الصفحة 2
الصفحة 2
New strategies in treating and diagnosing of Myeloid Leukemia
Leukemia is a cancer of white blood cells. It is characterized by an abnormal accumulation of WBC in the bone marrow which leads to bone marrow failure. in this project, we will observe myeloid leukemias (acute & chronic), Clinical Practice Guidelines for leukemia provide recommendations on the diagnostic evaluation, and applied treatment in Syria and Germany for induction and consolidation for patients and we're going to devote a special paragraph on therapy with monoclonal antibodies. Gilteritinib are new therapies for acute myeloid leukemia and we're going to suggest them in detail.
New product development : An empirical approach to study of the effects of innovation strategy, organization learning and market Conditions
New product development (NPD) is considered as a process of learning. Successful NPD projects typically rely on knowledge and experience of multi-function teams. In addition to corporate strategy and organization learning, the external factors such as, market and competitive conditions also play a big role in driving business strategies.
New Frontiers in Social Innovation Research
Interest in social innovation continues to rise, from governments setting up social innovation 'labs' to large corporations developing social innovation strategies. Yet theory lags behind practice, and this hampers our ability to understand social innovation and make the most of its potential. This collection brings together work by leading social innovation researchers globally, exploring the practice and process of researching social innovation, its nature and effects. Combining theoretical chapters and empirical studies, it shows how social innovation is blurring traditional boundaries between the market, the state and civil society, thereby developing new forms of services, relationships and collaborations. It takes a critical perspective, analyzing potential downsides of social innovation that often remain unexplored or are glossed over, yet concludes with a powerful vision of the potential for social innovation to transform society.
New Concepts of Antiviral Therapy
Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA).
Neurology Oral Boards Review : A Concise and Systematic Approach to Clinical Practice
Rapid recall of vast amounts of factual material is the key to success in both the Neurology Oral Board examination and in everyday patient care. In Neurology Oral Boards Review: A Concise and Systematic Approach to Clinical Practice, Eroboghene E. Ubogu offers a comprehensive review of relevant topics and examination strategies needed to pass the American Board of Psychiatry and Neurology (ABPN) Part II (Oral) exam, complete with up-to-date, evidence-based guidelines on diagnosis and management in clinical neurology. The author has written the book specifically to satisfy the requirements of the ABPN, with clinical case vignettes designed to allow the examinee to localize the plausible disease process, to indicate which investigations may help in establishing a diagnosis, to deduce treatment plans, and to make a prognosis, including patient and family counseling. The emergency cases test the ability to think critically when faced with a neurological emergency, putting a premium on resuscitation, patient safety, and rapid high-yield investigations. The general neurology cases reflect the breadth of disorders experienced in hospital and outpatient settings. The author also provides a detailed description of the oral ABPN examination and suggests a study regimen that takes into account the difficulties of allotting time to prepare while in post-residency training or practice.
Neurocutaneous disorders : A clinical, ciagnostic and therapeutic approach
Provides extensive data on the more common and many of the more rare congenital and hereditary syndromes that manifest in the nervous system and skin. Though often complex and multi-systemic, these disorders can frequently be diagnosed using a combination of simple visual inspection and sound clinical expertise. Drawing on fully referenced information from thousands of articles, the international editorial team has prepared a comprehensive overview that includes historical perspectives, clinical features, the pathogenesis, and diagnostic and therapeutic strategies. In addition, it addresses the biochemical, molecular, and genetic basis of the disorders.
NEURO-COVID-19 : Neuroinvasive potential and neurological complications of SARS-CoV-2
From the earliest days of the COVID-19 pandemic, there have been reports of significant neurological and psychological symptoms following SARS-CoV-2 infection. This research paper is designed to examine the potential psychoneuroendocrine pathogenic mechanisms by which SARS-CoV-2 elicits psychiatric sequelae, as well as to posit potential pharmacologic strategies to address and reverse these pathologies. Following a brief overview of the presence and prevalence of neuropsychiatric manifestation in COVID-19 patients, we address mechanisms by which SARS-CoV-2 could enter or otherwise elicit changes in the CNS.
Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders : Novel Strategies for Research and Treatment
Over the past few decades the involvement of neurosteroids in brain function and mental health has attracted much interest, not only from a neuroscience perspective, but also from clinical and therapeutic aspects. In recent years, much of the research has focused on the multifunctional position of neurosteroids in the nervous system. The areas that have been explored, in particular, are the cellular and molecular mechanisms involved in the activity of neurosteroids in the brain, the role of neurosteroids in brain development, neurodegeneration and neuroplasticity, and their pharmacological properties. The large increase in the number of publications highlights this amplified interest in neurosteroids. Over the last 7 years at least 400 papers have been published describing the putative role of neurosteroids in the modulation of basic brain function and in the etiology and treatment of psychiatric and neurological disorders.
