الصفحة 2
الصفحة 2
Neurodevelopmental Disorders
The book comprises a number of topics related to psychosocial and motor development and is exemplary with regard to its comprehensiveness, as reviews of the topics presented are generally not available in a single publication. It starts with a timely and critical discussion of the genetics of attention deficit hyperactivity disorder by Dr. Buitelaar in which prospects and challenges of this approach are outlined. The next chapter by Drs. Nicolson and Fawcett deals with dyslexia and its relationship to cerebellar function providing a framework that can explain motor, speed, and phonological deficits in a unified approach. Diagnostic and treatment aspects of speech development disorders are the focus of Dr. Zorowka’s contribution in which, among other issues, the necessity of mul- professional cooperation is stressed. Dr. Sigmundsson then focuses on disorders of motor development. 6-10 % of children have motor competence well below the norm, which often persist.
Network and Parallel Computing ; IFIP International Conference, NPC 2007, Dalian, China, September 18-21, 2007, Proceedings
The goal of NPC is to establish an international forum for researchers and practitioners to present their - cellent ideas and experiences in all system fields of network and parallel computing. The main focus of NPC 2007 was on the most critical areas of network and parallel computing: network applications, network technologies, network and parallel arc- tectures, and parallel and distributed software.
Neonatal Immunity
New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
Neo-Liberalism, Globalization and Human Capital Learning : Reclaiming Education for Democratic Citizenship
Throughout the world, neoliberalism functions to decouple learning from the most important elements of civic education, transforming education into training and students into consumers. Neoliberalism, Globalization, and Human Capital Learning is an enormously important book that reveals in painstaking detail how neoliberal ideology destroys critical education. But it does much more. It also provides the insights and tools for educators to both overcome the market-based attack on critical education and address schooling as a democratic public sphere and the classroom as a laboratory for the nurturing of critical agency and social responsibility. This dynamic book should stir a public outcry among concerned citizens and educators through out the globe.
Nb3Sn Accelerator Magnets : Designs, Technologies and Performance
This book is written by world-recognized experts in the fields of applied superconductivity and superconducting accelerator magnet technologies. It provides a contemporary review and assessment of the experience in research and development of high-field accelerator dipole magnets based on Nb3Sn superconductor over the past five decades. The reader attains clear insight into the development and the main properties of Nb3Sn composite superconducting wires and Rutherford cables, and details of accelerator dipole designs, technologies and performance. Special attention is given to innovative features of the developed Nb3Sn magnets. The book concludes with a discussion of accelerator magnet needs for future circular colliders.
Nanostructured Materials by High-Pressure Severe Plastic Deformation
Recently, it was reported that nanostructured materials processed under high pressure by HPT and ECAP have an extraordinary combination of both high strength and high ductility, which are two desirable, but rarely co-existing properties. These findings indicate that high-pressure is a critical factor that can be employed to process nanostructured materials with superior mechanical, and possibly also physical, properties. It is the objective of this workshop to review our current knowledge, identify issues for future research, and discuss future directions on the processing and properties of nanostructured materials via SPD techniques, with a special emphasis on high-pressure effects.
Nanomechanics of Materials and Structures
This book is derived from the proceedings of the International Workshop on Nanomechanics held at Asilomar Conference Grounds in Pacific Grove, California on July 14-17, 2004. The main objective was to convene leading researchers in the nanotechnology community to assess the current state-of-the-art and disseminate recent progress, critical issues, barriers to applications, and directions for future research in nanomechanics.
Nanoinformatics
Brings out the state of the art on how informatics-based tools are used and expected to be used in nanomaterials research. There has been great progress in the area in which “big-data” generated by experiments or computations are fully utilized to accelerate discovery of new materials, key factors, and design rules. Data-intensive approaches play indispensable roles in advanced materials characterization. "Materials informatics" is the central paradigm in the new trend. "Nanoinformatics" is its essential subset, which focuses on nanostructures of materials such as surfaces, interfaces, dopants, and point defects, playing a critical role in determining materials properties. There have been significant advances in experimental and computational techniques to characterize individual atoms in nanostructures and to gain quantitative information. The collaboration of researchers in materials science and information science is growing actively and is creating a new trend in materials science and engineering.
Myosins : A Superfamily of Molecular Motors
Application of state-of-the-art cellular and molecular biological, structural biological, genetic, biochemical and biophysical techniques has provided and continues to provide critical information regarding the structure–function relationship; and the cellular roles of various myosins in organisms as diverse as protozoa, yeast, plants and higher animals. The association of myosins with diseases including neurological disorders, immu- deficiencies, cardiomyopathies, hearing and vision loss testify to the importance of understanding the biochemical properties and cellular roles of myosins. The 16 chapters in this volume summarize the tremendous progress made in studying members of the myosin superfamily in recent years and offer critical insight into what future research will yield.
