الصفحة 2
الصفحة 2
Microarray technology and cancer gene profiling
Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
Metabolomics : The frontier of systems biology
Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
Metabolome Analyses : Strategies for Systems Biology
Metabolome Analyses is intended as a follow-up to Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Kluwer, 2003). That text offered guidelines to currently available technology, bioinformatics and databases. Evidence was presented showing metabolic profiling as a valuable addition to genomics and proteomics strategies devoted to drug discovery and development. This book focuses on how metabolic profiling is being more comprehensively integrated with the other "omics" technologies. It provides more practical applications of such "panomics" or "Systems Biology" approaches. The expanding use of mass spectrometry as a measurement technology in metabolic profiling is addressed through demonstrated applications. The integration of metabolic profiling and proteomics is probably most developed for plant-based studies, which was not addressed in Volume 1. Other areas related to metabolic profiling continue to show significant development. These include database strategies and an increased acceptance by the pharmaceutical industry of metabolic profiling. Also covered is the use of in silico metabolic networks. Again the focus is primarily on the pharmaceutical industry but the importance of metabolic profiling to studies on human nutrition (a burgeoning area) is discussed.
Introduzione alla medicina molecolare = Introduction to molecular medicine
An indispensable guide for understanding a young science with rapid and promising developments. Now in its third completely revised edition, it presents in a concise yet comprehensive way the scientific and technological principles of this discipline and provides, in widely accessible language, the basic conceptual tools for understanding the human genome, gene expression and regulation, the various aspects of genetic engineering that allow for the manipulation of DNA, and human cloning.
Introduction to Computational Biology : An Evolutionary Approach
Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology. This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors.
Interval / Probabilistic Uncertainty and Non-Classical Logics
Contains proceedings of the first international workshop that brought together researchers working on interval and probabilistic uncertainty and on non-classical logics. We hope that this workshop will lead to a boost in the much-needed collaboration between the uncertainty analysis and non-classical logic communities, and thus, to better processing of uncertainty.
Intelligence and security informatics : Biosurveillance ; 2nd NSF Workshop, BioSurveillance 2007, New Brunswick, NJ, USA, May 22, 2007, Proceedings
The 2007 NSF BioSurveillance Workshop (BioSurveillance 2007) was built on the success of the first NSF BioSurveillance Workshop, hosted by the University of Arizona’s NSF BioPortal Center in March 2006.
Implementation and Application of Automata ; Vol. 4094 ; 11th International Conference, CIAA 2006, Taipei, Taiwan, August 21-23, 2006, Proceedings
This book constitutes the refereed proceedings of the 11th International Conference on Implementation and Application of Automata, CIAA 2006, held in Taipei, Taiwan, in August 2006.
Immunoinformatics
Immunoinformatics is an emerging subdiscipline of bioinformatics. It utilizes mathematics, information science, computer engineering, genomics, proteomics and immunological methods to bridge immunology and informatics. Similar to bioionformatics which became a driving force in genome research, immunoinformatics enables data-driven research strategies and systems approaches that aim at understanding the networks regulating the immune system. Considering the breath of topic, Immunoinformatics was composed to provide a cross-section of research ranging from data integration, epitope predictions to systems level applications. In ten chapters experts in the field introduce and discuss research strategies for immunologists and bioinformaticians who wish to endeavour existing and new approaches to gain insight into the workings of the immune system.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Immune mediators in cancer : Methods and protocols
Provides a comprehensive collection of classic and cutting-edge methodologies as well as bioinformatics and genome-editing approaches that are used to quantify immune mediators and analyze their function and biological activity in cancer cells and tissues. Beginning with a section on the detection of immune mediators in samples, the volume continues with sections covering cytokine bioassays, the expression and regulation of immune mediators in cancer cells, and methods to navigate the enormous datasets created by modern DNA and RNA sequencing and proteomic technology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immobilisation of DNA on Chips II
DNA chips are gaining increasing importance in different fields ranging from medicine to analytical chemistry with applications in the latter in food safety and food quality issues as well as in environmental protection. In the medical field, DNA chips are frequently used in arrays for gene expression studies to identify diseased cells due to over- or under-expression of certain genes, to follow the response of drug treatments, or to grade cancers), for genotyping of individuals, for the detection of single nucleotide polymorphisms, point mutations, and short tandem reports, or moreover for genome and transcriptome analyses in the quasi post-genomic sequencing era. Furthermore, due to some unique properties of DNA molecules, self-assembled layers of DNA are promising candidates in the field of molecular electronics.the main focus of these two volumes is on the immobilization chemistry, considering the various aspects of the immobilization process itself, since different types of nucleic acids, support materials, surface activation chemistries and patterning tools are of key concern.
