الصفحة 24
الصفحة 24
Drug safety evaluation
Presents an all-inclusive practical guide for those who are responsible for developing new drugs and ensuring the safety of an ever-expanding spectrum of therapeutics. This book helps readers understand how the safety of these products are evaluated for use. Extensively revised to reflect up-to-date information, this edition includes changes to the scope of products (vaccines, small synthetic, large protein moieties, cells and tissues), harmonized global and national regulatory requirements, the therapeutic development process, and available technologies to identify and evaluate the relevance of potential patient risks
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters.
Drug discovery and development
Presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.
Driving smart medical diagnosis through AI-powered technologies and applications
Driving Smart Medical Diagnosis Through AI-Powered Technologies and Applications serves as a solution in this era of transformative healthcare and addresses these challenges head-on. It unravels the complexities surrounding the implementation of AI in healthcare, offering in-depth discussions on the latest breakthroughs. From unraveling the mysteries of AI-driven cataract detection to exploring the implications of decentralized mammography classification, the book is a valuable resource that equips scholars with the knowledge to navigate this innovative landscape.
Driving digital transformation through data and AI : A practical guide to delivering data science and machine learning products
Explains how to build the organizational capability to deliver Data and AI products and drive immediate business results as new digital technologies significantly disrupt business Provides best practices, tools and templates for managing the organizational and technological change process to become an AI-driven enterprise Includes a variety of international case studies across several industries such as insurance, fashion, consumer goods, finance, technology and automotive Outlines how to develop a product strategy, build teams and design the platform and architecture Provides key principles for sharing knowledge, educating staff on data and AI, and effectively engaging top executives
Drawn to Design : Analyzing Architecture Through Freehand Drawing
A guide for students and teachers to understand the need for, the role of and the methods and techniques of freehand analytical sketching in architecture. The presentation focuses on drawing as an approach to and phase of architectural design. The conceptual goal of this approach is to use drawing not as illustration or depiction, but as exploration. The first part of the book discusses underlying concepts of freehand sketching in design education and practice as a complement to digital technologies. The main component is a series of chapters that constitute a typology of fundamental issues in architecture and urban design; for instance, issues of "façade" are illustrated with sketch diagrams that show how façades can be explored and sketched through a series of specific questions and step-by-step procedures.
Drawn to Design : Analyzing Architecture Through Freehand Drawing
A guide for students and teachers to understand the need for, the role of and the methods and techniques of freehand analytical sketching in architecture. The presentation focuses on drawing as an approach to and phase of architectural design. The conceptual goal of this approach is to use drawing not as illustration or depiction, but exploration. The first part of the book discusses underlying concepts of freehand sketching in design education and practice as a compliment to digital technologies. The main component is a series of chapters that constitute a typology of fundamental issues in architecture and urban design; for instance, issues of "facade" are illustrated with sketch diagrams that show how facades can be explored and sketched through a series of specific questions and step-by-step procedures.
Domain Decomposition Methods in Science and Engineering XVII
This volume contains a selection of papers presented at the 17th International Conference on Domain Decomposition Methods in Science and Engineering held at St. Wolfgang / Strobl, Austria, July 3 - 7, 2006. Domain decomposition is an active, interdisciplinary research area concerned with the development, analysis, and implementation of coupling and decoupling strategies in mathematical and computational models. Domain decomposition techniques provide efficient tools for treating problems in all Computational Sciences. The reader will become familiar with the newest domain decomposition technologies and their use for modeling and simulating of complex problems from different fields of applications.
DOM Scripting : Web Design with JavaScript and the Document Object Model
There are three main technologies married together to create usable, standards-compliant web designs: XHTML for data structure, Cascading Style Sheets for styling your data, and JavaScript for adding dynamic effects and manipulating structure on the fly using the Document Object Model. This book is about the latter of the three. DOM Scripting: Web Design with JavaScript and the Document Object Model gives you everything you need to start using JavaScript and the Document Object Model to enhance your web pages with client-side dynamic effects. Jeremy Keith starts off by giving you a basic crash course in JavaScript and the DOM, then moves on to provide you with several real-world examples built up from scratch, including dynamic image galleries and dynamic menus. Then, he shows you how to manipulate web page style using the CSS DOM, and create markup on the fly.
Do Smart Adaptive Systems Exist? : Best Practice for Selection and Combination of Intelligent Methods
This book is intended as a reference and a guide summarising and focusing on best practices when using intelligent techniques and building systems requiring a degree of adaptation and intelligence. Another attractive feature of the book is that it brings together experts from neural network, fuzzy, machine learning, evolutionary and hybrid systems communities who will provide their views on how these different intelligent technologies have contributed and will contribute to creation of smart adaptive systems of the future.
DNA manipulation and analysis
Details technologies on recombinant DNA and nucleic acid manipulation that underpin much of the biological sciences and instructions on how to conduct them successfully. Chapters guide the reader through the basics of oligonucleotide synthesis and DNA sequencing; recombinant DNA plasmid work; cell-free experiments and the latest developments in CRISPR approaches to genome modification.
Distributed embedded systems : Design, middleware and resources ; IFIP 20th World computer congress, TC10 Working conference on distributed and parallel embedded systems (DIPES 2008), September 7-10, 2008, Milano, Italy
The IFIP series publishes state-of-the-art results in the sciences and technologies of information and communication. The principal aim of the IFIP series is to encourage education and the dissemination and exchange of information about all aspects of computing.
