الصفحة 24
الصفحة 24
Computational biology in drug discovery and repurposing
Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin
Computational Aspects of General Equilibrium Theory : Refutable Theories of Value
This monograph presents a general equilibrium methodology for microeconomic policy analysis. It is intended to serve as an alternative to the now classical, axiomatic general equilibrium theory as exposited in Debreu`s Theory of Value (1959) or Arrow and Hahn`s General Competitive Analysis (1971). The methodology proposed in this monograph does not presume the existence of market equilibrium, accepts the inherent indeterminancy of nonparametric general equlibrium models, and offers effective algorithms for computing counterfactual equilibria in these models. It consists of several essays written over the last decade, some with colleagues or former graduate students, and an appendix by Charles Steinhorn on the elements of O-minimal structures, the mathematical framework for our analysis.
Computable Models of the Law : Languages, Dialogues, Games, Ontologies
This book originate from a workshop held at the European University Institute of Florence, Italy, in December 2006. The workshop was devoted to the discussion of the different ways of understanding and explaining contemporary law, for the purpose of building computable models of it -- especially models enabling the development of computer applications for the legal domain.
COMPSTAT 2008 ; Proceedings in Computational Statistics
Presents methodological developments in Applied/Computational Statistics. This work covers a range of topics including Advances on Statistical Computing Environments, Methods for Classification and Clustering, Computation for Graphical Models and Bayes Nets, Computational Econometrics, and, Computational Statistics and Data Mining.
Comprehensive mathematics for computer scientists 2 : Calculus and ODEs, splines, probability, fourier and wavelet theory, fractals and neural networks, categories and lambda calculus
This second volume of a comprehensive tour through mathematical core subjects for computer scientists completes the first volume in two - gards: Part III first adds topology, di?erential, and integral calculus to the t- ics of sets, graphs, algebra, formal logic, machines, and linear geometry, of volume 1. With this spectrum of fundamentals in mathematical e- cation, young professionals should be able to successfully attack more involved subjects, which may be relevant to the computational sciences. In a second regard, the end of part III and part IV add a selection of more advanced topics. In view of the overwhelming variety of mathematical approaches in the computational sciences, any selection, even the most empirical, requires a methodological justi?cation. Our primary criterion has been the search for harmonization and optimization of thematic - versity and logical coherence. This is why we have, for instance, bundled such seemingly distant subjects as recursive constructions, ordinary d- ferential equations, and fractals under the unifying perspective of c- traction theory.
Component-Based Software Testing with UML
Component-based software development regards software construction in terms of conventional engineering disciplines where the assembly of systems from readily-available prefabricated parts is the norm. Because both component-based systems themselves and the stakeholders in component-based development projects are different from traditional software systems, component-based testing also needs to deviate from traditional software testing approaches. Gross first describes the specific challenges related to component-based testing like the lack of internal knowledge of a component or the usage of a component in diverse contexts. He argues that only built-in contract testing, a test organization for component-based applications founded on building test artifacts directly into components, can prevent catastrophic failures like the one that caused the now famous ARIANE 5 crash in 1996. This book is the first comprehensive treatment of the intricacies of testing component-based software systems. With its strong modeling background, it appeals to researchers and graduate students specializing in component-based software engineering. Professionals architecting and developing component-based systems will profit from the UML-based methodology and the implementation hints based on the XUnit and JUnit frameworks.
Component models and systems for grid applications ; Proceedings of the Workshop on Component Models and Systems for Grid Applications held June 26, 2004 in Saint Malo, France.
This first volume of the CoreGRID series addresses such vital issues as the architecture of the Grid, the way software will influence the development of the Grid, and the practical applications of Grid technologies for individuals and businesses alike. Part I of the book, Application-Oriented Designs, focuses on development methodology and how it may contribute to a more component-based use of the Grid. Middleware Architecture, the second part, examines portable Grid engines, hierarchical infrastructures, interoperability, as well as workflow modeling environments. The final part of the book, Communication Frameworks, looks at dynamic self-adaptation, collective operations, and higher-order components. With Component Models and Systems for Grid Applications, editors Vladimir Getov and Thilo Kielmann offer the computing professional and the computing researcher the most informative, up-to-date, and forward-looking thoughts on the fast-growing field of Grid studies.
Complexity and Artificial Markets
In recent years, agent-based simulation has become a widely accepted tool when dealing with complexity in economics and other social sciences. The contributions presented in this book apply agent-based methods to derive results from complex models related to market mechanisms, evolution, decision making, and information economics. In addition, the applicability of agent-based methods to complex problems in economics is discussed from a methodological perspective. The papers presented in this collection combine approaches from economics, finance, computer science, natural sciences, philosophy, and cognitive sciences.
Complex decision making : Theory and practice
The increasingly complex environment of today's world, characterized by technological innovation and global communication, generates myriads of possible and actual interactions while limited physical and intellectual resources severely impinge on decision makers, be it in the public or private domains. At the core of the decision-making process is the need for quality information that allows the decision maker to better assess the impact of decisions in terms of outcomes, nonlinear feedback processes and time delays on the performance of the complex system invoked.
