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Applications of computational intelligence in biology : Current trends and open problems
The purpose of this book is to provide a medium for such an exchange of expertise and concerns. In order to achieve the goal, we have solicited cont- butions from both computational intelligence as well as biology researchers.
Applications and Innovations in Intelligent Systems XV ; Proceedings of AI-2007, the Twenty-seventh SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence
The papers in this volume are the refereed application papers presented at AI-2007, the Twenty-seventh SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence, held in Cambridge in December 2007.
Applications and innovations in intelligent systems XII ; Proceedings of AI-2004, the Twenty-fourth SGAI International Conference on Innhovative Techniques and Applications of Artificial Intelligence
The papers in this volume are the refereed application papers presented at AI-2004, the Twenty-fourth SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence, held in Cambridge 2004. The papers present new and innovative developments in the field, divided into sections on Synthesis and Prediction, Scheduling and Search, Diagnosis and Monitoring, Classification and Design, and Analysis and Evaluation. This is the twelth volume in the Applications and Innovations series. The series serves as a key reference on the use of AI Technology to enable organisations to solve complex problems and gain significant business benefits. The Technical Stream papers are published as a companion volume under the title Research and Development in Intelligent Systems XXI.
Antiangiogenic Agents in Cancer Therapy
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Anomalies of the Developing Dentition : A Clinical Guide to Diagnosis and Management
This book is an up-to-date, succinct, and easily accessible reference on the diverse anomalies that may arise in the developing dentition, including those relating to crown size and shape, tooth formation, tooth eruption, tooth number, and enamel and dentin.
Androgen Excess Disorders in Women
The field of androgen excess disorders has advanced substantially since the original publication of this book. The Androgen Excess Society (AES) was founded to bring together investigators in the field. A better understanding of the screening, progression, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has improved the clinical care and diagnostic accuracy of these patients. New criteria for the diagnosis of the polycystic ovary syndrome (PCOS) were proposed in Rotterdam, criteria that have resulted in controversy and, hopefully, initiation of new studies. The association of insulin resistance with PCOS has been strengthened, and the role of metformin in tre- ing the infertility of the PCOS has been validated. Risks for diabetes and, more cont- versially, cardiovascular disease in women with PCOS have received substantial investigation. Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance.
Analytics of Protein-DNA Interactions
This book covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. More information as well as the electronic version is available at springer.com.
Analysis of variance for random models, Vol. 2 : Unbalanced data : Theory, methods, applications, and data analysis
Analysis of variance (ANOVA) models have become widely used tools and play a fundamental role in much of the application of statistics today. In particular, ANOVA models involving random effects have found widespread application to experimental design in a variety of fields requiring measurements of variance, including agriculture, biology, animal breeding, applied genetics, econometrics, quality control, medicine, engineering, and social sciences. This two-volume work is a comprehensive presentation of different methods and techniques for point estimation, interval estimation, and tests of hypotheses for linear models involving random effects. Both Bayesian and repeated sampling procedures are considered. Volume I examines models with balanced data (orthogonal models); Volume II studies models with unbalanced data (nonorthogonal models).
Analysis of phylogenetics and evolution with R
This book integrates a wide variety of data analysis methods into a single and flexible interface: the R language. This open source language is available for a wide range of computer systems and has been adopted as a computational environment by many authors of statistical software. Adopting R as a main tool for phylogenetic analyses will ease the workflow in biologists' data analyses, ensure greater scientific repeatability, and enhance the exchange of ideas and methodological developments.
Analysis and Design of Intelligent Systems Using Soft Computing Techniques
This book comprises a selection of papers from IFSA 2007 on new methods for analysis and design of hybrid intelligent systems using soft computing techniques. Soft Computing (SC) consists of several computing paradigms, including fuzzy logic, neural networks, and genetic algorithms, which can be used to produce powerful hybrid intelligent systems for solving problems in pattern recognition, time series prediction, intelligent control, robotics and automation. Hybrid intelligent systems that combine several SC techniques are needed due to the complexity and high dimensionality of real-world problems. Hybrid intelligent systems can have different architectures, which have an impact on the efficiency and accuracy of these systems, for this reason it is very important to optimize architecture design. The architectures can combine, in different ways, neural networks, fuzzy logic and genetic algorithms, to achieve the ultimate goal of pattern recognition, time series prediction, intelligent control, or other application areas.
