الصفحة 28
الصفحة 28
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug repurposing and computational drug discovery strategies and advances
Defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates.
Drug discovery targeting drug-resistant bacteria
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included.
Drug delivery via nasal route
Over the past 10 years, the interest in intranasal drug delivery has increased. The objective of this research is to summarize recent developments on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, nevertheless, there are still formulation limitations and side effects to be optimized. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This research describes the anatomical, histological and physiological basis and summarizes currently approved drugs for administration via intranasal delivery. Further, the research focuses on advantages and disadvantages of intranasal applied compounds and discusses formulation aspects that need to be considered for drug development.
Drug Courts : A New Approach to Treatment and Rehabilitation
This cutting-edge sourcebook is ideal for physicians, addiction treatment practitioners, probation officers, testing programs, judges and anyone else facing challenges in practice with the treatment of drug court participants. This book includes knowledge in treatment of addiction and withdrawal, treatment for patients with dual diagnoses of mental illness and addiction, and treatment of diseases associated with drug use, such as tuberculosis, hepatitis, and HIV infection. Unparalleled discussions of the drug court system and the medical problems of drug court patients are presented.
Drug and Alcohol Abuse : A Clinical Guide to Diagnosis and Treatment
Gives professionals and students across the health and mental health disciplines a working knowledge of drug-related pathology, beginning with pharmacology, drug mechanisms, and genetic factors. This title features clinical/emergency orientation suited to both chronic misuse and acute situations.
D-Modules, Perverse Sheaves, and Representation Theory
D-modules continues to be an active area of stimulating research in such mathematical areas as algebra, analysis, differential equations, and representation theory. Key to D-modules, Perverse Sheaves, and Representation Theory is the authors' essential algebraic-analytic approach to the theory, which connects D-modules to representation theory and other areas of mathematics. Significant concepts and topics that have emerged over the last few decades are presented, including a treatment of the theory of holonomic D-modules, perverse sheaves, the all-important Riemann-Hilbert correspondence, Hodge modules, and the solution to the Kazhdan-Lusztig conjecture using D-module theory.
Distributed Cooperative Laboratories : Networking, Instrumentation, and Measurements
This is a highly interdisciplinary topic, where various aspects converge: multimedia communications and networking, sensor networks, Grid technology, Quality of Service (QoS) provisioning and control, network management, measurement instrumentation and methodology, architecture of measurement systems. The material is organized into six parts: Technologies for Real-Time Interactive Multimedia Communications; Monitoring, Management and Configuration of Networks and Networking Devices; Data Acquisition and Aggregation in Sensor Networks; Grid Structures for Distributed Cooperative Laboratories; Architectures and Techniques for Tele-Measurements; Virtual Immersive Communications and Distance Learning. Each contribution presents a self-contained treatment, within a framework that provides the reader with an up-to-date picture of the most recent state-of-the-art developments.
Distributed computing and Internet Technology ; 1st International Conference, ICDCIT 2004, Bhubaneswar, India, December 22-24, 2004, Proceedings
Taming the Dynamics of Disributed Data - DISTRIBUTED COMPUTING -- Data in Your Space -- Enabling Technologies for Harnessing Information Explosion -- Fair Leader Election by Randomized Voting -- An Efficient Leader Election Algorithm for Mobile Ad Hoc Networks -- Distributed Balanced Tables: A New Approach - Performance Evaluation of Gigabit Ethernet and SCI in a Linux Cluster -- Performance Evaluation of a Modified-Cyclic-Banyan Based ATM / IP Switching Fabric -- A Scalable and Robust QoS Architecture for WiFi P2P Networks -- NEC: Node Energy Based Clustering Protocol for Wireless Sensor Networks with Guaranteed Connectivity,and other
Dissipative Systems Analysis and Control : Theory and Applications
Dissipative Systems Analysis and Control (second edition) presents a fully revised and expanded treatment of dissipative systems theory, constituting a self-contained, advanced introduction for graduate students, researchers and practising engineers. It examines linear and nonlinear systems with examples of both in each chapter; some infinite-dimensional examples are also included. Throughout, emphasis is placed on the use of the dissipative properties of a system for the design of stable feedback control laws. The theory is substantiated by experimental results and by reference to its application in illustrative physical cases (Lagrangian and Hamiltonian systems and passivity-based and adaptive controllers are covered thoroughly).
Disorders of the Respiratory Tract : Common Challenges in Primary Care
In Disorders of the Respiratory Tract: the author covers the range of knowledge needed to provide excellent care for patients with respiratory disease, from the basics of pulmonary function testing to understanding and caring for common respiratory illnesses, including chronic obstructive pulmonary disease, asthma, allergic rhinitis, and pneumonia. Less common illnesses.
