الصفحة 22
الصفحة 22
Cancer
The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Calibrating the Cosmos : How Cosmology Explains Our Big Bang Universe
Calibrating the Cosmos describes hard science, but is gently written. It explains in clear, non-mathematical language the measurements and the interpretation of the resulting data that have led to the current understanding of the origin, evolution and properties of our expanding Big Bang universe. Many people have a sketchy idea of the work of cosmologists, but Professor Levin’s experience in teaching both scientific and liberal arts students has enabled him to impart much of our current thinking without resorting to difficult mathematics. Theoretical concepts are emphasized, in particular the symmetries of homogeneity and isotropy enjoyed by our universe on the largest scales, how these symmetries lead to only one quantity being needed to describe the growth of the universe from its infancy to the present time, and how the so-called parameters of the universe are the ingredients used to construct the model universes to which ours – the real thing – is compared.
Business incubator center
يهدف مشروع مركز حاضنات الأعمال إلى دعم رواد الأعمال والمشاريع الناشئة من خلال توفير بيئة محفزة وخدمات متكاملة تساعدهم على تطوير أفكارهم وتحويلها إلى شركات ناجحة. يقدم المركز خدمات مثل التدريب، والإرشاد، وتوفير المساحات المكتبية، وربط الحاضنين بالخبراء والمستثمرين. كما يساهم في تعزيز اﻻبتكار وتحفيز التنمية الاقتصادية المحلية من خلال دعم المشاريع الصغيرة والمتوسطة. يركز المشروع على بناء شبكة تعاون بين الحاضنين لتبادل الخبرات والموارد، مما يزيد فرص نجاحهم واستمراريتهم في السوق.
Building a Future with BRICs : The Next Decade for Offshoring
In 2003, Goldman Sachs published a startling report on the BRICs (Brazil, Russia, India, and China) region: These four countries would be larger than the G6 economics within 40 years, muscling their way to economic dominance over the coming decades, and powering past developed countries such as the United Kingdom, Germany, and Japan. This book focuses on the technology and technology-enabled services that underpin this social and economic revolution. The editor analyses the reasons why these four countries are in a unique position to lead a 21st century growth in international services. He then features 12 chapters written by the most important chief executives from the BRICs service economy. Indian technology leaders, such as Nandan Nilekani (Infosys), Shiv Nadar (HCL), and Rajendra Pawar (NIIT), feature alongside their peers from Brazil, Russia, and China outlining their views on the next decade for offshoring.
Building a Cashless Society : The Swedish Route to the Future of Cash Payments
This book tells the story of how Sweden is becoming a virtually cashless society. Its goal is to improve readers’ understanding of what is driving this transition, and of the factors that are fostering and hampering it. In doing so, the book covers the role of central banks, political factors, needs for innovation, and the stakeholders involved in developing a cashless ecosystem. Adopting a historical standpoint, and drawing on a unique dataset, it presents an academic perspective on Sweden’s leading role in this global trend. The global interest in the future of cash payments makes the Swedish case particularly interesting. As a country that is close to becoming a cashless economy, it offers a role model for many other countries to learn from - whether they want to stimulate or reduce the use of cash. This highly topical book will be of interest to politicians, researchers, businesses, financial service providers and payment service providers, as well as fintech start-ups, regulators and other authorities.
Brunet Saunier Architecture : Monospace and Simplexity
Discusses and analyzes this concept in detail, presenting trueto- scale floor plans, cross-sections, architectural views, and other information. The Monospace concept - which is based on a process of creative reduction down to essentials, i.e. "simplexity" - is adaptive rather than normative or prescriptive, and based on probabilities rather than determinism. It respects energy, even when it sometimes uses it. It takes the individual's experience into account, and starts from the position of the subject. It also permits changing perspectives. This design concept should attract attention far beyond the borders of France.
Brouwer meets Husserl : On the Phenomenology of Choice Sequences
Can the straight line be analysed mathematically such that it does not fall apart into a set of discrete points, as is usually done but through which its fundamental continuity is lost? And are there objects of pure mathematics that can change through time? The mathematician and philosopher L.E.J. Brouwer argued that the two questions are closely related and that the answer to both is "yes''. To this end he introduced a new kind of object into mathematics, the choice sequence. But other mathematicians and philosophers have been voicing objections to choice sequences from the start. This book aims to provide a sound philosophical basis for Brouwer's choice sequences by subjecting them to a phenomenological critique in the style of the later Husserl.
Broadband Opto-Electrical Receivers in Standard CMOS
Broadband Opto-Electrical Receivers in Standard CMOS starts from the basic fundamentals, necessary for the design of opto-electronic interface circuits. The book continues with an in-depth analysis of the photodiode, transimpedance amplifier (TIA) and limiting amplifier (LA). To thoroughly understand the light detection mechanisms in silicon, first a one-dimensional and second a two-dimensional model is developed. Analytical design equations are derived to guide the design of the amplifying circuits. For the TIA, the focus lies on the sensitivity-speed trade-off. For the LA, a high gain-bandwidth is pursued. Several practical design examples reveal the subtleties and challenges encountered during the design of high-performance analog circuits.
