الصفحة 20
الصفحة 20
Apoptosis, cell signaling, and human diseases : Molecular mechanisms ; Vol.1
Volume 1 is divided into two sections: “Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy.” Volume 2 follows a similar structure and is divided into sections entitled “Kinases and Phosphate” and “Molecular Basis of Cell Death.” All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.
Anxiety and Anxiolytic Drugs
The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.
Antioxidants effects in health : The bright and the dark side ; 1st ed.
Examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants’ historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.
Antioxidants as nutraceuticals
Provides a comprehensive overview of antioxidants and nutraceuticals, including their sources, mechanisms of action, and health benefits, this new volume first covers the basics of the types of antioxidants as nutraceuticals, including the importance of phytochemical antioxidants and their nutritional and pharmacological intervention in the treatment of disease. It discusses the natural origins of antioxidants, classification, mechanisms of action, calculation of antioxidant potential of nutraceutical substances, safety, toxicity, and their significant involvement in the prevention of many degenerative and chronic diseases.
Antimicrobial Resistance and Implications for the Twenty-First Century
This new volume of the Emerging Infectious Diseases of the 21st Century series is a collection of chapters by leading world authorities on antimicrobial resistance of common, important bacterial, viral and fungal pathogens. This unique book should be in the possession of anyone interested in the field of infectious diseases, microbiology, infection control & public health. The chapters, which are written by reknown experts, provide a wealth of contemporary information on microbiology, molecular mechanisms, epidemiology, clinical relevance, treatment, and prevention
Anticipatory Behavior in Adaptive Learning Systems : From Brains to Individual and Social Behavior
Anticipatory behavior in adaptive learning systems is steadily gaining the - terest of scientists, although many researchers still do not explicitly consider the actual anticipatory capabilities of their systems.The introductory chapter of this volume therefore does not only provide an overview of the contributions included in this volume but also proposes a taxonomy of how anticipatory mechanisms can improve adaptive behavior and learning in cognitive systems. During the workshop it became clear that ant- ipations are involved in various cognitive processes that range from individual anticipatory mechanisms to social anticipatory behavior.
Anticancer activity in heterocyclic organic structures : A pathway to novel drug development : Part 1
New Directions in Organic & Biological Chemistry, explores the development of cancer therapeutics, focusing on molecular chemistry and advanced drug design approaches. Written by experts in theoretical chemistry and molecular chemistry, they bridge the gap between theoretical chemistry, molecular biology, and drug development. In Part I, they focus on the fundamental properties of heterocyclic compounds and innovative methodologies being employed to enhance therapeutic potential. By exploring various classes of heterocyclic compounds and diverse anticancer mechanisms.
Antibiotics : Methods and protocols
Provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, as well as methods for the analysis and detection of microbial responses and adaptation strategies. Antibiotics: Methods and Protocols, Second Edition, guides readers through updated and entirely new chapters on production and design, mode of action, and response and resistance. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Anthropologies of Global Maternal and Reproductive Health : From Policy Spaces to Sites of Practice
This open access edited book brings together new research on the mechanisms by which maternal and reproductive health policies are formed and implemented in diverse locales around the world, from global policy spaces to sites of practice. The authors – both internationally respected anthropologists and new voices – demonstrate the value of ethnography and the utility of reproduction as a lens through which to generate rich insights into professionals’ and lay people’s intimate encounters with policy.
Angiogenesis in Inflammation : Mechanisms and Clinical Correlates
This volume relates the lessons learned from tumour biology applied to inflammation. This issue of Angiogenesis in Inflammation: Mechanisms and Clinical Correlates develops current knowledge on the mechanisms at the molecular and cellular levels as they relate to inflammation, including acute and chronic inflammation, neurogenic initiation, and the role of the multiple cellular components that comprise inflammation: granulocytes, macrophages, fibroblasts, dendritic cells and lymphocytes. This is related to inflammatory disease: not only the familiar angiogenesis dependent diseases of rheumatoid arthritis and psoriasis, but also loci such as the lung, gastric ulcers, the eye with uveitis, wound healing and periodontal disease and their therapy, how this knowledge may be used in the discovery of novel therapeutics. The volume brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and disease, culminating in a discourse on areas for future therapies.
Analyzing uncertainty in civil engineering
This volume addresses the issue of uncertainty in civil engineering from design to construction. Failures do occur in practice. Attributing them to a residual system risk or a faulty execution of the project does not properly cover the range of causes. A closer scrutiny of the adopted design, the engineering model, the data, the soil-construction-interaction and the model assumptions is required. Usually, the uncertainties in initial and boundary conditions are abundant. Current engineering practice often leaves these issues aside, despite the fact that new scientific tools have been developed in the past decades that allow a rational description of uncertainties of all kinds, from model uncertainty to data uncertainty. It is the aim of this volume to have a critical look at current engineering risk concepts in order to raise awareness of uncertainty in numerical computations, shortcomings of a strictly probabilistic safety concept, geotechnical models of failure mechanisms and their implications for construction management, execution, and the juristic question of responsibility. In addition, a number of the new procedures for modelling uncertainty are explained.