Human microbiome : Clinical implications and therapeutic interventions
The human microbiome refers to the complete microorganisms inhabiting the human body sites including skin, ear, nose, oral cavity, the genital, gastrointestinal and respiratory tracts, and body fluids such as breast milk, saliva, and urine. It is a significant and essential organ recognized for the body and has an established involvement in the host wellbeing, in terms of nutritional requirements and immunomodulation. Talks about how alteration and imbalance in the same can have clinical implications associated with a multitude of gastrointestinal, lifestyle-associated, and neurodegenerative disorders. How the proliferation of specific groups of bacteria and their metabolic activities, as a result of intestinal dysbiosis leads to the 'leaky gut' condition thereby influences brain activity via the bidirectional gut-brain axis. It also coves the importance of microbial seeding and how it can be influenced by the mode of delivery, nutrition, and medication. This book also provides various therapeutic interventions such as the establishment of stool banks and Faecal microbiota transplantation (FMT) that have recently proved promising in the treatment of ASD, Inflammatory Bowel Disease, and Ulcerative Colitis. This book provides a deeper understanding of the development of the human gut microbiome and the factors driving its dysbiosis. This book is a valuable read for health professionals, medical students, nutritionists, and scientific research communities who are eager to update themselves with recent trends in microbiome research. It will also aid gastroenterologists and nutritionists to make well-informed choices regarding therapeutic regimes.
Hepatitis Delta Virus ; Vol. 307
Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
Growth, Differentiation and Sexuality
Since publication of the first edition of Volume I in 1994, the field of fungal biology has developed tremendously, mainly through the advancement of various molecular techniques and international fungal genome projects. To accommodate these developments, the second edition has been completely updated. Six chapters have been revised by former authors, others by newly recruited experts, and also novel subjects, emerged in more recent years, have been added to the book. Leading scientists in the field have compiled comprehensive overviews as well as latest results obtained from cytological, genetic and molecular studies. Topics include: cellular and colony growth of fungi, cellular fusion and incompatibility, senescence and programmed cell death, environmental and physiological signalling in differentiation processes, asexual and sexual reproduction, mitosis and meiosis of various types of fungi. Both parallels and differences become visible between individual fungi as well as between fungal classes.
Grid computing in life science ; 1st International Workshop on Life Science Grid, LSGRID 2004 Kanazawa, Japan, May 31-June 1, 2004, Revised Selected and Invited Papers
Researchers in the ?eld of life sciences rely increasingly on information te- nology to extract and manage relevant knowledge. The complex computational and data management needs of life science research make Grid technologies an attractive support solution. However, many important issues must be addressed before the Life Science Grid becomes commonplace. The 1st International Life Science Grid Workshop (LSGRID 2004) was held in Kanazawa Japan, May 31–June 1, 2004. This workshop focused on life s- ence applications of grid systems especially for bionetwork research and systems biology which require heterogeneous data integration from genome to phenome, mathematical modeling and simulation from molecular to population levels, and high-performance computing including parallel processing, special hardware and grid computing.
Golden gate cloning : Methods and protocols
Provides an overview of the latest protocols that cover the full range of in silico, in vitro, and in vivo approaches to help researchers plan, design, and perform Golden Gate cloning experiments. The chapters in this book cover topics such as Golden Gate cloning of standardized parts; modular DNA construct design for high-throughput Golden Gate Assembly; Golden Gate cloning of Synthetic CRISPR RNA spacer sequences; Golden Gate cloning in Actinobacteria; and YeastFab cloning of toxic genes and protein expression optimization in yeast.
Genomics of Tropical Crop Plants
Genomics of Tropical Crop Plants summarizes recent progress on genomic research, including the development of molecular markers, genomic and cDNA libraries, expressed sequence tags (ESTs), genetic and physical maps, gene expression profiles, and whole genome sequences for 20 tropical crop plants. It offers background information about the evolutionary origin and environments of tropical crop species, international programs that are addressing the needs of tropical agriculture, and the potential for new technologies to increase the productivity and value of tropical crops. This book provides new dimensions to growing information concerning temperate crops and their morphology, physiology, and parallel evolution in diverse plant lineages.
Genomics of Disease
Genomics of Disease is the 24th volume in the Stadler Genetics Symposium series published by Springer, which has, over many years, served as a comprehensive collection of current trends and hot topics in the field of genetics. The current volume summarizes recent progress in our attempts to characterize the genomics of plant and animal diseases. Authoritative analytical reviews are specialized to be attractive to professional researchers, teachers, and students, while also being appealing to a wider audience of scientists in related disciplines. Genomics of Disease offers essential reference material for any scientist or teacher working in the fields of plant and animal diseases. Coverage of key areas of both animal and plant disease is a unique feature of this volume and one that allows direct comparisons between the systems. All academics, scientists, and industry professionals that desire to take advantage of the most up-to-date information on the continuously emerging and expanding field of the genomics of plant and animal diseases will find it an invaluable resource.
Genomic Disorders : The Genomic Basis of Disease
In Genomic Disorders: The Genomic Basis of Disease, distinguished experts and pioneers in the field of genomics and genome rearrangements summarize and synthesize the tremendous amount of data now available in the postgenomic era on the structural features, architecture, and evolution of the human genome.