Neonatal Cranial Ultrasonography
It provides important information on brain maturation in the (preterm) neonate and enables the detection of frequently occurring brain anomalies in both preterm and full term neonates. Furthermore, it can be repeated as often as is necessary. In this edition of Neonatal Cranial Ultrasonography, the focus is on the basics of the technique, from patient preparation through to screening strategies and the classification of abnormalities. Many new ultrasound images have been included to reflect the improvements in image quality since the first edition. Essential information is provided about both the procedure itself and the normal ultrasound anatomy. Standard technique using the anterior fontanelle as the acoustic window is described and illustrated, but emphasis is also placed on the value of supplementary acoustic windows.
Navigating digital communication and challenges for organizations
Presents a range of methods, strategies, and viewpoints on digital communication and offers an in-depth analysis of the wide range of organisational and strategic communication topics, related concepts, cross-cultural perspectives, and principles to develop interdisciplinary approaches to digital and organisational communication.
Nature Inspired Cooperative Strategies for Optimization (NICSO 2007)
The aim for NICSO 2007 was to provide a forum were the latest ideas and state of the art research related to cooperative strategies for problem solving arising from Nature could be discussed. The contributions collected in this book were strictly peer reviewed by at least three members of the international programme committee, to whom we are indebted for their support and assistance. The topics covered by the contributions include several well established nature inspired techniques like Genetic Algorithms, Ant Colonies, Artificial Immune Systems, Evolutionary Robotics, Evolvable Systems, Membrane Computing, Quantum Computing, Software Self Assembly, Swarm Intelligence, etc.
Natural Compounds as Drugs ; Vol. II
This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Natural Compounds as Drugs ; Vol. I
This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Nato And Terrorism : On Scene : New Challenges for First Responders and Civil Protection
This book provides information about how leading agencies across the NATO membership are preparing to confront and respond to terrorists deploying Weapons of Mass Destruction (WMD), Weapons of Mass Killing (WMK) and Weapons of Mass Disruption (WMDi). Based on contributions by experts from NATO member states, Israel and the Russian Federation, this book offers information on fourth generation warfare as a new challenge to first responders. It also provides a variety of insights into methods for preparing for and responding to WMD-, WMK-, and WMDi-events, using new technologies and strategies. Furthermore, the book offers solution for restoring the community to functioning after such a major terror attack. Topics include preparing, planning, operations, equipment, training and unique applications of existing technologies for countering terrorist attacks against cities and their infrastructure.
Narrowing the Achievement Gap : Strategies for Educating Latino, Black, and Asian Students
This volume is an important and impressive collection of scholarship that addresses one of the more intractable education problems of our times--ensuring that ALL children receive a quality education." -- Gloria Ladson-Billings, Kellner Family Professor in Urban Education University of Wisconsin at Madison, and 2005-2006 President of AERA "A major contribution to the field, the in-depth analyses provided by the chapter authors should be of substantial appeal to a wide audience because of its interdisciplinary approach and orientation to theory, research, and practice." -- Stanley Sue, Distinguished Professor of Psychology and Asian American Studies University of California at Davis "In considering the broad problems and in recommending solutions, the book provides breadth, concision, and unique organization." -- Edmund W. Gordon, John M.
Narrating China's Governance : Stories in Xi Jinping's Speeches
This book captures and elaborates on the skill of storytelling as one of the distinct leadership features of Xi Jinping, the General Secretary of the Communist Party of China and the President of the People’s Republic of China.
Nanotechnology in endodontics : Current and potential clinical applications
Provides detailed information on the emerging applications of nanomaterials and nanoparticles within endodontics, highlighting the exciting potential clinical impact of nanotechnology in the field. The range of applications covered is diverse, encompassing drug and gene delivery, tissue engineering, antibacterial strategies, dentin tissue stabilization, dentin pulp regeneration and use in restorative and endodontic materials. Important scientific background information relating to each application is provided, with clear coverage of basic principles. In addition, potential pitfalls are identified and explained. The cytotoxicity of nanomaterials and nanoparticles is also addressed in a separate chapter. The book will be of value both for endodontic practitioners and for all scientists and graduate students who are interested in the application of nanotechnology in endodontics.
Nanoparticle-Based Drug Delivery in Cancer Treatment
Discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Focuses on : Recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Material platforms that establish NPs and both localized and controlled gene silencing The most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment The most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells
Myelodysplastic Syndromes
This book summarizes our current knowledge of MDS, from very basic aspects to the clinical management. It provides guidance to the diagnosis, an understanding of disease mechanisms, and a discussion of treatment strategies.
Mutagenic Impurities : Strategies for Identification and Control
In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective.
