الصفحة 2
الصفحة 2
Immunity boosting medicinal plants of the Western Himalayas
Presents a comprehensive guide to traditional immunity-boosting medicinal plants of the Himalayas, their traditional uses, phytochemistry, pharmacology, diversity, conversation, biotechnology, toxicology, as well as future prospective. All the chapters cover the latest advances in ethnobotany, phytochemistry, biochemistry, and biotechnology.
High performance computing for drug discovery and biomedicine
Explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. Collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. And delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects.
High Density Lipoproteins : From Biological Understanding to Clinical Exploitation
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation.
Herbal Products : Toxicology and Clinical Pharmacology
Herbal Products: Toxicology and Clinical Pharmacology, Second Edition builds upon the informative foundation laid by its predecessor. This fully revised and expanded second edition boasts over 200 new references that document efficacy studies and adverse effects and four new chapters devoted to dietary products.
Harmful Cyanobacteria
The purpose of this work is to provide an up-to-date overview of the advances in our knowledge of harmful cyanobacteria. The work is directed towards graduate students and scientists in aquatic microbiology, aquatic ecology, environmental toxicology, and water management, and academic professionals in water management and environmental policy.
Handbook of research on nano-drug delivery and tissue engineering : Guide to strengthening healthcare systems
Provides an important and valuable collection of research accomplishments in nanomedicine, drug delivery, tissue engineering, processing, formulations, and their applications. Addresses topical issues in nano-drug delivery and nanotechnological approaches to tissue engineering. The first section offers research on a variety of diverse nano-based drug delivery systems, along with discussions of their efficacy, safety, toxicology, and applications for different purposes. Focusing on nanotechnology approaches to tissue engineering, part two of the volume considers the use of hydrogel systems, nanoceria and micro- and nano-structured biomaterials for bone tissue engineering, mesenchymal stem cells, and more. This volume is a systematic scientific reference of the novel research developments specifically in this area. The editors give special emphasis on the new trends and developments in the field of nanomedicine that will be very helpful for pharmaceutical and medical researchers, scientists, faculty, and students.
Handbook of plant and animal toxins in food : Occurrence, toxicity, and prevention
Focuses on various selected toxins in foods derived from plants as well as animals. The prominent plant toxins include solanine and chaconine, mushroom toxins, phytates, tannins, oxalates, goitrogens, gossypol, phytohemagglutinins, erucic acid, saponins, cyanogenic glycosides, enzyme inhibitors, BOAA (lathyrogens), toxic amino acids and toxic fatty acids. The prominent animal toxins covered in the book include various seafood toxins, shellfish toxins and biogenic amines. Presents complete information about a plethora of toxins Provides quick and easy access to data on major plant and animal toxins Covers distribution of toxins in the plant and animal kingdom Provides comprehensive information on chemistry, safety and precautions of each toxin
Handbook of pharmacokinetics and toxicokinetics
An effort to blend the common approaches to pharmacokinetics and toxicokinetics. It integrates the principles held in common by both fields through a logical and systematic approach, which includes mathematical descriptions of physical and physiological processes employed in approaches to PK/TK modeling. It emphasizes general principles and concepts and related isolated applications and case studies observations.The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advance courses/workshops and seminars.
Handbook of Drug Monitoring Methods : Therapeutics and Drugs of Abuse
In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic.
Groundwater Geochemistry : A Practical Guide to Modeling of Natural and Contaminated Aquatic Systems
Numerical groundwater flow, transport, and geochemical models are important tools besides classical deterministic and analytical approaches. Solving complex linear or non-linear systems of equations, commonly with hundreds of unknown parameters, is a routine task for a PC. Modeling hydrogeochemical processes requires a detailed and accurate water analysis, as well as thermodynamic and kinetic data as input. Thermodynamic data, such as complex formation constants and solubility-products, are often provided as databases within the respective programs. However, the description of surface-controlled reactions (sorption, cation exchange, surface complexation) and kinetically controlled reactions requires additional input data. Unlike groundwater flow and transport models, thermodynamic models, in principal, do not need any calibration.
