الصفحة 206
الصفحة 206
Antimalarial natural products
Begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type.
Antimalarial medicinal plants
Malaria continues to affect a large population of the world, especially in third world countries. The spread of drug-resistant parasites demonstrates the need for antimalarial agents with various modes of action. The search for remedies derived from medicinal plants for the treatment of malaria is reliant on accurate ethnobotanical and ethnopharmacological information obtained from traditional medical practitioners. Antimalarial Medicinal Plants provides information on bioactive compounds and therapeutic potentials of several antimalarial plant species found around the globe. This book evaluates these plant species with respect to their biology, diversity, distribution, and pharmacological values.
Anti-fragile ICT Systems
Introduces a novel approach to the design and operation of large ICT systems. It views the technical solutions and their stakeholders as complex adaptive systems and argues that traditional risk analyses cannot predict all future incidents with major impacts. To avoid unacceptable events, it is necessary to establish and operate anti-fragile ICT systems that limit the impact of all incidents, and which learn from small-impact incidents how to function increasingly well in changing environments. The book applies four design principles and one operational principle to achieve anti-fragility for different classes of incidents. It discusses how systems can achieve high availability, prevent malware epidemics, and detect anomalies. Analyses of Netflix’s media streaming solution, Norwegian telecom infrastructures, e-government platforms, and Numenta’s anomaly detection software show that cloud computing is essential to achieving anti-fragility for classes of events with negative impacts.
Antidiabetic plants for drug discovery pharmacology, secondary metabolite profiling, and ingredients with insulin mimetic activity
Takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants, examining their antihyperglycemic, hypoglycemic, and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products, or phytoconstituents, are promising candidates for antidiabetic pharmacological actions. The phytoconstituents, such as fl avonoids, terpenoids, saponins, carotenoids, alkaloids and glycosides, play vital roles in the current and future potent antidiabetic drug development programs. Each chapter reviews a particular plant with antidiabetic properties, explaining the therapeutic aspects, its active antidiabetic compounds, and relevant genome editing technology.
Antidepressants Beyond Depression, and Into Bacteria
Antidepressants are one of the most predominant drug groups in the pharmaceutical world, primary care units and the general public. Their original use was majorly for the treatment of depression along with other mental disorders. Today, antidepressant consume over 20% of the medical prescriptions and healthcare plans due to their recently discovered applications outside the psychiatry field. Due to the alarming rise of antibiotic resistance and the slow pace of new drug discovery, the world has been searching frantically for new or alternative drugs with antibacterial activity. Repurposing already FDA- approved drugs for uses that are off-label has become an important preposition in the pharmacy world due to its availability, low risk and low cost.
Anticoagulants and coronary artery disease
Blood thinners are medicines that help blood flow smoothly through your veins and arteries. There are two. The first is called anticoagulants (Warfarin, Heparin, Enoxaparin) and The second class of blood thinners is called antiplatelet (Aspirin, Ticagrelor , Clopidogrel). . Coronary arteries supply blood to the heart muscle. Coronary artery disorder or disease can have serious implications by reducing the flow of oxygen and nutrients to the heart muscle. This can lead to a heart attack and possibly death. Atherosclerosis. Medications to reduce the risk of blood clots, such as anticoagulants (including aspirin) and antiplatelet. , in particular aspirin, are effective in preventing platelet activation and thus thrombus formation and Clopidogrel is an inhibitor of platelet activation.
Anticipatory Behavior in Adaptive Learning Systems : From Brains to Individual and Social Behavior
Anticipatory behavior in adaptive learning systems is steadily gaining the - terest of scientists, although many researchers still do not explicitly consider the actual anticipatory capabilities of their systems.The introductory chapter of this volume therefore does not only provide an overview of the contributions included in this volume but also proposes a taxonomy of how anticipatory mechanisms can improve adaptive behavior and learning in cognitive systems. During the workshop it became clear that ant- ipations are involved in various cognitive processes that range from individual anticipatory mechanisms to social anticipatory behavior.
Anticipating and preparing for emerging skills and jobs : Key issues, concerns, and prospects
Analyzes the main drivers that are influencing the dramatic evolution of work in Asia and the Pacific and identifies the implications for education and training in the region.
Antibody-drug conjugates and cellular metabolic dynamics
Summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs.
Antibiotics : Methods and protocols
Provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, as well as methods for the analysis and detection of microbial responses and adaptation strategies. Antibiotics: Methods and Protocols, Second Edition, guides readers through updated and entirely new chapters on production and design, mode of action, and response and resistance. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Antibiotic policies : Theory and practice
This unique book assembles contributions from experts around the world concerned with responsible use of antibiotics and the consequences of overuse. For the first time, it provides up to the minute texts on both the theoretical aspects of antibiotic stewardship and the practical aspects of its implementation, with consideration of the key differences between developed and developing countries
Antibiotic pharmacokinetic : Pharmacodynamic considerations in the critically Ill
Provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
Anterior knee pain and patellar instability
This multidisciplinary book reviews the diagnosis and management of anterior knee pain and patellar instability in an eminently clinical and practical manner. The book reviews the therapeutic alternatives, both surgical and non-surgical, emphasizing the considerable importance of minimal intervention and non-surgical methods. Similarly, anterior knee pain following ACL reconstruction is covered in detail.