Analysis and Synthesis of Logics : How to Cut and Paste Reasoning Systems
Starting with simple examples showing the relevance of cutting and pasting logics, the monograph develops a mathematical theory of combining and decomposing logics, ranging from propositional and first-order based logics to higher-order based logics as well as to non-truth functional logics. The theory covers mechanisms for combining semantic structures and deductive systems either of the same or different nature (for instance, two Hilbert calculi or a Hilbert calculus and a tableau calculus). The important issue of preservation of properties is extensively addressed. For instance, sufficient conditions are provided for a combined logic to be sound and complete when the original component logics are known to be sound and complete.
Analysis and Numerics for Conservation Laws
The physical and chemical mechanisms as well as the sizes of these processes are quite different. So are the motivations for studying them scientifically.The super- 8 nova is a thermo-nuclear explosion on a scale of 10 cm. Astrophysicists try to understand them in order to get insight into fundamental properties of the universe. In hows around airfoils of commercial airliners at the scale of 3 10 cm shock waves occur that influence the stability of the wings as well as fuel consumption in ight. This requires appropriate design of the shape and structure of airfoils by engineers. Knocking occurs in combustion, a chemical 1 process, and must be avoided since it damages motors. The scale is 10 cm and these processes must be optimized for efficiency and environmental conside- tions. The common thread is that the underlying ?uid ?ows may at a certain scale of observation be described by basically the same type of hyperbolic s- tems of partial differential equations in divergence form, called conservation laws. Astrophysicists, engineers and mathematicians share a common interest in scientific progress on theory for these equations and the development of computational methods for solutions of the equations. Due to their wide applicability in modeling of continua. A substantial portion of mathematical research is related to the analysis and numerical approximation of solutions to such equations. Hyperbolic conservation laws in two or more space dimensions still poseone of the main challenges to modern mathematics.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Allosteric Regulatory Enzymes
This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Allocating public and private resources across generations : Riding the age waves ; Vol .2
The chapters in this volume greatly develop our understanding of the nature and measurement of transfers, their motives and mechanisms, and their macro-level dimensions, especially in the context of demographic transitions.
Agent-oriented software engineering V ; 5th International workshop, AOSE 2004, New York, NY, USA, July 2004, revised selected papers
The explosive growth of application areas such as electronic commerce, ent- prise resource planning and mobile computing has profoundly and irreversibly changed our views on software systems. Nowadays, software is to be based on open architectures that continuously change and evolve to accommodate new components and meet new requirements. Software must also operate on di?- ent platforms, without recompilation, and with minimal assumptions about its operating environment and its users. Furthermore, software must be robust and ¨ autonomous, capable of serving a naive user with a minimum of overhead and interference. Agent concepts hold great promise for responding to the new realities of software systems. They o?er higher-level abstractions and mechanisms which address issues such as knowledge representation and reasoning, communication, coordination, cooperation among heterogeneous and autonomous parties, p- ception, commitments, goals, beliefs, and intentions, all of which need conceptual modelling. On the one hand, the concrete implementation of these concepts can lead to advanced functionalities.
Agent-oriented information systems II ; 6th International bi-conference workshop, AOIS 2004, Riga, Latvia, June 8, 2004 and New York, NY, USA, July 20, 2004, revised selected papers
Information systems have become the backbone of all kinds of organizations - day. In almost every sector – manufacturing, education, health care, government and businesses large and small – information systems are relied upon for - eryday work, communication, information gathering and decision-making. Yet, the in?exibilities in current technologies and methods have also resulted in poor performance, incompatibilities and obstacles to change. As many organizations are reinventing themselves to meet the challenges of global competition and e-commerce, there is increasing pressure to develop and deploy new technologies that are ?exible, robust and responsive to rapid and unexpected change. Agent concepts hold great promise for responding to the new realities of - formation systems. They o?er higher-level abstractions and mechanisms which address issues such as knowledge representation and reasoning, communication, coordination, cooperation among heterogeneous and autonomous parties, p- ception, commitments, goals, beliefs, intentions, etc., all of which need conc- tual modelling. On the one hand, the concrete implementation of these concepts can lead to advanced functionalities.
Agent-mediated electronic commerce VI ; Theories for and engineering of distributed mechanisms and systems, AAMAS 2004 Workshop, Amec 2004, New York, NY, USA, July 19, 2004, revised selected papers
The design of intelligent trading agents, mechanisms, and systems has receivedgrowing atttention in the agents and multiagent systems communities in aneffort to address the increasing costs of search, transaction, and coordinationwhich follows from the increasing number of Internet-enabled distibuted elec-tronic markets. Furthermore, new technologies and supporting business modelsare resulting in a growing volume of open and horizontally integrated markets fortrading of an increasingly diverse set of goods and services. However, growth oftechnologies for such markets requires innovative solutions to a diverse set of ex-isting and novel technical problems which we are only beginning to understand.Specifically, distributed markets present not only traditional
Agent-mediated electronic commerce : Designing trading agents and mechanisms ; AAMAS 2005 Workshop, AMEC 2005, Utrecht, Netherlands, July 25, 2005, and IJCAI 2005 Workshop, TADA 2005, Edinburgh, UK, August 1, 2005, Selected and Revised Papers
This book constitutes the thoroughly refereed post-proceedings of the 7th International Workshop on Agent-Mediated Electronic Commerce, AMEC VII 2005, held in Utrecht, Netherlands in July 2005, as part of AAMAS 2005, and the third Workshop on Trading Agent Design and Analysis, TADA 2005, held in Edinburgh, UK in August 2005, in the course of the IJCAI 2005 conference meetings. The seven revised full AMEC 2005 papers presented were carefully selected.
