الصفحة 23
الصفحة 23
Classification and Modeling with Linguistic Information Granules : Advanced Approaches to Linguistic Data Mining
Many approaches have already been proposed for classification and modeling in the literature. These approaches are usually based on mathematical mod els. Computer systems can easily handle mathematical models even when they are complicated and nonlinear (e.g., neural networks). On the other hand, it is not always easy for human users to intuitively understand mathe matical models even when they are simple and linear. This is because human information processing is based mainly on linguistic knowledge while com puter systems are designed to handle symbolic and numerical information. A large part of our daily communication is based on words. We learn from various media such as books, newspapers, magazines, TV, and the Inter net through words. We also communicate with others through words. While words play a central role in human information processing, linguistic models are not often used in the fields of classification and modeling. If there is no goal other than the maximization of accuracy in classification and modeling, mathematical models may always be preferred to linguistic models. On the other hand, linguistic models may be chosen if emphasis is placed on interpretability.
Classification and Learning Using Genetic Algorithms : Applications in Bioinformatics and Web Intelligence
This book provides a unified framework that describes how genetic learning can be used to design pattern recognition and learning systems. The book is unique in the sense of describing how a search technique, the genetic algorithm, can be used for pattern classification mainly through approximating decision boundaries, and it demonstrates the effectiveness of the genetic classifiers vis-à-vis several widely used classifiers, including neural networks. It provides a balanced mixture of theories, algorithms and applications, and in particular results from the bioinformatics and Web intelligence domains.
Circular RNAs
Guide readers through circular RNA purification, in silico characterization, circRNA detection, sequence validation, quantification , techniques related to gain- and loss-of-function approaches, circular RNA synthesis, split ligation, engineering, nanoparticle packaging, RNA modifications on circular RNA biogenesis, RNA translation potential, and vaccines based on circular RNAs.
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. developments of basic science into effective new approaches to the patient.
Chronic kidney disease and its complications and treatment
Our research focuses on the relationship of chronic diseases in the kidney and complications resulting from these diseases, as we focused on three chronic diseases that affect the kidneys by identifying hypertension disease and its genetic role in affecting the kidney and the relationship between the kidney and high blood pressure that affects the long term and leads to kidney failure and identifying the indicators that Indicates the kidney function in patients with hypertension, high potassium values, and its direct effect on renal function, and treatment measures for hypertensive patients who suffer from a kidney problem.
Chromosomal alterations : Methods, results and importance in human health
Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.
Chromatin and Disease
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics.
Chemogenomics : Methods and protocols
Presents both theoretical guidance and protocols on chemogenomics including chemogenomics library assembly, compound profiling, and phenotypic assays. The chapters in this book cover topics such as the assembly and use of Kinase Chemogenomics; data mining for chemogenomic compound candidates; protocols for protein family-focused assay systems to profile chemogenomic compounds; functional and target engagement assays in cellular settings for broad characterization; and a discussion on phenotypic assays where chemogenomic sets may be applied.
Chemical Biology and Drug Discovery
Gives the reader, through the specific selection of chemical-biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems.
Chance Rules : An informal guide to probability, risk and statistics
This second edition of Chance Rules again recounts the story of chance through history and the various ways it impacts on our lives. Here you can read about the earliest gamblers who thought that the fall of the dice was controlled by the gods, as well as the modern geneticist and quantum theory researcher trying to integrate aspects of probability into their chosen speciality. Example included in the first addition such as the infamous Monty Hall problem, tossing coins, coincidences, horse racing, birthdays and babies remain, often with an expanded discussion, in this edition. Additional material in the second edition includes, a probabilistic explanation of why things were better when you were younger, consideration of whether you can use probability to prove the existence of God, how long you may have to wait to win the lottery, some court room dramas, predicting the future, and how evolution scores over creationism. Chance Rules lets you learn about probability without complex mathematics.
Challenges to Marine Ecosystems ; Proceedings of the 41st European Marine Biology Symposium
This volume presents a representative sample of contributions to the 41st European Marine Biology Symposium held in September 2005 in Cork, Ireland. The theme of the symposium was ‘Challenges to Marine Ecosystems’ and this was divided into four sub themes; Genetics, Marine Protected Areas, Global Climate Change and Marine Ecosystems, Sustainable Fisheries and Agriculture.
