الصفحة 27
الصفحة 27
Cell-Cell Channels
The biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. This concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are numerous observations which indicate that it is not the cells which serve as the basic units of biological life but that this property falls to some other, subcellular assemblage. To deal with this intricate problem concerning the fundamental unit of living matter, we proposed the so-called Cell Body concept which, in fact, devel ops an exceedingly original idea proposed by Julius Sachs at the end of the 19th century. In the case of eukaryotic cells, DNA-enriched nuclei are intimately associated with a microtubular cytoskeleton. In this configuration—as a Cell Body—these two items comprise the fundamental functional and struc tural unit of eukaryotic living matter. The Cell Body seems to be inherent to all cells in all organisms.
Cell Stress Proteins
This comprehensive volume, written by experts in the field, provides a current understanding of the molecular properties of the heat shock proteins and their roles in health and disease. Cell Stress Proteins includes advances in several aspects of stress protein research, with chapters ranging from basic studies of the role of heat shock proteins in protein folding to reviews examining the breakdown of stress protein regulation during disease. It also provides analysis of the biochemical and molecular properties of heat shock proteins which can be utilized in evaluating their role in human physiology and pathology. Cell Stress Proteins is an ideal book for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
CD137 Pathway : Immunology and Diseases
This comprehensive volume, written by experts in the field, covers nearly all aspects of ongoing research related to the CD137 pathway. Recent research has shown that the manipulation of CD137 pathway molecules is very promising in the treatment of cancer, viral infection, transplantation rejection and autoimmune diseases in experimental animal models. The volume includes research related to the identification and understanding of functional consequences of CD137 receptor and ligand molecules which represents a major effort in the field of immunology. CD137 Pathway: Immunology and Diseases is an ideal book for immunologists, microbiologists, cancer researchers, molecular biologists, biochemists, and pharmaceutical and biotechnology company scientists.
Case-Based Approximate Reasoning
Case-based reasoning (CBR) has received a great deal of attention in recent years and has established itself as a core methodology in the field of artificial intelligence. The key idea of CBR is to tackle new problems by referring to similar problems that have already been solved in the past. More precisely, CBR proceeds from individual experiences in the form of cases. The generalization beyond these experiences typically relies on a kind of regularity assumption demanding that 'similar problems have similar solutions'. Making use of different frameworks of approximate reasoning and reasoning under uncertainty, notably probabilistic and fuzzy set-based techniques, this book develops formal models of the above inference principle, which is fundamental to CBR. The case-based approximate reasoning methods thus obtained especially emphasize the heuristic nature of case-based inference and aspects of uncertainty in CBR. This way, the book contributes to a solid foundation of CBR which is grounded on formal concepts and techniques from the aforementioned fields. Besides, it establishes interesting relationships between CBR and approximate reasoning, which not only cast new light on existing methods but also enhance the development of novel approaches and hybrid systems.
Career paths in oral health
This book will serve as an essential reference guide for anyone considering a career in oral health. It will be ideal for readers seeking an introductory portrait of the different career paths in oral health, such as students. It will also be a useful source for those wishing to re-examine the field.
Cannabinoids
The present book is an outstanding summary of many aspects of cannabinoid research. It represents a stepping-stone to many unsolved problems in biochemistry, pharmacology, physiology and the clinic. Perhaps it will help generate novel ideas, such as how to approach the scientific study of emotions.
Calvinisms First Battleground : Conflict and Reform in the Pays de Vaud, 1528-1559
A specifically Calvinist identity and theology emerged out of two key conflicts in the region: first, the fight to turn away from Catholic practices and traditions a population that had been forced to convert to Protestantism by the Bernese after their conquest of Vaud in 1536; second, the struggle against the Zwinglian political and theological ideas that dominated the Swiss Confederation and differed from the Calvinists' understanding of ecclesiastical discipline, the Eucharist, and predestination. The Pays de Vaud was central to this struggle, for it was subject politically to Zwinglian, German-speaking Bern, but many of its ministers were more strongly influenced by Calvin. Calvin himself was initially excited about the prospects for reform in the region, but frustrations with the Swiss led him and the Genevans increasingly to focus their efforts on France.
