الصفحة 20
الصفحة 20
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gastrointestinal malignancies
Details the advances in drug discovery and delivery and the present need for emerging technologies. Throughout the text new micro and nanofabrication techniques are described, including methods such as electrohydrodynamic processes, additive manufacturing, and microfluidics, which have the potential to produce drug delivery systems that were not possible a few years ago. This book is of great use to both entry-level and experienced researchers in the field of emerging technologies for the manufacturing of drug delivery devices.
Gastroesophageal reflux disease : Principles of disease, diagnosis, and treatment
Gastroesophageal reflux disease (GERD) is one of the most common disorders with an increasing prevalence and incidence in the last two decades. This book presents clinically relevant information for gastroenterologists, internists, surgeons, residents and also nurses, who frequently care for GERD patients.
Gastroesophageal reflux disease : From pathophysiology to treatment
Offers a state-of-the-art description of the pathophysiology, diagnosis and treatment of gastroesophageal reflux disease (GERD). Although GERD is one of the most common gastrointestinal disorders, its diagnosis and management are often challenging. Expert physicians provide an evidence- and experience-based analysis in each chapter.
Gastric ulcers the cases and treatment
A gastric ulcer also known as stomach ulcer is an excoriated area of stomach caused principally by the digestive action of gastric juice Secretion in many ways the most common reasons are the taking non steroid anti-inflammatory drugs (NSAID) or an infection with Helicobacter pylori bacteria. It used to be Thought that stress or certain foods or drinking alcohol and smoking tobacco might cause stomach ulcer but in less cases. stomach ulcer can affect people of any age, including children, but mostly occur in people aged 50 or over. the common symptom is the pain in stomach and nausea with or without vomiting. the diagnosis through endoscopy is the best method to be sure about ulcer. the treatment of ulcer according to the reasons of ulcer is caused bacteria or not gastric ulcer It occurs in 80% of cases with the level of curvature The little one, especially the angle and antra, and effect men and women are the same.
Gallstones
Gallstones are hardened deposits of digestive fluid that can form in the gallbladder. the gallbladder is a small, pear-shaped organ on the right side of the abdomen, just beneath the liver. The gallbladder holds a digestive fluid called bile that's released into the small intestine. Gallstones range in size from as small as a grain of sand to as large as a golf ball. Some people develop just one gallstone, while others develop many gallstones at the same time.
Galaxy Formation
This second edition of Galaxy Formation is an up-to-date text on astrophysical cosmology, expounding the structure of the classical cosmological models from a contemporary viewpoint. This forms the background to a detailed study of the origin of structure and galaxies in the Universe. The derivations of many of the most important results are derived by simple physical arguments which illuminate the results of more advanced treatments. A very wide range of observational data is brought to bear upon these problems, including the most recent results from WMAP, the Hubble Space Telescope, galaxy surveys like the Sloan Digital Sky Survey and the 2dF Galaxy Redshift Survey, studies of Type 1a supernovae, and many other observations.
Fuzzy Models and Algorithms for Pattern Recognition and Image Processing
Fuzzy Models and Algorithms for Pattern Recognition and Image Processing presents a comprehensive introduction of the use of fuzzy models in pattern recognition and selected topics in image processing and computer vision. Unique to this volume in the Kluwer Handbooks of Fuzzy Sets Series is the fact that this book was written in its entirety by its four authors. A single notation, presentation style, and purpose are used throughout. The result is an extensive unified treatment of many fuzzy models for pattern recognition. The main topics are clustering and classifier design, with extensive material on feature analysis relational clustering, image processing and computer vision. Also included are numerous figures, images and numerical examples that illustrate the use of various models involving applications in medicine, character and word recognition, remote sensing, military image analysis, and industrial engineering.
Fuzzy Modeling and Fuzzy Control
Fuzzy logic methodology has been proven effective in dealing with complex nonlinear systems containing uncertainties that are otherwise difficult to model. Technology based on this methodology has been applied to many real-world problems, especially in the area of consumer products. This book presents the first unified and thorough treatment of fuzzy modeling and fuzzy control, providing necessary tools for the control of complex nonlinear systems.
Fuzzy Logic in Financial Analysis
This volume systematically sets out the basic elements on which to base financial analysis for business in the new century. It incorporates a previous work that can serve as the basis and foundation to the new contributions that are now being made in the field of financial economy and intend to provide business with instruments and models that are suitable for the treatment of the new economic context.
