الصفحة 2
الصفحة 2
Modulation of host gene expression and innate immunity by viruses
This book is reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases.
Modern Genome Annotation : The Biosapiens Network
An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.
Modeling Communication with Robots and Virtual Humans ; Second ZiF Research Group International Workshop on Embodied Communication in Humans and Machines, Bielefeld, Germany, April 5-8, 2006, Revised Selected Papers
The 17 articles in this state-of-the-art survey address artificial intelligence research on communicative agents and also provide an interdisciplinary perspective from linguistics, behavioral research, theoretical biology, philosophy, communication psychology, and computational neuroscience. The topics include studies on human multimodal communication; the modeling of feedback signals, facial expression, eye contact, and deception; the recognition and comprehension of hand gestures and head movements; communication interfaces for humanoid robots; the evolution of cognition and language; emotion and social appraisal in nonverbal communication; dialogue models and methodologies; theory of mind and intentionality; complex systems, dynamic field theory, and connectionist modeling.
Mix-Design and Application of Hydraulic Grouts for Masonry Strengthening
Provides guidance for the rational design and application of hydraulic grouts, based on a series of specific data (type of masonry, voids' width, targeted strength and durability level, available materials, etc.). To this end, the basic characteristics of a grout, i.e. its injectability (penetrability, fluidity and stability), its strength and durability, are taken into account by means of rational models and quantified expressions of all grout-design parameters. Thus, a holistic, rational mix design methodology for optimization of grout composition is given, permitting the preliminary design of grouts, without having to resort to multiple tests in advance.
Microsoft Visual C# Step by Step
Guide to Microsoft Visual C# fundamentals with Visual Studio. Expand your expertiseand teach yourself the fundamentals of programming with the latest version of Visual C# with Visual Studio. If you are an experienced software developer, you'll get all the guidance, exercises, and code you need to start building responsive, scalable, cloud-connected applications that can run almost anywhere. Discover how to: Quickly start creating Visual C# code and projects with Visual Studio Work with variables, operators, expressions, methods, and program flow Build more robust apps with error, exception, and resource management Spot problems fast with the Visual Studio debugger Make the most of improvements to C# methods, parameters, and switch statements Master the C# object model, and create your own functional data structures Leverage advanced properties, indexers, generics, and collection classes Create Windows 10 apps that share data, collaborate, and use cloud services Integrate Cortana to voice-enable your applications Perform complex queries over object collections with LINQ
Microarrays in Inflammation
The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to extend their knowledge about microarrays and the application thereof. After reading the book a researcher or clinician should be in the position to plan, perform and analyse or to critically review microarray experiments related to inflammation research.
Microarray technology and cancer gene profiling
Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
Methods of microarray data analysis V
In this volume, all investigators analyzed a single dataset on the lifecycle of the most deadly of malaria parasites, Plasmodium falciparum. The emphasis this year is on the application of novel and existing computational methodologies towards infectious disease. We highlight an introductory chapter by Raphael D. Isokpehi, a leading expert in the field of malaria. Ten of the papers presented at the conference are included, which range from the inference of genetic networks to the analysis of the spatial correlation of array data. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art in microarray data analysis.
Methods of microarray data analysis IV
As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA conference plays a role in this evolving field by providing a forum in which investors can analyze the same data sets using different methods. METHODS OF MICROARRAY DATA ANALYSIS IV is the fourth book in this series, and focuses on the important issue of associating array data with a survival endpoint. Previous books in this series focused on classification (Volume I), pattern recognition (Volume II), and quality control issues (Volume III). In this volume, four lung cancer data sets are the focus of analysis. We highlight three tutorial papers, including one to assist with a basic understanding of lung cancer, a review of survival analysis in the gene expression literature, and a paper on replication. In addition, 14 papers presented at the conference are included. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art of microarray data analysis.
