Leptomeningeal Metastases
Leptomeningeal Metastases provides the reader with an overview of the state-of-the-art therapy for the leptomeningeal patient with additional information on epidemiology, symptom management, new clinical trials, and current basic research in animal models for experimental therapies. "Leptomeningeal metastases remains a devastating manifestation of hematologic malignancies and solid tumors. Leading figures in the field review the pathophysiology and clinical consequences of this process. State-of-the-art treatment strategies are presented highlighting advances in current management."
Lenses and Waves : Christiaan Huygens and the Mathematical Science of Optics in the Seventeenth Century
this book offers the first account of the development of Huygens’ mathematical analysis of lenses and telescopes and its significance for the origin of the wave theory of light. As Huygens applied his mathematical proficiency to practical issues pertaining to telescopes – including trying to design a perfect telescope by means of mathematical theory – his dioptrics is significant for our understanding of seventeenth-century relations between theory and practice. With this full account of Huygens’ optics, this book sheds new light on the history of seventeenth-century optics and the rise of the new mathematical sciences, as well as Huygens’ oeuvre as a whole. Students of the history of optics, of early mathematical physics, and the Scientific Revolution, will find this book enlightening.
Leibniz and the natural world : Activity, passivity and corporeal substances in Leibniz's Philosophy
In the present book, Pauline Phemister argues against traditional Anglo-American interpretations of Leibniz as an idealist who conceives ultimate reality as a plurality of mind-like immaterial beings and for whom physical bodies are ultimately unreal and our perceptions of them illusory. Re-reading the texts without the prior assumption of idealism allows the more material aspects of Leibniz's metaphysics to emerge. Leibniz is found to advance a synthesis of idealism and materialism. His ontology posits indivisible, living, animal-like corporeal substances as the real metaphysical constituents of the universe; his epistemology combines sense-experience and reason; and his ethics fuses confused perceptions and insensible appetites with distinct perceptions and rational choice. In the light of his sustained commitment to the reality of bodies, Phemister re-examines his dynamics, the doctrine of pre-established harmony and his views on freedom.
Leibniz : What Kind of Rationalist?
The chapters of the book are the result of intense discussion in the course of an international conference focused on the title question of this book, and were selected in view of their contribution to this topic. They are clustered in thematically organized parts. No effort has been made to hide the controversies underlying the different interpretations of Leibniz’s “rationalism” – in each particular domain and as a whole. On the contrary, the editor firmly believes that only through a variety of conflicting interpretive perspectives can the multi-faceted nature of an oeuvre of such a magnitude and variety as Leibniz’s be brought to light and understood as it deserves.
Lectures on Advances in Combinatorics
The main focus of these lectures is basis extremal problems and inequalities – two sides of the same coin. Additionally they prepare well for approaches and methods useful and applicable in a broader mathematical context. Highlights of the book include a solution to the famous 4m-conjecture of Erdös/Ko/Rado 1938, one of the oldest problems in combinatorial extremal theory, an answer to a question of Erdös (1962) in combinatorial number theory "What is the maximal cardinality of a set of numbers smaller than n with no k+1 of its members pair wise relatively prime?", and the discovery that the AD-inequality implies more general and sharper number theoretical inequalities than for instance Behrend's inequality.
Leading Pharmaceutical Innovation : Trends and Drivers for Growth in the Pharmaceutical Industry
Pharmaceutical giants have doubled their investments in drug development in the past decade only to see new drug approvals remain constant. This book investigates and highlights a set of proactive strategies aimed at generating sustainable competitive advantage based on value-generating business practices. We focus on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R&D, and new forms of cooperation and internationalization, such as open innovation in the early phases of R&D. Our findings are illustrated by cases from Europe, the US, and Asia.
Leadership and Performance in Public Sector Networks
Analyses two key aspects of network management in the public sector: leadership and performance. It investigates what integrative leadership is, and how it differentiates from leadership in single-agency structures. It also examines the performance of public interest networks by proposing an analytical framework that highlights which factors lead to high performance networks.
