الصفحة 22
الصفحة 22
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene Expression and Regulation
This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. Presented in the following five sections, this book covers a full spectrum of topics: The History; The Machinery; The Regulators; The Genome; and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The Special Topics section discusses several selected topics ranging from bacterial and plant gene expression to DNA topology and interference RNA. The book’s focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Gallstones
Gallstones are hardened deposits of digestive fluid that can form in the gallbladder. the gallbladder is a small, pear-shaped organ on the right side of the abdomen, just beneath the liver. The gallbladder holds a digestive fluid called bile that's released into the small intestine. Gallstones range in size from as small as a grain of sand to as large as a golf ball. Some people develop just one gallstone, while others develop many gallstones at the same time.
Galling Arthropods and Their Associates ; Ecology and Evolution
The book addresses recent developments in the ecology, evolution, systematics, physiology, and biodiversity of gall-inducing arthropods, with individual contri butions ranging in scope from detailed descriptions to profoundly synthetic stud ies. One underlying theme of the book is the various impacts of gall induction that indirectly affect insect communities on the host plant. The other important contri bution is the highly intricate and dynamic interactions between galling arthropods and their uniquely specialized host plants. Included also are chapters that discuss biodiversity and distribution patterns of gall-inducing arthropods, and biological control of invasive gall-inducing arthropods and of invasive trees. We believe that this book makes an important contribution to the knowledge of galling arthropods and their associates and to the development of robust, general principles of the ecology and evolution of these organisms.
Galaxy Formation
This second edition of Galaxy Formation is an up-to-date text on astrophysical cosmology, expounding the structure of the classical cosmological models from a contemporary viewpoint. This forms the background to a detailed study of the origin of structure and galaxies in the Universe. The derivations of many of the most important results are derived by simple physical arguments which illuminate the results of more advanced treatments. A very wide range of observational data is brought to bear upon these problems, including the most recent results from WMAP, the Hubble Space Telescope, galaxy surveys like the Sloan Digital Sky Survey and the 2dF Galaxy Redshift Survey, studies of Type 1a supernovae, and many other observations.
Gaithers Dictionary of Scientific Quotations
Finding words of wisdom about science is now easy with Gaither's Dictionary of Scientific Quotations. Organized thematically and indexed alphabetically by author, this work makes readily available an unprecedented collection of approximately 18,000 quotations related to a broad range of scientific topics, including astronomy, biology, chemistry, engineering, and physics. The thematic organization allows you to effortlessly find a pertinent quotation from a variety of sources and perspectives.
Fuzzy systems and knowledge discovery ; Vol. 4223 ; Third International Conference, FSKD 2006, Xi'an, China, September 24-28, 2006, Proceedings
ICNC-FSKD 2006 featured the most up-to-date research results in com- tational algorithms inspired from nature, including biological, ecological, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide rangeof techniques and methods arebeing studied for dealing with large, complex, and dynamic problems.
Fuzzy systems and knowledge discovery ; Vol. 3614 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part II
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Fuzzy systems and knowledge discovery ; Vol. 3613 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part I
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Future healthcare design
Describes how architects can design better healthcare buildings for a rapidly changing context and climate. Innovation in the design of healthcare estates is essential to the sustainability of our health services. Design thinking in this field is being influenced by a range of factors, such as economic constraints, an ageing demographic, complex health conditions (co-morbidities), and climate change.
Funology : From usability to enjoyment
This book reflects the move in Human Computer Interaction studies from standard usability concerns towards a wider set of problems to do with fun, enjoyment, aesthetics and the experience of use. Traditionally HCI has been concerned with work and task based applications but as digital technologies proliferate in the home fun becomes an important issue. There is an established body of knowledge and a range of techniques and methods for making products and interfaces usable, but far less is known about how to make them enjoyable.
Fungal Immunology: From an Organ Perspective
This book will serve as a comprehensive review of all known immune mechanisms for common medically important fungal pathogens. Its novelty lies in the organization: Rather than chapters devoted to specific fungi, chapters are organized by organ system. All other texts in the field, which are now quite old, are arranged according to specific fungi.
