الصفحة 29
الصفحة 29
Drug safety evaluation
Presents an all-inclusive practical guide for those who are responsible for developing new drugs and ensuring the safety of an ever-expanding spectrum of therapeutics. This book helps readers understand how the safety of these products are evaluated for use. Extensively revised to reflect up-to-date information, this edition includes changes to the scope of products (vaccines, small synthetic, large protein moieties, cells and tissues), harmonized global and national regulatory requirements, the therapeutic development process, and available technologies to identify and evaluate the relevance of potential patient risks
Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Drug interactions in infectious diseases : Antimicrobial drug interactions
Delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
Drug disposition and pharmacokinetics : Principles and applications for medicine, toxicology and biotechnology
Delivers an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.
Drug Discovery and Evaluation
The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described.
Drug delivery via nasal route
Over the past 10 years, the interest in intranasal drug delivery has increased. The objective of this research is to summarize recent developments on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, nevertheless, there are still formulation limitations and side effects to be optimized. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This research describes the anatomical, histological and physiological basis and summarizes currently approved drugs for administration via intranasal delivery. Further, the research focuses on advantages and disadvantages of intranasal applied compounds and discusses formulation aspects that need to be considered for drug development.
Drug delivery systems using quantum computing
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells, and subcellular organs for drug release and absorption through a variety of drug carriers. By controlling the precise level and/or location of a given drug in the body, side effects are reduced, doses are lowered, and new therapies are possible. Nevertheless, there are still significant obstacles to delivering certain medications to particular cells. Drug delivery methods change pharmacokinetic, pharmacodynamic, and drug release patterns to enhance product efficacy and safety, as well as patient convenience and compliance.
Drousi: A private lessons management system
Private teaching is considered to be an effective way to increase academic achievement of students and it seen as being a supplementary education, so it has become very common all around the world, however, previous studies have come to different conclusions regarding its necessity, so Drousi application had been made ,it’s a user-friendly mobile application to manage and arrange private lessons, and There has never been a better time to become a private tutor, as class sizes in schools increase, this can result in teachers being unable to give their undivided attention to students, and this document lays out a project plan for the development of “Drousi”, The plan will include a summary of the system functionality and how it implemented.
Driving digital transformation through data and AI : A practical guide to delivering data science and machine learning products
Explains how to build the organizational capability to deliver Data and AI products and drive immediate business results as new digital technologies significantly disrupt business Provides best practices, tools and templates for managing the organizational and technological change process to become an AI-driven enterprise Includes a variety of international case studies across several industries such as insurance, fashion, consumer goods, finance, technology and automotive Outlines how to develop a product strategy, build teams and design the platform and architecture Provides key principles for sharing knowledge, educating staff on data and AI, and effectively engaging top executives
Drawing Ideas
Focuses on the three key types of drawing, explanatory sketches, notational sketches and visual narratives that help designers think through and communicate their ideas. Through these three fundamentals, Drawing Ideas provides a thorough course in creating clear graphic layouts and diagrams, including expressive human forms, thumbnailing a process, adding effective colour and text and more. In addition, a drawing boot camp provides a refesher course in accurately drawing geometric forms. By getting back to the basics, readers will not only benefit from updated freehand drawing skills, but will also succeed in presenting and explaining their drawings and designs to others.
Drawing architecture and the Urban
Provides an instrumental approach to drawing, especially computer-generated drawings; it outlines how drawings should be used to convey clear and analytical information in the process of design, as well as the communication and discussion of a project. In depth examples are provided how to communicate effectively. The final section demonstrates how to transform case-studies, directly connecting an analytical approach with the design process.
DOM Scripting : Web Design with JavaScript and the Document Object Model
There are three main technologies married together to create usable, standards-compliant web designs: XHTML for data structure, Cascading Style Sheets for styling your data, and JavaScript for adding dynamic effects and manipulating structure on the fly using the Document Object Model. This book is about the latter of the three. DOM Scripting: Web Design with JavaScript and the Document Object Model gives you everything you need to start using JavaScript and the Document Object Model to enhance your web pages with client-side dynamic effects. Jeremy Keith starts off by giving you a basic crash course in JavaScript and the DOM, then moves on to provide you with several real-world examples built up from scratch, including dynamic image galleries and dynamic menus. Then, he shows you how to manipulate web page style using the CSS DOM, and create markup on the fly.
Diversity Training for Classroom Teaching : A Manual for Students and Educators
This book encourages readers to generate their own construction of effective multicultural education and learn how to adapt it across various student populations and educational problems. At the same time, learning activities encourage readers to respect and seek to understand the experiences and worldviews of different people and how these diverse realities influence what is meant by multicultural education
Disturbed soil properties and geotechnical design
Describes the developments leading to the Original Cam Clay model, focusing on fundamentals of the shearing of soil. The aim is to lay the groundwork of understanding that should form the basis of geotechnical design, guiding engineers towards the class of behaviour to be expected under different combinations of effective stress and water content.
Distributed Consensus in Multi-vehicle Cooperative Control : Theory and Applications
Distributed Consensus in Multi-vehicle Cooperative Control develops distributed consensus strategies designed to ensure that the information states of all vehicles in a network converge to a common value. This approach strengthens the team, minimizing power consumption and the deleterious effects of range and other restrictions.
Distributed Autonomous Robotic System 6
DARS is now a well-established conference that gathers every two years the main researchers in Distributed Robotics systems. Even if the field is growing, it has been maintained a one-track conference in order to enforce effective exchanges between the main researchers in the field. It now a well-established tradition to publish the main contributions as a book from Springer. There are already 5 books entitled "Distributed Autonomous Robotic Systems" 1 to 5.
Disrupted Development and the Future of Inequality in the Age of Automation
This book examines the future of inequality, work and wages in the age of automation with a focus on developing countries. The authors argue that the rise of a global ‘robot reserve army’ has profound effects on labor markets and economic development, but, rather than causing mass unemployment, new technologies are more likely to lead to stagnant wages and premature deindustrialization.
Disease in Wild Animals : Investigation and Management
Wildlife diseases have become increasingly important recently due to their effect upon human health, veterinary medicine, wildlife, and conservation biology. Gary Wobeser's successful book from 1994 has been completely updated and enlarged in a new second edition. An in-depth overview of the available techniques for the investigation and management of disease in free-ranging animals is provided. The subjects are illustrated with examples drawn from around the world, with emphasis on the special requirements involved in working with wild animals. Techniques are assessed critically with regard to their efficacy and effectiveness.
Direct Democracy in Europe : Developments and Prospects
The initiative and referendum process offers extra channels of participation and can serve as an important supplementary institution in representative democratic systems. This first volume of the new series Direct Democracy in Modern Europe features sixteen systematic and broadly empirical approaches to the study of modern direct democracy within the context of European politics including - system contexts and effects of the initiative and referendum process - theoretical approaches and basic values in modern direct democracy - the quality and institutional design of direct democratic mechanisms - aspects of information and communication - institutional performance and economic effectiveness - transnational challenges and the development of direct democracy in Europe
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
