الصفحة 2
الصفحة 2
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Fundamentals of implant dentistry ; Vol.1 : Prosthodontic Principles
Focuses on the design and fabrication of implantretained prostheses. The authors of this definitive textbook cover the full range of restorative treatment options for edentulous and partially edentulous situations, from relatively simple problems that can be handled by a solo practitioner to those with substantial prosthodontic complexities, periodontal compromise of existing dentition, and significant bone and soft tissue defects. Throughout, the authors emphasize the importance of an interdisciplinary approach and demonstrate how it encourages the best results, particularly when restoring partially edentulous patients.
Equilibrium statistical physics : Phases of matter and phase transitions
This is a textbook which gradually introduces the student to the statistical mechanical study of the different phases of matter and to the phase transitions between them. Throughout, only simple models of both ordinary and soft matter are used but these are studied in full detail. The subject is developed in a pedagogical manner, starting from the basics, going from the simple ideal systems to the interacting systems, and ending with the more modern topics. The latter include the renormalisation group approach to critical phenomena, the density functional theory of interfaces, the topological defects of nematic liquid crystals and the kinematic aspects of the phase transformation process. This textbook provides the student with a complete overview, intentionally at an introductory level, of the theory of phase transitions. References include suggestions for more detailed treatments and four appendices supply overviews of the mathematical tools employed in the text.
Endodontic Advances and Evidence-Based Clinical Guidelines : New perspectives and evidence–based clinical guidelines
Provides a comprehensive and up-to-date description of recent research findings and their impact on clinical practice. Using an innovative approach to the field, the book enables readers to translate the current body of knowledge on endodontic diseases and treatment into guidelines for enhancing patient care. Presents the latest understanding of current literature, evidence, and clinical practice Examines new trends, treatments, and advanced diagnostic techniques in the field Covers a wide range of topics, including management of root canals, repair of perforation defects, removal of root filling materials, and alternatives to root canal treatment
Echocardiography in Adult Congenital Heart Disease
This book provides the cardiologist with access to the considerable wealth of imaging data from Royal Brompton Hospital and National Heart and Lung Institute in London, UK. Consequently, the book contains numerous echocardiographic images to illustrate the appearances of rare defects and demonstrates areas for using non-invasive imaging to assess cardiac physiology in different disease.
Dilute III-V Nitride Semiconductors and Material Systems : Physics and Technology
A major current challenge for semiconductor devices is to develop materials for the next generation of optical communication systems and solar power conversion applications. Recently, extensive research has revealed that an introduction of only a few percentages of nitrogen into III-V semiconductor lattice leads to a dramatic reduction of the band gap. This discovery has opened the possibility of using these material systems for applications ranging from lasers to solar cells. Physics and Technology of Dilute III-V Nitride Semiconductors & Novel Dilute Nitride Material Systems reviews the current status of research and development in dilute III-V nitrides, with 24 chapters from prominent research groups covering recent progress in growth techniques, experimental characterization of band structure, defects carrier transport, transport properties, dynamic behavior of N atoms, device applications, modeling of device design, novel optoelectronic integrated circuits, and novel nitrogen containing III-V materials.
Diagnosis and treatment of furcation-involved teeth
Offers dental professionals a comprehensive review of the aetiology and diagnosis of furcation defects, including treatment options. Provides a practical manual for the successful diagnosis and treatment of a therapeutic challenge for general dentists and periodontists Presents illustrative photographs of clinical cases and procedures Offers a helpful chapter on patient-reported outcomes Includes a companion website with video clips and case studies
Dental implants and bone grafts : materials and biological issues
Provides detailed coverage of biomaterials for dental implants and bone graft, enabling scientists and clinicians to gain a thorough knowledge of advances and applications in this field. As tooth loss and alveolar bony defects are common and pose a significant health problem in dental clinics, this book deals with timely topics, including alveolar bone structures and pathological changes, reviews of indications and advantages of biomaterials for dental implants and bone graft, design and surface modification, biological interaction and biocompatibility of modern dental implants and bone graft, and new frontiers.This book is a highly valuable resource for scientists, clinicians and implantologists interested in biomaterial and regenerative strategies for alveolar bone reconstruction.
Defects of Secretion in Cystic Fibrosis
This book brings together physicians, physiologists, and other scientists involved in basic research, from molecular biology to drug design and introduces novel investigative and therapeutic aspects of secretion disorders relevant in cystic fibrosis and related diseases. This book will be of interest to Molecular biologists, physiologists, scientists working in pharmaceutical research and drug developement, physicians and researchers in Cystic fibrosis and related diseases.
Defects in High-k Gate Dielectric Stacks : Nano-Electronic Semiconductor Devices
One of the key obstacles to high-k integration into Si nano-technology are the electronic defects in high-k materials. It has been established that defects do exist in high-k dielectrics and they play an important role in device operation. However, very little is known about the nature of the defects or about possible techniques to eliminate, or at least minimize them. Given the absence of a feasible alternative in the near future, well-focused scientific research and aggressive development programs on high-k gate dielectrics and related devices must continue for semiconductor electronics to remain a competitive income producing force in the global market.
