الصفحة 27
الصفحة 27
Geomagnetics for aeronautical safety : A case study in and around the Balkans
Flying safely in aircraft implies the use of navigation instruments. Among them, the magnetic compass is still a first choice for orientation and it is compulsory in all aircraft. In our increasingly sophisticated but fragile world of global navigation systems and gyroscopic sensors, the compass is especially useful as a back-up: it is highly reliable and likely to survive in harsh electromagnetic aggressions or when all power supplies fail. This book examines in detail how the science of geomagnetism is able to promote correct use of the magnetic compass for navigation. A selected group of specialists met in Ohrid, Macedonia to expose their approaches to the question. Using techniques from Geology, Instrument science, Magnetism, Chaos theory and Potential Fields applied to the Balkan region and surroundings, they put together a roadmap to fully tackle the issue of measurement, analysis, mapping and forecasting the magnetic declination in support of aeronautical safety.
Gentamicin : Biosynthesis, medicinal applications and potential side effects
Discusses the biosynthesis, medicinal applications and potential side effects of Gentamicin. Topics include Gentamicin used in combination therapy and applied to medicinal materials for clinical applications; use of natural products to enhance the antibiotic activity of Gentamicin and other aminoglycosides; regiospecific Gentamicin functionalization; Gentamicin and particle engineering; and the indications and adverse effects of Gentamicin.
Genetic surgery : from genes to solutions
As a tool for modifying the genome, gene editing technologies has developed rapidly in recent years, the application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability...
Genetic Engineering of Mesenchymal Stem Cells
MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.
Generalized Curvatures
The central object of this book is the measure of geometric quantities describing N a subset of the Euclidean space (E ,), endowed with its standard scalar product. Let us state precisely what we mean by a geometric quantity. Consider a subset N S of points of the N-dimensional Euclidean space E , endowed with its standard N scalar product. LetG be the group of rigid motions of E . We say that a 0 quantity Q(S) associated toS is geometric with respect toG if the corresponding 0 quantity Q[g(S)] associated to g(S) equals Q(S), for all g?G . For instance, the 0 diameter ofS and the area of the convex hull ofS are quantities geometric with respect toG . But the distance from the origin O to the closest point ofS is not, 0 since it is not invariant under translations ofS. It is important to point out that the property of being geometric depends on the chosen group. For instance, ifG is the 1 N group of projective transformations of E , then the property ofS being a circle is geometric forG but not forG , while the property of being a conic or a straight 0 1 line is geometric for bothG andG . This point of view may be generalized to any 0 1 subsetS of any vector space E endowed with a groupG acting on it.
General ultrasound in the critically ill
General ultrasound in the critically ill describes a bedside tool destined for use by the intensivist and any physician involved in emergencies. It specifically deals with findings of immediate clinical relevance throughout the body. New emergency applications of ultrasound in the abdomen, the vessels, the head and the heart are considered. The major topic, the lung, is extensively discussed. Interventional ultrasound forms part of nearly every chapter. Flow charts simplify daily concerns: acute dyspnea, shock, unexplained fever, etc. The strong points and pitfalls of ultrasound are reviewed. Technical notes are mingled with general considerations. Benefiting from the extensive experience of an intensivist intimately familiar with ultrasound, this book accurately answers most daily problems arising in the critically ill. it offers not only an exhaustive atlas but also a permanent aid to the therapeutic decision. All in all, General ultrasound in the critically ill provides a key for practicing a kind of visual medicine. Since 1990 Daniel Lichtenstein has been an intensivist in a medical ICU which already occupied a pioneering place in echocardiography. He has from the beginning devoted his efforts to the development of general ultrasound. He regularly publishes studies on lung ultrasound, his main topic, in the international literature.
General Principles of Tumor Immunotherapy : Basic and Clinical Applications of Tumor Immunology
Brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.
General Medicine and Surgery for Dental Practitioners
Aimed at the practising clinician provides a welcome detailed overview of the medical and surgical conditions that affect patients seen in everyday dental practice.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene delivery systems development and applications
Covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.
Gastrointestinal Cancer
Gastrointestinal cancer includes cancer of the digestive system - the esophagus, colon, rectum, anus, liver, pancreas, and other digestive organs. Taken as a whole, there are an estimated 250,600 new cases in the US. Colon and rectum cancer is the third leading cause of cancer and cancer deaths in the US. Gastrointestinal Cancer is the third volume in the M.D. Anderson Cancer Care series, featuring the current standard approach to GI cancer care from the experts at M.D. Anderson Cancer Center. Designed for the practicing oncologist, this clinical guidebook allows for quick, authoritative access to the latest and best multimodality therapies. Topics covered in this volume include AJCC staging of gastrointestinal malignancies, recent advances in histopathology of gastroinestinal cancers, imaging techniques and endoscopy in the management of GI malignancies, colorectal cancer, liver cancer, gastric cancer, esophageal cancer, anal cancer, and palliative therapy. Each of the 20 chapters ends with an up-to-date list of suggested readings, as well as "key practice points" highlighting the most principles and practices of each chapter for at-a-glance reference. More than 80 illustrations complement the text. This thorough, practical volume is the essential clinical guide for the oncologists, surgeons, and all physicians involved in the care of patients with GI cancer.