Compiler construction ; Vol. 3923 : 15th International Conference, CC 2006, Held as Part of the Joint European Conferences on Theory and Practice of Software, ETAPS 2006, Vienna, Austria, March 30-31, 2006, Proceedings
ETAPS 2006 was the ninth instance of the European Joint Conferences on Theory and Practice of Software. ETAPS is an annual federated conference that was established in 1998 by combining a number of existing and new conferences. The events that comprise ETAPS address various aspects of the system devel- ment process, including speci?cation, design, implementation, analysis and impro- ment. The languages, methodologies and tools which support these activities are all well within its scope. Di?erent blends of theory and practice are represented, with an inclination towards theory with a practical motivation on the one hand and soundly based practice on the other.
Competence and Vulnerability in Biomedical Research
In this book, the author develops a novel justificatory framework for making judgments of decisional competence to consent to biomedical research with reference to five groups of cognitively vulnerable individuals - older children and adolescents, adults with intellectual disabilities, adults with depression, adults with schizophrenia and adults with dementia, including Alzheimer’s disease.
Compendium for Early Career Researchers in Mathematics Education
The book provides a state-of-the-art overview of important theories from mathematics education and the broad variety of empirical approaches currently widely used in mathematics education research.
Comparative risk assessment and environmental decision making
Decision making in environmental projects is typically a complex and confusing process characterized by trade-offs between socio-political, environmental, and economic impacts. Comparative Risk Assessment (CRA) is a methodology applied to facilitate decision making when various activities compete for limited resources. CRA has become an increasingly accepted research tool and has helped to characterize environmental profiles and priorities on the regional and national level. CRA may be considered as part of the more general but as yet quite academic field of multi-criteria decision analysis (MCDA). Considerable research in the area of MCDA has made available methods for applying scientific decision theoretical approaches to multi-criteria problems, but its applications, especially in environmental areas, are still limited. The papers show that the use of comparative risk assessment can provide the scientific basis for environmentally sound and cost-efficient policies, strategies, and solutions to our environmental challenges.
Comparative Evaluation of XML Information Retrieval Systems ; 5th International Workshop of the Initiative for the Evaluation of XML Retrieval, INEX 2006 Dagstuhl Castle, Germany, December 17-20, 2006 Revised and Selected Papers
This book covered methodology and seven additional tracks on ad-hoc, natural language processing, heterogeneous collection, multimedia, interactive, use case, as well as document mining.
Comparative Education Research : Approaches and Methods
Approaches and methods in comparative education research are of obvious importance, but do not always receive adequate attention. This book contributes new insights within the longstanding traditions of the field. A particular feature is the focus on different units of analysis. Individual chapters compare places, systems, times, cultures, values, policies, curricula and other units. These chapters are contextualised within broader analytical frameworks which identify the purposes and strengths of the field. The book includes a focus on intra-national as well as cross-national comparisons, and highlights the value of approaching themes from different angles. The book will be of great value not only to producers of comparative education research but also to consumers who wish to understand more thoroughly the parameters and value of the field.
Communicative figurations : Transforming communications in times of deep mediatization
This open access volume is about how to research the influence of our changing media environment. Today, there is not one single medium that is the driving force of change. With the spreading of various technical communication media such as mobile phone and internet platforms, we are confronted with a media manifold of deep mediatization. But how can we investigate its transformative capability? This book answers this question by taking a non-media-centric perspective, researching the various figurations of collectivities and organizations humans are involved in. The first part of the book outlines a fundamental understanding of the changing media environment of deep mediatization and its transformative capacity. The second part focuses on collectivities and movements: communities in the city, critical social movements, maker, online gaming groups and networked groups of young people. The third part moves institutions and organizations into the foreground, discussing the transformation of journalism, religion, politics, and education, whilst the fourth and final part is dedicated to methodologies and perspectives.
Communications and Discoveries from Multidisciplinary Data
In this book, we aim at urging the development of data-based methods and methodologies for interdisciplinary and creative communications for solving emerging social problems. The reader shall view the direction to combine three methodological frameworks: data mining, data sharing, and communication in the contexts of sciences and businesses.
Communicating with One Another : Toward a Psychology of Spontaneous Spoken Discourse
In other words, this book is a call for a paradigm shift in the study of oral communication. It is a must read for people interested in language use, as well as for specialists in language studies. "The authors have identified crucial theoretical and methodological assumptions that have hampered scholarship on language use. Their critical assessment is grounded in nuanced theoretical analysis and rigorous empirical studies. As a result, they reveal the complexity, elegance, and moral aspects of day to day dialogical communication."
Clinical nuclear medicine
Clinical Nuclear Medicine … focuses on the universal state of the art in both diagnostic and therapeutic radionuclide methodology. … This book is easily readable, with presentation of essential points and plentiful references, and the quality of the figures and tables is excellent. … is a useful guide to students, technologists, and practitioners in nuclear medicine and radiology, as well as to general physicians who request nuclear diagnosis or treatment. … will be a welcome contribution to the bookshelf of nuclear medicine or radiology clinics.
Climate Change Impacts for the Conterminous USA : An Integrated Assessment
In this volume, an improved Integrated Assessment methodology is used to analyse climate change impacts on agriculture, water resources, unmanaged ecosystems, irrigation, and land use in the United States and the economic implications of these impacts. This book contains a series of papers documenting the methods, models, analysis and results of this integrated assessment for a wide ranging set of scenarios describing future climate change. Innovations described include the integration of water resource and agricultural modeling and the refinement of an agriculture and land-use economics model to incorporate results from process-level ecosystem models of agriculture, water and natural ecosystem resources. Scenarios selected for this study address a range of uncertainties associated with choice of climate model, presence or absence of a ‘CO2-fertilization effect’, impacts on international trade in agricultural commodities and their consequences for producers and consumers.