Multiple Bonds between Metal Atoms
The 3rd edition of the Multiple Bonds between Metal Atoms deals with one of the most active fields of inorganic chemistry … . It presents an extensive, critical review and discussion of preparations, reactions, bonding, and physical properties of more than 4000 compounds … heartily recommend it to inorganic and materials chemists, and to all scientists concerned with the synthesis, spectroscopy, and structures of transition-metal compounds. It also belongs in academic, industrial, and government research libraries.
Multimodality in architecture : Collaboration, technology and education
Examines multimodality in architecture and its impacts on collaborative, technical and educational processes or systems. Multimodality is becoming increasingly critical in contemporary architectural practice and education. Creative design teams face new challenges when they embrace new modes of communication, technology, and knowledge development processes. From diverse online modes of communication to shared digital environments, generative AI and advanced hardware solutions, new modes of information creation, sharing, and application are changing the ways architects and designers work. The book presents new research which empowers international researchers and designers to work more effectively in a diverse range of digital environments. Whether the readers are architects, teachers, students, or scholars, this book provides critical insights and practical tools for understanding and optimising processes in architecture and design.
Multidetector-Row CT of the Thorax
With the advent of multidetector-row technology, excitement has returned to computed tomography. Not only can we now image faster and with better resolution than ever before; more importantly, the development of sophisticated image acquisition techniques has enabled us to venture into areas previously considered to be beyond the scope of CT imaging. The knowledge, experience, and vision of a host of renowned international experts in cutting-edge thoracic applications of multidetector-row CT are condensed within this book. The result is a critical, comprehensive review of the novel opportunities, but also the new challenges, brought about by the development of ever-faster CT acquisition techniques.
Multi-Agent and Multi-Agent-Based Simulation ; Joint Workshop MABS 2004
The aim of the workshop was to provide a forum for work in both appli- tions of multi-agent-based simulation and the technical challenges of simulating large multi-agent systems (MAS). There has been considerable recent progress in modelling and analyzing multi-agent systems, and in techniques that apply MAS models to complex real-world systems such as social systems and organi- tions. Simulation is an increasingly important strand that weaves together this work. In high-risk, high-cost situations, simulations provide critical cost/benefit leverage, and make possible explorations that cannot be carried out in situ: – Multi-agent approaches to simulating complex systems are keytools in interdisciplinary studies of social systems. Agent-based social simulation (ABSS) research simulates and synthesizes social behavior in order to understand real social systems with properties of self-organization, scalability, robustness, and openness. – In the MAS community, simulation has been applied to awide range of MAS research and design problems, from models of complex individual agents - ploying sophisticated internal mechanisms to models of large-scale societies of relatively simple agents which focus more on the interactions between agents.
Moving Millions : Transport Strategies for Sustainable Development in Megacities
The Alliance for Global Sustainability is an international partnership among four of the leading scienti?c and technological universities worldwide: • The Massachusetts Institute of Technology (MIT-AGS); • The University of Tokyo (UT); • The Swiss Federal Institute of Technology (ETH); and • The Chalmers University of Technology. Created in 1997, the AGS today brings together hundreds of university scientists, engineers, and social scientists to address complex issues that lie at the intersection of environmental, economic, and social policy goals. Since its inception, the AGS has promoted and supported multidisciplinary research teams drawn from its partner institutions. Working on critical issues in sustainability across several ?elds encompassing energy and climate, mobility, urban systems, water and agriculture, cleaner technologies, public policy, and communications, these teams have developed a signi?cant body of new knowledge.
Molecular Mechanisms of Synaptogenesis
Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders. In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.
Molecular Mechanisms of Parasite Invasion
All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Molecular Gas Dynamics : Theory, Techniques, and Applications
This self-contained work is an up-to-date treatment of the basic theory of molecular gas dynamics and its various applications. Recent progress in the field has greatly enhanced the original theory and stimulated interesting and critical gas dynamic phenomena and problems. This book, unique in the literature, presents working knowledge, theory, techniques, and typical phenomena in rarefied gases for theoretical development and applications.
Molecular Biology of the Parathyroid
Caintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Molecular Biology of Human Cancers: An Advanced Student's Textbook
Presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Modern Mathematics Education for Engineering Curricula in Europe : A Comparative Analysis of EU, Russia, Georgia and Armenia
Provides a comprehensive overview of the core subjects comprising mathematical curricula for engineering studies in five European countries and identifies differences between two strong traditions of teaching mathematics to engineers. The collective work of experts from a dozen universities critically examines various aspects of higher mathematical education.