Gastroesophageal reflux disease : Principles of disease, diagnosis, and treatment
Gastroesophageal reflux disease (GERD) is one of the most common disorders with an increasing prevalence and incidence in the last two decades. This book presents clinically relevant information for gastroenterologists, internists, surgeons, residents and also nurses, who frequently care for GERD patients.
Gastroesophagal reflux disease (GERD)
Gastroesophageal reflux disease (GERD) is a common disease with a high prevalence worldwide and a great socioeconomic burden. GERD is a multifactorial disease in which anatomical and functional factors both play a pathogenetic role. The disease can manifest in various symptoms which can be grouped into typical, atypical and extra-esophageal symptoms. The pathophysiology of GERD is complex and not completely understood. An abnormal LES pressure and increased reflux during transient LES relaxations are believed to be key etiologic factors. Prolonged exposure of the esophagus to acid is another. Heartburn and acid regurgitation are the most common symptoms of GERD, although pathologic reflux can result in a wide variety of clinical presentations.
Gases and Toxins that Cause Pulmonary Edema
Pulmonary edema is a major health problem in the lung, it is a cardinal feature of congestive heart failure. Pulmonary edema defined as excessive extravascular water in the lungs, is a common and serious clinical problem. Pulmonary edema can be life-threatening, but effective therapy is available to rescue patients from the deleterious consequences of disturbed lung fluid balance, which usually can be identified and, in many instances, corrected. So we like to talk about this common disease because of its importance and its wide spread around the world. Other important causes of pulmonary edema are human exposure to some gases and toxins, the most important of which is chlorine gas, phosgene, mustard gas, heroin, paraquat and ammonia. This research paper will discuss also the procedures that are included, as well as a wider knowledge of these toxins and gases.
Gas Transport in Porous Media
This book presents a compilation of state-of-the art studies on gas and vapor transport processes in porous and fractured media. A broad set of models and processes is presented, including advection/diffusion, the Dusty Gas Model, enhanced vapor diffusion, phase change, coupled processes, solid/vapor sorption, and vapor-pressure lowering. Numerous applications are also presented that illustrate these processes and models in current problems facing the scientific community.
Fuzzy and Rough Techniques in Medical Diagnosis and Medication
This volume provides readers with selected fuzzy and rough tools used to medical tasks, especially diagnosing and medication. To build a link between theoretical, mathematical excerpts and practical medical applications, the contents is formed as a sequence of occurrences in which a patient appears to be diagnosed and cured. The fuzzy and rough elements are inserted in the book in the order required by the presentation of medical substance to maintain the logical unity of the book’s essence. In conformity with this pattern the essay presents in turn some necessary elements of fuzzy set theory, the classical fuzzy diagnostic model with extensions, the fuzzy diagnostic model with clinical examinations extended throughout time based on distance theory, methods of drug effectiveness measurements and algorithms selecting the optimal medicine. As the complement, the solution of an approximation problem is suggested to find a curve that surrounds two-dimensional clock-like point sets with the little approximation error.
Future healthcare design
Describes how architects can design better healthcare buildings for a rapidly changing context and climate. Innovation in the design of healthcare estates is essential to the sustainability of our health services. Design thinking in this field is being influenced by a range of factors, such as economic constraints, an ageing demographic, complex health conditions (co-morbidities), and climate change.
Fundamentals of x-ray imaging : Basic principles, quality control, clinical applications, and safety
Covers all X-ray modalities, including CT, mammography, fluoroscopy, dental radiography, and fusion imaging like PET-CT and SPECT-CT. It simplifies complex concepts for beginners while offering depth for advanced learners. Each chapter is engaging and addresses common questions from students and professionals.
Fundamentals of risk management : Understanding, evaluating and implementing effective enterprise risk management
This book covers the key principles of risk management and how to deal with the different types of risk organizations face. The frameworks of business continuity planning, enterprise risk management, and project risk management are covered alongside an overview of international risk management standards and frameworks, strategy and policy.
Fundamentals of operative dentistry : A contemporary approach
Updated with full-color illustrations throughout and substantial revisions in every chapter to incorporate the latest scientific developments and current research findings. In addition, new chapters on color study and shade matching address new areas of focus in the preclinical curriculum. A valuable resource for understanding the scientific basis for current treatment options in dentistry.
