الصفحة 2
الصفحة 2
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Molecular Biology of the Parathyroid
Caintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Modulation of host gene expression and innate immunity by viruses
This book is reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases.
Modulated Temperature Differential Scanning Calorimetry : Theoretical and Practical Applications in Polymer Characterisation
This book provides both a basic and advanced treatment of the theory of the technique followed by a detailed exposition of its application to reacting systems, blends and semicrystalline polymers by the leaders in all of these fields. It is an essential text for anybody interested in calorimetry or polymer characterization, especially if they have found that conventional DSC cannot help them with their problems.
Modular Programming Languages ; 7th Joint Modular Languages Conference, JMLC 2006, Oxford, UK, September 13-15, 2006, Proceedings
On behalf of the Steering Committee we are pleased to present the proceedings of the 2006 Joint Modular Languages Conference (JMLC), organized by Oxford Brookes University, Oxford, UK and held at Jesus College, Oxford. The mission of JMLC is to explore the concepts of well-structured programming languages and software and those of teaching good design and programming style. JMLC 2006 was the seventh in a series of successful conferences with themes including the construction of large and distributed software systems, and software en- neering aspects in new and dynamic application areas.
Modular Forms
It provides the reader with the basic knowledge of elliptic modular forms necessary to understand the recent developments in number theory. The first part gives the general theory of modular groups, modular forms and Hecke operators, with emphasis on the Hecke-Weil theory of the relation between modular forms and Dirichlet series. The second part is on the unit groups of quaternion algebras, which are seldom dealt with in books. The so-called Eichler-Selberg trace formula of Hecke operators follows next and the explicit computable formula is given. In the last chapter, Eisenstein series with parameter are discussed following the recent work of Shimura: Eisenstein series are likely to play a very important role in the future progress of number theory, and this chapter provides a good introduction to the topic.
Modular Algorithms in Symbolic Summation and Symbolic Integration
Brings together two streams in computer algebra: symbolic integration and summation on the one hand, and fast algorithmics on the other hand. In many algorithmically oriented areas of computer science, the analysis of al gorithms placed into the lime light by DonKnuth’stalkat the 1970ICM –provides a crystal-clear criterion for success. The researcher who designs an algorithm that is faster (asymptotically, in the worst case) than any previous method receives instant gratification : her result will be recognized as valuable. Al as, the downside is that such results come along quite infrequently, despite our best efforts. An alternative evaluation method is to run a new algorithm on examples; this has its obvious problems, but is sometimes the best we can do. George Collins, one of the fathers of computer algebra and a great experimenter,wrote in 1969: “I think this demonstrates again that a simple analysis is often more revealing than a ream of empirical data (although both are important). ” Within computer algebra, some areas have traditionally followed the former methodology, notably some parts of polynomial algebra and linear algebra. Other areas, such as polynomial system solving, have not yet been amenable to this - proach. The usual “input size” parameters of computer science seem inadequate, and although some natural “geometric” parameters have been identified (solution dimension, regularity), not all (potential) major progress can be expressed in this framework. Symbolic integration and summation have been in a similar state.
Models, Methods and Tools for Product Service Design : The Manutelligence Project
This book summarizes research being pursued within the Manutelligence project, the goal of which is to help enterprises develop smart, social and flexible products with high value added services. Manutelligence has improved Product and Service Design by developing suitable models and methods, and connecting them through a modular, collaborative and secure ICT Platform. The use of real data collected in real time by Internet of Things (IoT) technologies underpins the design of product-service systems and makes it possible to monitor them throughout their life cycle. Available data allows costs and sustainability issues to be more accurately measured and simulated in the form of Life Cycle Cost (LCC) and Life Cycle Assessment (LCA). Analysing data from IoT systems and sharing LCC and LCA information via the ICT Platform can help to accelerate the design of product-service systems, reduce costs and better understand customer needs. Industrial partners involved in Manutelligence provide a clear overview of the project's outcomes, and demonstrate how its technological solutions can be used to improve the design of product-service systems and the management of product-service life cycles.
Modeling and simulation tools for emerging telecommunication networks : Needs, trends, challenges and solutions
This book contains a selection of papers presented at a symposium organized under the aegis of COST Telecommunications Action 285. The main objective of the Action is to enhance existing tools and develop new modeling and simulation tools for research in emerging multi-service telecommunication networks in the areas of model performance improvements, multilayer traffic modeling, and the important issue of evaluation and validation of the new modeling tools.