Braid Groups
Braids and braid groups have been at the heart of mathematical development over the last two decades. Braids play an important role in diverse areas of mathematics and theoretical physics. The special beauty of the theory of braids stems from their attractive geometric nature and their close relations to other fundamental geometric objects, such as knots, links, mapping class groups of surfaces, and configuration spaces. In this presentation the authors thoroughly examine various aspects of the theory of braids, starting from basic definitions and then moving to more recent results. The advanced topics cover the Burau and the Lawrence--Krammer--Bigelow representations of the braid groups, the Alexander--Conway and Jones link polynomials, connections with the representation theory of the Iwahori--Hecke algebras, and the Garside structure and orderability of the braid groups.
Boundary Representation Modelling Techniques
Boundary representation is the principle solid modelling method used in modern CAD/CAM systems. There have been a long series of developments on which currently available systems are based, full details of which are only partially known. Ian Stroud’s thorough coverage of these developments puts this technology in perspective. Ian Stroud started working with boundary representation solid modelling in 1977. Since then he has researched and is researching a wide variety of topics in and around this field. The information in the book comes from the results of this research.
Botanical drug products : Recent developments and market trends
Botanicals, which have been part of human food and medicine for thousands of years, are perceived as being safer than synthetic pharmaceuticals. The global botanical drug market was expected to reach $26.6 billion by 2017. In terms of FDA regulations, botanical drugs are no different from non-botanical products, having to meet the safety and effectiveness standards of a new drug in accordance. This book comprises a complete start-to-end process from drug-idea conception, to drug development process.
Boss It : Control Your Time, Your Income and Your Life
In this invigorating and highly practical book, serial entrepreneur Carl Reader provides exactly the fire and guidance you need to get started. Designed to cut through the business jargon, this handy guide will take you through everything you need to establish and run your own business - from the mindset it takes to turn a dream into a plan, to the need-to-know practical stuff for running and growing a business.
Bonding in Microsystem Technology
Bonding in Microsystem Technology starts with descriptions of terminology, kinds of microsystems and market analysis. Followed by the presentation of mechanisms of wet etching, set of process parameters, description of micromachining methods, examples of procedures, process flow-charts and applications of basic micromechanical structures in microsystems are shown. Next, high-temperature, low temperature and room-temperature bonding and their applications in microsystem technology are presented. The following part of the book contains the detailed description of anodic bonding, starting from analysis of properties of glasses suitable for anodic bonding, and discussion of the nature of the process. Next all types of anodic bonding and sealing procedures used in microsystem technology are presented.
Body Sensor Networks
While the problems of long-term stability and biocompatibility are being addressed, several promising prototypes are starting to emerge for managing patients with acute diabetes, for treatment of epilepsy and other debilitating neurological disorders and for monitoring of patients with chronic cardiac diseases. Despite the technological developments in sensing and monitoring devices, issues related to system integration, sensor miniaturization, low-power sensor interface circuitry design, wireless telemetric links and signal processing still have to be investigated.
Biotechnologies for plant mutation breeding : Protocols
This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.
Biophotonics and Coherent Systems in Biology
Biophotonics and Coherent Systems in Biology offers a timely research volume derived from papers submitted at the 3rd International Alexander Gurwitsch Conference. Biophotonics and Coherent Systems in Biology covers the major aspects of modern biophotonics and related biological and biophysical problems of interest to researchers today.Key topics include: Coherency of biophoton emission and its related physical and biological properties , Biological effects of microwaves, Photon emission from living samples, starting from human bodies up to cell cultures, Fundamental role of water in bioenergetics and the influence of electromagnetic fields upon hydrophobic-hydrophilic balance
Biometric Authentication ; International ECCV 2002 Workshop Copenhagen, Denmark, June 1, 2002 Proceedings
Biometric authentication refers to identifying an individual based on his or her distinguishing physiological and/or behavioral characteristics. It associates an individual with a previously determined identity based on that individual s appearance or behavior. Because many physiological or behavioral characteristics (biometric indicators) are distinctive to each person, biometric identifiers are inherently more reliable and more capable than knowledge-based (e.g., password) and token-based (e.g., a key) techniques in differentiating between an authorized person and a fraudulent impostor. For this reason, more and more organizations are looking to automated identity authentication systems to improve customer satisfaction, security, and operating efficiency as well as to save critical resources.
Biology and Control Theory : Current Challenges
Creating some links between control feedback and biology modeling communities based on similarities in modeling, observing and perceiving alive structures, and analyzing interconnections between biological structures and subsystems was the main objective of this volume. The idea of this book was conceived in the context mentioned above with the objective to help in claiming many of the problems for control researchers, starting discussions and opening interactive debates between the control and biology communities, and, finally, to alert graduate students to the many interesting ideas at the frontier between control feedback theory and biology.
Biological invaders in inland waters : Profiles, distribution, and threats
The book examines the identity, distribution, and impact of freshwater non-indigenous species and the dynamics of their invasion. Rather than providing a broad and comprehensive review of the issue, Biological invaders in inland waters focuses on old and new invaders and also raises questions and opens perspectives that provide a starting point for further research. The ultimate purpose of this book is to help define a more general framework for our knowledge of invasions in fresh waters. Such a framework will be indispensable to the planning of a science-based management program.
Bioinformatics for oral cancer : Current insights and advances
Offering a deep dive into the multifaceted landscape of oral cancer research and bioinformatics. Readers will uncover a wealth of knowledge, starting with foundational chapters introducing bioinformatics and establishing the backdrop of oral cancer. The book then progresses into the realm of diagnostic biomarkers, revealing cutting-edge methodologies for their identification in the context of oral cancer. The book’s keen focus extends to gene expression profiles and the intricacies of gene sequencing in the context of oral cancer progression.
