الصفحة 28
الصفحة 28
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Cancer and War
Armed conflict, especially the most intense types, indirectly impacts civilian mortality. The estimates suggest that almost 30 million civilian deaths were indirectly attributable to armed conflict globally between 1990 and 2017, two thirds of which were due to communicable, maternal, neonatal, and nutritional diseases. Broader and more robust measures of civilian impacts at subnational and national levels are needed to inform policy and advocacy to prevent war and protect civilians. This could include greater use of linkage studies that incorporate data from routine health and demographic sources, exposure to conflict-specific environmental risks, and quantitative epidemiological methods such as national and subnational victimisation surveys.
Cadmium toxicity : challenges and solutions
Offers a comprehensive collection of review and case chapters that cover cadmium toxicity and remediation. It covers sources of cadmium contamination, its impact on human health, and prospective remediation strategies, taking a multi-disciplinary approach a focus on application of recent advanced biological technology. The chapters here bring together a diverse group of environmental science, sustainability and health researchers to address the challenges caused by cadmium contamination, explaining the routes of exposure to environmental cadmium, how cadmium is transported in ecosystems, and the health risks linked to cadmium exposure in food and the environment.
Business trends in practice : The 25+ trends that are redefining organizations
In Business Trends in Practice: The 25+ Trends That Are Redefining Organizations, best-selling business author and strategist Bernard Marr breaks down the social and technological forces underlying these rapidly advancing changes and the impact of those changes on key industries.
Business Education and Emerging Market Economies : Perspectives and Best Practices
Business Education in Emerging Market Economies discusses the impact of business education on emerging markets and explores curricular innovation, pedagogical approaches, and strategic alliances in the context of industrializing economies. Emerging markets consist of eighty percent of the world's population and some 75% of its trade growth in the foreseeable future according to the U.S. Department of Commerce. The potential economic growth of emerging markets has prompted a need to understand the dynamics of these markets, their business institutions, and their educational systems. The pressures of globalization and the recent economic reforms that swept across emerging, developing, and transitioning, economies have had a positive impact on the demand for business education and business knowledge from the developed and industrialized countries. As a result, many methods were developed to transfer know-how from the developed markets including learning through imitation, using western style pedagogical approaches, attending universities in industrialized countries, learning through experience and practice, and using information technology. The conclusion we reach is that business and management education in emerging markets is fast changing the way in which these markets operate and are perceived – business educators are catalysts for greater economic integration.
Business agility and information technology diffusion ; IFIP TC8 WG 8.6 International working Conference, May 8-11, 2005, Atlanta, Georgia, USA
Addresses issues related to business agility and the diffusion of Information Technology (IT). Success, even survival, in today's business environment has been made complex and difficult by technologically-based competitive pressure. One promising strategy is to be agile and ready to adapt quickly to changes in the environment or market. Such strategy takes shape as an agile software development, agile manufacturing, agile modeling and agile iterations. In contrast, successful IT diffusion is known to be a process that takes time and careful effort. Many IT projects that succeeded in developing a product have subsequently failed in changing the behavior of the target group when diffusion just didn't happen. Therefore this volume responds to the question: What is the relationship between agility and IT diffusion? The book's scope will cover information systems and technology issues, as well as organizational and managerial issues, related to agility and IT diffusion. The planned perspectives include topics such as diffusion of agile methods, enabling business agility with IT, creating agile environments that facilitate diffusion of IT, theories and frameworks for understanding diffusion and agility issues, best practices relating to business agility and IT diffusion, software process improvement and agility, diffusion studies of specific agile technologies, and impacts of diffusion of IT agile methods.
Building design, construction and performance in tropical climates
Outlines: the functional requirements of buildings in tropical climates; the challenges associated with the sustainability of the built environment, building form and whole life performance in the context of a tropical setting; the impact of potentially hostile tropical conditions upon building pathology and the durability of components, structure and fabric; the tasks which face those responsible for appraising the design, condition, maintenance and conservation of built heritage in tropical regions; the facilities management issues faced in tropical climates; and the refurbishment, upgrade and renewal of the tropical built environment.
Building construction and technology
Highlights various aspects of building construction industry based on data from field studies. It discusses the challenges, methodologies, technological applications in building construction, technology, and management. The book presents new approaches to effective building construction and an understanding of the impact of applications of latest technologies.
Broadband in Europe: How Brussels Can Wire the Information Society
Broadband is a key enabler of the information society, increasing productivity and competitiveness across all sectors of the economy. Unlike traditional n- rowband connections, broadband provides high speed, always-on connections to the Internet and supports innovative content and services. Direct consumer welfare gains from mass-market adoption of broadband across the EU could easily reach 50 billion euros or more per annum. This is quite apart from the more profound societal shifts that ubiquitous broadband could bring. It may allow the individual to distribute content and ideas independent of traditional media and bring together communities of interest without regard to borders. Public policy for broadband will have a big impact on whether and how quickly these benefits are realised. Getting policy right could bring large benefits for consumers.
