الصفحة 245
الصفحة 245
EQ-5D concepts and methods : a developmental history
The EuroQol Group is an international, cross-disciplinary group set up in 1987 to investigate issues related to the valuation of health. This book presents a series of papers from the early 1990s that illustrate the aspects of the development of EQ-5D including: the descriptive system, self-rated health, valuation issues, and semantic issues. Read less
Epiphyseal Growth Plate Fractures
This comprehensive reference work covers all aspects of growth plate fractures and their complications. Following general reviews of growth plate fractures, 21 chapters deal with each epiphyseal growth plate in the body. All of these chapters are constructed similarly for easy and quick retrieval of the required information. The main emphasis is on evaluation (diagnosis) and management (treatment). A separate section is devoted to premature partial physeal arrest, as this is by far the most common and feared complication of a growth plate fracture and its treatment is involved and controversial. The case studies included are often based on 20- to 30-year follow-ups, revealing cases that originally appeared to be quite satisfactory at the conclusion of growth but were found to have turned out quite poorly years later.
Epilepsy and Intellectual Disabilities
Epilepsy and Intellectual Disabilities brings together findings from research and clinical practice, with comprehensive coverage of the important aspects of epilepsy in persons with intellectual disabilities.
Epilepsy
Epilepsy has remained a significant social concern and financial burden globally. It is the most common neurological disease of the brain. Around 1% of the people worldwide have epilepsy and this disease affects people of all ages, Although the different types of epilepsy vary greatly, medication appropriate can control seizures in about 70% of patients, Medications are mainstays in controlling epileptic seizures, Partial seizures, which are the most common seizure type in adults, can be effectively controlled by virtually all the standard and newer antiepileptic drugs (AEDs). For the generalized epilepsies, valproate remains the drug of choice.
Epigenome editing : Methods and protocols
This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Epigenetics in oncology
Covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Epidemiology of Drug Abuse
As the drug abuse epidemic evolves, so do the tools needed to understand and treat it. Accordingly, Epidemiology of Drug Abuse takes the long view, cogently outlining what the book calls "the natural history of drug abuse" and redefining its complex phenomena to reflect our present-day knowledge. Twenty-six eminent contributors discuss the state and future of the field, balancing the practical concerns involved in gathering drug abuse data with the ethics of using the information.
Enzymes and drugs
Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.
Enzyme-Catalyzed Synthesis of Polymers
New polymers have been developed and "old" polymers have been generated using novel synthetic strategies. This book contains seven chapters that cover in great deatail the use of enzymes to synthesize a range of polymers. It also makes use of a large number of examples to summarize the salient features of the enzymatic reactions and resulting polymeric properties.
Enzyme-Based Organic Synthesis
In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice.
Enzyme Biocatalysis : Principles and Applications
This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds.
Environments for Multi-Agent Systems III ; 3rd International Workshop, E4MAS 2006, Hakodate, Japan, May 8, 2006, Selected Revised and Invited Papers
This book are organized in topical sections on models, architecture, and design, mediated interaction and stigmery, governing environment, and applications.
Environments for Multi-Agent Systems II ; 2nd International Workshop, E4MAS 2005, Utrecht, The Netherlands, July 25, 2005, Selected Revised and Invited Papers
This book constitutes the thoroughly refereed post-proceedings of the Second International Workshop on Environments for Multiagent Systems, E4MAS 2005, held in July 2005. The 16 revised papers presented were carefully reviewed and selected from the lectures given at the workshop.
Environments for Multi-Agent Systems ; 1st International Workshop, E4MAS, 2004, New York, NY, July 19, 2004, Revised Selected Papers
The modern ?eld of multiagent systems has developed from two main lines of earlier research. Its practitioners generally regard it as a form of arti?cial intelligence (AI). Some of its earliest work was reported in a series of workshops in the US dating from1980,revealinglyentitled,“DistributedArti?cialIntelligence,”andpioneers often quoted a statement attributed to Nils Nilsson that “all AI is distributed. ” The locus of classical AI was what happens in the head of a single agent, and much MAS research re?ects this heritage with its emphasis on detailed modeling of the mental state and processes of individual agents. From this perspective, intelligenceisultimatelythepurviewofasinglemind,thoughitcanbeampli?ed by appropriate interactions with other minds. These interactions are typically mediated by structured protocols of various sorts, modeled on human conver- tional behavior. But the modern ?eld of MAS was not born of a single parent. A few - searchershavepersistentlyadvocatedideasfromthe?eldofarti?ciallife(ALife). These scientists were impressed by the complex adaptive behaviors of commu- ties of animals (often extremely simple animals, such as insects or even micro- ganisms). The computational models on which they drew were often created by biologists who used them not to solve practical engineering problems but to test their hypotheses about the mechanisms used by natural systems. In the ar- ?cial life model, intelligence need not reside in a single agent, but emerges at the level of the community from the nonlinear interactions among agents. - cause the individual agents are often subcognitive, their interactions cannot be modeled by protocols that presume linguistic competence.
Environmentally-Friendly Product Development: Methods and Tools
Presents a survey of eco-friendly product design. This work is aimed at researchers and academics in design engineering and practitioners and managers in the industry
Environmentally Friendly Coastal Protection ; Proceedings of the NATO Advanced Research Workshop on Environmentally Friendly Coastal Protection Structures, Varna, Bulgaria, 25-27 May 2004
Coast lines have been and are the central lines of civilization around the world with increasing pressure from both sides - the hinterland and the sea. This book features papers covering related aspects of Environmentally Friendly Coastal Structures - coast, engineering structures, water, sediments, ecosystems in their complicated interaction
Environmental Value Transfer : Issues and Methods
The transfer of environmental values in time and space has increased rapidly with the widespread use of cost benefit analysis in project evaluation and regulatory assessments over the last three decades. The purpose of this volume is to take a snapshot of the research that is ongoing in the area of value transfer (benefit transfer). It includes papers by some of the most influential authors in the area, and covers the latest developments in the field. It will be useful for academics conducting research in this area and for practitioners in government agencies and ministries, as well as consulting firms.
Environmental valuation with discrete choice experiments : Guidance on design, implementation and data analysis
This book offers up-to-date advice and practical guidance on how to undertake a discrete choice experiment as a tool for environmental valuation. It discusses crucial issues in designing, implementing and analysing choice experiments. Compiled by leading experts in the field, the book promotes discrete choice analysis in environmental valuation through a more solid scientific basis for research practice. Instead of providing strict guidelines, the book helps readers avoid common mistakes often found in applied work. It is based on the collective reflections of the scientific network of researchers using discrete choice modelling in the field of environmental valuation (www.envecho.com).