Calibrating the Cosmos : How Cosmology Explains Our Big Bang Universe
Calibrating the Cosmos describes hard science, but is gently written. It explains in clear, non-mathematical language the measurements and the interpretation of the resulting data that have led to the current understanding of the origin, evolution and properties of our expanding Big Bang universe. Many people have a sketchy idea of the work of cosmologists, but Professor Levin’s experience in teaching both scientific and liberal arts students has enabled him to impart much of our current thinking without resorting to difficult mathematics. Theoretical concepts are emphasized, in particular the symmetries of homogeneity and isotropy enjoyed by our universe on the largest scales, how these symmetries lead to only one quantity being needed to describe the growth of the universe from its infancy to the present time, and how the so-called parameters of the universe are the ingredients used to construct the model universes to which ours – the real thing – is compared.
Calculus of one variable
Aimed at first-year undergraduates in mathematics and the physical sciences, the only prerequisites are basic algebra, coordinate geometry and the beginnings of differentiation as covered in school. The transition from school to university mathematics is addressed by means of a systematic development of important classes of techniques, and through careful discussion of the basic definitions and some of the theorems of calculus, with proofs where appropriate, but stopping short of the rigour involved in Real Analysis.The influence of technology on the learning and teaching of mathematics is recognised through the use of the computer algebra and graphical package MAPLE to illustrate many of the ideas.
CADD and informatics in drug discovery
Updates knowledge on recent advances in computational and bioinformatics tools/techniques and their practical applications in modern drug design and discovery programme. Also it encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas / presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, RandD personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, De-novo drug design, Pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and system biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to different stakeholders working in the pharmaceutical and biotechnology industries (RandD), the academic as well as research sectors. .
By its cover : Modern American book cover design
i JUDGING THE BOOK Books are a thing of beauty,but so are horse-drawn carriages. 1 DICK BRASS Vice President of Technology Development, Microsoft Is the printed book destined for eventual extinction? Is the thoughtfully designed book cover approaching obsolescence? The availability of ebooks has indeed increased, and print-on-demand technology will likely change the way books are marketed and purchased. But there is something special about the mass-produced book as an object– it is more than just a presentation of the ideas of an author.
Business process management Workshops ; Vol. 4103 : BPM 2006 International Workshops, BPD, BPI, ENEI, GPWW, DPM, semantics4ws, Vienna, Austria, September 4-7, 2006, Proceedings
BPM 2006 was the fourth in a conference series that provides a forum for - searchers and practitioners in all areas of business process management. In c- junction with BPM 2006, a series of workshops were held. They were meant to facilitate the exchange of ideas and experiences between active researchers, and to stimulate discussions on new and emerging topics in line with the conference topics. We see the workshops as a necessary extension to the main conference. BPM has established itself rapidly as a high quality conference with a highly competitive selection process.
Business process management : Concepts, languages, architectures
Business process management is usually treated from two different perspectives: business administration and computer science. While business administration professionals tend to consider information technology as a subordinate aspect for experts to handle, by contrast computer scientists often consider business goals and organizational regulations as terms that do not deserve much thought but require the appropriate level of abstraction.This textbook is ideally suited for classes on business process management, information systems architecture, and workflow management. It is also valuable for project managers and IT professionals working in business process management.
Buildings : Theory and Applications
This book treats Jacques Tits's beautiful theory of buildings, making that theory accessible to readers with minimal background. It includes all the material of the earlier book Buildings by the second-named author, published by Springer-Verlag in 1989, which gave an introduction to buildings from the classical (simplicial) point of view. This new book also includes two other approaches to buildings, which nicely complement the simplicial approach: On the one hand, buildings may be viewed as abstract sets of chambers with a Weyl-group-valued distance function; this point of view has become increasingly important in the theory and applications of buildings. On the other hand, buildings may be viewed as metric spaces. Beginners can still use parts of the new book as a friendly introduction to buildings, but the book also contains valuable material for the active researcher.