Le forme spastiche della paralisi cerebrale infantile : Guida all'esplorazione delle funzioni adattive = Spastic forms of cerebral palsy : A guide to exploring adaptive functions
Offers "travel notes" on the topics covered, to spark reflection and comparisons with the readers' experience. The authors address the topics from a pathophysiological perspective that guides their interpretation of the nature of the defect (functional diagnosis), the problems related to prognosis (as a natural history hypothesis), and rehabilitation (as a modification of the architecture of the function in an adaptive sense).The text is accompanied by an extensive glossary of terms used and a DVD with clinical cases, organized according to the authors' classification. This material also highlights the volume's great educational value, both for those already working in this field (physicians, child neuropsychiatrists and physiatrists, rehabilitation therapists) and for students completing their first and second level degrees in rehabilitation and attending postgraduate schools.
Lasers, lights, and energy devices
Offers a step-by-step, practical approach to this challenging area of dermatology, Procedures in Cosmetic Dermatology: Lasers, Lights, and Energy Devices, 5th Edition, enables you to master the up-to-date cosmetic techniques that produce the superior results your patients expect. It provides an overview of the underlying scientific principles of lasers and lights in dermatology, as well as the latest treatment options—all abundantly illustrated and evidence based. A substantial video library demonstrating applications and technical aspects helps you successfully incorporate the latest procedures into your practice.
Laser Dermatology
The continual array of laser technology throughout the world has been nothing short of miraculous. Over the last fifteen years, this field has continued to grow and expand with new technologies. This book represents the most up to date description of the latest in laser and light source technology.
Landscapes Under Pressure : Theory and Practice of Cultural Heritage Research and Preservation
This book investigates the newly emerging scope of interests and project agendas to investigate and preserve cultural landscapes. It presents the historic, archaeological, ethnographic, and environmental traditions of cultural landscape study and the attempts to reconstruct and analyze the complex processes of cultural changes through prehistoric and historic times.The "guiding light" of the book is that the fullest understanding of a cultural landscape will materialize through interdisciplinary cooperation, which should involve an ecological approach with historical ecology as the guiding tool, applied archaeology, and environmental planning.
Landscape Design in Color : History, Theory, and Practice 1750 to Today
Posits that though color and lighting effects appear natural, fleeting, and difficult to comprehend, the sensory palette of built landscapes and gardens has been carefully constructed to shape our experience and evoke meaning and place character. Landscape Design in Color: History, Theory, and Practice 1750 to Today is an inquiry into the themes, theories, and debates on color and its impact on practice in Western landscape architecture over the past three centuries.
L’osservazione delle stelle variabili = The observation of variable stars
The observation of variable stars is one of the main contributions that amateur astronomers can offer to science and this book provides all the information necessary to pursue it profitably. In the first part the different classes of variables are presented in detail, with examples, light curves and physical descriptions. The second section, on the other hand, covers all the practical aspects of observation: from preparation and planning, to observation techniques, up to the management and processing of data.
L’esprit de l’aiguille : L’apport du Yi Jing à la pratique de l’acupuncture = The Spirit of the Needle: The contribution of the Yi Jing to the practice of acupuncture
Acupuncture deciphers and heals human beings in all their mutations. The symbolism of Yi Jing joins the humanism of this Traditional Medicine for a dynamic reading of the changes and transformations at work in human beings. The double reflection generates a global vision of the human being and the approach to patients is changed. After an approach to the state of mind, encountered in these two fields, the author sets out to find the oldest roots of the notions of Yin and Yang. This allows him to identify the main strengths of the constitution of a human being and to deepen its symbolic construction. Three fields of application of this approach are then studied. The Extraordinary Meridians are viewed from a descriptive and behavioral perspective, which makes them extremely lively and familiar. Luo points, human being's relationship points with Reality, are also considered on a practical level using a symbolic reading of the links of Heaven, Earth and Man. Many examples shed light on these aspects. The last application is a detailed and comprehensive presentation of the fundamental and symbolic functions of the twelve main meridians through the hexagrams which correspond to their ancient Shu points. This original book is intended for any practitioner of traditional Chinese medicine curious to broaden their field of investigation. Dr M. Vinogradoff has been practicing acupuncture for 25 years. He is a member of the French Acupuncture Association, the French Acupuncture College and the Ricci Institute. After having published the complete translation of Yi Jing, in 2006 he published a novel, the action of which is set in Ancient China.