Disordered Materials : An Introduction
This self-contained text introduces the physics of structurally disordered condensed systems at the level of advanced undergraduate and graduate students. Among the topics are the geometry and symmetries of the structural units used as building blocks of extended structures, the various kinds of disorder, the phenomenology and the main theories of the glass transition, the structure of amorphous systems and the techniques to investigate it, the evolution of system's structure with its size (clusters) and the presence of orientational order in the absence of translational order (quasicrystals). In the second edition, the treatment of the mode coupling theory of the glass transition has been enlarged and connects now to a new section on collective excitations in disordered systems. Special attention has been devoted to nanometer-sized disordered systems, with emphasis on cluster-assembled materials. Questions of what governs the occurrence and stability of quasicrystals, the features of the amorphous to quasicrystal transformation and its reverse transition are discussed. The conditions leading to nano-quasicrystalline phases of technological interest are examined. Throughout the text relevant recent experimental and theoretical results are discussed so as to give readers insight into the currently most vibrant research topics.
Disinfection of root canal systems : The Ttreatment of apical periodontitis
An evidence-based manual that describes root canal anatomy, the endodontic biofilm, and the role of disinfection before presenting the most up-to-date methods of irrigation and disinfection. Individual chapters are devoted to each method, such as positive pressure irrigation, apical negative pressure irrigation, sonic activation, photodynamic therapy, laser technology, and ozonization and electrochemical activation. Clinical photographs throughout show proper irrigation and disinfection techniques.
Discrete-time Markov jump linear systems
Safety critical and high-integrity systems, such as industrial plants and economic systems, can be subject to abrupt changes - for instance, due to component or interconnection failure, sudden environment changes, etc. Combining probability and operator theory, Discrete-Time Markov Jump Linear Systems provides a unified and rigorous treatment of recent results for the control theory of discrete jump linear systems, which are used in these areas of application. The book is designed for experts in linear systems with Markov jump parameters, but is also of interest for specialists in stochastic control since it presents stochastic control problems for which an explicit solution is possible - making the book suitable for course use.
Direct and indirect resin composite veneers
Re-establishing a patient’s lost dental asthetic appearance is one of the most important topics for contemporary dentistry.New treatment materials and methods have been coming on the scene, day by day, in order to achieve such an aim. Most dentists prefer more conservative and aesthetic approaches. Laminate veneers are restorations which are envisioned to correct existing abnormalities, esthetic deficiencies and discolorations. Laminate veneer restorations may be processed in two different ways: direct or indirect. Direct resin composite veneers are one of the most commonly used restorations in the treatment of poor esthetics in anterior teeth presenting unsatisfactory colour and shape, defective restorations, slight misalignment and fractures.
Dirac Operators in Representation Theory
This monograph presents a comprehensive treatment of important new ideas on Dirac operators and Dirac cohomology. Dirac operators are widely used in physics, differential geometry, and group-theoretic settings (particularly, the geometric construction of discrete series representations). The related concept of Dirac cohomology, which is defined using Dirac operators, is a far-reaching generalization that connects index theory in differential geometry to representation theory. Using Dirac operators as a unifying theme, the authors demonstrate how some of the most important results in representation theory fit together when viewed from this perspective.
Dilated Cardiomyopathy : From Genetics to Clinical Management
This book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up.
Digitization in Dentistry : Clinical Applications
Provides evidence-based guidance on the clinical applications of digital dentistry, that is, the use of dental technologies or devices that incorporate digital or computer-controlled components for the performance of dental procedures. Readers will find practically oriented information on the digital procedures currently in use in various fields of dental practice, including, for example, diagnosis and treatment planning, oral radiography, endodontics, orthodontics, implant dentistry, and esthetic dentistry. The aim is to equip practitioners with the knowledge required in order to enhance their daily practice. To this end, a problem-solving approach is adopted, with emphasis on key concepts and presentation of details in a sequential and easy to follow manner. Clear recommendations are set out, and helpful tips and tricks are highlighted.
Digital Signal Processing : An Experimental Approach
Digital Signal Processing is a mathematically rigorous but accessible treatment of digital signal processing that intertwines basic theoretical techniques with hands-on laboratory instruction. Divided into three parts, the book covers various aspects of the digital signal processing (DSP) "problem".
Digital Restorative Dentistry : A Guide to Materials, Equipment, and Clinical Procedures
Offers up-to-date, readily understandable guidance on the materials and equipment employed in digital restorative dentistry and on the specific clinical procedures that may be performed using the new technologies. The key components of digital restorative dentistry – image acquisition, prosthetic/restorative design, and fabrication – are fully addressed. Readers will find helpful information on scanners, the software for prosthetic design, and the materials and technologies for prosthesis fabrication, including laser sintering, 3D printing, CAD/CAM, and laser ablation. The section on clinical procedures explains all aspects of the use of digital technologies in the treatment of patients requiring removable partial dentures, complete dentures, fixed partial prostheses, crowns, endodontics, and implant surgery and prosthodontics. The field of restorative and prosthetic dentistry is undergoing rapid transition as these new technologies come to play an increasingly central role in everyday dental practice. In bridging the knowledge gap that this technological revolution has created in the field of dentistry, the book will satisfy the needs of both dentists and dental students.