Cereals and millets
Genome Mapping and Molecular Breeding in Plants presents the current status of the elucidation and improvement of plant genomes of economic interest. The focus is on genetic and physical mapping, positioning, cloning, monitoring of desirable genes by molecular breeding and the most recent advances in genomics. The series comprises seven volumes: Cereals and Millets; Oilseeds; Pulses, Sugar and Tuber Crops; Fruits and Nuts; Vegetables; Technical Crops; and Forest Trees.
Cereal genomics
Through these basic studies, it also became fairly apparent that the genomes of all cereals are related and were derived from the same lineage, million of years ago.
Cellular Genetic Algorithms
CELLULAR GENETIC ALGORITHMS defines a new class of optimization algorithms based on the concepts of structured populations and Genetic Algorithms (GAs). The authors explain and demonstrate the validity of these cellular genetic algorithms throughout the book. This class of genetic algorithms is shown to produce impressive results on a whole range of domains, including complex problems that are epistatic, multi-modal, deceptive, discrete, continuous, multi-objective, and random in nature. The focus of this book is twofold. On the one hand, the authors present new algorithmic models and extensions to the basic class of Cellular GAs in order to tackle complex problems more efficiently. On the other hand, practical real world tasks are successfully faced by applying Cellular GA methodologies to produce workable solutions of real-world applications.
Cell-secreted vesicles : Methods and protocols
Pesents hands-on technological protocols used to target an array of cell-secreted extracellular vesicles (EVs) in a variety of biological systems. Beginning with methods for EV purification and analysis, the book continues with sections on the study of EV functions as well as specific systems and models allowing for the study of EVs of different origin. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cell Stress Proteins
This comprehensive volume, written by experts in the field, provides a current understanding of the molecular properties of the heat shock proteins and their roles in health and disease. Cell Stress Proteins includes advances in several aspects of stress protein research, with chapters ranging from basic studies of the role of heat shock proteins in protein folding to reviews examining the breakdown of stress protein regulation during disease. It also provides analysis of the biochemical and molecular properties of heat shock proteins which can be utilized in evaluating their role in human physiology and pathology. Cell Stress Proteins is an ideal book for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Celiac disease
Celiac Disease is a chronic small intestinal immune-mediated enteropathy caused by the ingestion of dietary gluten proteins in genetically susceptible individuals. CD is one of the most common autoimmune diseases, affecting around 1.4% of the population globally . Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options. Finding alternative diet and trying different lifestyle still under debates. However, complete exclusion of the gluten-containing food from the patient's diet is the only effective treatment to avoid the disease complications
Cardiac gene therapy : Methods and protocols
Discussions on topics such as gene suppression, editing, and reprogramming; cardiac gene therapy vectors and promoters; cardiac gene delivery methods; pulmonary hypertension; and patient screening and measuring the efficacy of cardiac gene therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cannabinoids and the brain
Cannabinoids and the Brain gives a comprehensive overview of all the essential literature concerning the endocannabinoid and related systems in the nervous tissue. It is a rapidly expanding research field and the widespread presence of cannabinoids in most physiopathological mechanisms appear to hinder the effort to fully cover the subject. By the end of the book, the reader will have a solid knowledge of the genetics, molecular biology, anatomy, pharmacology, and physiology of the endocannabinoid system and its involvement in neurological and psychiatric disorders, and will eventually discover a natural relationship among marijuana, aspirin, and chili pepper.
Cancerimmunotherapies : Solid tumors and hematologic malignancies
Presents the clinical scope of cancer immunotherapeutic agents for solid tumors and Hematologic malignancies, elaborates on the scientific details of their modes of action, and presents the impact of these agents on oncology, patients and the broader healthcare system. At present, cancer immunotherapies fall broadly into three categories: immune checkpoint inhibitors (ICIs), adoptive T cell therapies, and cancer vaccines which have distinct mechanisms of action. Immune checkpoint inhibitors rely upon disrupting tumor antigen recognition as self by the immune system through inhibition of checkpoint molecules. Adoptive T cell therapies involve the engineering of T cells ex vivo to target and destroy tumor cells. The first part of this book will provide an overview of the discovery and mechanistic details of the technology. The second part will be devoted to elaborating on the clinical outcomes, successes and limitations for specific tumor subtypes, which includes both solid tumors and hematologic malignances for both pediatric and adult populations.