Future Satellite Gravimetry and Earth Dynamics
Currently, a first generation of dedicated satellite missions for the precise mapping of the Earth’s gravity field is in orbit (CHAMP, GRACE, and soon GOCE). The gravity data from these satellite missions provide us with very new information on the dynamics of planet Earth. In particular, on the mass distribution in the Earth’s interior, the entire water cycle (ocean circulation, ice mass balance, continental water masses, and atmosphere), and on changes in the mass distribution. The results are fascinating, but still rough with respect to spatial and temporal resolution. Technical progress in satellite-to-satellite tracking and in gravity gradiometry will allow more detailed results in the future. In this special issue, Earth scientists develop visions of future applications based on follow-on high-precision satellite gravimetry missions.
Future approaches for safe and effective pain management
Pain is defined as an unpleasant sensory and emotional experience that is associated with actual or potential tissue damage or described in terms of such damage. It is subjective and considered an important physiological mechanism by which humans prevent themselves from developing tissue injury. However, pain patients do not respond to treatment in the same way, which makes it challenging to issue a consistent treatment for all pain conditions. Excessive pain can markedly increase psychological health problems and decrease health‐related quality of life; therefore, pain should be managed appropriately by analgesics. Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. Pain severities as well as responses to analgesics, can also be very variable among sufferer.
Fundamentals of treatment planning : Guidelines on how to develop, plan, write, and deliver a prosthodontic care project
Helps dentists, prosthodontists, and students form and organize their thinking and formulate correct diagnoses and therapies that start with appropriate treatment planning
Fundamentals of Solid State Engineering
Fundamentals of Solid State Engineering, 2nd Edition, provides a multi-disciplinary introduction to Solid State Engineering, combining concepts from physics, chemistry, electrical engineering, materials science and mechanical engineering. Basic physics concepts are introduced, followed by a thorough treatment of the technology for solid state engineering. Topics include compound semiconductor bulk and epitaxial thin films growth techniques, current semiconductor device processing and nano-fabrication technologies. Examples of semiconductor devices and a description of their theory of operation are then discussed, including transistors, semiconductor lasers and photodetectors.
Fundamentals of Robotic Mechanical Systems : Theory, Methods, and Algorithms
Fundamentals of Robotic Mechanical Systems, Third Edition addresses robots at large - such as multi-fingered hands, walking machines, flight simulators, and machine tools - that rely on mechanical systems to perform their tasks. The author establishes the foundations on which the design, control, and implementation of the underlying mechanical subsystems are based. The treatment assumes familiarity with some calculus, linear algebra, and elementary mechanics; however, the elements of rigid-body mechanics and linear transformations are reviewed in the first chapters, making the presentation self-contained.
Fundamentals of operative dentistry : A contemporary approach
Updated with full-color illustrations throughout and substantial revisions in every chapter to incorporate the latest scientific developments and current research findings. In addition, new chapters on color study and shade matching address new areas of focus in the preclinical curriculum. A valuable resource for understanding the scientific basis for current treatment options in dentistry.
Fundamentals of implant dentistry ; Vol.1 : Prosthodontic Principles
Focuses on the design and fabrication of implantretained prostheses. The authors of this definitive textbook cover the full range of restorative treatment options for edentulous and partially edentulous situations, from relatively simple problems that can be handled by a solo practitioner to those with substantial prosthodontic complexities, periodontal compromise of existing dentition, and significant bone and soft tissue defects. Throughout, the authors emphasize the importance of an interdisciplinary approach and demonstrate how it encourages the best results, particularly when restoring partially edentulous patients.
Fundamentals of Data Mining in Genomics and Proteomics
The book presents key analytical techniques used to analyze genomic and proteomic data by detailing their underlying principles, merits and limitations. An important goal of this text is to provide a highly intuitive and conceptual (as opposed to intricate mathematical) account of the discussed methodologies. This treatment will enable readers with interest in analysis of genomic and proteomic data to quickly learn and appreciate the essential properties of relevant data mining methodologies without recourse to advanced mathematics.
Fundamentals of craniofacial malformations ; Vol.2 : Treatment principles
Readers will find detailed discussion of the treatment principles for craniosynostoses, orofacial clefts, branchio-oculo-facial syndromes, soft tissue malformations, dysgnathia and rare syndromes. In addition to description of important facets of treatment and the treatment planning process, guidance is offered on diagnosis and disease classification.
Fundamentals of clinical research : Bridging medicine, statistics and operations
The scope of clinical research is to evaluate the effect of a treatment on the evolution of a disease in the human species.The treatment can be pharmacological, surgical, psychological/behavioral or organizational/logistic. The disease, intended as an impairment of a state of well-being or a condition capable of provoking such impairment over time, can be universally accepted as such (e.g. a cancer or a bone fracture) or perceived as such only by limited groups of individuals in a given cultural context (e.g. hair loss or weight gain). The course of the disease that ones wishes to change can be the one with no intervention or, more frequently, the one observed with the available treatment. The evaluation of the effect of a treatment on the course of a disease is a lengthy process, which progresses in increasingly complex stages.