Analyse céphalométrique fonctionnelle et esthétique de profil = Functional and aesthetic cephalometric profile analysis
The complexity of the craniofacial architecture explains the multiplicity of cephalometric analyzes, too often based on points without phylogenetic, ontogenetic, anatomical or biomechanical justification. The value of a reliable and rapid analysis designed from indisputable fundamental foundations is essential. It enables the use of cephalometry in the daily practice of orthodontists, maxillofacial surgeons and facial plastic surgeons. This functional and aesthetic cephalometric analysis is carried out from fourteen anatomical points, ten bony points and four skin points, which all have in common that they are exo-basicranial. This analysis is easy to understand and use. It only takes five minutes to be learned and five minutes to be traced (fifteen seconds if it is computerized). The resulting results are reliable. The functional and aesthetic analysis is developed through four chapters. The first is devoted to the fundamental bases, the second to the analysis itself and to clinical cases, the third to the comparative study of different cephalometric analyzes, and finally the fourth chapter revisits the work of Arne Björk.
An overview of systemic lupus erythematosus (SLE) : Pathogenesis, classification, and management
Systemic lupus erythematosus (SLE), commonly referred to as lupus, is a complex and chronic autoimmune disorder that poses significant challenges to patients and healthcare providers alike. Affecting predominantly women of childbearing age, over 90% of those diagnosed are female, resulting in a striking female-to-male ratio of approximately 9:1. This condition exemplifies the intricate interplay between immune dysregulation and tissue damage, influenced by a combination of genetic predispositions, environmental triggers, hormonal factors, and immunological aberrations
An Introduction to Knowledge Engineering
Knowledge Engineering refers to the development of systems that use knowledge, rather than data, to solve many novel computing problems. This is achieved by the application of computing techniques, closely associated with human cognitive processes, for transforming data into knowledge. An Introduction to Knowledge Engineering presents a simple but detailed exploration of current and established work in the field.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Alzheimers Disease : Advances in genetics, molecular and cellular biology
Alzheimer’s Disease: Advances in Genetics, Cellular and Molecular Biology provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. The studies and advances described in this volume will help to accelerate the process of rational drug discovery and soon serve to extend and enhance the mental health and lifespan of our burgeoning elderly population.
Alzheimer : 100 Years and Beyond
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4th, 1906 in Tübingen. The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiative of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, at the very site of the original lecture, namely the Institute of Psychiatry at the University of Tübingen in Germany from November 2nd to 5th, 2006, was the highlight of the Alzheimer Year. Over the last century of Alzheimer research (1906-2006), remarkable progress has been achieved. Most of the authors of the major discoveries and the people involved in research in this field will present, during the meeting and in this volume, the pioneering research explaining the conditions under which they were conducted. The goal of this book is to honor the work accomplished, to summarize the most important knowledge and to provide material for the history of science.
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Altering nature ; Vol.2 : Religion, Biotechnology, and Public Policy
The two volumes of Altering Nature consider the complex ways that concepts of 'nature' and 'the natural' are understood and the relevance of those understandings to discussions of biotechnology.Volume Two, Religion, Biotechnology, and Public Policy, reviews recent religious and ethical analyses of four specific areas of biotechnology: assisted reproduction, genetic therapy and enhancement, human-machine incorporation, and biodiversity. It identifies and explores the richer normative themes that inform particular debates and suggests ways that policy choices in biotechnology may be illuminated by devoting greater attention to religious perspectives.
Alkaliphiles : Genetic properties and applications of enzymes
The pioneering work of Dr. Koki Horikoshi on the discovery, research and applications of alkaliphilic bacteria are described here in their entirety. The isolation, distribution and taxonomy of alkaliphilic microorganisms as well as their cell structure and physiology are discussed for a basic understanding of these entities. The molecular biology and genome sequencing of some alkaliphilic bacterial strains are also presented. Part II of the volume focuses on enzymes of alkaliphiles and their applications. These include alkaline proteases, starch-degrading enzymes and numerous others. Some of these enzymes are currently in wide commercial use as laundry detergent additives and in wastewater treatment. Alkaliphiles are a relatively recent field of research that will no doubt provide avenues to a wide range of further discoveries and applications for a new generation of workers in bioscience and technology.
Algorithms in Bioinformatics ; Vol.4175 : 6th International Workshop, WABI 2006, Zurich, Switzerland, September 11-13, 2006, Proceedings
This book constitutes the refereed proceedings of the 6th International Workshop on Algorithms in Bioinformatics, WABI 2006, held in Zurich, Switzerland in September 2006 in the course of the ALGO 2006 conference meetings. The 36 revised full papers presented were carefully reviewed and selected from 100 submissions. All current issues of algorithms in bioinformatics are addressed, ranging from mathematical tools to experimental studies of approximation algorithms and reports on significant computational analyses. Numerous biological problems are dealt with, including genetic mapping, sequence alignment and sequence analysis, phylogeny, comparative genomics, and protein structure. For the first time also machine-learning approaches along with combinatorial optimization are covered.