Methods in Gut microbial ecology for ruminants
As a result of various human activities, such as increase in human population,decrease in arable land due to soil degradation, urbanization, industrialization and associated increase in the demand for livestock products, dramatic changes are occurring in the global ruminant livestock sector. These changes includeshift inthesize of regional livestock populations and in the types of management and feeding systems under which ruminant livestock are held, and increased demand of a wider range of quality attributes from animal agriculture, not just of the products themselves but also of the methods used in their production. The livestock sector will need to respond to new challenges of increasing live stock productivity while protecting environment and human health and conservingbiodiversity and natural resources. The micro-organisms in the digestive tracts of ruminant livestock have a profound in?uence on the conversion offeedinto end products, which can impact on the- imal and theenvironment. As the livestock sector grows particularly in developing countries, there will be an increasing need to understand these processes for b- ter management and use ofbothfeed and other natural resources that underpinthe development of sustainable feeding systems.
Metabolomics : The frontier of systems biology
Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
Measurement Uncertainty : An Approach via the Mathematical Theory of Evidence
This text is the first to make full use of the mathematical theory of evidence to express the uncertainty in measurements. It gives an overview of the current standard, then pinpoints and constructively resolves its limitations through its unique approach. The text presents various tools for evaluating uncertainty, beginning with the probabilistic approach and concluding with the expression of uncertainty using random-fuzzy variables. The exposition is driven by numerous examples. The book is designed for immediate use and application in research and laboratory work.
Meaning and Language : Phenomenological Perspectives
This book is the first anthology to provide a wide-ranging picture of how phenomenology relates to language. It contains both in-depth studies on new aspects of language in Husserl’s thought as well as original phenomenological research that explores the respective potentials and limits of linguistic expression and conceptualization.
Introduzione alla medicina molecolare = Introduction to molecular medicine
An indispensable guide for understanding a young science with rapid and promising developments. Now in its third completely revised edition, it presents in a concise yet comprehensive way the scientific and technological principles of this discipline and provides, in widely accessible language, the basic conceptual tools for understanding the human genome, gene expression and regulation, the various aspects of genetic engineering that allow for the manipulation of DNA, and human cloning.
Introduction to Systems Biology
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
Introduction aux méthodes numériques
Au cours de l’histoire, les méthodes de calcul ont été l’expression de pratiques sans cesse renouvelées. Le développement de l’informatique a largement contribué à une rapide progression de l’ensemble des techniques numériques. En moins de cinquante ans, le paysage algorithmique a été complètement transformé. Aujourd’hui, la plupart des logiciels que nous employons font appel à des méthodes de plus en plus efficaces. Dans les simulations, comme dans les modélisations, l’analyse numérique occupe une place centrale. Composants essentiels de la vie scientifique, les méthodes et algorithmes qui sont présentés ici, illustrés par de nombreux exemples, sont mis à la portée de tous. De l’approximation polynomiale à la résolution d’équations aux dérivées partielles par des méthodes de différences, de volumes et d’éléments finis, ce livre offre un large panorama des méthodes numériques actuelles.
Introducing architectural tectonics
Focuses on the tectonic analysis of twenty contemporary works of architecture located in eleven countries including Germany, Italy, United States, Chile, Japan, Bangladesh, Spain, and Australia and designed by such notable architects as Tadao Ando, Herzog & de Meuron, Kengo Kuma, Olson Kundig, and Peter Zumthor. Although similarities do exist between the projects, their distinctly different characteristics – location and climate, context, size, program, construction methods – and range of interpretations of tectonic expression provide the most significant lessons of the book, helping you to understand tectonic theory. Written in clear, accessible language, these investigations examine the poetic creation of architecture, showing you lessons and concepts that you can integrate into your own work, whether studying in a university classroom or practicing in a professional office.
Intermediate Filaments
Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.
Interferon : The 50th Anniversary
A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine's most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction.
Intercultural Collaboration ; 1st International Workshop, IWIC 2007 Kyoto, Japan, January 25-26, 2007 Invited and Selected Papers
This book presents 29 revised invited and selected lectures given by top-researchers at the First International Workshop on Intercultural Collaboration, IWIC 2007, held in Kyoto, Japan in January 2007.
