الصفحة 26
الصفحة 26
Cannabinoids
The present book is an outstanding summary of many aspects of cannabinoid research. It represents a stepping-stone to many unsolved problems in biochemistry, pharmacology, physiology and the clinic. Perhaps it will help generate novel ideas, such as how to approach the scientific study of emotions.
Cancerimmunotherapies : Solid tumors and hematologic malignancies
Presents the clinical scope of cancer immunotherapeutic agents for solid tumors and Hematologic malignancies, elaborates on the scientific details of their modes of action, and presents the impact of these agents on oncology, patients and the broader healthcare system. At present, cancer immunotherapies fall broadly into three categories: immune checkpoint inhibitors (ICIs), adoptive T cell therapies, and cancer vaccines which have distinct mechanisms of action. Immune checkpoint inhibitors rely upon disrupting tumor antigen recognition as self by the immune system through inhibition of checkpoint molecules. Adoptive T cell therapies involve the engineering of T cells ex vivo to target and destroy tumor cells. The first part of this book will provide an overview of the discovery and mechanistic details of the technology. The second part will be devoted to elaborating on the clinical outcomes, successes and limitations for specific tumor subtypes, which includes both solid tumors and hematologic malignances for both pediatric and adult populations.
Cancer immunotherapy : Methods and protocols
Details multiple areas of new and emerging methods to develop the next generation of immunotherapy treatments. Chapters guide readers through analysis and characterisation of the interactions between tumour and immune cells, and cell engineering tools for cancer treatment, to provide a unique and compelling set of techniques instrumental to work with, and engineer, immune cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cancer immunotherapy
Defining Cancer as a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body, making it an enormous medical and economic burden accounting for 9.6 million deaths in 2018. Cancer treatments were being introduced for a long time. The development of specific therapies to treat cancer really depends on the continued discovery of the molecular changes that lead to the malignant progression of human cancers. More and more drugs are being developed to block cancer pathways that lead to impaired growth and survival of cancer cells. In this dissertation, the concept of cellular and immunotherapy of cancer will be discussed briefly, taking into considerations the mechanisms of action, the advantages, challenges and drawbacks of the different types of monoclonal antibodies and CAR T-Cell therapy.
Cancer cell biology : methods and protocols
Provides detailed methods on the mechanisms of underlying cancer cell biology. Chapters guide readers through techniques for culturing cancer cell lines, xenografts, cryopreservation of tumor cells, analyzing the co-culture of breast cancer cells, protein secretion by ELISA, flow cytometry-based, multi-parametric immunofluorescence analysis, protein expression by western blot, analysis of surface protein levels, protein recycling by biotinylation assay, and proteomics analysis by liquid chromatography-mass spectrometry.
Cancer and War
Armed conflict, especially the most intense types, indirectly impacts civilian mortality. The estimates suggest that almost 30 million civilian deaths were indirectly attributable to armed conflict globally between 1990 and 2017, two thirds of which were due to communicable, maternal, neonatal, and nutritional diseases. Broader and more robust measures of civilian impacts at subnational and national levels are needed to inform policy and advocacy to prevent war and protect civilians. This could include greater use of linkage studies that incorporate data from routine health and demographic sources, exposure to conflict-specific environmental risks, and quantitative epidemiological methods such as national and subnational victimisation surveys.
Cancer : Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related.
Calvinisms First Battleground : Conflict and Reform in the Pays de Vaud, 1528-1559
A specifically Calvinist identity and theology emerged out of two key conflicts in the region: first, the fight to turn away from Catholic practices and traditions a population that had been forced to convert to Protestantism by the Bernese after their conquest of Vaud in 1536; second, the struggle against the Zwinglian political and theological ideas that dominated the Swiss Confederation and differed from the Calvinists' understanding of ecclesiastical discipline, the Eucharist, and predestination. The Pays de Vaud was central to this struggle, for it was subject politically to Zwinglian, German-speaking Bern, but many of its ministers were more strongly influenced by Calvin. Calvin himself was initially excited about the prospects for reform in the region, but frustrations with the Swiss led him and the Genevans increasingly to focus their efforts on France.