Antennas & propagation for wireless communication systems ; 2nd ed.
Antennas and propagation are of fundamental importance to the coverage, capacity and quality of all wireless communication systems. This book provides a solid grounding in antennas and propagation, covering terrestrial and satellite radio systems in both mobile and fixed contexts. Building on the highly successful first edition, this fully updated text features significant new material and brand new exercises and supplementary materials to support course tutors. A vital source of information for practising and aspiring wireless communication engineers as well as for students at postgraduate and senior undergraduate levels, this book provides a fundamental grounding in the principles of antennas and propagation without excessive recourse to mathematics. It also equips the reader with practical prediction techniques for the design and analysis of a very wide range of common wireless communication systems.
Antecedents of venture firms' internationalization : A conjoint analysis of international entrepreneurship in the net economy
With the continuing dispersion of the global digital network and performance improvements of information and communication technologies, resource-poor start-ups with online business models have emerged in large numbers. These firms are able to deploy their competitive advantages across their country borders early in their life-cycle and engage in international commerce at a fast pace. An increased immediacy between the firms and the globally accessible customer is observed. Julia Christofor’s study aims to analyze the conditions of the initial internationalization decision in the Net Economy. Based on Information Systems, International Entrepreneurship, and Entrepreneurship literature, factors, which constitute the internationalization propensity, are derived. The results of this study suggest that a holistic perspective including the founder, business model and the firm level should be considered when explaining the internationalization propensity of entrepreneurs.
Ant Colony Optimization and Swarm Intelligence ; 5th International Workshop, ANTS 2006, Brussels, Belgium, September 4-7, 2006, Proceedings
ANTS – The International Workshop on Ant Colony Optimization and Swarm Intelligence is now at its ?fth edition. The series started in 1998 with the - ganization of ANTS 1998. At that time the goal was to gather in a common meeting those researchers interested in ant colony optimization: more than 50 researchers from around the world joined for the ?rst time in Brussels, Belgium, to discuss ant colony optimization and swarm intelligence related research. A selectionofthebest paperspresentedatthe workshopwaspublished asa special issue of the Future Generation Computer Systems journal (Vol. 16, No. 8, 2000). Two years later, ANTS 2000, organized again in Brussels, attracted more than 70 participants. The 41 extended abstracts presented as talks or posters at the workshopwere collected in a booklet distributed to participants, and a selection of the best papers was published as a special section of the IEEE Transactions on Evolutionary Computation (Vol. 6, No. 4, 2002).
Ansel's pharmaceutical dosage forms
Reflects the CAPE, APhA, and NAPLEX® competencies, and covers physical pharmacy, pharmacy practice, pharmaceutics, compounding, and dosage forms and the clinical application of the various dosing forms in patient care.
Anomaly Detection : Techniques and Applications
When information in the data warehouse is processed, it follows a definite pattern. An unexpected deviation in the data pattern from the usual behavior is called an anomaly. The anomaly in the data is also referred to as noise, outlier, spammer, deviations, novelties and exceptions. Identification of the rare items, events, observations, patterns which raise suspension by differing significantly from the majority of data is called anomaly detection. With progress in the technologies and the widespread use of data for the purpose for business the increase in the spams faced by the individuals and the companies are increasing day by day. This noisy data has boomed as a major problem in various areas such as Internet of Things, web service, Machine Learning, Artificial Intelligence, Deep learning, Image Processing, Cloud Computing, Audio processing, Video Processing, VoIP, Data Science, Wireless Sensor etc. Identifying the anomaly data and filtering them before processing is a major challenge for the data analyst. This anomaly is unavoidable in all areas of research. This book covers the techniques and algorithms for detecting the deviated data.
Annual bibliography of the history of the printed book and libraries ; Vol.31 : Publications of 2000 and additions from the preceding years
The Annual Bibliography of the History of the Printed Book and Libraries aims at recording articles of scholarly value which relate to the history of the printed book, to the history of arts, crafts, techniques and equipment, and of the economic social and cultural environment, involved in its production, distribution, conservation and description.
Animating Unpredictable Effects : Nonlinearity in Hollywood’s R&D Complex
Uncanny computer-generated animations of splashing waves, billowing smoke clouds, and characters’ flowing hair have become a ubiquitous presence on screens of all types since the 1980s. This Open Access book charts the history of these digital moving images and the software tools that make them. Unpredictable Visual Effects uncovers an institutional and industrial history that saw media industries conducting more private R&D as Cold War federal funding began to wane in the late 1980s. In this context studios and media software companies took concepts used for studying and managing unpredictable systems like markets, weather, and fluids and turned them into tools for animation. Unpredictable Visual Effects theorizes how these animations are part of a paradigm of control evident across society, while at the same time exploring what they can teach us about the relationship between making and knowing.