Defect-Oriented Testing for Nano-Metric CMOS VLSI Circuits
Failures of nano-metric technologies owing to defects and shrinking process tolerances give rise to significant challenges for IC testing. As the variation of fundamental parameters such as channel length, threshold voltage, thin oxide thickness and interconnect dimensions goes well beyond acceptable limits, new test methodologies and a deeper insight into the physics of defect-fault mappings are needed. In Defect-Oriented Testing for Nano-Metric CMOS VLSI Circuits state of the art of defect-oriented testing is presented from both a theoretical approach as well as from a practical point of view. Step-by-step handling of defect modeling, defect-oriented testing, yield modeling and its usage in common economics practices enables deeper understanding of concepts.
Defect and Material Mechanics ; Proceedings of the International Symposium on Defect and Material Mechanics (ISDMM), held in Aussois, France, March 25–29, 2007
This volume presents recent developments in the theory of defects and the mechanics of material forces. Most of the contributions were presented at the International Symposium on Defect and Material Forces (ISDMM2007), held in Aussois, France, March 25-29, 2007.
Craniofacial and dental developmental defects : Diagnosis and management
Provides the practitioner with a framework for establishing a diagnosis and developing a suitable treatment plan in patients presenting with a range of developmental defects of the teeth. The conditions covered include failure of tooth eruption, hypodontia, premature tooth exfoliation, defects of enamel development, and defects of dentin development, with full consideration of both syndromic and non-syndromic defects.
Constructing a consumer-focused industry : cracks, cladding and crisis in the residential construction sector
Through evidence-based research and international case studies, this book focuses on the effects that dangerous defects have on the housing consumer.
Concrete bridge strengthening and repair
Covering a wide range of structural elements and related defects, this collection of twenty concrete bridge strengthening and repair case studies showcases solutions to real problems encountered in the field and the processes by which those solutions were developed. Drawing on a lifetime of experience Atkins consultant Iain Kennedy Reid provides insight into methods of investigation and diagnosis of problems relating to beams, slabs, columns and panel walls, as well as how to apply demand-led research to these problems in a practical way.
Color Atlas of Congenital Heart Surgery
Color Atlas of Congenital Heart Surgery covers the full spectrum of congenital heart defects, first depicting the pathology in pre-repair photographs and then detailing step-by-step the operative procedure. Dr. Litwin depicts the most common procedures along with the most complex ones, providing a range of information vital to residents and fellows in training as well as clinicians in practice.
Mass Vaccination : Global Aspects - Progress and Obstacles
Mass immunization is the blitzkrieg of vaccination practice. It serves to rapidly protect populations, both because of the high coverage achieved and because of the herd immunity thereby induced. However, as in war, mass immunization campaigns must be conducted intelligently, with careful strategy and strong attention to logistics of supply and deployment. If conducted badly, mass immunization may fail or even be counter-productive. In this volume, some of the most successful practitioners of mass im- nization tell us about its art and science. David Heymann and Bruce Aylward of WHO begin the book with a theoretical and practical overview of mass immunization. Michael Lane, who participated in the successful effort to eradicate smallpox relates how this was done using mass vaccination and other strategies. Application of mass immunization by the US military is c- ered by John Grabenstein and Remington Nevin, who have a large experience in these matters. Karen Noakes and David Salisbury recount the striking s- cesses of mass immunization in the United Kingdom. The global control of the clostridia that produce diphtheria toxin is described by Charles Vitek. Hepa- tis A is decreasing dramatically under the impact of large-scale vaccination, as Francis André illustrates. The French experience with Hepatitis B vac- nation has been mixed, and François Denis and Daniel Levy-Bruhl explain the circumstances. In?uenza vaccination is an annual example of large-scale campaigns, the complexity of which is recounted by Benjamin Schwartz and Pascale Wortley.
Maintenance of brick and stone masonry structures
Deals with all the tasks related to brick and stone masonry structures, from the initial identification of defects and their diagnosis to their treatment and monitoring of its cost-effectiveness.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lifetime Spectroscopy : A Method of Defect Characterization in Silicon for Photovoltaic Applications
Lifetime spectroscopy is one of the most sensitive diagnostic tools for the identification and analysis of impurities in semiconductors. Since it is based on the recombination process, it provides insight into precisely those defects that are relevant to semiconductor devices such as solar cells. This book introduces a transparent modeling procedure that allows a detailed theoretical evaluation of the spectroscopic potential of the different lifetime spectroscopic techniques. The various theoretical predictions are verified experimentally with the context of a comprehensive study on different metal impurities. The quality and consistency of the spectroscopic results, as explained here, confirms the excellent performance of lifetime spectroscopy.