British Media Coverage of the Press Reform Debate : Journalists Reporting Journalism
This book provides a detailed exploration of the British media coverage of the press reform debate that arose from the News of the World phone hacking scandal and the Leveson Inquiry. Gathering data from a content analysis of 870 news articles, Ogbebor shows how journalists cover debates on media policy and illustrates the impact of their coverage on democracy
Bridging divides : Maritime canals as invasion corridors
Maritime canals dissolve natural barriers to the dispersal of marine organisms, thus providing novel opportunities for natural dispersal, as well as for shipping-mediated transport. The introduction of alien species has proved to be one of the most profound and damaging of anthropogenic deeds - with both ecological and economic costs. This book is the first to assess the impacts of the world’s three principal maritime canals – the Kiel, the Panama, the Suez – as invasion corridors for alien biota. These three canals differ in their hydrological regimes, the types of biotas they connect, and in their permeability to invasions.
Breath odors : Origin, diagnosis, and management
Presents a comprehensive and cohesive science-based approach to bad breath, combining basic research with clinical approaches to diagnosis and treatment. All aspects of the subject are examined thoroughly and critically, including the psychological impact of breath odor and future prospects.
Brand metrics : Measuring brand efficacy along the customer journey
The metrics covered in the book correspond with the customer journey, moving through measuring brand awareness, consideration and purchase, to customer loyalty and brand advocacy, and finally an overall analysis of the brand's strength. The book not only shows the formula for a metric and explains how it should be interpreted, but also considers what each metric really measures, how it impacts the brand's equity and how is it related to other metrics.
Brain Metastases
Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria.
Bodily Integrity and the Politics of Circumcision : Culture, Controversy, and Change
This book explores the problem of male and female circumcision in modern society from religious, anthropological, psychological, medical, legal, and ethical perspectives. Bodily Integrity and the Politics of Circumcision provides a much-needed, thoughtful, and detailed analysis of the devastating impact of circumcision on bodily integrity and human rights, and it provides hope for change.
Blind Equalization and System Identification : Batch Processing Algorithms, Performance and Applications
Discrete-time signal processing has had a momentous impact on advances in engineering and science over recent decades. The rapid progress of digital and mixed-signal integrated circuits in processing speed, functionality and cost-effectiveness has led to their ubiquitous employment in signal processing and transmission in diverse milieux. Topics covered include: • SISO, MIMO and 2-d non-blind equalization (deconvolution) algorithms. • SISO, MIMO and 2-d blind equalization (deconvolution) algorithms. • SISO, MIMO and 2-d blind system identification algorithms. • algorithm analyses and improvements. • applications of SISO, MIMO and 2-d blind equalization/identification algorithms.
Bird species : How they arise, modify and vanish
The average person can name more bird species than they think, but do we really know what a bird “species” is? This open access book takes up several fascinating aspects of bird life to elucidate this basic concept in biology. From genetic and physiological basics to the phenomena of bird song and bird migration, it analyzes various interactions of birds – with their environment and other birds. Lastly, it shows imminent threats to birds in the Anthropocene, the era of global human impact.This book brings together various disciplines involved in observing bird species come into existence, modify, and vanish. It is a rich resource for bird enthusiasts who want to understand various processes at the cutting edge of current research in more detail. At the same time it offers students the opportunity to see primarily unconnected, but booming big-data approaches such as genomics and biogeography meet in a topic of broad interest. Lastly, the book enables conservationists to better understand the uncertainties surrounding “species” as entities of protection.
Bioproducts From Canadas Forests : New Partnerships in the Bioeconomy
For the first time, this opportune book provides a comprehensive treatment of the many innovative, non-timber bioproducts that may be derived from Canada’s vast forests, including their potential economic, social and environmental impacts. It also offers a balanced discussion of the technological, policy and regulatory issues surrounding the emerging global bioeconomy. This book will not only be of interest to Canadian forestry professionals and entrepreneurs, but also to those interested in the contribution of forestry to the bioeconomy worldwide.
Biopharmaceutics : From fundamentals to industrial practice
Beginning with an expansive introduction to the basics of biopharmaceutics and the context that underpins the field, the included resources go on to discuss how biopharmaceutics are integrated into product development within the pharmaceutical industry. Explorations of how the regulatory aspects of biopharmaceutics function, as well as the impact of physiology and anatomy on the rate and extent of drug absorption, follow.
Biomimetic restorative dentistry
Biomimetic dentistry represents a significant advancement in restorative practices, emphasizing the preservation of natural tooth structure and the use of innovative materials that closely mimic biological tissues. This article explores the potential impact of biomimetic approaches on patient outcomes, highlighting key findings that demonstrate improved longevity of dental restorations and reduced incidence of secondary caries.