Bulk Metallic Glasses : An Overview
Bulk Metallic Glasses explores an emerging field of materials known as bulk metallic glasses. It summarizes the rapid development of these materials over the last decade and includes documentation on diverse applications of bulk metallic glasses; from structural applications to microcomponents. Some of the applications covered are pressure sensors, microgears for motors, magnetic cores for power supplies, and nano-dies for replacing next generation DVDs. The chapters cover current theories and recent research including an atomistic theory of local topological fluctuations, atomistic simulations, and unique microstructures of these amorphous materials. Other topics include glass formation, glass forming ability, and the underlying mechanisms and physical insights of these criteria. The mechanical deformation of bulk metallic glasses, fatigue, fracture, and corrosion behaviors of these materials are also reviewed.
Broadband Opto-Electrical Receivers in Standard CMOS
Broadband Opto-Electrical Receivers in Standard CMOS starts from the basic fundamentals, necessary for the design of opto-electronic interface circuits. The book continues with an in-depth analysis of the photodiode, transimpedance amplifier (TIA) and limiting amplifier (LA). To thoroughly understand the light detection mechanisms in silicon, first a one-dimensional and second a two-dimensional model is developed. Analytical design equations are derived to guide the design of the amplifying circuits. For the TIA, the focus lies on the sensitivity-speed trade-off. For the LA, a high gain-bandwidth is pursued. Several practical design examples reveal the subtleties and challenges encountered during the design of high-performance analog circuits.
Bridging divides : Maritime canals as invasion corridors
Maritime canals dissolve natural barriers to the dispersal of marine organisms, thus providing novel opportunities for natural dispersal, as well as for shipping-mediated transport. The introduction of alien species has proved to be one of the most profound and damaging of anthropogenic deeds - with both ecological and economic costs. This book is the first to assess the impacts of the world’s three principal maritime canals – the Kiel, the Panama, the Suez – as invasion corridors for alien biota. These three canals differ in their hydrological regimes, the types of biotas they connect, and in their permeability to invasions.
Breath odors : Origin, diagnosis, and management
Presents a comprehensive and cohesive science-based approach to bad breath, combining basic research with clinical approaches to diagnosis and treatment. All aspects of the subject are examined thoroughly and critically, including the psychological impact of breath odor and future prospects.
Breast cancer genetics, immunology, and immunotherapy : An interdisciplinary approach
Publishes comprehensive volumes on immune and genetic mechanisms of breast cancer diagnosis and prognosis. The role of molecular genetics, interleukins, chemokine receptor, and tumor-infiltrated lymphocytes-TILS in breast cancer are explained. Targeting myeloid determinants, SiRNA loaded in drug delivery nanosystems, nucleic acid and drug dual agent nanoplatforms, and oncolytic virotherapy are also discussed in the treatment of breast cancer, particularly in multidrug resistant and metastatic breast cancer.
Breast cancer chemosensitivity
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
Branching Morphogenesis
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Brain, vision, and artificial intelligence ; 1st International Symposium, BVAI 2005, Naples, Italy, October 19-21, 2005, Proceedings
This book constitutes the refereed proceedings of the First International Symposium on Brain, Vision and Artificial Intelligence, BVAI 2005, held in Naples, Italy in October 2005. The 48 revised papers presented together with 6 invited lectures were carefully reviewed and selected from more than 80 submissions for inclusion in the book. The papers are addressed to the following main topics and sub-topics: brain basics - neuroanatomy and physiology, development, plasticity and learning, synaptic, neuronic and neural network modelling; natural vision - visual neurosciences, mechanisms and model systems, visual perception, visual cognition; artificial vision - shape perception, shape analysis and recognition, shape understanding; artificial inteligence - hybrid intelligent systems, agents, and cognitive models.
Brain tumor pathology : Current diagnostic hotspots and pitfalls
Since Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
Brain Repair
Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics.
Brain development in Drosophila melanogaster
The central nervous system (CNS) represents the organ with the highest structural and functional complexity. Accordingly, uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one of the major challenges in developmental biology. The developing CNS of the fruitfly Drosophila melanogaster is an ideal model system to study these processes. Several principle questions regarding neurogenesis (like stem cell formation, cell fate specification, axonal pathfinding) have been addressed in Drosophila by focusing on the relatively simply structured truncal parts of the nervous system. This book provides an overview of some major facets of recent research on Drosophila brain development.
Brain and Heart Dynamics
Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling.
