canvas, Wardley mapping, domain storytelling, and event storming, while also learning how to test-drive the system to create solutions that exhibit high degrees of internal quality.
DNA Methylation and Cancer Therapy
DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
Diversity and Evolution of Butterfly Wing Patterns : An Integrative Approach
is book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as “evo-devo,” “eco-devo,” ”developmental genetics,” “ecology and adaptation,” “food plants,” and “theoretical modeling.”
Distributed Embedded Control Systems : Improving Dependability with Coherent Design
Distributed Embedded Control Systems handles the domains encountered when designing a distributed embedded computer control system as an integrated whole. First to be discussed are some basic issues about real-time systems and their properties, specifically safety. Then, system and hardware architectures are dealt.
Distributed computing and internet technology ; 17th International Conference, ICDCIT 2021, Bhubaneswar, India, January 7–10, 2021, Proceedings
This book constitutes the proceedings of the 17th International Conference on Distributed Computing and Internet Technology, ICDCIT 2020, held in Bhubaneswar, India, in January 2021. The 13 full papers presented together with 4 short papers were carefully reviewed and selected from 99 submissions. The papers were organized in topical sections named: invited talks, cloud computing and networks, distributed algorithms, concurrency and parallelism, graph algorithms and security, social networks and machine learning, and short papers.
Dissecting the Molecular Anatomy of Tissue
The book provides an updated overview of molecular analysis of human tissues, and the impact this analysis has on diagnosis and prognosis of human diseases. Special emphasis is placed on human cancer and the future directions of the field. Methods of handling clinical tissue samples, including the impact of handling on subsequent molecular analysis, are also discussed. In addition, detailed protocols for molecular analysis of DNA, RNA and protein, with special emphasis on molecular analysis of highly complex human tissue samples containing mixtures of cell populations, are provided.
Disordered Materials : An Introduction
This self-contained text introduces the physics of structurally disordered condensed systems at the level of advanced undergraduate and graduate students. Among the topics are the geometry and symmetries of the structural units used as building blocks of extended structures, the various kinds of disorder, the phenomenology and the main theories of the glass transition, the structure of amorphous systems and the techniques to investigate it, the evolution of system's structure with its size (clusters) and the presence of orientational order in the absence of translational order (quasicrystals). In the second edition, the treatment of the mode coupling theory of the glass transition has been enlarged and connects now to a new section on collective excitations in disordered systems. Special attention has been devoted to nanometer-sized disordered systems, with emphasis on cluster-assembled materials. Questions of what governs the occurrence and stability of quasicrystals, the features of the amorphous to quasicrystal transformation and its reverse transition are discussed. The conditions leading to nano-quasicrystalline phases of technological interest are examined. Throughout the text relevant recent experimental and theoretical results are discussed so as to give readers insight into the currently most vibrant research topics.
Dislocation and Degradation of Proteins from the Endoplasmic Reticulum
The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made.