Distributed Cooperative Laboratories : Networking, Instrumentation, and Measurements
This is a highly interdisciplinary topic, where various aspects converge: multimedia communications and networking, sensor networks, Grid technology, Quality of Service (QoS) provisioning and control, network management, measurement instrumentation and methodology, architecture of measurement systems. The material is organized into six parts: Technologies for Real-Time Interactive Multimedia Communications; Monitoring, Management and Configuration of Networks and Networking Devices; Data Acquisition and Aggregation in Sensor Networks; Grid Structures for Distributed Cooperative Laboratories; Architectures and Techniques for Tele-Measurements; Virtual Immersive Communications and Distance Learning. Each contribution presents a self-contained treatment, within a framework that provides the reader with an up-to-date picture of the most recent state-of-the-art developments.
Distributed computing and Internet Technology ; 1st International Conference, ICDCIT 2004, Bhubaneswar, India, December 22-24, 2004, Proceedings
Taming the Dynamics of Disributed Data - DISTRIBUTED COMPUTING -- Data in Your Space -- Enabling Technologies for Harnessing Information Explosion -- Fair Leader Election by Randomized Voting -- An Efficient Leader Election Algorithm for Mobile Ad Hoc Networks -- Distributed Balanced Tables: A New Approach - Performance Evaluation of Gigabit Ethernet and SCI in a Linux Cluster -- Performance Evaluation of a Modified-Cyclic-Banyan Based ATM / IP Switching Fabric -- A Scalable and Robust QoS Architecture for WiFi P2P Networks -- NEC: Node Energy Based Clustering Protocol for Wireless Sensor Networks with Guaranteed Connectivity,and other
Distributed applications and interoperable systems ; Vol. 3543 ; 5th IFIP WG 6.1 International conference, DAIS 2005, Athens, Greece, June 15-17, 2005, Proceedings
ThisvolumecontainstheproceedingsoftheIFIPWG6. 1InternationalWorking Conference on Distributed Applications and Interoperable Systems V held in Athens, Greece, on June 15–17, 2005. The conference program presented the state of the art in research concerning distributed and interoperable systems. The emergence of 4th-generation c- munication systems, the evolution of Internet technologies, the convergence of telecom and datacom, wireless and ?xed communication systems and appli- tions pave the path for ubiquitous service and application provision. Innovative solutions are required for the development, implementation and operation of distributed applications in complex IT environments full of diversity and h- erogeneity. Today, the emerging wide spectrum of distributed systems.
Distributed and parallel computing ; 6th International conference on algorithms and architectures for parallel processing, ICA3PP, Melbourne, Australia, October 2-3, 2005, Proceedings
There are many applications that require parallel and distributed processing to allow complicated engineering, business and research problems to be solved in a reasonable time. Parallel and distributed processing is able to improve company profit, lower costs of design, production, and deployment of new technologies, and create better business environments. The major lesson learned by car and aircraft engineers, drug manufacturers, genome researchers and other specialist is that a computer system is a very powerful tool that is able to help them solving even more complicated problems. That has led computing specialists to new computer system architecture and exploiting parallel computers, clusters of clusters, and distributed systems in the form of grids.
Dissemination of information in communication networks : Broadcasting, gossiping, leader election, and fault-tolerance
Preface Due to the development of hardware technologies (such as VLSI) in the early 1980s, the interest in parallel and distributive computing has been rapidly growingandinthelate1980sthestudyofparallelalgorithmsandarchitectures became one of the main topics in computer science. To bring the topic to educatorsandstudents,severalbooksonparallelcomputingwerewritten. The involvedtextbook“IntroductiontoParallelAlgorithmsandArchitectures”by F. Thomson Leighton in 1992 was one of the milestones in the development of parallel architectures and parallel algorithms. But in the last decade or so the main interest in parallel and distributive computing moved from the design of parallel algorithms and expensive parallel computers to the new distributive reality – the world of interconnected computers that cooperate (often asynchronously) in order to solve di?erent tasks.
Disrupting Finance : FinTech and Strategy in the 21st Century
This Pivot demonstrates how a variety of technologies act as innovation catalysts within the banking and financial services sector. Traditional banks and financial services are under increasing competition from global IT companies such as Google, Apple, Amazon and PayPal whilst facing pressure from investors to reduce costs, increase agility and improve customer retention. Technologies such as blockchain, cloud computing, mobile technologies, big data analytics and social media therefore have perhaps more potential in this industry and area of business than any other. This book defines a fintech ecosystem for the 21st century, providing a state-of-the art review of current literature, suggesting avenues for new research and offering perspectives from business, technology and industry.
Disrupted Development and the Future of Inequality in the Age of Automation
This book examines the future of inequality, work and wages in the age of automation with a focus on developing countries. The authors argue that the rise of a global ‘robot reserve army’ has profound effects on labor markets and economic development, but, rather than causing mass unemployment, new technologies are more likely to lead to stagnant wages and premature deindustrialization.
Digitization of the management accounting function : A case study analysis on manufacturing companies
Analyzes the impact of digitization on management accounting in five manufacturing companies. It is one of the first in-depth empirical studies on the intersection of management accounting and digitization. The study suggests that there are two archetypes of digitization of the management accounting function. The first archetype emphasizes top-down-driven changes that aim to enhance efficiency, such as conducting tasks with a higher degree of automation in a leaner structure with fewer resources. The second archetype is strongly driven and initiated by employees in the management accounting function (bottom-up). The focus is on improving the use of data by applying innovative analytics methods, integrating additional sources of data, and benefiting from new technologies like artificial intelligence. The results of the study also indicate that digitization of the management accounting function is mostly in line with the overall company strategy.