Good Research Practice in Non-Clinical Pharmacology and Biomedicine
This book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Good laboratory practice : The why and the how
The GLP regulations have developed from rules on how to exactly document the planning, conduct and reporting of toxicity studies to a quality system for the management of a multitude of study types, from the simple determination of a physical/chemical parameter to the most complex field studies or ecotoxicology studies. At the same time the term “Good Laboratory Practice” has become somewhat of a slogan with the aim to characterise any reliably conducted laboratory work.
Gene drives at tipping points : Precautionary technology assessment and governance of new approaches to genetically modify animal and plant populations
This book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer look at genetically engineered oilseed rape, genetically engineered olive flies as well as plants and animals with so-called gene drives. The book mainly adresses researchers.
Gases and Toxins that Cause Pulmonary Edema
Pulmonary edema is a major health problem in the lung, it is a cardinal feature of congestive heart failure. Pulmonary edema defined as excessive extravascular water in the lungs, is a common and serious clinical problem. Pulmonary edema can be life-threatening, but effective therapy is available to rescue patients from the deleterious consequences of disturbed lung fluid balance, which usually can be identified and, in many instances, corrected. So we like to talk about this common disease because of its importance and its wide spread around the world. Other important causes of pulmonary edema are human exposure to some gases and toxins, the most important of which is chlorine gas, phosgene, mustard gas, heroin, paraquat and ammonia. This research paper will discuss also the procedures that are included, as well as a wider knowledge of these toxins and gases.
Fundamentals of analytical toxicology : Clinical and forensic ; 2nd ed.
An integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques. Focuses on analytical, statistical, and pharmacokinetic principles / Describes basic methodology, including colour tests and immunoassay and enzyme-based assays / Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation / Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides / Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS)
Forensic Pathology Reviews ; Vol. 4
Building on the excellent foundation laid in earlier volumes of the series, leading forensic pathologists from the United States and around the world again provide in Forensic Pathology Reviews, Volume 4 evidence-based accounts of special topics of current interest from various fields of forensic pathology and death-scene investigation. The authors offer cutting-edge insights into death from environmental conditions (lightning and elder abuse), homicide by sharp force, death from natural causes (asthma, Marfan syndrome, and peliosis of the liver and spleen), and pathology of human endothelium in septic organ failure.
Food safety and toxicology : Present and future perspectives
Safety assurance of consumer goods has become a global challenge. The presence of natural and synthetic contaminants in food compromises food safety and poses a risk to public health. Discusses biological and chemical food contaminants, predictive and detection methods of food toxicants, survival mechanism of food pathogens, legislation on microbial contaminants to prevent public health risks and strategies to mitigate contamination.
Fish and Diadromy in Europe (ecology, management, conservation)
This book contains selected papers from an international symposium organised by the Diadfish network held in Bordeaux (France) in 2005. Readers will find up-to-date information on the ecology, ecotoxicology and physiology of several diadromous species (Atlantic salmon, shads, lampreys, eels) and this whole group in Europe. Main impacts are also documented and analysed in case studies, and solutions or remediation actions are presented.
Exosomes based drug delivery strategies for brain disorders
Provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.
Eutrophication Management and Ecotoxicology
This book aims to bridge the gap between ecotoxicology and limnology. The intended readers of the book are water managers, policy makers with a scientific background as well as researchers/advisors in the area of water management. The book provides an ecotoxicological perspective on lake management and describes eutrophication of shallow, temperate lakes. It surveys the influence of toxic substances (e.g., agricultural pesticides) on the aquatic ecosystem, especially the relation between algae and daphnids. The message of the book is that nutrients such as phosphorus are not the only important factor in explaining and managing eutrophication: toxic disturbance of to-down control is also an important factor to be considered. The results of extensive studies and experiments (some unpublished) on lake eutrophication are presented in this book.