Modeling and Simulation in Scilab
Scilab is a free open-source software package for scientific computation. It includes hundreds of general purpose and specialized functions for numerical computation, organized in libraries called toolboxes, which cover such areas as simulation, optimization, systems and control, and signal processing. One important Scilab toolbox is Scicos. Scicos provides a block diagram graphical editor for the construction and simulation of dynamical systems. The objective of this book is to provide a tutorial for the use of Scilab/Scicos with a special emphasis on modeling and simulation tools. The book is divided into two parts. The first part concerns Scilab and includes a tutorial covering the language features, the data structures and specialized functions for doing graphics, importing, exporting data and interfacing external routines. It also covers in detail Scilab numerical solvers for ordinary differential equations and differential-algebraic equations. Even though the emphasis is placed on modeling and simulation applications, this part provides a global view of Scilab. The second part is dedicated to modeling and simulation of dynamical systems in Scicos. This type of modeling tool is widely used in industry because it provides a means for constructing modular and reusable models. This part contains a detailed description of the editor and its usage, which is illustrated through numerous examples.
Modeling and Simulation for RF System Design
The focus of Modeling and Simulation for RF System Design lies on RF specific modeling and simulation methods and the consideration of system and circuit level descriptions. It contains application-oriented training material for RF designers which combines the presentation of a mixed-signal design flow.
Model Driven Engineering Languages and Systems ; 11th International Conference, MoDELS 2008, Toulouse, France, September 28 - October 3, 2008. Proceedings
The book also contains three keynote speeches and contributions to workshops, symposia, tutorials and panels at the conference. The papers are organized in topical sections on Model Transformation: Foundations; Requirements Modeling; Domain-Specific Modeling; Model Transformation: Techniques, Composition and Analysis of Behavioral Models; Model Comprehension; Model Management; Behavioral Conformance and Refinement; Metamodeling and Modularity; Constraints; Model Analysis; Service-Oriented Architectures; Adaptive and Autonomic Systems; Empirical Studies; Evolution and Reverse Engineering; Modeling Language Semantics; Dependability Analysis and Testing; Aspect-Oriented Modeling; Structural Modeling;and Embedded Systems.
Model and Design of Bipolar and MOS Current-Mode Logic : CML, ECL and SCL Digital Circuits
many works and results have been published which reinforce the importance of Current-Mode digital circuits. In the topic of Current-Mode digital circuits, the authors properly exploited classical paradigms developed and used in the analog circuit domain (a topic in which one of the authors maturated a great experience).
MIMO Signals and Systems
The book provide a basic understanding of the fundamentals, implementation, and of MIMO techniques. For easier comprehension, these applications techniques, in conjunction with several "classic" algorithms, are illustrated by means of numerous worked examples.
Microwave engineering ; 4th ed.
Includes more material on active circuits, noise, nonlinear effects, and wireless systems. Chapters on noise and nonlinear distortion, and active devices have been added along with the coverage of noise and more material on intermodulation distortion and related nonlinear effects. On active devices, there's more updated material on bipolar junction and field effect transistors. New and updated material on wireless communications systems, including link budget, link margin, digital modulation methods, and bit error rates is also part of the new edition. Other new material includes a section on transients on transmission lines, the theory of power waves, a discussion of higher order modes and frequency effects for microstrip line, and a discussion of how to determine unloaded Q from resonator measurements
Microinvasive Dentistry : Clinical Strategies and Tools
A comprehensive guide to techniques, technologies and tools used in microinvasive dentistry. Divided into four sections, the text begins with an overview of caries and its prevention. The following sections provide in depth discussion on diagnosis through various imaging devices, then different treatment options and technologies. The final section covers future developments including enamel regeneration and photobiomodulation.
Medicinal roots and tubers for pharmaceutical and commercial applications
The root and tuber are vital parts of medicinal plants providing mechanical support, producing critical growth regulators, and storing food. Bioactive compounds obtained from plant roots and tubers demonstrate health benefits presenting antioxidative, antimicrobial, hypoglycaemic, hypocholesterolaemic, and immunomodulatory properties. Roots of many medicinal plants have been used for the treatment of disease and formulation of drugs, and they are also known for their commercial value, being used as an ingredient in the pharmaceutical and cosmetic industries.
Medicinal foods as potential therapies for type-2 diabetes and associated diseases : The chemical and pharmacological basis of their action
Focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. Provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries.
Medicinal compounds in modern healthcare : From tradition to innovation
Reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.
IQ Calibration Techniques for CMOS Radio Tranceivers
There are a lot of factors that degrade the matching of gains and phases between I/Q signals: the instinct layout mismatch, the random mismatch of the devices, the different temperatures over the I/Q signal paths. IQ Calibration Techniques For CMOS Radio Transceivers describes a fully-analog compensation technique without baseband circuitry to control the calibration process. This book will use an 802.11g transceiver design as an example to give a detailed description on the I/Q gains and phases imbalance auto-calibration mechanism.