Building Theories : Architecture as the Art of Building
Discusses the content of treatises, essays, articles, and letters by those who have been, throughout history, committed to the art of building. In this, Building Theories argues for the return of a practice of architectural theory that is set amongst building, buildings, and builders. This journey of close reading reinterprets the words of Vitruvius, Alberti, de L’Orme, Le Camus de Mézières, Boullée, Laugier, Rondelet, Semper, Viollet-le-Duc, Hübsch, Bötticher, Berlage, Muthesius, Wagner, Behrendt, Gropius, and Arup. With chapters dedicated to texts from antiquity, the Renaissance, and the nineteenth century, and with a critical eye on architectural theory popularized in the Anglo-Saxon world post-1968, readers are introduced to a wider, more inclusive definition of architectural ideas.
Building Systems for Interior Designers ; 3rd ed.
The ultimate interior designer's guide to building systems and safety Building Systems for Interior Designers, Third Edition is the single-source technical reference that every designer needs, and an ideal solution for NCIDQ exam preparation. Addresses the special concerns of the interior designer within the context of the entire design team. New coverage includes the latest information on sustainable design and energy conservation, expanded coverage of security and building control systems, and a new and expanded art program with over 250 new illustrations. Covering systems from HVAC to water to waste to lighting, this book explains technical building systems and engineering issues in a clear and accessible way to help interior designers communicate more effectively with architects, engineers, and contractors.
Building construction : From principle to detail ; Vol.1 : Fundamentals
Construction is the means by which designing architects and engineers transform a design idea into built reality. It is from this perspective that the subject of 'building construction design' is dealt with by the architect José Luis Moro in three comprehensive volumes. Each is dedicated to the methodological, physical and functional fundamentals, the conception of a constructional solution, and finally its implementation in the constructional detail. Not only do the three volumes provide extensive content; they also ensure the greatest possible clarity in the text and graphics, in order to make it easier for learners to access the material. Importantly, they focus not only on conveying technical and scientific information, but also on demonstrating the complex relationships and interactions between design, material and construction.
Buddhism and comparative constitutional law
The first comprehensive account of the entanglements of Buddhism and constitutional law,The authors also highlight the important ways in which Buddhist actors have (re)conceived Western liberal ideals such as constitutionalism, rule of law, and secularism.
Buchi neri nel mio bagno di schiuma : L’enigma di Einstein = Black holes in my bubble bath : Einstein's riddle
Einstein's Enigma, or black holes in my foam bath, tells the story of the theory of gravitation, from its beginnings to the latest developments in astrophysics, focusing on Albert Einstein's theory of general relativity and the physics of black holes. Through engaging conversations and diagrams scribbled on paper napkins, the rudiments of relativity, space-time and many aspects of modern physics follow one another. In skits narrated with pedagogical skill and remarkable literary talent, the reader will come across the informal lessons that a cosmopolitan astrophysicist gives to his friend Alfie, a free lance organizer of research projects. Join in the intellectual fun and get excited with sparkling ideas, while with your imagination you enjoy a relaxing soak in this magical tub!
Browning Agents and Active Particles : Collective Dynamics in the Natural and Social Sciences
Lays out a vision for a coherent framework for understanding complex systems'' (from the foreword by J. Doyne Farmer). By developing the genuine idea of Brownian agents, the author combines concepts from informatics, such as multiagent systems, with approaches of statistical many-particle physics. This way, an efficient method for computer simulations of complex systems is developed which is also accessible to analytical investigations and quantitative predictions. The book demonstrates that Brownian agent models can be successfully applied in many different contexts, ranging from physicochemical pattern formation, to active motion and swarming in biological systems, to self-assembling of networks, evolutionary optimization, urban growth, economic agglomeration and even social systems.