Kristian Birkeland : The First Space Scientist
PREFACEThisscientific biography of Kristian Birkeland (1867–1917) was written to bring the story ofa Norwegian national hero to the attention ofthe English-speaking world. Birkeland’sheroic stature was established not on a field of military battle,but in the bitter cold of the Artic wilderness ashe sought to answer basic questions abouthow the Sun controlled northern lights andmag-netic storms. He was also afather of Norsk Hydro one ofNorway’s largest industries. Birkel and died before reaching the age of 50.Because Birkel and never kept adiary, documented information about his family and private life is sparse. Before he died, Olaf Devik, the last of Birke-ffland’s close friends, gave along interview and graciously transferred his personal archive to A.E. Birkeland’s 82 scientific papers and three book-length publications map the progress of his investigations. addressed this book questions that had vexed European scientists for centuries. Why do the northern lights appear overhead when the Earth’s magnetic field is disturbed? How are magnetic storms connected to disturbances on the Sun? To answer these questions Birkeland interpreted his advance laboratory simulations and daring campaigns in the Arctic wilderness in the light of Maxwell’s newly discovered laws of electricity and magnetism. Birkeland’s ideas were dismissed for decades, only to be vindicated when satellites could fly above the Earth’s atmosphere.
Knowledge, practices, and awareness of safety risks associated with antiemetic use: A cross-sectional study
Highlighted a high prevalence of self-medication, with most participants keeping these drugs at home due to their accessibility and low cost. A strong correlation was observed between educational level and awareness; individuals with higher education were more likely to seek professional advice and carefully read drug leaflets. Conversely, lower educational groups and younger participants showed a greater tendency to repeat doses without consultation or rely on home remedies.
Knowing the Salween River : Resource Politics of a Contested Transboundary River
Focuses on the Salween River, shared by China, Myanmar, and Thailand, that is increasingly at the heart of pressing regional development debates. The basin supports the livelihoods of over 10 million people, and within it there is great socio-economic, cultural and political diversity. The basin is witnessing intensifying dynamics of resource extraction, alongside large dam construction, conservation and development intervention, that is unfolding within a complex terrain of local, national and transnational governance. With a focus on the contested politics of water and associated resources in the Salween basin, this book offers a collection of empirical case studies that highlights local knowledge and perspectives. Given the paucity of grounded social science studies in this contested basin, this book provides conceptual insights at the intersection of resource governance, development, and politics of knowledge relevant to researchers, policy-makers and practitioners at a time when rapid change is underway.
Julie Snow Architects
This, the first monograph on Snow's work, provides in depth documentation of 14 of her residential, institutional, corporate, and public projects, including the Koehler Residence in New Brunswick, Canada, a series of Minneapolis Light Rail Stations, the Minnesota Children's Museum, and the University of South Dakota School of Business.
Judges and Adjudication in Constitutional Democracies : A View from Legal Realism
Offers contributions to a philosophical and realistic approach to the place of adjudication in contemporary constitutional democracies. Bringing together scholars from different legal and philosophical backgrounds, purports to cast light on the role(s) of judges and the function of judicial interpretation inside of constitutional states, from the standpoint of legal realism as a revisited and sophisticated jurisprudential outlook. In so doing, also copes with a few major jurisprudential issues, like, e.g., determining the ideas that make up the core of legal realism, exploring the relation between legal realism and legal positivism, identifying the boundaries of judicial interpretation as they appear from a realist standpoint, as well as considering some skeptical outlooks on the very claims of contemporary legal realism.
Jubilee Line Extension : From concept to completion
Details the story of London Underground's award winning Jubilee Line Extension (JLE), how it came to being, how it was planned, how it was designed, built and commissioned, and how the millennium deadline imposed by the Dome was met. Always in the public eye and the political spotlight, the JLE has played a significant role in the success of the Canary Wharf development, improved public transport immeasurably in the areas of southeast and east London, and set new standards for London Underground and public transport.



