Fundamentals of Radiation Materials Science : Metals and Alloys
adiation Materials Science teaches readers the fundamentals of the effects of radiation on metals and alloys. When energetic particles strike a solid, numerous processes occur that can change the physical and mechanical properties of the material. Metals and alloys represent an important class of materials that, by virtue of their use in nuclear reactor cores, are subject to intense radiation fields. Radiation causes metals and alloys to swell, distort, blister, harden, soften and deform. This textbook and reference covers the basics of particle-atom interaction for a range of particle types, the amount and spatial extent of the resulting radiation damage, the physical effects of irradiation and the changes in mechanical behavior of irradiated metals and alloys. Concepts are developed systematically and quantitatively, supported by examples, references for further reading and problems at the end of each chapter
Fundamentals of implant dentistry ; Vol.1 : Prosthodontic Principles
Focuses on the design and fabrication of implantretained prostheses. The authors of this definitive textbook cover the full range of restorative treatment options for edentulous and partially edentulous situations, from relatively simple problems that can be handled by a solo practitioner to those with substantial prosthodontic complexities, periodontal compromise of existing dentition, and significant bone and soft tissue defects. Throughout, the authors emphasize the importance of an interdisciplinary approach and demonstrate how it encourages the best results, particularly when restoring partially edentulous patients.
Fundamentals of Financial Instruments : An Introduction to Stocks, Bonds, Foreign Exchange, and Derivatives
Securities.In the newly revised Second Edition of Fundamentals of Financial Instruments: An Introduction to Stocks, Bonds, Foreign Exchange, and Derivatives, renowned finance trainer Sunil Parameswaran delivers a comprehensive introduction to the full range of financial products commonly offered in the financial markets.
Fundamentals of electrical drives
This brings us to the purpose of this book namely to help students and engineers appreciate and understand the fundamental concepts of modern electrical drives. An interactive learning approach is taken in this text: theory and calculations are augmented by generic models which are transposed to a simulation platform. The 'build and play' method used in this text visualizes the dynamic operation of a comprehensive set of modules ranging from an inductance to a novel 'ideal rotating transformer' (IRTF). This module is at the center of the generic models used in this text to explore the dynamic and steady state operation of grid and converter fed induction, synchronous and DC machines. The section on modulation and control emphasizes the role of power electronics and digital signal processors in drives. Downloadable files that accompany this text have an extensive set of 'build and play' tutorials, in Simulink R° and Caspoc. The latter is a simulation platform which allows direct access to the 'build and play' modules, without further licensing needs. All figures in this text are included in the downloadable files in order to help with the preparation of customized Power Point type lecture material.
Fundamentals of building construction : Materials and methods
Reference for thousands of professionals and students of architecture, engineering, and construction technology for over thirty years. The materials and methods described in this new seventh edition have been thoroughly updated to reflect the latest advancements in the industry. Carefully selected and logically arranged topics-ranging from basic building methods to the principles of structure and enclosure-help readers gain a working knowledge of the field in an enjoyable, easy-to-understand manner. All major construction systems, including light wood frame, mass timber, masonry, steel frame, light gauge steel, and reinforced concrete construction, are addressed. Now in its seventh edition, Fundamentals of building construction contains substantial revisions and updates.
Fundamentals of analytical toxicology : Clinical and forensic ; 2nd ed.
An integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques. Focuses on analytical, statistical, and pharmacokinetic principles / Describes basic methodology, including colour tests and immunoassay and enzyme-based assays / Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation / Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides / Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS)
Fundamentals of Algebraic Graph Transformation
Graphs are widely used to represent structural information in the form of objects and connections between them. Graph transformation is the rule-based manipulation of graphs, an increasingly important concept in computer science and related fields. This is the first textbook treatment of the algebraic approach to graph transformation, based on algebraic structures and category theory.
Fundamentals of nanoscale film analysis
The book describes the fundamentals of materials characterization from the standpoint of the incident photons or particles which interrogate nanoscale structures. These induced reactions lead to the emission of a variety of detected of particles and photons. It is the energy and intensity of the detected beams that is the basis of the characterization of the materials. The array of experimental techniques used in nanoscale materials analysis covers a wide range of incident particle and detected beam interactions.
